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163 results

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Page 1
Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model.
Aly NSM, Matsumori H, Dinh TQ, Sato A, Miyoshi SI, Chang KS, Yu HS, Cao DT, Kim HS. Aly NSM, et al. Pathogens. 2023 Mar 1;12(3):398. doi: 10.3390/pathogens12030398. Pathogens. 2023. PMID: 36986320 Free PMC article.
We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application for children. ...
We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we eva …
Evaluating the activity of N-89 as an oral antimalarial drug.
Aly NSM, Matsumori H, Dinh TQ, Sato A, Miyoshi SI, Chang KS, Yu HS, Kubota T, Kurosaki Y, Cao DT, Rashed GA, Kim HS. Aly NSM, et al. Parasites Hosts Dis. 2023 Aug;61(3):282-291. doi: 10.3347/PHD.23044. Epub 2023 Aug 21. Parasites Hosts Dis. 2023. PMID: 37648233 Free PMC article.
This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, an …
This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent …
Formulation and evaluation of the antimalarial N-89 as a transdermal drug candidate.
Aly NSM, Matsumori H, Dinh TQ, Sato A, Miyoshi SI, Chang KS, Yu HS, Kim HS. Aly NSM, et al. Parasitol Int. 2023 Apr;93:102720. doi: 10.1016/j.parint.2022.102720. Epub 2022 Dec 11. Parasitol Int. 2023. PMID: 36516945
In this report, we formulate and evaluate transdermal (td) 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the Plasmodium berghei rodent malaria parasite in vivo model. The selected solvent for the ointment type of td N-89 was polyethylene glycol (PEG) [PEG400:PEG 4000 …
In this report, we formulate and evaluate transdermal (td) 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the Plasmodium berghei …
Preparation, characterisation and thermal properties of calcium alginate/n-nonadecane microcapsules fabricated by electro-coextrusion for thermo-regulating textiles.
Kamali Moghaddam M, Mortazavi SM. Kamali Moghaddam M, et al. J Microencapsul. 2015;32(8):737-44. doi: 10.3109/02652048.2015.1073388. Epub 2015 Aug 21. J Microencapsul. 2015. PMID: 26299209
Electro-coextrusion process fabricated a series of microencapsulated phase change material (MEPCM) based on n-nonadecane core and alginate shell. The influence of the flow rate ratio of the shell/core on the formation, encapsulation efficiency and thermal behaviour …
Electro-coextrusion process fabricated a series of microencapsulated phase change material (MEPCM) based on n-nonadecane core …
Thermodynamic Analysis of n-Nonadecane (C(19)H(40))/1-Octadecanol (C(18)H(37)OH) Blends.
Guo W, Xing Y, Wen W, Su W, Hou C, Li G, Ye L. Guo W, et al. Molecules. 2024 Jun 7;29(12):2722. doi: 10.3390/molecules29122722. Molecules. 2024. PMID: 38930788 Free PMC article.
The article delves into the intricate phase transitions of 1-Octadecanol and n-Nonadecane within a binary system, unveiling dynamic structural changes under varying conditions. ...
The article delves into the intricate phase transitions of 1-Octadecanol and n-Nonadecane within a binary system, unveiling dy …
Insights into the mode of action of 1,2,6,7-tetraoxaspiro [7.11] nonadecane (N-89) against adult Schistosoma mansoni worms.
Blay EA, Kumagai T, Yamabe M, Hino A, Shimogawara R, Kim HS, Sato A, Ichimura K, Ayi I, Iwanaga S, Ohta N. Blay EA, et al. Parasitol Int. 2018 Aug;67(4):403-412. doi: 10.1016/j.parint.2018.03.006. Epub 2018 Apr 1. Parasitol Int. 2018. PMID: 29617630
Here, a murine model was infected with Schistosoma mansoni and treated with oral 1,2,6,7-tetraoxaspiro [7.11] nonadecane (N-89), which caused a significant reduction in fecundity and egg burden and reduced morbidity when administered at 5-weeks post-infection. ...
Here, a murine model was infected with Schistosoma mansoni and treated with oral 1,2,6,7-tetraoxaspiro [7.11] nonadecane (N-89), whic …
Do Abiotic Stresses Affect the Aroma of Damask Roses?
Charoimek N, Phusuwan S, Petcharak C, Huanhong K, Prasad SK, Junmahasathien T, Khemacheewakul J, Sommano SR, Sunanta P. Charoimek N, et al. Plants (Basel). 2023 Sep 28;12(19):3428. doi: 10.3390/plants12193428. Plants (Basel). 2023. PMID: 37836168 Free PMC article. Review.
The essential oils obtained are high in volatile organic compounds (VOCs), which are in demand across the pharmaceutical, food, perfume, and cosmetic industries. Citronellol, nonadecane, heneicosane, caryophyllene, geraniol, nerol, linalool, and phenyl ethyl acetate are th …
The essential oils obtained are high in volatile organic compounds (VOCs), which are in demand across the pharmaceutical, food, perfume, and …
2,7,12,17-Tttraoxa-3,4:5,6:13,14:15,16-tetrabenzodispiro[8.1.8.0]nonadecane.
Stadnicka K, Szlachcic P. Stadnicka K, et al. Acta Crystallogr C. 2003 Mar;59(Pt 3):o129-31. doi: 10.1107/s0108270103001963. Epub 2003 Feb 18. Acta Crystallogr C. 2003. PMID: 12711785
The crystal structure of the dispiro product, 2,7,12,17-tetraoxa-3,4:5,6:13,14:15,16-tetrabenzodispiro[8.1.8.0]nonadecane, C(31)H(26)O(4), revealed that the conformations of the nine-membered heterocyclic rings are due to interactions between the pi-electron system of the …
The crystal structure of the dispiro product, 2,7,12,17-tetraoxa-3,4:5,6:13,14:15,16-tetrabenzodispiro[8.1.8.0]nonadecane, C(31)H(26) …
Molecular docking analysis of long-chain alkanes with the β-lactamase BEL-1 from P. aeruginosa.
Gayathri VR, Prakash B, Yashika JV, Selvi SV, Jegadeesh Kumar D. Gayathri VR, et al. Bioinformation. 2022 May 31;18(5):460-463. doi: 10.6026/97320630018460. eCollection 2022. Bioinformation. 2022. PMID: 36945220 Free PMC article.
Therefore, it is of interest to document the molecular docking analysis data of three long-chain alkanes, namely, eicosane, triacontane, and nonadecane with beta-lactamase BEL-1. Data shows that nonadecane have good binding features and drug-likeness when compared t …
Therefore, it is of interest to document the molecular docking analysis data of three long-chain alkanes, namely, eicosane, triacontane, and …
163 results