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Quoted phrase not found in phrase index: "steoroids"
Page 1
6,7-Dimethoxy-2-[3-(5-[(11)C]methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-1,2,3,4-tetrahydro-isoquinoline.
Leung K. Leung K. 2010 Jun 24 [updated 2010 Sep 15]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2010 Jun 24 [updated 2010 Sep 15]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20862794 Free Books & Documents. Review.
Injection of unlabeled efflux pump substrates increases the retention of the radioactivity in the tumor by blocking the efflux rather than reducing radioactivity as seen with receptor-binding radiotracer blocking studies. Overexpression of P-gp in tumor cells (such …
Injection of unlabeled efflux pump substrates increases the retention of the radioactivity in the tumor by blocking the efflux rather …
6,7-Dimethoxy-2-{3-[4-[(11)C]methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-propyl}-1,2,3,4-tetrahydro-isoquinoline.
Leung K. Leung K. 2010 Jun 24 [updated 2010 Sep 15]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2010 Jun 24 [updated 2010 Sep 15]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20862795 Free Books & Documents. Review.
Overexpression of P-gp in tumor cells (such as renal carcinoma, hepatoma, pheochromocytoma, and colon carcinoma) leads to resistance to anticancer drugs (3). ...Calcium channel blockers (such as verapamil), cyclosporine (CsA, P-gp inhibitor) and CsA's non-immunosuppressive …
Overexpression of P-gp in tumor cells (such as renal carcinoma, hepatoma, pheochromocytoma, and colon carcinoma) leads to resistance …
Isoquinoline small molecule ligands are agonists and probe-dependent allosteric modulators of the glucagon subfamily of GPCRs.
Yuliantie E, Nh Trinh P, Hick C, Ebenhoch R, Nar H, Weichert D, Christopoulos A, M Sexton P, Wootten D. Yuliantie E, et al. Biochem Pharmacol. 2024 Nov;229:116483. doi: 10.1016/j.bcp.2024.116483. Epub 2024 Aug 13. Biochem Pharmacol. 2024. PMID: 39147328 Free article.
Class B1 G protein-coupled receptors (GPCRs) are peptide hormone receptors and well validated therapeutic targets, however development of non-peptide drugs targeting this class of receptors is challenging. Recently, a series of isoquinoline-based derivates were repo …
Class B1 G protein-coupled receptors (GPCRs) are peptide hormone receptors and well validated therapeutic targets, however developmen …
Berberine as a potential autophagy modulator.
Mohammadinejad R, Ahmadi Z, Tavakol S, Ashrafizadeh M. Mohammadinejad R, et al. J Cell Physiol. 2019 Sep;234(9):14914-14926. doi: 10.1002/jcp.28325. Epub 2019 Feb 15. J Cell Physiol. 2019. PMID: 30770555 Review.
Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell cycle arrest mechanisms. In the present review, we discuss the effect of berberine on diverse cellular pathways and describe how berberine …
Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell …
Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases.
Plazas E, Avila M MC, Muñoz DR, Cuca S LE. Plazas E, et al. Pharmacol Res. 2022 Mar;177:106126. doi: 10.1016/j.phrs.2022.106126. Epub 2022 Feb 10. Pharmacol Res. 2022. PMID: 35151857 Review.
Complex diseases such as neurodegenerative disorders and cancer constitute a growing public health problem due to the rising incidence and lack in effective therapies. ...This review offers an exhaustive compilation of the pharmacological relevance and multi-target potenti …
Complex diseases such as neurodegenerative disorders and cancer constitute a growing public health problem due to the rising incidenc …
Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity.
Rodrigues-Junior DM, Raminelli C, Hassanie H, Trossini GHG, Perecim GP, Caja L, Moustakas A, Vettore AL. Rodrigues-Junior DM, et al. Sci Rep. 2022 Dec 7;12(1):21113. doi: 10.1038/s41598-022-25534-2. Sci Rep. 2022. PMID: 36477472 Free PMC article.
Glioblastoma (GBM) is the most aggressive and common primary malignant brain tumor with limited available therapeutic approaches. Despite improvements in therapeutic options for GBM patients, efforts to develop new successful strategies remain as major unmet medical needs. …
Glioblastoma (GBM) is the most aggressive and common primary malignant brain tumor with limited available therapeutic approaches. Des …
Effect and mechanism of berberine against polycystic ovary syndrome.
Zhang SW, Zhou J, Gober HJ, Leung WT, Wang L. Zhang SW, et al. Biomed Pharmacother. 2021 Jun;138:111468. doi: 10.1016/j.biopha.2021.111468. Epub 2021 Mar 16. Biomed Pharmacother. 2021. PMID: 33740526 Free article. Review.
For women of reproductive age, polycystic ovary syndrome (PCOS) is not a rare heterogeneous endocrine disorder and metabolic dysfunction. Menstrual problems, hyperandrogenism, polycystic ovary (PCO) and infertility often affect these women, and they ar …
For women of reproductive age, polycystic ovary syndrome (PCOS) is not a rare heterogeneous endocrine disorder and meta …
Isoquinolines: Important Cores in Many Marketed and Clinical Drugs.
Luo C, Ampomah-Wireko M, Wang H, Wu C, Wang Q, Zhang H, Cao Y. Luo C, et al. Anticancer Agents Med Chem. 2021;21(7):811-824. doi: 10.2174/1871520620666200424132248. Anticancer Agents Med Chem. 2021. PMID: 32329698 Review.
BACKGROUND: Isoquinoline analogs are an important, structurally diverse class of compounds that are extensively used as pharmaceuticals. Derivatives containing the isoquinoline scaffold have become a focus of therapeutic research because of their wide range of biolo …
BACKGROUND: Isoquinoline analogs are an important, structurally diverse class of compounds that are extensively used as pharmaceutica …
Berberine and its impact on breast cancer: unveiling key signalling pathways.
Chakraborty S, Ghosh BN. Chakraborty S, et al. Mol Biol Rep. 2025 Jul 16;52(1):719. doi: 10.1007/s11033-025-10815-6. Mol Biol Rep. 2025. PMID: 40668488 Review.
This short review sheds light on the present-day information on the activity of berberine in ameliorating breast cancer, by evaluation of the mechanisms involved at the cellular and molecular level. Its ability to interact with key receptors and effector proteins as well i …
This short review sheds light on the present-day information on the activity of berberine in ameliorating breast cancer, by evaluatio …
Aporphines: A privileged scaffold in CNS drug discovery.
Zhu R, Jiang G, Tang W, Zhao X, Chen F, Zhang X, Ye N. Zhu R, et al. Eur J Med Chem. 2023 Aug 5;256:115414. doi: 10.1016/j.ejmech.2023.115414. Epub 2023 May 6. Eur J Med Chem. 2023. PMID: 37172474 Review.
Aporphine alkaloids embedded in 4H-dibenzo[de,g]quinoline four-ring structures belong to one of the largest subclasses of isoquinoline alkaloids. Aporphine is a privileged scaffold in the field of organic synthesis and medicinal chemistry for the discovery of new therapeut …
Aporphine alkaloids embedded in 4H-dibenzo[de,g]quinoline four-ring structures belong to one of the largest subclasses of isoquinoline …
1,290 results