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The RNA binding protein human antigen R is a gatekeeper of liver homeostasis.
Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. Subramanian P, et al. Hepatology. 2022 Apr;75(4):881-897. doi: 10.1002/hep.32153. Epub 2021 Dec 5. Hepatology. 2022. PMID: 34519101 Free article.
BACKGROUND AND AIMS: NAFLD is initiated by steatosis and can progress through fibrosis and cirrhosis to HCC. The RNA binding protein human antigen R (HuR) controls RNAs at the posttranscriptional level; hepatocyte HuR has been implicated in the regulation of …
BACKGROUND AND AIMS: NAFLD is initiated by steatosis and can progress through fibrosis and cirrhosis to HCC. The RNA binding protein huma
Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.
Govindappa PK, Patil M, Garikipati VNS, Verma SK, Saheera S, Narasimhan G, Zhu W, Kishore R, Zhang J, Krishnamurthy P. Govindappa PK, et al. FASEB J. 2020 Feb;34(2):2238-2251. doi: 10.1096/fj.201901995R. Epub 2019 Dec 16. FASEB J. 2020. PMID: 31907992 Free PMC article.
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene expression in several pathophysiological conditions. ...Human failing hearts show higher HuR levels. Diabetic milieu activates HuR express …
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene expression i …
RNA-binding proteins and their role in kidney disease.
Seufert L, Benzing T, Ignarski M, Müller RU. Seufert L, et al. Nat Rev Nephrol. 2022 Mar;18(3):153-170. doi: 10.1038/s41581-021-00497-1. Epub 2021 Nov 3. Nat Rev Nephrol. 2022. PMID: 34732838 Review.
RBPs also contribute to a wide spectrum of kidney disorders. For example, human antigen R has been reported to have a renoprotective function in acute kidney injury (AKI) but might also contribute to the development of glomerulosclerosis, tubulointerstitial f …
RBPs also contribute to a wide spectrum of kidney disorders. For example, human antigen R has been reported to have a r …
RNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease.
Guo J, Lei M, Cheng F, Liu Y, Zhou M, Zheng W, Zhou Y, Gong R, Liu Z. Guo J, et al. Cell Death Dis. 2020 Jun 2;11(6):413. doi: 10.1038/s41419-020-2630-x. Cell Death Dis. 2020. PMID: 32487989 Free PMC article.
Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and the most common cause of end-stage renal disease, for which no effective therapies are yet available. RNA-binding proteins (RBPs) play a pivotal role in epigenetic regulation; tri
Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and the most common cause of end-stage rena
Human antigen R mediated post-transcriptional regulation of epithelial-mesenchymal transition related genes in diabetic nephropathy.
Yu C, Xin W, Zhen J, Liu Y, Javed A, Wang R, Wan Q. Yu C, et al. J Diabetes. 2015 Jul;7(4):562-72. doi: 10.1111/1753-0407.12220. Epub 2015 Jan 15. J Diabetes. 2015. PMID: 25265983
BACKGROUND: Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein that modulates gene expression at the post-transcriptional level. While cytoplasmic HuR expression was identified as a marker in epithelial-mesenchymal transition (EMT) process …
BACKGROUND: Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein that modulates gene expression at the …
HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes.
Si R, Cabrera JTO, Tsuji-Hosokawa A, Guo R, Watanabe M, Gao L, Lee YS, Moon JS, Scott BT, Wang J, Ashton AW, Rao JN, Wang JY, Yuan JX, Makino A. Si R, et al. JCI Insight. 2021 Nov 8;6(21):e147982. doi: 10.1172/jci.insight.147982. JCI Insight. 2021. PMID: 34747371 Free PMC article.
However, the molecular mechanism by which diabetes promotes CMD is poorly understood. RNA-binding protein human antigen R (HuR) is a key regulator of mRNA stability and translation; therefore, we investigated the role of HuR in the development of CMD i …
However, the molecular mechanism by which diabetes promotes CMD is poorly understood. RNA-binding protein human antigen
Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteins.
Khera TK, Dick AD, Nicholson LB. Khera TK, et al. Prog Retin Eye Res. 2010 Nov;29(6):610-21. doi: 10.1016/j.preteyeres.2010.08.003. Epub 2010 Sep 8. Prog Retin Eye Res. 2010. PMID: 20813201 Review.
Common to many cytokines, TNFalpha mRNA 3' untranslated region (UTR) contains an AU-rich element (ARE), which drives repression by mRNA-binding proteins (RBPs). These include tristetraprolin (TTP), T cell antigen-1 (TIA-1), TIA-1-related protein (TIAR), human ant
Common to many cytokines, TNFalpha mRNA 3' untranslated region (UTR) contains an AU-rich element (ARE), which drives repression by mRNA-bind …
Role of post-transcriptional regulation of mRNA stability in renal pathophysiology: focus on chronic kidney disease.
Feigerlová E, Battaglia-Hsu SF. Feigerlová E, et al. FASEB J. 2017 Feb;31(2):457-468. doi: 10.1096/fj.201601087RR. Epub 2016 Nov 14. FASEB J. 2017. PMID: 27849555 Review.
Recent progress in the understanding of post-transcriptional regulation of mRNA stability has helped the identification of both the trans- and cis-acting elements of mRNA as potential markers and therapeutic targets for difficult-to-diagnose and -treat diseases, including CKDs su …
Recent progress in the understanding of post-transcriptional regulation of mRNA stability has helped the identification of both the trans- a …
Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells.
Platania CBM, Pittalà V, Pascale A, Marchesi N, Anfuso CD, Lupo G, Cristaldi M, Olivieri M, Lazzara F, Di Paola L, Drago F, Bucolo C. Platania CBM, et al. Biochem Pharmacol. 2020 May;175:113908. doi: 10.1016/j.bcp.2020.113908. Epub 2020 Mar 19. Biochem Pharmacol. 2020. PMID: 32171729
The ELAVL1 (or human antigen R - HuR) RNA binding protein stabilizes the mRNA, with an AU-rich element, of several genes such as growth factors (i.e. ...We hereby carried out a virtual screening campaign in order to identify and test novel HuR-mRNA disruptors …
The ELAVL1 (or human antigen R - HuR) RNA binding protein stabilizes the mRNA, with an AU-rich element, of several gene …
19 results