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570 results

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Filters applied: Abstract, Review. Clear all
Quoted phrase not found in phrase index: "layers of liver"
Page 1
CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential.
Schlaepfer IR, Joshi M. Schlaepfer IR, et al. Endocrinology. 2020 Feb 1;161(2):bqz046. doi: 10.1210/endocr/bqz046. Endocrinology. 2020. PMID: 31900483 Free article. Review.
The CPT1 family of proteins contains 3 isoforms: CPT1A, CPT1B, and CPT1C. This review focuses on CPT1A, the liver isoform that catalyzes the rate-limiting step of converting acyl-coenzyme As into acyl-carnitines, which can then cross membranes to get into the mitochondria. …
The CPT1 family of proteins contains 3 isoforms: CPT1A, CPT1B, and CPT1C. This review focuses on CPT1A, the liver isoform that cataly …
Alkaline Phosphatases: Biochemistry, Functions, and Measurement.
Makris K, Mousa C, Cavalier E. Makris K, et al. Calcif Tissue Int. 2023 Feb;112(2):233-242. doi: 10.1007/s00223-022-01048-x. Epub 2022 Dec 26. Calcif Tissue Int. 2023. PMID: 36571614 Free article. Review.
Alkaline phosphatases (ALPs) are a group of isoenzymes, situated on the external layer of the cell membrane; they catalyze the hydrolysis of organic phosphate esters present in the extracellular space. ...Although ALPs are available in various body tissues and have distinc …
Alkaline phosphatases (ALPs) are a group of isoenzymes, situated on the external layer of the cell membrane; they catalyze the hydrol …
The intestinal barrier: a fundamental role in health and disease.
Vancamelbeke M, Vermeire S. Vancamelbeke M, et al. Expert Rev Gastroenterol Hepatol. 2017 Sep;11(9):821-834. doi: 10.1080/17474124.2017.1343143. Epub 2017 Jun 26. Expert Rev Gastroenterol Hepatol. 2017. PMID: 28650209 Free PMC article. Review.
Also reviewed is the importance of diet and lifestyle factors on intestinal barrier function, and three prototypes of chronic diseases (inflammatory bowel disease, celiac disease and nonalcoholic fatty liver disease) that have been linked to barrier defects are discussed. …
Also reviewed is the importance of diet and lifestyle factors on intestinal barrier function, and three prototypes of chronic diseases (infl …
Recent advances in polymeric transdermal drug delivery systems.
Sabbagh F, Kim BS. Sabbagh F, et al. J Control Release. 2022 Jan;341:132-146. doi: 10.1016/j.jconrel.2021.11.025. Epub 2021 Nov 20. J Control Release. 2022. PMID: 34813879 Review.
Since drugs administered by transdermal delivery systems avoid the gastrointestinal tract, and thus avoid conversion by the liver, the likelihood of liver dysfunction and gastrointestinal tract irritation as side effects is low. ...Transdermal drug delivery is achie …
Since drugs administered by transdermal delivery systems avoid the gastrointestinal tract, and thus avoid conversion by the liver, th …
Feline comorbidities: What do we really know about feline triaditis?
Černá P, Kilpatrick S, Gunn-Moore DA. Černá P, et al. J Feline Med Surg. 2020 Nov;22(11):1047-1067. doi: 10.1177/1098612X20965831. J Feline Med Surg. 2020. PMID: 33100169 Free PMC article. Review.
Cholangitis may be accompanied by increased serum liver enzymes, total bilirubin and bile acid concentrations, and variable ultrasonographic changes. ...Diagnosis of IBD is challenging without histopathology; ultrasound findings vary from normal to mucosal thickening or lo …
Cholangitis may be accompanied by increased serum liver enzymes, total bilirubin and bile acid concentrations, and variable ultrasono …
Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.
Yu S, Meng S, Xiang M, Ma H. Yu S, et al. Mol Metab. 2021 Nov;53:101257. doi: 10.1016/j.molmet.2021.101257. Epub 2021 May 18. Mol Metab. 2021. PMID: 34020084 Free PMC article. Review.
BACKGROUND: Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especially in the liver and kidney. Accumulating evidence has shown that the enhanced activity of PCK leads to increased glucose output and e …
BACKGROUND: Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especial …
Applications of single-cell multi-omics in liver cancer.
Peeters F, Cappuyns S, Piqué-Gili M, Phillips G, Verslype C, Lambrechts D, Dekervel J. Peeters F, et al. JHEP Rep. 2024 Apr 15;6(7):101094. doi: 10.1016/j.jhepr.2024.101094. eCollection 2024 Jul. JHEP Rep. 2024. PMID: 39022385 Free PMC article. Review.
Primary liver cancer, more specifically hepatocellular carcinoma (HCC), remains a significant global health problem associated with increasing incidence and mortality. ...In this review, we will highlight the different established single-cell sequencing techniques and expl …
Primary liver cancer, more specifically hepatocellular carcinoma (HCC), remains a significant global health problem associated with i …
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics.
Duan Y, Gong K, Xu S, Zhang F, Meng X, Han J. Duan Y, et al. Signal Transduct Target Ther. 2022 Aug 2;7(1):265. doi: 10.1038/s41392-022-01125-5. Signal Transduct Target Ther. 2022. PMID: 35918332 Free PMC article. Review.
Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and cancers, particularly the CVD in which the accumulation of lipids (mainly the cholesteryl esters) within macrophag …
Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD), neuro …
Effects of dietary components on intestinal permeability in health and disease.
Khoshbin K, Camilleri M. Khoshbin K, et al. Am J Physiol Gastrointest Liver Physiol. 2020 Nov 1;319(5):G589-G608. doi: 10.1152/ajpgi.00245.2020. Epub 2020 Sep 9. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32902315 Free PMC article. Review.
The normal intestinal barrier consists of multiple components in the lumen, epithelial cell layer and the lamina propria. Diverse methods are available to measure intestinal permeability. ...Effects of these dietary items in disease states, such as metabolic syndrome, l …
The normal intestinal barrier consists of multiple components in the lumen, epithelial cell layer and the lamina propria. Diverse met …
From Omics to Multi-Omics: A Review of Advantages and Tradeoffs.
Hayes CN, Nakahara H, Ono A, Tsuge M, Oka S. Hayes CN, et al. Genes (Basel). 2024 Nov 29;15(12):1551. doi: 10.3390/genes15121551. Genes (Basel). 2024. PMID: 39766818 Free PMC article. Review.
The second major shift has been the attempt to integrate two or more different classes of omics data in a single multimodal analysis to identify patterns that bridge biological layers. For example, unraveling the cause of disease may reveal a metabolite deficiency caused b …
The second major shift has been the attempt to integrate two or more different classes of omics data in a single multimodal analysis to iden …
570 results