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226 results

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Page 1
Enantiomeric separation of malathion and malaoxon and the chiral residue analysis in food and environmental matrix.
Hua Y, Zhou Q, Wang P, Zhou Z, Liu D. Hua Y, et al. Chirality. 2020 Aug;32(8):1053-1061. doi: 10.1002/chir.23229. Epub 2020 May 4. Chirality. 2020. PMID: 32365418
Malathion is a widely used chiral phosphorus insecticide, which has a more toxic chiral metabolite malaoxon. In this work, the enantiomers of malathion and malaoxon were separated by high-performance liquid chromatography-mass/mass (HPLC-MS/MS) with chiral columns u …
Malathion is a widely used chiral phosphorus insecticide, which has a more toxic chiral metabolite malaoxon. In this work, the enanti …
An ultrasensitive "mix-and-detect" kind of fluorescent biosensor for malaoxon detection using the AChE-ATCh-Ag-GO system.
Alex A V, Mukherjee A. Alex A V, et al. RSC Adv. 2023 May 9;13(21):14159-14170. doi: 10.1039/d3ra02253f. eCollection 2023 May 9. RSC Adv. 2023. PMID: 37180011 Free PMC article.
Malaoxon, a highly toxic metabolite of malathion, can lead to severe harm or death if ingested. ...The biosensor also demonstrated superior inhibitory efficacy towards malaoxon compared to other OP pesticides, indicating its resistance to external influences. ...
Malaoxon, a highly toxic metabolite of malathion, can lead to severe harm or death if ingested. ...The biosensor also demonstrated su …
Engineering of a phosphotriesterase with improved stability and enhanced activity for detoxification of the pesticide metabolite malaoxon.
Job L, Köhler A, Testanera M, Escher B, Worek F, Skerra A. Job L, et al. Protein Eng Des Sel. 2023 Jan 21;36:gzad020. doi: 10.1093/protein/gzad020. Protein Eng Des Sel. 2023. PMID: 37941439
Whereas wild-type BdPTE can hydrolyse pesticides like paraoxon, chlorpyrifos-oxon and mevinphos with high catalytic efficiencies, kcat/KM >2 107 M-1 min-1, degradation of malaoxon is unsatisfactory (kcat/KM 1 104 M-1 min-1). Here, we report the rational engineerin …
Whereas wild-type BdPTE can hydrolyse pesticides like paraoxon, chlorpyrifos-oxon and mevinphos with high catalytic efficiencies, kcat/KM &g …
Involvement of superoxide in malaoxon-induced toxicity in primary cultures of cortical neurons.
Rieger DK, Dos Santos AA, Suñol C, Farina M. Rieger DK, et al. J Toxicol Environ Health A. 2017;80(19-21):1106-1115. doi: 10.1080/15287394.2017.1357305. Epub 2017 Aug 29. J Toxicol Environ Health A. 2017. PMID: 28849997
The aim of this study was to investigate the potential occurrence of oxidative stress as a critical step in the toxicity induced by the OP malaoxon(MAL) using primary cultures of mouse cortical neurons, as well as to distinguish MAL-induced oxidative stress and cell toxici …
The aim of this study was to investigate the potential occurrence of oxidative stress as a critical step in the toxicity induced by the OP …
The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells.
Angelini DJ, Moyer RA, Cole S, Willis KL, Oyler J, Dorsey RM, Salem H. Angelini DJ, et al. Int J Toxicol. 2015 Sep-Oct;34(5):433-41. doi: 10.1177/1091581815593933. Epub 2015 Jul 14. Int J Toxicol. 2015. PMID: 26173615
To elucidate the mechanism of OP-induced cytotoxicity, we examined the effects of parathion and malathion and their respective metabolites, paraoxon and malaoxon, on primary cultured human large and small airway cells. Exposure to paraoxon and malaoxon produced a do …
To elucidate the mechanism of OP-induced cytotoxicity, we examined the effects of parathion and malathion and their respective metabolites, …
Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion.
Berkman CE, Quinn DA, Thompson CM. Berkman CE, et al. Chem Res Toxicol. 1993 Sep-Oct;6(5):724-30. doi: 10.1021/tx00035a019. Chem Res Toxicol. 1993. PMID: 8292752
The biomolecular reaction constants (ki), dissociation constants (Kd), and phosphorylation constants (kp) were determined for the enantiomers of malaoxon against rat brain acetylcholinesterase, and for the stereoisomers of isomalathion against rat brain acetylcholinesteras …
The biomolecular reaction constants (ki), dissociation constants (Kd), and phosphorylation constants (kp) were determined for the enantiomer …
Study on Spontaneous Reactivation and Aging of Acetylcholinesterase Inhibited by Paraoxon and Malaoxon in Ten Species.
Gao M, Ni Z, Li G, Wu G, Huang B. Gao M, et al. Int J Mol Sci. 2023 Sep 18;24(18):14213. doi: 10.3390/ijms241814213. Int J Mol Sci. 2023. PMID: 37762515 Free PMC article.
The differences in the AChE sensitivity to paraoxon among the ten species were much greater than in the sensitivity to malaoxon. Compared to paraoxon, malaoxon was more selective for Cavia porcellus. Coleoptera insects showed a stronger dephosphorylation ability tha …
The differences in the AChE sensitivity to paraoxon among the ten species were much greater than in the sensitivity to malaoxon. Comp …
Growth, photosynthesis and removal responses of the cyanobacteria Chroococcus sp. to malathion and malaoxon.
Martínez-Aguilar K, Pérez-Legaspi IA, Ramírez-Fuentes E, Trujillo-Tapia MN, Alfredo Ortega-Clemente L. Martínez-Aguilar K, et al. J Environ Sci Health B. 2018;53(12):771-776. doi: 10.1080/03601234.2018.1505070. Epub 2018 Sep 10. J Environ Sci Health B. 2018. PMID: 30199345
Malathion is an organophosphorus pesticide widely used in agricultural crops, despite its toxicity. In addition, malaoxon occurs by oxidation of malathion being more toxic. The toxic effects of malathion and malaoxon in humans include hepatoxicity, breast cancer, ge …
Malathion is an organophosphorus pesticide widely used in agricultural crops, despite its toxicity. In addition, malaoxon occurs by o …
Functional analysis of an overexpressed glutathione S-transferase BdGSTd5 involved in malathion and malaoxon detoxification in Bactrocera dorsalis.
Zhang S, Chen M, Meng L, Dou W, Wang J, Yuan G. Zhang S, et al. Pestic Biochem Physiol. 2023 Aug;194:105498. doi: 10.1016/j.pestbp.2023.105498. Epub 2023 Jun 16. Pestic Biochem Physiol. 2023. PMID: 37532320
Molecular docking analysis further indicated the interactive potential of BdGSTd5 with malathion and its toxic oxide malaoxon. The recombinant BdGSTd5 exhibited glutathione-conjugating activity toward 1-chloro-2, 4-dinitrobenzene and malathion and malaoxon metabolic …
Molecular docking analysis further indicated the interactive potential of BdGSTd5 with malathion and its toxic oxide malaoxon. The re …
226 results