Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1974 1
1976 1
1981 1
1984 2
1985 2
1986 2
1988 4
1989 6
1990 3
1991 2
1992 4
1993 4
1994 4
1995 8
1996 7
1997 2
1998 8
1999 4
2000 6
2001 2
2002 3
2003 2
2004 3
2005 5
2006 7
2007 6
2008 3
2009 1
2010 4
2011 7
2012 5
2013 5
2014 4
2015 4
2016 3
2017 5
2018 5
2019 8
2020 3
2021 3
2022 3
2023 2
2024 1
2025 2
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

158 results

Results by year

Filters applied: . Clear all
Page 1
Coffee and its consumption: benefits and risks.
Butt MS, Sultan MT. Butt MS, et al. Crit Rev Food Sci Nutr. 2011 Apr;51(4):363-73. doi: 10.1080/10408390903586412. Crit Rev Food Sci Nutr. 2011. PMID: 21432699 Review.
The health-promoting properties of coffee are often attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, hydroxyhydroquinone (HHQ), etc. Many research investigations, epidemiological studies, and meta-analyses regarding coffee consumpt …
The health-promoting properties of coffee are often attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic aci …
Hydroxyhydroquinone impairs fat utilization in mice by reducing nitric oxide availability.
Ishida K, Misawa K, Yamamoto M, Shimotoyodome A. Ishida K, et al. J Physiol Sci. 2018 Nov;68(6):855-864. doi: 10.1007/s12576-018-0605-9. Epub 2018 Mar 23. J Physiol Sci. 2018. PMID: 29572772 Free PMC article.
Habitual consumption of chlorogenic acid compounds (CGAs) from coffee increases fat catabolism and reduces body fat; however, the contribution of roasted coffee remains unclear. Hydroxyhydroquinone (HHQ) impairs the vasodilatory and antihypertensive effects of CGAs by redu …
Habitual consumption of chlorogenic acid compounds (CGAs) from coffee increases fat catabolism and reduces body fat; however, the contributi …
DNA Mutagenicity of Hydroxyhydroquinone in Roasted Coffee Products and Its Suppression by Chlorogenic Acid, a Coffee Polyphenol, in Oxidative-Damage-Sensitive SAMP8 Mice.
Unno K, Taguchi K, Hase T, Meguro S, Nakamura Y. Unno K, et al. Int J Mol Sci. 2024 Jan 5;25(2):720. doi: 10.3390/ijms25020720. Int J Mol Sci. 2024. PMID: 38255794 Free PMC article.
Hydroxyhydroquinone (HHQ) is an oxidative component produced by roasting coffee beans and has been reported to generate relatively large amounts of reactive oxygen species (ROS). ...
Hydroxyhydroquinone (HHQ) is an oxidative component produced by roasting coffee beans and has been reported to generate relatively la …
Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure.
Yamaguchi T, Chikama A, Mori K, Watanabe T, Shioya Y, Katsuragi Y, Tokimitsu I. Yamaguchi T, et al. Nutr Metab Cardiovasc Dis. 2008 Jul;18(6):408-14. doi: 10.1016/j.numecd.2007.03.004. Epub 2007 Oct 22. Nutr Metab Cardiovasc Dis. 2008. PMID: 17951035 Clinical Trial.
However, trial results concerning the effects of coffee on blood pressure (BP) are not consistent. A recent study suggested that hydroxyhydroquinone (HHQ), produced by the roasting of green coffee beans, inhibits the effect of CGA. ...
However, trial results concerning the effects of coffee on blood pressure (BP) are not consistent. A recent study suggested that hydroxyh …
Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats.
Suzuki A, Fujii A, Jokura H, Tokimitsu I, Hase T, Saito I. Suzuki A, et al. Am J Hypertens. 2008 Jan;21(1):23-7. doi: 10.1038/ajh.2007.3. Am J Hypertens. 2008. PMID: 18091740
BACKGROUND: Coffee is a rich source of antioxidative polyphenols, but epidemiological studies and interventional trials have failed to demonstrate any clear beneficial effects of coffee consumption on hypertension. The interaction between hydroxyhydroquinone (HHQ) and 5-ca …
