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Quoted phrase not found in phrase index: "steoroids"
Page 1
In vitro and in vivo endocrine disrupting effects of the azole fungicides triticonazole and flusilazole.
Draskau MK, Boberg J, Taxvig C, Pedersen M, Frandsen HL, Christiansen S, Svingen T. Draskau MK, et al. Environ Pollut. 2019 Dec;255(Pt 2):113309. doi: 10.1016/j.envpol.2019.113309. Epub 2019 Oct 3. Environ Pollut. 2019. PMID: 31610510
However, apart from their desired antifungal properties, several azoles also exhibit endocrine disrupting properties in mammals, both in vitro and in vivo. Here, we have tested two currently used agricultural azole fungicides, triticonazole and flusilazole, for thei …
However, apart from their desired antifungal properties, several azoles also exhibit endocrine disrupting properties in mammals, both …
Association between Environmental Exposure to Multiclass Organic Pollutants and Sex Steroid Hormone Levels in Women of Reproductive Age.
Peng FJ, Palazzi P, Mezzache S, Adelin E, Bourokba N, Bastien P, Appenzeller BMR. Peng FJ, et al. Environ Sci Technol. 2023 Dec 5;57(48):19383-19394. doi: 10.1021/acs.est.3c06095. Epub 2023 Nov 7. Environ Sci Technol. 2023. PMID: 37934613
Associations with nine sex steroid hormones, including progesterone, androstenedione (AD), testosterone (T), estrone (E1), and 17beta-estradiol (E2), and eight related hormone ratios were explored on 54 pollutants from polychlorinated biphenyl (PCB), p …
Associations with nine sex steroid hormones, including progesterone, androstenedione (AD), testosterone (T), estrone (E1), and …
Transcriptome analysis of fetal rat testis following intrauterine exposure to the azole fungicides triticonazole and flusilazole reveals subtle changes despite adverse endocrine effects.
Draskau MK, Lardenois A, Evrard B, Boberg J, Chalmel F, Svingen T. Draskau MK, et al. Chemosphere. 2021 Feb;264(Pt 1):128468. doi: 10.1016/j.chemosphere.2020.128468. Epub 2020 Oct 1. Chemosphere. 2021. PMID: 33032228 Free article.
Azoles are used in agriculture and medicine to combat fungal infections. We have previously examined the endocrine disrupting properties of the agricultural azole fungicides triticonazole and flusilazole. ...This suggests that the observed influence of flusilazol …
Azoles are used in agriculture and medicine to combat fungal infections. We have previously examined the endocrine disrupting propert …
Conazole fungicides inhibit Leydig cell testosterone secretion and androgen receptor activation in vitro.
Roelofs MJE, Temming AR, Piersma AH, van den Berg M, van Duursen MBM. Roelofs MJE, et al. Toxicol Rep. 2014 May 22;1:271-283. doi: 10.1016/j.toxrep.2014.05.006. eCollection 2014. Toxicol Rep. 2014. PMID: 28962244 Free PMC article.
Conazole fungicides are widely used in agriculture despite their suspected endocrine disrupting properties. In this study, the potential (anti-)androgenic effects of ten conazoles were assessed and mutually compared with existing data. Effects of cyproconazole (CYPR …
Conazole fungicides are widely used in agriculture despite their suspected endocrine disrupting properties. In this study, the potent …
Mechanism of inhibition of estrogen biosynthesis by azole fungicides.
Egbuta C, Lo J, Ghosh D. Egbuta C, et al. Endocrinology. 2014 Dec;155(12):4622-8. doi: 10.1210/en.2014-1561. Epub 2014 Sep 22. Endocrinology. 2014. PMID: 25243857 Free PMC article.
Biosynthesis of estrogens from androgens is catalyzed by cytochrome P450 aromatase. Aromatase inhibition by the triazole compounds letrozole (LTZ) and anastrozole is a prevalent therapy for estrogen-dependent postmenopausal breast cancer. ...We have ev …
Biosynthesis of estrogens from androgens is catalyzed by cytochrome P450 aromatase. Aromatase inhibition by the triazole compo …
Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach.
