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14 results

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Page 1
Assessment of DNA damage induced by broadband and narrowband UVB in cultured lymphoblasts and keratinocytes using the comet assay.
Tzung TY, Rünger TM. Tzung TY, et al. Photochem Photobiol. 1998 Jun;67(6):647-50. Photochem Photobiol. 1998. PMID: 9648530
At equal doses, broadband UVB produced more DNA damage than narrowband UVB. However, in phototherapy of psoriasis, up to 10-fold higher doses are used with TL01. When therapeutically equivalent doses were compared (10-fold correction for narrowband …
At equal doses, broadband UVB produced more DNA damage than narrowband UVB. However, in phototherapy of psoriasi …
Cytotoxicity and Mutagenicity of Narrowband UVB to Mammalian Cells.
Buglewicz DJ, Mussallem JT, Haskins AH, Su C, Maeda J, Kato TA. Buglewicz DJ, et al. Genes (Basel). 2020 Jun 11;11(6):646. doi: 10.3390/genes11060646. Genes (Basel). 2020. PMID: 32545288 Free PMC article.
The radiation dose required to reduce survival to 10% (D(10) value) demonstrated BB-UVB was 10 times more cytotoxic than NB-UVB, and revealed that NB-UVB also induces DNA damage repaired by nucleotide excision repair. We also found that BB-UVB more efficiently induc …
The radiation dose required to reduce survival to 10% (D(10) value) demonstrated BB-UVB was 10 times more cytotoxic than NB-UVB, and reveale …
Cyclobutane Pyrimidine Dimers Produced with Narrowband UVB Are on Average More Mutagenic than Those with Broadband UVB in Mouse Skin.
Ikehata H, Yamamoto M. Ikehata H, et al. Photochem Photobiol. 2022 Jul;98(4):916-924. doi: 10.1111/php.13568. Epub 2021 Dec 6. Photochem Photobiol. 2022. PMID: 34843117
Although narrowband UVB (NB-UVB) has replaced broadband UVB (BB-UVB) because of its greater effectiveness in dermatological phototherapy, it is twice as carcinogenic as BB-UVB at an equivalent inflammatory dose. To clarify the basis of the different genotoxicities, …
Although narrowband UVB (NB-UVB) has replaced broadband UVB (BB-UVB) because of its greater effectiveness in dermatological ph …
Distinguishing Myth from Fact: Photocarcinogenesis and Phototherapy.
Thompson KG, Kim N. Thompson KG, et al. Dermatol Clin. 2020 Jan;38(1):25-35. doi: 10.1016/j.det.2019.08.003. Epub 2019 Oct 18. Dermatol Clin. 2020. PMID: 31753190 Review.
Ultraviolet (UV) radiation contributes to the development of skin cancer through direct and indirect DNA damage, production of reactive oxygen species, and local immunomodulation. The association between UV radiation and skin cancer has raised concern for the risk o …
Ultraviolet (UV) radiation contributes to the development of skin cancer through direct and indirect DNA damage, production of …
Time kinetics of cyclobutane pyrimidine dimer formation by narrowband and broadband UVB irradiation.
Toriyama E, Masuda H, Torii K, Ikumi K, Morita A. Toriyama E, et al. J Dermatol Sci. 2021 Sep;103(3):151-155. doi: 10.1016/j.jdermsci.2021.07.009. Epub 2021 Jul 24. J Dermatol Sci. 2021. PMID: 34391606
BACKGROUND: Maximum cyclobutane pyrimidine dimer (CPD) formation in the skin induced by ultraviolet B (UVB) irradiation is thought to occur within a few minutes and is immediately decreased by the DNA repair system. OBJECTIVE: We evaluated the time course and differential …
BACKGROUND: Maximum cyclobutane pyrimidine dimer (CPD) formation in the skin induced by ultraviolet B (UVB) irradiation is thought to occur …
Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype.
