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2020 5
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Page 1
Epidemiology of Hospital-Onset Versus Community-Onset Sepsis in U.S. Hospitals and Association With Mortality: A Retrospective Analysis Using Electronic Clinical Data.
Rhee C, Wang R, Zhang Z, Fram D, Kadri SS, Klompas M; CDC Prevention Epicenters Program. Rhee C, et al. Crit Care Med. 2019 Sep;47(9):1169-1176. doi: 10.1097/CCM.0000000000003817. Crit Care Med. 2019. PMID: 31135503
OBJECTIVES: Prior studies have reported that hospital-onset sepsis is associated with higher mortality rates than community-onset sepsis. ...Hospital-onset sepsis preferentially afflicted ill patients but even after risk-adj …
OBJECTIVES: Prior studies have reported that hospital-onset sepsis is associated with higher mortality rates than commu …
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis.
Baghdadi JD, Brook RH, Uslan DZ, Needleman J, Bell DS, Cunningham WE, Wong MD. Baghdadi JD, et al. JAMA Intern Med. 2020 Apr 6;180(5):707-16. doi: 10.1001/jamainternmed.2020.0183. Online ahead of print. JAMA Intern Med. 2020. PMID: 32250412
Published evidence on the association of SEP-1 with mortality is mixed and largely excludes cases of hospital-onset sepsis. OBJECTIVE: To assess the association of the SEP-1 bundle with mortality and organ dysfunction in cohorts with hospital-onset
Published evidence on the association of SEP-1 with mortality is mixed and largely excludes cases of hospital-onset sepsis
Adherence to the SEP-1 Sepsis Bundle in Hospital-Onset v. Community-Onset Sepsis: a Multicenter Retrospective Cohort Study.
Baghdadi JD, Wong MD, Uslan DZ, Bell D, Cunningham WE, Needleman J, Kerbel R, Brook R. Baghdadi JD, et al. J Gen Intern Med. 2020 Apr;35(4):1153-1160. doi: 10.1007/s11606-020-05653-0. Epub 2020 Feb 10. J Gen Intern Med. 2020. PMID: 32040837
Limited evidence suggests that adherence to the sepsis bundle is lower in cases of hospital-onset sepsis. OBJECTIVE: To compare sepsis bundle adherence in hospital-onset vs. community-onset sepsis. ...CONCLUSIONS: Inp …
Limited evidence suggests that adherence to the sepsis bundle is lower in cases of hospital-onset sepsis. OBJECT …
Preventing Bloodstream Infections and Death in Zambian Neonates: Impact of a Low-cost Infection Control Bundle.
Mwananyanda L, Pierre C, Mwansa J, Cowden C, Localio AR, Kapasa ML, Machona S, Musyani CL, Chilufya MM, Munanjala G, Lyondo A, Bates MA, Coffin SE, Hamer DH. Mwananyanda L, et al. Clin Infect Dis. 2019 Sep 27;69(8):1360-1367. doi: 10.1093/cid/ciy1114. Clin Infect Dis. 2019. PMID: 30596901
BACKGROUND: Sepsis is a leading cause of neonatal mortality in low-resource settings. As facility-based births become more common, the proportion of neonatal deaths due to hospital-onset sepsis has increased. ...Hospital-associated sepsis
BACKGROUND: Sepsis is a leading cause of neonatal mortality in low-resource settings. As facility-based births become more common, th …
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Rhee C, Filbin MR, Massaro AF, Bulger AL, McEachern D, Tobin KA, Kitch BT, Thurlo-Walsh B, Kadar A, Koffman A, Pande A, Hamad Y, Warren DK, Jones TM, O'Brien C, Anderson DJ, Wang R, Klompas M; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program. Rhee C, et al. Crit Care Med. 2018 Oct;46(10):1585-1591. doi: 10.1097/CCM.0000000000003261. Crit Care Med. 2018. PMID: 30015667 Free PMC article. Clinical Trial.

