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645 results

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Page 1
Glycitein: A comprehensive review of its bioactivities, molecular mechanisms, and therapeutic potential.
Wang MM, Liu T, Gan JY, Xu CQ, Zhong YL, Cao YB, Chen J. Wang MM, et al. Phytomedicine. 2025 Nov 25;148:157430. doi: 10.1016/j.phymed.2025.157430. Epub 2025 Oct 21. Phytomedicine. 2025. PMID: 41161188
BACKGROUND: Glycitein, a distinct soy isoflavone with a unique 6-methoxy substitution, possesses significant antioxidant capacity and ROS scavenging abilities, making it a focus in nutritional and pharmacological research. PURPOSE: This review synthesizes recent advancemen …
BACKGROUND: Glycitein, a distinct soy isoflavone with a unique 6-methoxy substitution, possesses significant antioxidant capacity and …
Isoflavones.
Křížová L, Dadáková K, Kašparovská J, Kašparovský T. Křížová L, et al. Molecules. 2019 Mar 19;24(6):1076. doi: 10.3390/molecules24061076. Molecules. 2019. PMID: 30893792 Free PMC article. Review.
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis.
Ma F, Li Z, Liu H, Chen S, Zheng S, Zhu J, Shi H, Ye H, Qiu Z, Gao L, Han B, Yang Q, Wang X, Zhang Y, Cheng L, Fan H, Lv S, Zhao X, Zhou H, Li J, Hong M. Ma F, et al. Cell Metab. 2024 Nov 5;36(11):2367-2382.e5. doi: 10.1016/j.cmet.2024.08.007. Epub 2024 Sep 10. Cell Metab. 2024. PMID: 39260371 Free article.
Specifically, we discovered that Parabacteroides distasonis (P. distasonis) uses beta-glucosidase (beta-GC) to release glycitein (GLY) from the diet in response to daily nutritional cues, influencing RA inflammatory rhythms dependent on the sirtuin 5-nuclear factor-kappaB …
Specifically, we discovered that Parabacteroides distasonis (P. distasonis) uses beta-glucosidase (beta-GC) to release glycitein (GLY …
A balance between glycitein and glyceollins governed by isoflavone 6-hydroxylase confers soybean resistance to Phytophthora sojae.
Yang Q, Wang Y, Xu X, Yuan J, Zhang F, Qin H, Li S, Li J, Lin H, Li L, Tian Z, Wang G. Yang Q, et al. Proc Natl Acad Sci U S A. 2025 Dec 16;122(50):e2525627122. doi: 10.1073/pnas.2525627122. Epub 2025 Dec 11. Proc Natl Acad Sci U S A. 2025. PMID: 41380000 Free PMC article.
A single amino acid substitution in GmIF6H1 accounts for the domestication-associated reduction of glycitein-type isoflavonoids. Upon Phytophthora sojae infection, (malonyl)glycitins undergo sustained deglycosylation to release glycitein aglycone, underscoring its d …
A single amino acid substitution in GmIF6H1 accounts for the domestication-associated reduction of glycitein-type isoflavonoids. Upon …
Glycitein prevents reserpine-induced depression and associated comorbidities in mice: modulation of lipid peroxidation and TNF-alpha levels.
Diksha, Singh L. Diksha, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug;397(8):6153-6163. doi: 10.1007/s00210-024-03007-9. Epub 2024 Mar 2. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38430231
Therefore, the current study was designed to explore the potential of glycitein, an isoflavone in managing reserpine-induced depression and associated comorbidities in mice. ...Whereas, no significant effect was seen on the brain GSH level. Glycitein (6 mg/kg) was f …
Therefore, the current study was designed to explore the potential of glycitein, an isoflavone in managing reserpine-induced depressi …
Glycitein exerts neuroprotective effects in Rotenone-triggered oxidative stress and apoptotic cell death in the cellular model of Parkinson's disease.
