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Year Number of Results
1947 1
1970 2
1971 4
1972 5
1973 1
1974 1
1975 1
1976 4
1977 1
1979 1
1980 3
1981 5
1982 8
1983 6
1984 25
1985 37
1986 35
1987 41
1988 45
1989 62
1990 148
1991 167
1992 260
1993 413
1994 712
1995 1045
1996 1199
1997 1397
1998 1646
1999 1938
2000 2491
2001 2385
2002 2438
2003 2439
2004 2403
2005 2588
2006 2446
2007 2335
2008 2325
2009 2226
2010 2310
2011 2491
2012 2486
2013 2535
2014 2820
2015 2933
2016 3026
2017 3093
2018 3211
2019 3339
2020 3759
2021 4376
2022 4195
2023 4476
2024 4503
2025 38

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76,141 results

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Page 1
Various AAV Serotypes and Their Applications in Gene Therapy: An Overview.
Issa SS, Shaimardanova AA, Solovyeva VV, Rizvanov AA. Issa SS, et al. Cells. 2023 Mar 1;12(5):785. doi: 10.3390/cells12050785. Cells. 2023. PMID: 36899921 Free PMC article. Review.
Advances in genetic engineering methods have enabled the development of effective gene therapy methods for various diseases based on adeno-associated viruses (AAVs). Today, many AAV-based gene therapy medications are being investigated in preclinical a …
Advances in genetic engineering methods have enabled the development of effective gene therapy methods for various diseases ba …
Gene therapy: a double-edged sword with great powers.
Tang R, Xu Z. Tang R, et al. Mol Cell Biochem. 2020 Nov;474(1-2):73-81. doi: 10.1007/s11010-020-03834-3. Epub 2020 Jul 21. Mol Cell Biochem. 2020. PMID: 32696132 Review.
However, concerns about its efficacy and safety have accompanied gene therapy since its birth. In the present manuscript, we first introduce various strategies employed in gene therapy, which includes ex vivo gene delivery v.s. in vivo gene delivery; g …
However, concerns about its efficacy and safety have accompanied gene therapy since its birth. In the present manuscript, we f …
Gene therapy in cancer.
Cesur-Ergün B, Demir-Dora D. Cesur-Ergün B, et al. J Gene Med. 2023 Nov;25(11):e3550. doi: 10.1002/jgm.3550. Epub 2023 Jun 24. J Gene Med. 2023. PMID: 37354071 Review.
This treatment has various strategies such as therapeutic gene activation or silencing of unwanted or defective genes; therefore a wide variety of genes and viral or nonviral vectors are being used in studies. Gene therapy strategies in cancer can be classified as i …
This treatment has various strategies such as therapeutic gene activation or silencing of unwanted or defective genes; therefore a wide vari …
Advances in gene therapy hold promise for treating hereditary hearing loss.
Jiang L, Wang D, He Y, Shu Y. Jiang L, et al. Mol Ther. 2023 Apr 5;31(4):934-950. doi: 10.1016/j.ymthe.2023.02.001. Epub 2023 Feb 8. Mol Ther. 2023. PMID: 36755494 Free PMC article. Review.
Therefore, in order to further advance the development of inner ear gene therapy and promote its broad application in other forms of genetic disease, it is imperative to review the progress of gene therapy for HHL. ...Finally, we elaborate on the chall …
Therefore, in order to further advance the development of inner ear gene therapy and promote its broad application in other fo …
Gene therapy clinical trials, where do we go? An overview.
Arabi F, Mansouri V, Ahmadbeigi N. Arabi F, et al. Biomed Pharmacother. 2022 Sep;153:113324. doi: 10.1016/j.biopha.2022.113324. Epub 2022 Jun 29. Biomed Pharmacother. 2022. PMID: 35779421 Free article. Review.
There have been many ups and downs since the introduction of gene therapy as a therapeutic modality for diseases. However, the journey of gene therapy has reached a fundamental milestone, as evidenced by the increasing number of gene therapy …
There have been many ups and downs since the introduction of gene therapy as a therapeutic modality for diseases. However, the …
Gene therapy for heart failure and cardiomyopathies.
Argirò A, Ding J, Adler E. Argirò A, et al. Rev Esp Cardiol (Engl Ed). 2023 Dec;76(12):1042-1054. doi: 10.1016/j.rec.2023.06.009. Epub 2023 Jul 26. Rev Esp Cardiol (Engl Ed). 2023. PMID: 37506969 Free article. Review. English, Spanish.
Gene therapy strategies encompass a range of approaches, including gene replacement and gene editing. ...This review aims to summarize the mechanisms behind different gene therapy strategies, the available delivery systems, the primary risks associated …
Gene therapy strategies encompass a range of approaches, including gene replacement and gene editing. ...This review aims to s …
Applications of Gene Therapy in Cardiomyopathies.
Argiro A, Bui Q, Hong KN, Ammirati E, Olivotto I, Adler E. Argiro A, et al. JACC Heart Fail. 2024 Feb;12(2):248-260. doi: 10.1016/j.jchf.2023.09.015. Epub 2023 Oct 7. JACC Heart Fail. 2024. PMID: 37966402 Review.
Notably, gene therapy for Duchenne muscular dystrophy has recently been approved and pivotal clinical trials are testing gene therapy approaches in rare myocardial conditions such as Danon disease and Fabry disease. Furthermore, promising results have …
Notably, gene therapy for Duchenne muscular dystrophy has recently been approved and pivotal clinical trials are testing ge …
Gene Therapy for Parkinson's Disease, An Update.
Axelsen TM, Woldbye DPD. Axelsen TM, et al. J Parkinsons Dis. 2018;8(2):195-215. doi: 10.3233/JPD-181331. J Parkinsons Dis. 2018. PMID: 29710735 Free PMC article. Review.
The current mainstay treatment of Parkinson's disease (PD) consists of dopamine replacement therapy which, in addition to causing several side effects, does not delay disease progression. The field of gene therapy offers a potential means to improve current therapy. …
The current mainstay treatment of Parkinson's disease (PD) consists of dopamine replacement therapy which, in addition to causing several si …
Gene therapy in epilepsy.
Zhang L, Wang Y. Zhang L, et al. Biomed Pharmacother. 2021 Nov;143:112075. doi: 10.1016/j.biopha.2021.112075. Epub 2021 Sep 3. Biomed Pharmacother. 2021. PMID: 34488082 Free article. Review.
Gene therapy may constitute a promising alternative to conventional pharmacological tools and surgeries for epilepsy. ...Creating gene vectors tailored for different situations is the key to expanding gene therapy, and choosing the appropriate therapeu …
Gene therapy may constitute a promising alternative to conventional pharmacological tools and surgeries for epilepsy. ...Creat …
Gene therapy vector-related myocarditis.
Silver E, Argiro A, Hong K, Adler E. Silver E, et al. Int J Cardiol. 2024 Mar 1;398:131617. doi: 10.1016/j.ijcard.2023.131617. Epub 2023 Nov 27. Int J Cardiol. 2024. PMID: 38030043 Free article. Review.
Gene therapy is a technique to correct genetic abnormalities, through introduction of a functional gene or through direct genome editing. ...This review explores the immunological reactions to AAV-based gene therapy, their potential toxic effects, with …
Gene therapy is a technique to correct genetic abnormalities, through introduction of a functional gene or through direct geno …
76,141 results
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