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354 results

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Page 1
Epicardium in Heart Development.
Cao Y, Duca S, Cao J. Cao Y, et al. Cold Spring Harb Perspect Biol. 2020 Feb 3;12(2):a037192. doi: 10.1101/cshperspect.a037192. Cold Spring Harb Perspect Biol. 2020. PMID: 31451510 Free PMC article. Review.
The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regeneration and has been implicated in potential strategies for cardiac repair. The heterogenous cell population that composes the epicardium …
The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regen …
Epicardium and Coronary Vessels.
Ruiz-Villalba A, Guadix JA, Pérez-Pomares JM. Ruiz-Villalba A, et al. Adv Exp Med Biol. 2024;1441:155-166. doi: 10.1007/978-3-031-44087-8_8. Adv Exp Med Biol. 2024. PMID: 38884710 Review.
The aim of this chapter is to provide a succint account of the key elements of coronary blood vessel development, especially in the context of the role played by the epicardium and epicardial cellular derivatives. We will discuss the importance of the epicardium in …
The aim of this chapter is to provide a succint account of the key elements of coronary blood vessel development, especially in the context …
The epicardium as a hub for heart regeneration.
Cao J, Poss KD. Cao J, et al. Nat Rev Cardiol. 2018 Oct;15(10):631-647. doi: 10.1038/s41569-018-0046-4. Nat Rev Cardiol. 2018. PMID: 29950578 Free PMC article. Review.
The epicardium is essential for muscle regeneration in the zebrafish model of innate heart regeneration, and the epicardium also participates in fibrotic responses in mammalian hearts. ...In this Review, we describe recent advances in our understanding of the biolog …
The epicardium is essential for muscle regeneration in the zebrafish model of innate heart regeneration, and the epicardium al …
Epicardium-myocardium crosstalk orchestrates heart development.
Nusrat A, Wu M. Nusrat A, et al. Front Cell Dev Biol. 2025 Sep 24;13:1655878. doi: 10.3389/fcell.2025.1655878. eCollection 2025. Front Cell Dev Biol. 2025. PMID: 41070347 Free PMC article. Review.
The epicardium is critical in heart development, functioning as a paracrine signaling hub and a source of progenitor cells. ...This review presents a comprehensive overview of epicardium-myocardium crosstalk across species, emphasizing how this crosstalk influences …
The epicardium is critical in heart development, functioning as a paracrine signaling hub and a source of progenitor cells. ...This r …
The Role of the Epicardium During Heart Development and Repair.
Quijada P, Trembley MA, Small EM. Quijada P, et al. Circ Res. 2020 Jan 31;126(3):377-394. doi: 10.1161/CIRCRESAHA.119.315857. Epub 2020 Jan 30. Circ Res. 2020. PMID: 31999538 Free PMC article. Review.
Although the epicardium becomes dormant after birth, cardiac injury reactivates developmental gene programs that stimulate epithelial-to-mesenchymal transition; however, it is not clear how the epicardium contributes to disease progression or repair in the adult. In …
Although the epicardium becomes dormant after birth, cardiac injury reactivates developmental gene programs that stimulate epithelial …
Epicardium-derived fibroblasts in heart development and disease.
Fang M, Xiang FL, Braitsch CM, Yutzey KE. Fang M, et al. J Mol Cell Cardiol. 2016 Feb;91:23-7. doi: 10.1016/j.yjmcc.2015.12.019. Epub 2015 Dec 22. J Mol Cell Cardiol. 2016. PMID: 26718723 Free PMC article. Review.
The majority of cardiac fibroblasts in a mature mammalian heart are derived from the epicardium during prenatal development and reactivate developmental programs during the progression of fibrotic disease. ...Here we review cellular and molecular mechanisms that control …
The majority of cardiac fibroblasts in a mature mammalian heart are derived from the epicardium during prenatal development and react …
Myocardial regeneration: role of epicardium and implicated genes.
Saifi O, Ghandour B, Jaalouk D, Refaat M, Mahfouz R. Saifi O, et al. Mol Biol Rep. 2019 Dec;46(6):6661-6674. doi: 10.1007/s11033-019-05075-0. Epub 2019 Sep 23. Mol Biol Rep. 2019. PMID: 31549371 Review.
Studies investigated the underlying mechanism of myocardial regeneration in species capable to do so, to see its applicability on mammals. The epicardium, the mesothelial outer layer of the vertebrate heart, has proven to play an important role in the process of repair and …
Studies investigated the underlying mechanism of myocardial regeneration in species capable to do so, to see its applicability on mammals. T …
The epicardium as a candidate for heart regeneration.
Smart N, Riley PR. Smart N, et al. Future Cardiol. 2012 Jan;8(1):53-69. doi: 10.2217/fca.11.87. Future Cardiol. 2012. PMID: 22185446 Free PMC article. Review.
There is an urgent need, therefore, to develop novel therapies for myocardial and coronary vascular regeneration. The epicardium-derived cells present a tractable resident progenitor source with the potential to stimulate neovasculogenesis and contribute de novo cardiomyoc …
There is an urgent need, therefore, to develop novel therapies for myocardial and coronary vascular regeneration. The epicardium-deri …
The epicardium as a source of multipotent adult cardiac progenitor cells: Their origin, role and fate.
Smits AM, Dronkers E, Goumans MJ. Smits AM, et al. Pharmacol Res. 2018 Jan;127:129-140. doi: 10.1016/j.phrs.2017.07.020. Epub 2017 Jul 24. Pharmacol Res. 2018. PMID: 28751220 Free article. Review.
In the adult heart, injury activates the epicardium, and an embryonic-like response is observed which includes EMT and differentiation of the EPDCs into cardiac cell types. Furthermore, paracrine communication between the epicardium and myocardium improves the regen …
In the adult heart, injury activates the epicardium, and an embryonic-like response is observed which includes EMT and differentiatio …
Epicardium-derived cells in cardiogenesis and cardiac regeneration.
Winter EM, Gittenberger-de Groot AC. Winter EM, et al. Cell Mol Life Sci. 2007 Mar;64(6):692-703. doi: 10.1007/s00018-007-6522-3. Cell Mol Life Sci. 2007. PMID: 17380310 Free PMC article. Review.
During cardiogenesis, the epicardium grows from the proepicardial organ to form the outermost layer of the early heart. Part of the epicardium undergoes epithelial-mesenchymal transformation, and migrates into the myocardium. ...
During cardiogenesis, the epicardium grows from the proepicardial organ to form the outermost layer of the early heart. Part of the …
354 results