Dong N, Yang Z. Dong N, et al. Acta Biochim Pol. 2022 Jun 12;69(2):447-452. doi: 10.18388/abp.2020_5963. Acta Biochim Pol. 2022. PMID: 35691030 Free article.
Additionally, it was found that the increased ROS levels triggered by rotenone in human SK-N-SH neuroblastoma cells were significantly (P<0.05) diminished upon glycitein treatment. Glycitein treatment also restored the mitochondrial membrane potential of the rote …
Additionally, it was found that the increased ROS levels triggered by rotenone in human SK-N-SH neuroblastoma cells were significantly (P< …
Glycitein in Zhi-Zi-Chi decoction alleviates anxiety via inosine enrichment mediated by Akkermansia muciniphila to regulate MT3-Sema7a interaction.
Yang Q, Huo J, Peng R, Qiu S, Li P, Wei W, Zhou J, Tang Q, Wang W. Yang Q, et al. Phytomedicine. 2026 Jan;150:157622. doi: 10.1016/j.phymed.2025.157622. Epub 2025 Nov 29. Phytomedicine. 2026. PMID: 41351979
Further, -a major isoflavone in ZZCD-was confirmed as a key anxiolytic compound, acting by promoting inosine production from A. muciniphila and regulating Metallothionein3-Sema7a protein interaction in the hippocampus. CONCLUSION: Glycitein in ZZCD exerts anxiolytic effect …
Further, -a major isoflavone in ZZCD-was confirmed as a key anxiolytic compound, acting by promoting inosine production from A. muciniphila …
Glycitein induces reactive oxygen species-dependent apoptosis and G0/G1 cell cycle arrest through the MAPK/STAT3/NF-kappaB pathway in human gastric cancer cells.
Zang YQ, Feng YY, Luo YH, Zhai YQ, Ju XY, Feng YC, Wang JR, Yu CQ, Jin CH. Zang YQ, et al. Drug Dev Res. 2019 Aug;80(5):573-584. doi: 10.1002/ddr.21534. Epub 2019 Mar 27. Drug Dev Res. 2019. PMID: 30916421
Glycitein is an isoflavone that reportedly inhibits the proliferation of human breast cancer and prostate cancer cells. ...Thus, glycitein has the potential to a novel targeted therapeutic agent for human gastric cancer....
Glycitein is an isoflavone that reportedly inhibits the proliferation of human breast cancer and prostate cancer cells. ...Thus, g …
Mechanism of Glycitein in the Treatment of Colon Cancer Based on Network Pharmacology and Molecular Docking.
Xiang T, Jin W. Xiang T, et al. Lifestyle Genom. 2023;16(1):1-10. doi: 10.1159/000527124. Epub 2022 Sep 30. Lifestyle Genom. 2023. PMID: 36183698 Free article.
Five potential targets of glycitein for treating colon cancer were identified (CCNA2, ESR1, ESR2, MAPK14, and PTGS2). ...A scientific basis is provided for glycitein application in treating colon cancer....
Five potential targets of glycitein for treating colon cancer were identified (CCNA2, ESR1, ESR2, MAPK14, and PTGS2). ...A scientific …
Glycitein Mitigates Doxorubicin-Induced Cardiotoxicity by Mitigating Apoptosis and Inflammatory Responses in Albino Rats.
Jingya Z, Peng L. Jingya Z, et al. J Biochem Mol Toxicol. 2025 Sep;39(9):e70489. doi: 10.1002/jbt.70489. J Biochem Mol Toxicol. 2025. PMID: 40936427
In this study, we aimed to evaluate the ameliorative effect of bioactive compound glycitein against DOX-triggered myocardial toxicity. DOX-treated Wistar rats were subsequently administered with two different doses of glycitein. ...Inflammatory inducers and apoptoti …
In this study, we aimed to evaluate the ameliorative effect of bioactive compound glycitein against DOX-triggered myocardial toxicity …
645 results