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Page 1
Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool.
Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP. Brown DG, et al. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. Cancer Metab. 2016. PMID: 27275383 Free PMC article.
METHODS: Seventeen CRC patients participated in this pilot study and provided CRC, adjacent mucosa ~10 cm proximal to the tumor, and stool. Metabolomes were analyzed by gas chromatography-mass spectrometry (GC/MS) and ultra-performance liquid chromatography-mass spectromet …
METHODS: Seventeen CRC patients participated in this pilot study and provided CRC, adjacent mucosa ~10 cm proximal to the tumor, and …
Excipient-Free Ionizable Polyester Nanoparticles for Lung-Selective and Innate Immune Cell Plasmid DNA and mRNA Transfection.
Chakraborty A, Dharmaraj S, Truong N, Pearson RM. Chakraborty A, et al. ACS Appl Mater Interfaces. 2022 Dec 28;14(51):56440-56453. doi: 10.1021/acsami.2c14424. Epub 2022 Dec 16. ACS Appl Mater Interfaces. 2022. PMID: 36525379 Free PMC article.
Here, we report the development of a single-component and excipient-free, polyester-based nucleic acid delivery nanoparticle platform comprising ionizable N-methyldiethanolamine (MDET) and various hydrophobic alkyl diols (Cp) that achieves lung-selective nucleic aci …
Here, we report the development of a single-component and excipient-free, polyester-based nucleic acid delivery nanoparticle platform compri …
Chemoenzymatic Synthesis of Cholesterol-g-Poly(amine-co-ester) Amphiphilic Copolymer as a Carrier for miR-23b Delivery.
Chen J, Jiang W, Han H, Yang J, Chen W, Wang Y, Tang J, Li Q. Chen J, et al. ACS Macro Lett. 2017 May 16;6(5):523-528. doi: 10.1021/acsmacrolett.7b00211. Epub 2017 Apr 25. ACS Macro Lett. 2017. PMID: 35610880
The lipase-catalyzed polymerization of N-methyldiethanolamine, diethyl sebacate and omega-pentadecanolide was performed to construct a cationic poly(amine-co-ester), and a hydrophobic N-(2-bromoethyl)carbamoyl cholesterol was then grafted onto its main chain through …
The lipase-catalyzed polymerization of N-methyldiethanolamine, diethyl sebacate and omega-pentadecanolide was performed to con …
Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery.
Wang A, Gao H, Sun Y, Sun YL, Yang YW, Wu G, Wang Y, Fan Y, Ma J. Wang A, et al. Int J Pharm. 2013 Jan 30;441(1-2):30-9. doi: 10.1016/j.ijpharm.2012.12.021. Epub 2012 Dec 20. Int J Pharm. 2013. PMID: 23262421
A series of temperature- and pH-responsive polyurethanes based on hexamethylene diisocyanate (HDI) and 4,4'-diphenylmethane diisocyanate (MDI) were synthesized by a coupling reaction with bis-1,4-(hydroxyethyl) piperazine (HEP), N-methyldiethanolamine (MDEA) and N-b …
A series of temperature- and pH-responsive polyurethanes based on hexamethylene diisocyanate (HDI) and 4,4'-diphenylmethane diisocyanate (MD …
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.
Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. Han L, et al. ACS Nano. 2016 Apr 26;10(4):4209-18. doi: 10.1021/acsnano.5b07573. Epub 2016 Mar 16. ACS Nano. 2016. PMID: 26967254 Free PMC article.
Thus, the low delivery efficiency renders many of these agents ineffective in treating brain cancer. In this report, we proposed an "autocatalytic" approach for increasing the transport of nanoparticles into the brain. ...We further demonstrated that ABTT NPs were capable …
Thus, the low delivery efficiency renders many of these agents ineffective in treating brain cancer. In this report, we proposed an " …
Micelles of enzymatically synthesized PEG-poly(amine-co-ester) block copolymers as pH-responsive nanocarriers for docetaxel delivery.
Zhang X, Liu B, Yang Z, Zhang C, Li H, Luo X, Luo H, Gao D, Jiang Q, Liu J, Jiang Z. Zhang X, et al. Colloids Surf B Biointerfaces. 2014 Mar 1;115:349-58. doi: 10.1016/j.colsurfb.2013.12.029. Epub 2013 Dec 24. Colloids Surf B Biointerfaces. 2014. PMID: 24398083
A series of PEGylated poly(amine-co-ester) terpolymers were successfully synthesized in one step via lipase-catalyzed copolymerization of omega-pentadecalactone (PDL), diethyl sebacate (DES), and N-methyldiethanolamine (MDEA) comonomers in the presence of poly(ethyl …
A series of PEGylated poly(amine-co-ester) terpolymers were successfully synthesized in one step via lipase-catalyzed copolymerization of om …
PEGylated poly(amine-co-ester) micelles as biodegradable non-viral gene vectors with enhanced stability, reduced toxicity and higher in vivo transfection efficacy.
Zhang X , Tang W , Yang Z , Luo X , Luo H , Gao D , Chen Y , Jiang Q , Liu J , Jiang Z . Zhang X , et al. J Mater Chem B. 2014 Jul 7;2(25):4034-4044. doi: 10.1039/c4tb00439f. Epub 2014 May 27. J Mater Chem B. 2014. PMID: 32261654
PEG-PPMS copolymers with various compositions were synthesized in one step via lipase-catalyzed copolymerization of omega-pentadecalactone (PDL), N-methyldiethanolamine (MDEA) and diethyl sebacate (DES) with poly(ethylene glycol) methyl ether (MeO-PEG-OH). ...Althou …
PEG-PPMS copolymers with various compositions were synthesized in one step via lipase-catalyzed copolymerization of omega-pentadecalactone ( …
Nitrobenzyl mustard quaternary salts: a new class of hypoxia-selective cytotoxins capable of releasing diffusible cytotoxins on bioreduction.
Denny WA, Wilson WR, Tercel M, Van Zijl P, Pullen SM. Denny WA, et al. Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):317-21. doi: 10.1016/0360-3016(94)90282-8. Int J Radiat Oncol Biol Phys. 1994. PMID: 8195026
METHODS AND MATERIALS: The parent compound N,N-bis(2-chloroethyl)-N-methyl-N-(2-nitrobenzyl)ammonium chloride (SN 25246) was prepared by reaction of 2-nitrobenzyl chloride with N-methyldiethanolamine, and reaction of the resulting quaternary diol with thionyl chlori …
METHODS AND MATERIALS: The parent compound N,N-bis(2-chloroethyl)-N-methyl-N-(2-nitrobenzyl)ammonium chloride (SN 25246) was prepared by rea …