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Year Number of Results
1985 2
1986 2
1987 1
1988 8
1989 1
1990 4
1991 1
1992 5
1993 5
1994 6
1995 2
1996 7
1997 5
1998 1
1999 1
2001 2
2002 1
2003 3
2004 4
2005 5
2006 5
2007 4
2008 3
2009 4
2010 3
2011 4
2012 6
2013 6
2014 6
2015 11
2016 9
2017 10
2018 9
2019 7
2020 12
2021 17
2022 10
2023 6
2024 1

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187 results

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Page 1
A metabolome atlas of the aging mouse brain.
Ding J, Ji J, Rabow Z, Shen T, Folz J, Brydges CR, Fan S, Lu X, Mehta S, Showalter MR, Zhang Y, Araiza R, Bower LR, Lloyd KCK, Fiehn O. Ding J, et al. Nat Commun. 2021 Oct 15;12(1):6021. doi: 10.1038/s41467-021-26310-y. Nat Commun. 2021. PMID: 34654818 Free PMC article.
Yet, the complexity of the brain metabolome and its changes during diseases or aging remain poorly understood. Here, we generate a metabolome atlas of the aging wildtype mouse brain from 10 anatomical regions spanning from adolescence to old age. ...We show that metabolic …
Yet, the complexity of the brain metabolome and its changes during diseases or aging remain poorly understood. Here, we generate a metabolom …
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium; Jackson Laboratory; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource Center; MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA. Dickinson ME, et al. Nature. 2016 Sep 22;537(7621):508-514. doi: 10.1038/nature19356. Epub 2016 Sep 14. Nature. 2016. PMID: 27626380 Free PMC article.
Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,000 knockout mouse …
Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As …
The Deep Genome Project.
Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM. Lloyd KCK, et al. Genome Biol. 2020 Feb 3;21(1):18. doi: 10.1186/s13059-020-1931-9. Genome Biol. 2020. PMID: 32008577 Free PMC article. No abstract available.
Generating mouse models for biomedical research: technological advances.
Gurumurthy CB, Lloyd KCK. Gurumurthy CB, et al. Dis Model Mech. 2019 Jan 8;12(1):dmm029462. doi: 10.1242/dmm.029462. Dis Model Mech. 2019. PMID: 30626588 Free PMC article. Review.
Over the past decade, new methods and procedures have been developed to generate genetically engineered mouse models of human disease. This At a Glance article highlights several recent technical advances in mouse genome manipulation that have transformed our abilit …
Over the past decade, new methods and procedures have been developed to generate genetically engineered mouse models of human disease …
Centralized mouse repositories.
Donahue LR, Hrabe de Angelis M, Hagn M, Franklin C, Lloyd KC, Magnuson T, McKerlie C, Nakagata N, Obata Y, Read S, Wurst W, Hörlein A, Davisson MT. Donahue LR, et al. Mamm Genome. 2012 Oct;23(9-10):559-71. doi: 10.1007/s00335-012-9420-4. Epub 2012 Sep 4. Mamm Genome. 2012. PMID: 22945696 Free PMC article.
Because the mouse is used so widely for biomedical research and the number of mouse models being generated is increasing rapidly, centralized repositories are essential if the valuable mouse strains and models that have been developed are to be securely prese …
Because the mouse is used so widely for biomedical research and the number of mouse models being generated is increasing rapid …
Principles and application of LIMS in mouse clinics.
Maier H, Schütt C, Steinkamp R, Hurt A, Schneltzer E, Gormanns P, Lengger C, Griffiths M, Melvin D, Agrawal N, Alcantara R, Evans A, Gannon D, Holroyd S, Kipp C, Raj NP, Richardson D, LeBlanc S, Vasseur L, Masuya H, Kobayashi K, Suzuki T, Tanaka N, Wakana S, Walling A, Clary D, Gallegos J, Fuchs H, de Angelis MH, Gailus-Durner V. Maier H, et al. Mamm Genome. 2015 Oct;26(9-10):467-81. doi: 10.1007/s00335-015-9586-7. Epub 2015 Jul 25. Mamm Genome. 2015. PMID: 26208973 Free PMC article. Review.
Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually tracked and subjected to phenotyping procedures according to a standardised s …
Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from …
Animal models for studies of HIV-1 brain reservoirs.
Waight E, Zhang C, Mathews S, Kevadiya BD, Lloyd KCK, Gendelman HE, Gorantla S, Poluektova LY, Dash PK. Waight E, et al. J Leukoc Biol. 2022 Nov;112(5):1285-1295. doi: 10.1002/JLB.5VMR0322-161R. Epub 2022 Aug 31. J Leukoc Biol. 2022. PMID: 36044375 Free PMC article. Review.
Efficient mouse genome engineering by CRISPR-EZ technology.
Modzelewski AJ, Chen S, Willis BJ, Lloyd KCK, Wood JA, He L. Modzelewski AJ, et al. Nat Protoc. 2018 Jun;13(6):1253-1274. doi: 10.1038/nprot.2018.012. Epub 2018 May 10. Nat Protoc. 2018. PMID: 29748649 Free PMC article.
CRISPR/Cas9 technology has transformed mouse genome editing with unprecedented precision, efficiency, and ease; however, the current practice of microinjecting CRISPR reagents into pronuclear-stage embryos remains rate-limiting. ...In a side-by-side comparison in the high- …
CRISPR/Cas9 technology has transformed mouse genome editing with unprecedented precision, efficiency, and ease; however, the current …
Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes.
Higgins K, Moore BA, Berberovic Z, Adissu HA, Eskandarian M, Flenniken AM, Shao A, Imai DM, Clary D, Lanoue L, Newbigging S, Nutter LMJ, Adams DJ, Bosch F, Braun RE, Brown SDM, Dickinson ME, Dobbie M, Flicek P, Gao X, Galande S, Grobler A, Heaney JD, Herault Y, de Angelis MH, Chin HG, Mammano F, Qin C, Shiroishi T, Sedlacek R, Seong JK, Xu Y; IMPC Consortium; Lloyd KCK, McKerlie C, Moshiri A. Higgins K, et al. Sci Rep. 2022 Dec 1;12(1):20791. doi: 10.1038/s41598-022-19710-7. Sci Rep. 2022. PMID: 36456625 Free PMC article.
We searched a database of single-gene knockout (KO) mice produced by the International Mouse Phenotyping Consortium (IMPC) to identify candidate ciliopathy genes. We first screened for phenotypes in mouse lines with both ocular and renal or reproductive trait abnorm …
We searched a database of single-gene knockout (KO) mice produced by the International Mouse Phenotyping Consortium (IMPC) to identif …
The Mutant Mouse Resource and Research Center (MMRRC): the NIH-supported National Public Repository and Distribution Archive of Mutant Mouse Models in the USA.
Amos-Landgraf J, Franklin C, Godfrey V, Grieder F, Grimsrud K, Korf I, Lutz C, Magnuson T, Mirochnitchenko O, Patel S, Reinholdt L, Lloyd KCK. Amos-Landgraf J, et al. Mamm Genome. 2022 Mar;33(1):203-212. doi: 10.1007/s00335-021-09894-0. Epub 2021 Jul 27. Mamm Genome. 2022. PMID: 34313795 Free PMC article. Review.
The Mutant Mouse Resource and Research Center (MMRRC) Program is the pre-eminent public national mutant mouse repository and distribution archive in the USA, serving as a national resource of mutant mice available to the global scientific community for biomed …
The Mutant Mouse Resource and Research Center (MMRRC) Program is the pre-eminent public national mutant mouse repositor …
187 results