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Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.
Govindappa PK, Patil M, Garikipati VNS, Verma SK, Saheera S, Narasimhan G, Zhu W, Kishore R, Zhang J, Krishnamurthy P. Govindappa PK, et al. FASEB J. 2020 Feb;34(2):2238-2251. doi: 10.1096/fj.201901995R. Epub 2019 Dec 16. FASEB J. 2020. PMID: 31907992 Free PMC article.
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene expression in several pathophysiological conditions. ...Human failing hearts show higher HuR levels. Diabetic milieu activates HuR express ā€¦
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene expression i ā€¦
RNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease.
Guo J, Lei M, Cheng F, Liu Y, Zhou M, Zheng W, Zhou Y, Gong R, Liu Z. Guo J, et al. Cell Death Dis. 2020 Jun 2;11(6):413. doi: 10.1038/s41419-020-2630-x. Cell Death Dis. 2020. PMID: 32487989 Free PMC article.
Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and the most common cause of end-stage renal disease, for which no effective therapies are yet available. RNA-binding proteins (RBPs) play a pivotal role in epigenetic regulation; tri ā€¦
Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and the most common cause of end-stage rena ā€¦
Human antigen R mediated post-transcriptional regulation of epithelial-mesenchymal transition related genes in diabetic nephropathy.
Yu C, Xin W, Zhen J, Liu Y, Javed A, Wang R, Wan Q. Yu C, et al. J Diabetes. 2015 Jul;7(4):562-72. doi: 10.1111/1753-0407.12220. Epub 2015 Jan 15. J Diabetes. 2015. PMID: 25265983
BACKGROUND: Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein that modulates gene expression at the post-transcriptional level. While cytoplasmic HuR expression was identified as a marker in epithelial-mesenchymal transition (EMT) process ā€¦
BACKGROUND: Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein that modulates gene expression at the ā€¦
Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells.
Platania CBM, PittalĆ  V, Pascale A, Marchesi N, Anfuso CD, Lupo G, Cristaldi M, Olivieri M, Lazzara F, Di Paola L, Drago F, Bucolo C. Platania CBM, et al. Biochem Pharmacol. 2020 May;175:113908. doi: 10.1016/j.bcp.2020.113908. Epub 2020 Mar 19. Biochem Pharmacol. 2020. PMID: 32171729
The ELAVL1 (or human antigen R - HuR) RNA binding protein stabilizes the mRNA, with an AU-rich element, of several genes such as growth factors (i.e. ...We hereby carried out a virtual screening campaign in order to identify and test novel HuR-mRNA disruptors ā€¦
The ELAVL1 (or human antigen R - HuR) RNA binding protein stabilizes the mRNA, with an AU-rich element, of several gene ā€¦
Role of post-transcriptional regulation of mRNA stability in renal pathophysiology: focus on chronic kidney disease.
FeigerlovĆ” E, Battaglia-Hsu SF. FeigerlovĆ” E, et al. FASEB J. 2017 Feb;31(2):457-468. doi: 10.1096/fj.201601087RR. Epub 2016 Nov 14. FASEB J. 2017. PMID: 27849555 Review.
Recent progress in the understanding of post-transcriptional regulation of mRNA stability has helped the identification of both the trans- and cis-acting elements of mRNA as potential markers and therapeutic targets for difficult-to-diagnose and -treat diseases, including CKDs su ā€¦
Recent progress in the understanding of post-transcriptional regulation of mRNA stability has helped the identification of both the trans- a ā€¦
Mechanisms of TNFĪ± regulation in uveitis: focus on RNA-binding proteins.
Khera TK, Dick AD, Nicholson LB. Khera TK, et al. Prog Retin Eye Res. 2010 Nov;29(6):610-21. doi: 10.1016/j.preteyeres.2010.08.003. Epub 2010 Sep 8. Prog Retin Eye Res. 2010. PMID: 20813201 Review.
Common to many cytokines, TNFalpha mRNA 3' untranslated region (UTR) contains an AU-rich element (ARE), which drives repression by mRNA-binding proteins (RBPs). These include tristetraprolin (TTP), T cell antigen-1 (TIA-1), TIA-1-related protein (TIAR), human ant ā€¦
Common to many cytokines, TNFalpha mRNA 3' untranslated region (UTR) contains an AU-rich element (ARE), which drives repression by mRNA-bind ā€¦
Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease.
Shi Q, Lee DY, FĆ©liers D, Abboud HE, Bhat MA, Gorin Y. Shi Q, et al. Mol Metab. 2020 Jun;36:100968. doi: 10.1016/j.molmet.2020.02.011. Epub 2020 Feb 28. Mol Metab. 2020. PMID: 32240965 Free PMC article.
Nox4 mRNA 3' untranslated region (3'-UTR) contains numerous AU-rich elements (AREs) that are potential binding sites for the RNA-binding protein human antigen R (HuR). We show that HG promotes HuR activation/expression and that HuR is required for HG-induced ā€¦
Nox4 mRNA 3' untranslated region (3'-UTR) contains numerous AU-rich elements (AREs) that are potential binding sites for the RNA-binding pro ā€¦
Investigation of RNA Editing Sites within Bound Regions of RNA-Binding Proteins.
Weirick T, Militello G, Hosen MR, John D, Moore Iv JB, Uchida S. Weirick T, et al. High Throughput. 2019 Nov 29;8(4):19. doi: 10.3390/ht8040019. High Throughput. 2019. PMID: 31795425 Free PMC article.
Moreover, the presence of RNA editing sites are more frequent when RNA editing islands were examined, which are regions in which RNA editing sites are present in clusters. When the binding of one RBP, human antigen R [HuR; encoded by ELAV-like protein 1 (ELAV ā€¦
Moreover, the presence of RNA editing sites are more frequent when RNA editing islands were examined, which are regions in which RNA editing ā€¦
The induced RNA-binding protein, HuR, targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis.
Ouhara K, Munenaga S, Kajiya M, Takeda K, Matsuda S, Sato Y, Hamamoto Y, Iwata T, Yamasaki S, Akutagawa K, Mizuno N, Fujita T, Sugiyama E, Kurihara H. Ouhara K, et al. Clin Exp Immunol. 2018 Jun;192(3):325-336. doi: 10.1111/cei.13110. Epub 2018 Mar 8. Clin Exp Immunol. 2018. PMID: 29393507 Free PMC article.
RNA-binding proteins (RBPs) regulate mRNA stability by binding to the 3'-untranslated region (UTR) region of mRNA. Human antigen-R (HuR), one of the RBPs, is involved in the progression of diseases, such as rheumatoid arthritis, diabetes mellitus ā€¦
RNA-binding proteins (RBPs) regulate mRNA stability by binding to the 3'-untranslated region (UTR) region of mRNA. Human antigen ā€¦
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