MEASUREMENTS AND MAIN RESULTS: Of 851 sepsis cases in the cohort, 281 (33%) passed SEP-1 and 570 (67%) failed. SEP-1 failures had higher rates of septic shock (20% vs 9%; p < 0.001), hospital-onset sepsis (11% vs 4%; p = 0.001), and vague presenting

MEASUREMENTS AND MAIN RESULTS: Of 851 sepsis cases in the cohort, 281 (33%) passed SEP-1 and 570 (67%) failed. SEP-1 failures had hig …
Validation of automated sepsis surveillance based on the Sepsis-3 clinical criteria against physician record review in a general hospital population: observational study using electronic health records data.
Valik JK, Ward L, Tanushi H, Müllersdorf K, Ternhag A, Aufwerber E, Färnert A, Johansson AF, Mogensen ML, Pickering B, Dalianis H, Henriksson A, Herasevich V, Nauclér P. Valik JK, et al. BMJ Qual Saf. 2020 Feb 6:bmjqs-2019-010123. doi: 10.1136/bmjqs-2019-010123. Online ahead of print. BMJ Qual Saf. 2020. PMID: 32029574 Free article.
The aim was to develop and validate a fully-automated Sepsis-3 based surveillance system in non-intensive care wards using electronic health record (EHR) data, and demonstrate utility by determining the burden of hospital-onset sepsis and variations be …
The aim was to develop and validate a fully-automated Sepsis-3 based surveillance system in non-intensive care wards using electronic …
Lactate Testing in Suspected Sepsis: Trends and Predictors of Failure to Measure Levels.
Rhee C, Murphy MV, Li L, Platt R, Klompas M; Centers for Disease Control and Prevention Prevention Epicenters Program. Rhee C, et al. Crit Care Med. 2015 Aug;43(8):1669-76. doi: 10.1097/CCM.0000000000001087. Crit Care Med. 2015. PMID: 25962082 Free PMC article.
On multivariate analysis, hospital-onset sepsis and hospitalization on a nonmedical service were significant predictors of failure to measure lactates (adjusted odds ratio, 7.56; 95% CI, 6.31-9.06 and adjusted odds ratio, 2.08; 95% CI, 1.76-2.24, respectively …
On multivariate analysis, hospital-onset sepsis and hospitalization on a nonmedical service were significant predictors …
Temporal trends in the systemic inflammatory response syndrome, sepsis, and medical coding of sepsis.
Thomas BS, Jafarzadeh SR, Warren DK, McCormick S, Fraser VJ, Marschall J. Thomas BS, et al. BMC Anesthesiol. 2015 Nov 24;15:169. doi: 10.1186/s12871-015-0148-z. BMC Anesthesiol. 2015. PMID: 26597871 Free PMC article.
BACKGROUND: Recent reports using administrative claims data suggest the incidence of community- and hospital-onset sepsis is increasing. ...METHODS: We performed a temporal-trend study from 2008 to 2012 using administrative claims data and patient-level clini …
BACKGROUND: Recent reports using administrative claims data suggest the incidence of community- and hospital-onset sepsis
Improvements in Sepsis-associated Mortality in Hospitalized Patients with Cancer versus Those without Cancer. A 12-Year Analysis Using Clinical Data.
Cooper AJ, Keller SP, Chan C, Glotzbecker BE, Klompas M, Baron RM, Rhee C. Cooper AJ, et al. Ann Am Thorac Soc. 2020 Apr;17(4):466-473. doi: 10.1513/AnnalsATS.201909-655OC. Ann Am Thorac Soc. 2020. PMID: 31800299
Rationale: There have been advances in both cancer and sepsis treatment over the past several decades, yet little is known about trends in sepsis-associated mortality in patients with versus without cancer.Objectives: To assess trends in sepsis-associated mor …
Rationale: There have been advances in both cancer and sepsis treatment over the past several decades, yet little is known about tren …
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