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Year Number of Results
1919 1
1941 1
1945 2
1946 1
1947 5
1948 7
1949 9
1950 1
1951 3
1952 2
1953 7
1954 1
1955 3
1956 5
1957 5
1958 7
1959 5
1960 9
1961 16
1962 6
1963 6
1964 5
1965 5
1966 12
1967 13
1968 11
1969 13
1970 8
1971 6
1972 8
1973 4
1974 7
1975 24
1976 30
1977 17
1978 21
1979 25
1980 35
1981 31
1982 38
1983 34
1984 32
1985 62
1986 71
1987 58
1988 71
1989 76
1990 95
1991 100
1992 91
1993 104
1994 96
1995 115
1996 128
1997 99
1998 104
1999 134
2000 119
2001 133
2002 128
2003 140
2004 169
2005 195
2006 208
2007 222
2008 210
2009 219
2010 239
2011 246
2012 246
2013 268
2014 257
2015 248
2016 288
2017 263
2018 241
2019 268
2020 286
2021 304
2022 325
2023 310
2024 318
2025 309
2026 172

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7,481 results

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Page 1
An update on the safety of hydroquinone.
Shivaram K, Edwards K, Mohammad TF. Shivaram K, et al. Arch Dermatol Res. 2024 Jun 8;316(7):378. doi: 10.1007/s00403-024-02990-6. Arch Dermatol Res. 2024. PMID: 38850450 Review.
The recent U.S. ban on over-the-counter skin lightening products containing hydroquinone has prompted further questioning of the safety of this widely used agent. While there have been prior informative, large-scale reviews on the safety of hydroquinone, new finding …
The recent U.S. ban on over-the-counter skin lightening products containing hydroquinone has prompted further questioning of the safe …
Hydroquinone.
[No authors listed] [No authors listed] 2026 Mar 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2026 Mar 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 29999728 Free Books & Documents. Review.
Topical hydroquinone has not been studied during breastfeeding. Although hydroquinone is not contraindicated during breastfeeding, some experts feel that long-term use of hydroquinone should not be used in nursing mothers.[1,2] If hydroquinone is used, …
Topical hydroquinone has not been studied during breastfeeding. Although hydroquinone is not contraindicated during breastfeed …
Hydroquinone: myths and reality.
Searle T, Al-Niaimi F, Ali FR. Searle T, et al. Clin Exp Dermatol. 2021 Jun;46(4):636-640. doi: 10.1111/ced.14480. Epub 2020 Nov 7. Clin Exp Dermatol. 2021. PMID: 33159818 Review.
Hydroquinone has pharmacological uses in disorders of pigmentation because of its ability to competitively inhibit the enzyme tyrosinase. Our contemporary review presents the strongest evidence supporting the use of hydroquinone with the most effective and tolerable …
Hydroquinone has pharmacological uses in disorders of pigmentation because of its ability to competitively inhibit the enzyme tyrosin …
Hyperpigmentation: Looking beyond hydroquinone.
Charoo NA. Charoo NA. J Cosmet Dermatol. 2022 Oct;21(10):4133-4145. doi: 10.1111/jocd.14746. Epub 2022 Jan 12. J Cosmet Dermatol. 2022. PMID: 35020267 Review.
Prolonged use of hydroquinone has been associated with cancer risk and exogenous ochronosis. The CARES (The Coronavirus Aid, Relief, and Economic Security Act) Act of 2020 has instituted significant changes to hydroquinone containing OTC (over the counter) products, …
Prolonged use of hydroquinone has been associated with cancer risk and exogenous ochronosis. The CARES (The Coronavirus Aid, Relief, …
Hydroquinone.
Schwartz C, Jan A, Zito PM. Schwartz C, et al. 2023 Aug 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2023 Aug 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 30969515 Free Books & Documents.
Hydroquinone cream is the standard depigmentation or skin lightening agent. Clinically it is used to treat areas of dyschromia, such as in melasma, chloasma, solar lentigines, freckles, and post-inflammatory hyperpigmentation. This activity outlines the indications, mechan …
Hydroquinone cream is the standard depigmentation or skin lightening agent. Clinically it is used to treat areas of dyschromia, such …
Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.
