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259 results

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Page 1
Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Sun J, Zheng T, Jia M, Wang Y, Yang J, Liu Y, Yang P, Xie Y, Sun H, Tong Q, Li J, Yang J, Fu G, Shi Y, Qi J, Liu W, Liu J, Tian WX, Gao GF, Bi Y. Sun J, et al. Nat Commun. 2024 Nov 19;15(1):10012. doi: 10.1038/s41467-024-54374-z. Nat Commun. 2024. PMID: 39562538 Free PMC article.
The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. ...
The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (A …
A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases.
Liang Z, Lin X, Sun L, Edwards KM, Song W, Sun H, Xie Y, Lin F, Ling S, Liang T, Xiao B, Wang J, Li M, Leung CY, Zhu H, Bhandari N, Varadarajan R, Levine MZ, Peiris M, Webster R, Dhanasekaran V, Leung NHL, Cowling BJ, Webby RJ, Ducatez M, Zanin M, Wong SS. Liang Z, et al. Nat Commun. 2024 Jul 3;15(1):5593. doi: 10.1038/s41467-024-49884-9. Nat Commun. 2024. PMID: 38961067 Free PMC article.
Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reactivity of N2 antibodies aga …
Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus …
Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957.
Pappas C, Viswanathan K, Chandrasekaran A, Raman R, Katz JM, Sasisekharan R, Tumpey TM. Pappas C, et al. PLoS One. 2010 Jun 21;5(6):e11158. doi: 10.1371/journal.pone.0011158. PLoS One. 2010. PMID: 20574518 Free PMC article.
Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin (HA) warrants investigation of this subtype …
Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 …
Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).
Natali A, Pilotti E, Valcavi PP, Chezzi C, Oxford JS. Natali A, et al. J Infect. 1998 Jul;37(1):19-23. doi: 10.1016/s0163-4453(98)90260-2. J Infect. 1998. PMID: 9733372
Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.9% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H1N1) viruses. ...These age groups also appeared to have 'protective' …
Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.9% of positive …
Development and pre-clinical evaluation of two LAIV strains against potentially pandemic H2N2 influenza virus.
Isakova-Sivak I, de Jonge J, Smolonogina T, Rekstin A, van Amerongen G, van Dijken H, Mouthaan J, Roholl P, Kuznetsova V, Doroshenko E, Tsvetnitsky V, Rudenko L. Isakova-Sivak I, et al. PLoS One. 2014 Jul 24;9(7):e102339. doi: 10.1371/journal.pone.0102339. eCollection 2014. PLoS One. 2014. PMID: 25058039 Free PMC article.
In ferrets, the live attenuated vaccines induced high virus neutralizing, haemagglutination and neuraminidase inhibition titers, however; the vaccine based on the A/California/1/66 wt virus induced higher homologous and better cross-reactive antibody responses than …
In ferrets, the live attenuated vaccines induced high virus neutralizing, haemagglutination and neuraminidase inhibition titers, howe …
Infection of human airway epithelia with H1N1, H2N2, and H3N2 influenza A virus strains.
Slepushkin VA, Staber PD, Wang G, McCray PB Jr, Davidson BL. Slepushkin VA, et al. Mol Ther. 2001 Mar;3(3):395-402. doi: 10.1006/mthe.2001.0277. Mol Ther. 2001. PMID: 11273782 Free PMC article.
Three subtypes of influenza A virus cause human disease: H1N1, H2N2, and H3N2. Although all result in respiratory illness, little is known about how these subtypes infect differentiated airway epithelia. ...In this model system, viral infectivity was highest when virus …
Three subtypes of influenza A virus cause human disease: H1N1, H2N2, and H3N2. Although all result in respiratory illness, little is …
Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic.
Xu R, McBride R, Paulson JC, Basler CF, Wilson IA. Xu R, et al. J Virol. 2010 Feb;84(4):1715-21. doi: 10.1128/JVI.02162-09. Epub 2009 Dec 9. J Virol. 2010. PMID: 20007271 Free PMC article.
The hemagglutinin (HA) envelope protein of influenza viruses mediates essential viral functions, including receptor binding and membrane fusion, and is the major viral antigen for antibody neutralization. The 1957 H2N2 subtype (Asian flu) was one of the three great …
The hemagglutinin (HA) envelope protein of influenza viruses mediates essential viral functions, including receptor binding and membrane fus …
Inhibitory effect and possible mechanism of action of patchouli alcohol against influenza A (H2N2) virus.
Wu H, Li B, Wang X, Jin M, Wang G. Wu H, et al. Molecules. 2011 Aug 3;16(8):6489-501. doi: 10.3390/molecules16086489. Molecules. 2011. PMID: 21814161 Free PMC article.
In the present study, the anti-influenza A (H2N2) virus activity of patchouli alcohol was studied in vitro, in vivo and in silico. The CC50 of patchouli alcohol was above 20 M. Patchouli alcohol could inhibit influenza virus with an IC50 of 4.03 0.23 M. MTT assa …
In the present study, the anti-influenza A (H2N2) virus activity of patchouli alcohol was studied in vitro, in vivo and in silico. Th …
Deletions in the neuraminidase stalk region of H2N2 and H9N2 avian influenza virus subtypes do not affect postinfluenza secondary bacterial pneumonia.
Chockalingam AK, Hickman D, Pena L, Ye J, Ferrero A, Echenique JR, Chen H, Sutton T, Perez DR. Chockalingam AK, et al. J Virol. 2012 Apr;86(7):3564-73. doi: 10.1128/JVI.05809-11. Epub 2012 Jan 25. J Virol. 2012. PMID: 22278240 Free PMC article.
Deletions in the NA stalk (deltaNA) had no effect on NA activity or on the adherence of S. pneumoniae to virus-infected human alveolar epithelial (A549) and mouse lung adenoma (LA-4) cells, although it delayed virus elution from turkey red blood cells. ...Difference …
Deletions in the NA stalk (deltaNA) had no effect on NA activity or on the adherence of S. pneumoniae to virus-infected human alveola …
259 results