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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 1
1996 3
1997 2
1998 5
1999 4
2000 8
2001 21
2002 23
2003 36
2004 47
2005 76
2006 123
2007 139
2008 205
2009 311
2010 241
2011 145
2012 176
2013 201
2014 196
2015 213
2016 229
2017 209
2018 235
2019 81
2020 2
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2,575 results
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Page 1
Galectins Control mTOR in Response to Endomembrane Damage.
Jia J, et al. Mol Cell 2018. PMID 29625033 Free PMC article.
The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from endomembrane damage are transmitted to mTOR to orchestrate autophagic responses is not known. Here we show that mTOR is inhibited by lysosomal damage. ...
The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays add …
Locally translated mTOR controls axonal local translation in nerve injury.
Terenzio M, et al. Science 2018. PMID 29567716 Free PMC article.
How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic target of rapamycin) was activated and then up-regulated in injured axons, owing to local translation of mTOR messenger RNA (mRNA). This mRNA was transported into axons by the cell size-regulating RNA-binding protein nucleolin. Furthermore, mTOR controlled local translation in injured axons. ...
How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic target of rapamycin) was activated and …
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.
Morita M, et al. Mol Cell 2017. PMID 28918902 Free article.
Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fission GTPase dynamin-related protein 1 (DRP1). Potent active-site mTOR inhibitors engender mitochondrial hyperfusion due to the diminished translation of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs). ...
Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fission GTPase dynamin-related protein
UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice.
Hussain S, et al. Blood 2018. PMID 30257881 Free PMC article.
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular proliferation and metabolism. Depending on its binding partners, mTOR is at the core of 2 complexes that either promote protein biosynthesis (mTOR complex 1; mTORC1) or provide survival and proliferation signals (mTORC2). ...To address this, we used proximity-based proteomics to identify molecular complexes with which UCH-L1 associates in malignant B cells. ...
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular proliferation and metabolism. Depending on its binding …
PI3Kγ is a molecular switch that controls immune suppression
Kaneda MM, et al. Nature 2016. PMID 27642729 Free PMC article.
PI3Kγ signalling through Akt and mTor inhibits NFκB activation while stimulating C/EBPβ activation, thereby inducing a transcriptional program that promotes immune suppression during inflammation and tumour growth. ...
PI3Kγ signalling through Akt and mTor inhibits NFκB activation while stimulating C/EBPβ activation, thereby inducing a transcriptiona …
P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.
Bowling S, et al. Nat Commun 2018. PMID 29720666 Free PMC article.
Here we identify that in the early mouse embryo and upon exit from naive pluripotency, the confrontation of cells with different fitness levels leads to an inhibition of mTOR signalling in the less fit cell type, causing its elimination. We show that during this process, p53 acts upstream of mTOR and is required to repress its activity. Finally, we demonstrate that during normal development around 35% of cells are eliminated by this pathway, highlighting the importance of this mechanism for embryonic development....
Here we identify that in the early mouse embryo and upon exit from naive pluripotency, the confrontation of cells with different fitness lev …
DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.
Chen H, et al. Hepatology 2018. PMID 29457836 Free PMC article.
Aberrant activation of mTORC1 was likely attributed to the defects of the DEP domain-containing mTOR-interacting protein (DEPTOR) and the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1) in the liver of chronic-plus-binge ethanol-fed mice and in the liver of patients with ALD. ...Mechanistically, the lipid-lowering effect of hepatic DEPTOR was attributable to decreased proteolytic processing, nuclear translocation, and transcriptional activity of the lipogenic transcription factor sterol regulatory element-binding protein-1 (SREBP-1). ...
Aberrant activation of mTORC1 was likely attributed to the defects of the DEP domain-containing mTOR-interacting protein (DEPT …
Milk protein synthesis is regulated by T1R1/T1R3, a G protein-coupled taste receptor, through the mTOR pathway in the mouse mammary gland.
Liu J, et al. Mol Nutr Food Res 2017. PMID 28497545
The mammalian target of rapamycin (mTOR) pathway is a crucial modulator of protein synthesis. In this study, we want to investigate if T1R1/T1R3 can regulate milk protein synthesis and mediate the mTOR pathway in the mice mammary gland in vivo. ...Activation of the mTOR pathway was repressed by inhibition of T1R3 or T1R1 knockout in mammary gland explants. CONCLUSION: T1R1/T1R3 modulates the mTOR pathway to regulate milk protein synthesis in the mouse mammary gland in vivo....
The mammalian target of rapamycin (mTOR) pathway is a crucial modulator of protein synthesis. In this study, we want to invest …
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Hopkins BD, et al. Nature 2018. PMID 30051890 Free PMC article.
We hypothesized that insulin feedback induced by PI3K inhibitors may reactivate the PI3K-mTOR signalling axis in tumours, thereby compromising treatment effectiveness(7,8). ...
We hypothesized that insulin feedback induced by PI3K inhibitors may reactivate the PI3K-mTOR signalling axis in tumours, thereby com …
Dietary protein sources differentially affect microbiota, mTOR activity and transcription of mTOR signaling pathways in the small intestine.
Kar SK, et al. PLoS One 2017. PMID 29149221 Free PMC article.
Dietary protein sources can have profound effects on host-microbe interactions in the gut that are critically important for immune resilience. ...They mostly related to the mTOR pathway. In addition, an increased (P < 0.05) concentration of granulocyte colony-stimulating factor was observed in serum of SBM-fed mice compared to other dietary groups. ...
Dietary protein sources can have profound effects on host-microbe interactions in the gut that are critically important for immune re …
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