BACKGROUND: Coffee is a rich source of antioxidative polyphenols, but epidemiological studies and interventional trials have failed to demon …
Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca(2+) concentration in rat thymic lymphocytes.
Kamae R, Nojima S, Akiyoshi K, Setsu S, Honda S, Masuda T, Oyama Y. Kamae R, et al. Food Chem Toxicol. 2017 Apr;102:39-45. doi: 10.1016/j.fct.2017.01.025. Epub 2017 Jan 30. Food Chem Toxicol. 2017. PMID: 28153638
Hydroxyhydroquinone (HHQ) is generated during coffee bean roasting. A cup of coffee contains 0.1-1.7 mg of HHQ. ...
Hydroxyhydroquinone (HHQ) is generated during coffee bean roasting. A cup of coffee contains 0.1-1.7 mg of HHQ. ...
Desulfovibrio inopinatus, sp. nov., a new sulfate-reducing bacterium that degrades hydroxyhydroquinone.
Reichenbecher W, Schink B. Reichenbecher W, et al. Arch Microbiol. 1997 Oct;168(4):338-44. doi: 10.1007/s002030050507. Arch Microbiol. 1997. PMID: 9297472
A new sulfate-reducing bacterium was isolated from marine sediment with hydroxyhydroquinone (1,2,4-trihydroxybenzene) as the sole electron and carbon source. Strain HHQ 20 grew slowly with doubling times of > 20 h and oxidized hydroxyhydroquinone, lactate, pyruva …
A new sulfate-reducing bacterium was isolated from marine sediment with hydroxyhydroquinone (1,2,4-trihydroxybenzene) as the sole ele …
Hydroxyhydroquinone reductase, the initial enzyme involved in the degradation of hydroxyhydroquinone (1,2,4-trihydroxybenzene) by Desulfovibrio inopinatus.
Reichenbecher W, Philipp B, Suter MJ, Schink B. Reichenbecher W, et al. Arch Microbiol. 2000 Mar;173(3):206-12. doi: 10.1007/s002039900130. Arch Microbiol. 2000. PMID: 10763753
The recently isolated sulfate reducer Desulfovibrio inopinatus oxidizes hydroxyhydroquinone (1,2,4trihydroxybenzene; HHQ) to 2 mol acetate and 2 mol CO2 (mol substrate)-1, with stoichiometric reduction of sulfate to sulfide. ...
The recently isolated sulfate reducer Desulfovibrio inopinatus oxidizes hydroxyhydroquinone (1,2,4trihydroxybenzene; HHQ) to 2 mol ac …
Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension.
Kajikawa M, Maruhashi T, Hidaka T, Nakano Y, Kurisu S, Matsumoto T, Iwamoto Y, Kishimoto S, Matsui S, Aibara Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Watanabe T, Tone H, Hibi M, Osaki N, Katsuragi Y, Higashi Y. Kajikawa M, et al. Eur J Nutr. 2019 Apr;58(3):989-996. doi: 10.1007/s00394-018-1611-7. Epub 2018 Jan 12. Eur J Nutr. 2019. PMID: 29330659 Free PMC article. Clinical Trial.
Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. ...R …
Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydr …
Occurrence and diversity of the oxidative hydroxyhydroquinone pathway for the anaerobic degradation of aromatic compounds in nitrate-reducing bacteria.
Pacheco-Sánchez D, Rama-Garda R, Marín P, Martirani-Von Abercron SM, Marqués S. Pacheco-Sánchez D, et al. Environ Microbiol Rep. 2019 Aug;11(4):525-537. doi: 10.1111/1758-2229.12752. Epub 2019 Mar 27. Environ Microbiol Rep. 2019. PMID: 30884168
The nitrate-reducing betaproteobacteria Azoarcus anaerobius and Thauera aromatica AR-1 use an oxidative mechanism to anaerobically degrade resorcinol and 3,5-dihydroxybenzoate (3,5-DHB), respectively, rendering hydroxyhydroquinone as intermediate. The first pathway step is …
The nitrate-reducing betaproteobacteria Azoarcus anaerobius and Thauera aromatica AR-1 use an oxidative mechanism to anaerobically degrade r …
158 results