Fragki S, Hoogenveen R, van Oostrom C, Schwillens P, Piersma AH, Zeilmaker MJ. Fragki S, et al. Toxicology. 2022 Jan 15;465:153060. doi: 10.1016/j.tox.2021.153060. Epub 2021 Dec 4. Toxicology. 2022. PMID: 34871708
For developmental toxicity this requires scaling the in vitro observed dose-response characteristics to in vivo fetal exposure, while integrating maternal in vivo kinetics during pregnancy, in particular transplacental transfer. Here the transfer of substances across the p …
For developmental toxicity this requires scaling the in vitro observed dose-response characteristics to in vivo fetal exposure, while integr …
Developmental toxic effects of antifungal flusilazole administered by gavage to mice.
Farag AT, Ibrahim HH. Farag AT, et al. Birth Defects Res B Dev Reprod Toxicol. 2007 Feb;80(1):12-7. doi: 10.1002/bdrb.20098. Birth Defects Res B Dev Reprod Toxicol. 2007. PMID: 17187383
BACKGROUND: The developmental toxicity of flusilazole was studied in CD-1 mice after oral administration. METHODS: Pregnant mice were given flusilazole at doses of 0 (corn oil), 10, 20, and 40 mg/kg/day, by gavage, on gestational days (GD) 6-15. ...
BACKGROUND: The developmental toxicity of flusilazole was studied in CD-1 mice after oral administration. METHODS: Pregnant mice were …
Current perspectives on the use of alternative species in human health and ecological hazard assessments.
Perkins EJ, Ankley GT, Crofton KM, Garcia-Reyero N, LaLone CA, Johnson MS, Tietge JE, Villeneuve DL. Perkins EJ, et al. Environ Health Perspect. 2013 Sep;121(9):1002-10. doi: 10.1289/ehp.1306638. Epub 2013 Jun 14. Environ Health Perspect. 2013. PMID: 23771518 Free PMC article. Review.
METHODS: We reviewed and compared data derived from high throughput in vitro assays to fish reproductive tests for seven chemicals. We investigated whether human-focused assays can be predictive of chemical hazards in the environment. ...RESULTS: We examined how dose-depen …
METHODS: We reviewed and compared data derived from high throughput in vitro assays to fish reproductive tests for seven chemicals. W …
New insights into triazole fungicide-caused hematopoietic abnormality in zebrafish based on GRα screening developmental toxicity.
Wang Y, Ren L, Ren Y, Chai M, Ning X, Li G, Sang N. Wang Y, et al. Environ Pollut. 2023 Oct 1;334:122182. doi: 10.1016/j.envpol.2023.122182. Epub 2023 Jul 11. Environ Pollut. 2023. PMID: 37442323
To address this gap, we first used a glucocorticoid receptor alpha (GRalpha)-mediated dual luciferase reporter gene system to explore the possible development toxicity of ten TFs and found that flusilazole (FLU) exhibited stronger agonistic activity against GRalpha. …
To address this gap, we first used a glucocorticoid receptor alpha (GRalpha)-mediated dual luciferase reporter gene system to explore …
Probabilistic dietary risk assessment of triazole and dithiocarbamate fungicides for the Brazilian population.
Jardim ANO, Mello DC, Brito AP, van der Voet H, Boon PE, Caldas ED. Jardim ANO, et al. Food Chem Toxicol. 2018 Aug;118:317-327. doi: 10.1016/j.fct.2018.05.002. Epub 2018 May 5. Food Chem Toxicol. 2018. PMID: 29733884
About 16% of the samples contained TR, mainly grape (53.5%), and 16.2% contained DT, mainly apple (59.3%). Flusilazole was the index compound used for the acute effects of TR for women of child-bearing-age (cranium-facial malformation and skeletal variation), cyproconazole …
About 16% of the samples contained TR, mainly grape (53.5%), and 16.2% contained DT, mainly apple (59.3%). Flusilazole was the index …
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