Lima PB, Dias JAF, Cassiano DP, Esposito ACC, Miot LDB, Bagatin E, Miot HA. Lima PB, et al. J Eur Acad Dermatol Venereol. 2021 Sep;35(9):1881-1887. doi: 10.1111/jdv.17344. Epub 2021 Jun 7. J Eur Acad Dermatol Venereol. 2021. PMID: 33988887 Clinical Trial.
Patients were randomly assigned to apply a double layer of 0.2% Thiamidol twice a day or 4% hydroquinone cream at bedtime, for 90 days. Both groups received tinted sunscreen (sun protection factor 60, PPD 20). ...CONCLUSION: The melasma improvement achieved using 0.2% Thia …
Patients were randomly assigned to apply a double layer of 0.2% Thiamidol twice a day or 4% hydroquinone cream at bedtime, for 90 day …
Exogenous ochronosis associated with hydroquinone: a systematic review.
Ishack S, Lipner SR. Ishack S, et al. Int J Dermatol. 2022 Jun;61(6):675-684. doi: 10.1111/ijd.15878. Epub 2021 Sep 6. Int J Dermatol. 2022. PMID: 34486734
Exogenous ochronosis is a potential side effect associated with hydroquinone, and treatment is often unsatisfactory. Our study objectives were to review data on hydroquinone-associated ochronosis to determine risk factors for patients experiencing this adverse event …
Exogenous ochronosis is a potential side effect associated with hydroquinone, and treatment is often unsatisfactory. Our study object …
The safety of hydroquinone.
Nordlund JJ, Grimes PE, Ortonne JP. Nordlund JJ, et al. J Eur Acad Dermatol Venereol. 2006 Aug;20(7):781-7. doi: 10.1111/j.1468-3083.2006.01670.x. J Eur Acad Dermatol Venereol. 2006. PMID: 16898897 Review.
Hydroquinone is one of the most effective molecules for the treatment of hyperpigmentary disorders, with over 40 years of efficacy and safety data. ...This article reviews the evidence for the safety of hydroquinone in the treatment of hyperpigmentation conditions.. …
Hydroquinone is one of the most effective molecules for the treatment of hyperpigmentary disorders, with over 40 years of efficacy an …
Efficacy and Tolerability of a New Facial 2-Mercaptonicotinoyl Glycine-Containing Depigmenting Serum Versus Hydroquinone 4% over 3-Month Treatment of Facial Melasma.
Passeron T, Kerob D, Le Dantec G, Demessant-Flavigny AL, do Nascimento AR, Moura R, Salah S, Feiges M, Fernandez E, Alexis A. Passeron T, et al. Dermatol Ther (Heidelb). 2025 Sep;15(9):2379-2390. doi: 10.1007/s13555-025-01473-4. Epub 2025 Jun 30. Dermatol Ther (Heidelb). 2025. PMID: 40586974 Free PMC article.
INTRODUCTION: Topical treatment with hydroquinone 4% and hydroquinone-based preparations is the gold standard of care for melasma; however, it is limited by complications. 2-Mercaptonicotinoyl glycine (Melasyl ) is a new active ingredient targeting melanin synthesis …
INTRODUCTION: Topical treatment with hydroquinone 4% and hydroquinone-based preparations is the gold standard of care for mela …
Hydroquinone: environmental pollution, toxicity, and microbial answers.
Enguita FJ, Leitão AL. Enguita FJ, et al. Biomed Res Int. 2013;2013:542168. doi: 10.1155/2013/542168. Epub 2013 Jul 15. Biomed Res Int. 2013. PMID: 23936816 Free PMC article. Review.
Human exposure to hydroquinone can occur by dietary, occupational, and environmental sources. In the environment, hydroquinone showed increased toxicity for aquatic organisms, being less harmful for bacteria and fungi. ...Due to the recent research development on …
Human exposure to hydroquinone can occur by dietary, occupational, and environmental sources. In the environment, hydroquinone …
7,481 results