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123 results

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Quoted phrase not found in phrase index: "medulla of thymus"
Page 1
The thymus medulla and its control of alphabetaT cell development.
Cosway EJ, James KD, Lucas B, Anderson G, White AJ. Cosway EJ, et al. Semin Immunopathol. 2021 Feb;43(1):15-27. doi: 10.1007/s00281-020-00830-z. Epub 2020 Dec 11. Semin Immunopathol. 2021. PMID: 33306154 Free PMC article. Review.
Experiments in both wild-type and genetically modified mice have been essential in revealing complex cellular and molecular mechanisms that regulate thymus function. In particular, studies have demonstrated the diverse and critical role that the thymus medulla …
Experiments in both wild-type and genetically modified mice have been essential in revealing complex cellular and molecular mechanisms that …
Mechanisms of thymus medulla development and function.
Anderson G, Baik S, Cowan JE, Holland AM, McCarthy NI, Nakamura K, Parnell SM, White AJ, Lane PJ, Jenkinson EJ, Jenkinson WE. Anderson G, et al. Curr Top Microbiol Immunol. 2014;373:19-47. doi: 10.1007/82_2013_320. Curr Top Microbiol Immunol. 2014. PMID: 23612988 Review.
The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the alphabeta form of the T-cell receptor (alphabetaTCR) takes place in the thymus, a primary lymphoid organ containing distinct cortical and medullary microenvironments. ...Here, we summarize current …
The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the alphabeta form of the T-cell receptor (alphabetaTCR) takes plac …
Invariant NKT Cells and Control of the Thymus Medulla.
White AJ, Lucas B, Jenkinson WE, Anderson G. White AJ, et al. J Immunol. 2018 May 15;200(10):3333-3339. doi: 10.4049/jimmunol.1800120. J Immunol. 2018. PMID: 29735644 Free PMC article. Review.
Additionally, the thymus also supports the production of T cell subsets that express alphabeta TCRs but display unique developmental and functional features distinct from conventional alphabeta T cells. ...In this article, we review evidence for an intrathymic innate lymph …
Additionally, the thymus also supports the production of T cell subsets that express alphabeta TCRs but display unique developmental …
The Mechanisms of T Cell Selection in the Thymus.
Takaba H, Takayanagi H. Takaba H, et al. Trends Immunol. 2017 Nov;38(11):805-816. doi: 10.1016/j.it.2017.07.010. Epub 2017 Aug 19. Trends Immunol. 2017. PMID: 28830733 Review.
T cells undergo positive and negative selection in the thymic cortex and medulla, respectively. A promiscuous expression of a wide array of self-antigens in the thymus is essential for the negative selection of self-reactive T cells and the establishment of central …
T cells undergo positive and negative selection in the thymic cortex and medulla, respectively. A promiscuous expression of a wide ar …
Thymus medulla fosters generation of natural Treg cells, invariant gammadelta T cells, and invariant NKT cells: what we learn from intrathymic migration.
Cowan JE, Jenkinson WE, Anderson G. Cowan JE, et al. Eur J Immunol. 2015 Mar;45(3):652-60. doi: 10.1002/eji.201445108. Epub 2015 Feb 13. Eur J Immunol. 2015. PMID: 25615828 Free PMC article. Review.
The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and development of immature T-cell precursors. ...While less is known about the intrathymic requirements of these nonconventional T cells, recent studi …
The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and develop …
Role of thymus in health and disease.
Gulla S, Reddy MC, Reddy VC, Chitta S, Bhanoori M, Lomada D. Gulla S, et al. Int Rev Immunol. 2023;42(5):347-363. doi: 10.1080/08830185.2022.2064461. Epub 2022 May 20. Int Rev Immunol. 2023. PMID: 35593192 Review.
The thymus decreases in size and cellularity with age referred to as thymus involution or atrophy. ...The mechanisms which act on the structural (cortex and medulla) matrix of the thymus, the gradual accumulation of genetic mutations, and altered gene …
The thymus decreases in size and cellularity with age referred to as thymus involution or atrophy. ...The mechanisms which act …
Control of the thymic medulla and its influence on alphabetaT-cell development.
Lucas B, McCarthy NI, Baik S, Cosway E, James KD, Parnell SM, White AJ, Jenkinson WE, Anderson G. Lucas B, et al. Immunol Rev. 2016 May;271(1):23-37. doi: 10.1111/imr.12406. Immunol Rev. 2016. PMID: 27088905 Free PMC article. Review.
The thymus is a primary lymphoid tissue that supports the generation of alphabetaT cells. In this review, we describe the processes that give rise to the thymus medulla, a site that nurtures self-tolerant T-cell generation following positive selection events …
The thymus is a primary lymphoid tissue that supports the generation of alphabetaT cells. In this review, we describe the processes t …
Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus.
Březina J, Vobořil M, Filipp D. Březina J, et al. Front Immunol. 2022 Jun 14;13:926625. doi: 10.3389/fimmu.2022.926625. eCollection 2022. Front Immunol. 2022. PMID: 35774801 Free PMC article. Review.
This process occurs largely in the thymic medulla where the strength of affinity between TCR and self-peptide MHC complexes is the factor determining thymocyte fate. Thus, the display of self-antigens in the thymus by thymic antigen presenting cells, which are compr …
This process occurs largely in the thymic medulla where the strength of affinity between TCR and self-peptide MHC complexes is the fa …
Thymus organogenesis.
Rodewald HR. Rodewald HR. Annu Rev Immunol. 2008;26:355-88. doi: 10.1146/annurev.immunol.26.021607.090408. Annu Rev Immunol. 2008. PMID: 18304000 Review.
The existence of epithelial progenitors common for cortex and medulla with the capacity for forming functional thymus after birth has been uncovered. ...It will be important to elucidate the pathways from putative thymus stem cells to mature thymus epi …
The existence of epithelial progenitors common for cortex and medulla with the capacity for forming functional thymus after bi …
The thymus is relevant in the migration of mature lymphocytes.
Pabst R. Pabst R. Cell Tissue Res. 2019 Apr;376(1):19-24. doi: 10.1007/s00441-019-02994-z. Epub 2019 Feb 14. Cell Tissue Res. 2019. PMID: 30762129 Review.
The different subsets of lymphocytes leave the thymus as recent thymic emigrants. Peripheral dendritic cells migrate to the thymus. In addition to the homing of hematopoietic progenitor cells to the thymus, there is evidence for lymphocyte entry from peripher …
The different subsets of lymphocytes leave the thymus as recent thymic emigrants. Peripheral dendritic cells migrate to the thymus …
123 results