Yogianti F, Kunisada M, Ono R, Sakumi K, Nakabeppu Y, Nishigori C. Yogianti F, et al. Mutagenesis. 2012 Nov;27(6):637-43. doi: 10.1093/mutage/ges029. Epub 2012 Jul 27. Mutagenesis. 2012. PMID: 22844076
Different wavelengths of ultraviolet (UV) light have different promoting effects on skin carcinogenesis. Narrowband UVB (NB-UVB) has a single-peak wavelength of 311 nm and is widely used for treating skin diseases. ...To explore whether the frequency of p53 mutation …
Different wavelengths of ultraviolet (UV) light have different promoting effects on skin carcinogenesis. Narrowband UVB (NB-UV …
Effect of narrowband ultraviolet B (311 nm) exposure on skin carcinogenesis in Wistar rats.
Krisanti RIA, Wanandi SI, Wuyung PE, Hoemardani ASD. Krisanti RIA, et al. J Adv Vet Anim Res. 2024 Dec 29;11(4):1105-1113. doi: 10.5455/javar.2024.k861. eCollection 2024 Dec. J Adv Vet Anim Res. 2024. PMID: 40013270 Free PMC article.
OBJECTIVE: The aim of this study is to determine narrowband UVB (NB-UVB) irradiation's effect on the promotion of skin cancer, particularly its effect on DNA damage, oxidative stress, inflammation, and histological changes in Wistar rat skin. ...CONCLU …
OBJECTIVE: The aim of this study is to determine narrowband UVB (NB-UVB) irradiation's effect on the promotion of skin cancer, …
Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure†.
Garcia-Ruiz A, Kornacker K, Brash DE. Garcia-Ruiz A, et al. Photochem Photobiol. 2022 Sep;98(5):987-997. doi: 10.1111/php.13683. Epub 2022 Aug 9. Photochem Photobiol. 2022. PMID: 35944237 Free PMC article.
The dominant DNA damage generated by UV exposure is the cyclobutane pyrimidine dimer (CPD), which alters skin cell physiology and induces cell death and mutation. ...We therefore exposed neonatal human epidermal keratinocytes to narrowband UVB and quan …
The dominant DNA damage generated by UV exposure is the cyclobutane pyrimidine dimer (CPD), which alters skin cell physiology …
Ascorbic Acid 2-Glucoside Pretreatment Protects Cells from Ionizing Radiation, UVC, and Short Wavelength of UVB.
Maeda J, Allum AJ, Mussallem JT, Froning CE, Haskins AH, Buckner MA, Miller CD, Kato TA. Maeda J, et al. Genes (Basel). 2020 Feb 25;11(3):238. doi: 10.3390/genes11030238. Genes (Basel). 2020. PMID: 32106443 Free PMC article.
Pretreatment with DMSO, AA, and AA2G showed comparative protective effects in CHO wild type and radiosensitive xrs5 cells for cell death against ionizing radiation with reducing the number of radiation-induced DNA damages. Pretreatment with AA and AA2G protected CHO wild t …
Pretreatment with DMSO, AA, and AA2G showed comparative protective effects in CHO wild type and radiosensitive xrs5 cells for cell death aga …
Formation of 8-hydroxy-2'-deoxyguanosine in the DNA of cultured human keratinocytes by clinically used doses of narrowband and broadband ultraviolet B and psoralen plus ultraviolet A.
Orimo H, Tokura Y, Hino R, Kasai H. Orimo H, et al. Cancer Sci. 2006 Feb;97(2):99-105. doi: 10.1111/j.1349-7006.2006.00151.x. Cancer Sci. 2006. PMID: 16441419 Free PMC article.
When HaCaT cells treated with 2000 mJ/cm(2) narrowband UVB were cultured and the amount of 8-OH-dG was monitored in the living cells, 65.6% of the residues were repaired 24 h after treatment. Our study provides a warning that widely used narrowband UVB …
When HaCaT cells treated with 2000 mJ/cm(2) narrowband UVB were cultured and the amount of 8-OH-dG was monitored in the living …
14 results