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Year Number of Results
1995 2
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1998 9
1999 4
2000 8
2001 6
2002 7
2003 4
2004 17
2005 6
2006 8
2007 9
2008 11
2009 14
2010 8
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2012 17
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247 results

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Page 1
ATXN2-mediated translation of TNFR1 promotes esophageal squamous cell carcinoma via m6A-dependent manner.
Li R, Zeng L, Zhao H, Deng J, Pan L, Zhang S, Wu G, Ye Y, Zhang J, Su J, Zheng Y, Deng S, Bai R, Zhuang L, Li M, Zuo Z, Lin D, Zheng J, Huang X. Li R, et al. Mol Ther. 2022 Mar 2;30(3):1089-1103. doi: 10.1016/j.ymthe.2022.01.006. Epub 2022 Jan 4. Mol Ther. 2022. PMID: 34995801 Free PMC article.
Mechanistically, a functional protein involved in m(6)A methylation, ATXN2, is identified that augments the translation of TNFRSF1A by binding to m(6)A-modified TNFRSF1A mRNA. Upregulation of the TNFRSF1A protein level, a vital upstream switch for TNFRSF1A …
Mechanistically, a functional protein involved in m(6)A methylation, ATXN2, is identified that augments the translation of TNFRSF1A b …
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D. Bolik J, et al. J Exp Med. 2022 Jan 3;219(1):e20201039. doi: 10.1084/jem.20201039. Epub 2021 Dec 17. J Exp Med. 2022. PMID: 34919140 Free PMC article.
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we identified the membrane-bound metal …
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of b …
Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib.
Yang Y, Sun M, Yao W, Wang F, Li X, Wang W, Li J, Gao Z, Qiu L, You R, Yang C, Ba Q, Wang H. Yang Y, et al. J Immunother Cancer. 2020 Mar;8(1):e000317. doi: 10.1136/jitc-2019-000317. J Immunother Cancer. 2020. PMID: 32179631 Free PMC article.
METHODS: Growth of two murine HCC cells was evaluated in an orthotopic model, a subcutaneous model, two postsurgical recurrence model, and a tumor rechallenge model with CKI and low-dose sorafenib combination treatment. ...CKI and sorafenib combination treatment prevented …
METHODS: Growth of two murine HCC cells was evaluated in an orthotopic model, a subcutaneous model, two postsurgical recurrence model, and a …
Investigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing Data.
Jiang YQ, Wang ZX, Zhong M, Shen LJ, Han X, Zou X, Liu XY, Deng YN, Yang Y, Chen GH, Deng W, Huang JH. Jiang YQ, et al. Oncoimmunology. 2021 Apr 2;10(1):1908010. doi: 10.1080/2162402X.2021.1908010. Oncoimmunology. 2021. PMID: 33868792 Free PMC article.
They highly expressed suppressive genes like HAVCR2 and KLRC1, cytotoxic genes like GZMB and FASLG and the tissue-residence-related gene CCL5. These cells had increased expression of survival-related and tissue-residence-related genes, like heat shock …
They highly expressed suppressive genes like HAVCR2 and KLRC1, cytotoxic genes like GZMB and FASLG and the tissue-residence-re …
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.
Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. Nakagawa H, et al. Cancer Cell. 2014 Sep 8;26(3):331-343. doi: 10.1016/j.ccr.2014.07.001. Epub 2014 Aug 14. Cancer Cell. 2014. PMID: 25132496 Free PMC article.
To determine whether and how ER stress contributes to obesity-driven hepatic tumorigenesis we fed wild-type (WT) and MUP-uPA mice, in which hepatocyte ER stress is induced by plasminogen activator expression, with high-fat diet. ...
To determine whether and how ER stress contributes to obesity-driven hepatic tumorigenesis we fed wild-type (WT) and MUP-uPA mice, in …
VB-111 for cancer.
Triozzi PL, Borden EC. Triozzi PL, et al. Expert Opin Biol Ther. 2011 Dec;11(12):1669-76. doi: 10.1517/14712598.2011.618122. Epub 2011 Oct 1. Expert Opin Biol Ther. 2011. PMID: 21961496 Review.
Phase I and Phase II clinical trials are also reviewed. EXPERT OPINION: VB-111 is a vascular-targeting gene therapeutic that is both tissue- and condition-specific, with effects limited to endothelial cells undergoing angiogenesis. Systemic administration produces selectiv …
Phase I and Phase II clinical trials are also reviewed. EXPERT OPINION: VB-111 is a vascular-targeting gene therapeutic that is both …
Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features.
Hausmann LD, de Almeida BS, de Souza IR, Drehmer MN, Fernandes BL, Wilkens RS, Vieira DSC, Lofgren SE, Lindenau JD, de Toledo E Silva G, Muniz YCN. Hausmann LD, et al. Biochem Genet. 2021 Oct;59(5):1233-1246. doi: 10.1007/s10528-021-10060-z. Epub 2021 Mar 22. Biochem Genet. 2021. PMID: 33751344
Several genes have been associated with breast cancer (BC) susceptibility. The tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), and interferon lambda receptor 1 (IFNLR1) genes encode receptors that mediate the acti …
Several genes have been associated with breast cancer (BC) susceptibility. The tumor necrosis factor receptor su …
Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts.
Tsai YT, Li CY, Huang YH, Chang TS, Lin CY, Chuang CH, Wang CY, Anuraga G, Chang TH, Shih TC, Lin ZY, Chen YL, Chung I, Lee KH, Chang CC, Sung SY, Yang KH, Tsui WL, Yap CV, Wu MH. Tsai YT, et al. Oncogene. 2022 May;41(21):3011-3023. doi: 10.1038/s41388-022-02309-7. Epub 2022 Apr 22. Oncogene. 2022. PMID: 35459781
The Gal-1-targeting effect was mediated by increased a disintegrin and metalloprotease 17 (ADAM17)-dependent TNF-receptor 1 (TNFR1) shedding/cleavage which inhibited the TNF-alpha JNK c-Jun/ATF2 signaling axis of pro-inflammatory gene transcription. Silencing Gal-1 in CAFs …
The Gal-1-targeting effect was mediated by increased a disintegrin and metalloprotease 17 (ADAM17)-dependent TNF-receptor 1 (TNFR1) shedding …
TNFα and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer?
Benoot T, Piccioni E, De Ridder K, Goyvaerts C. Benoot T, et al. Int J Mol Sci. 2021 Aug 13;22(16):8691. doi: 10.3390/ijms22168691. Int J Mol Sci. 2021. PMID: 34445397 Free PMC article. Review.
Tumor necrosis factor-alpha (TNFalpha) can bind two distinct receptors (TNFR1/2). ...This assortment empowers TNFalpha with a plethora of opposing roles in the processes of tumor cell survival (and apoptosis) and anti-tumor immune stimula …
Tumor necrosis factor-alpha (TNFalpha) can bind two distinct receptors (TNFR1/2). ...This assortment empowers TN …
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
Nagaishi T, Watabe T, Jose N, Tokai A, Fujii T, Matsuoka K, Nagahori M, Ohtsuka K, Watanabe M. Nagaishi T, et al. Digestion. 2016;93(1):40-6. doi: 10.1159/000441670. Epub 2016 Jan 14. Digestion. 2016. PMID: 26789263 Free article. Review.
However, the mechanism by which epithelial NF-x03BA;B activation leading to CAC development had not previously been rigorously studied. We and others had observed the increased expression of the type 2 receptor for tumor necrosis factor (TNFR2/TNFRSF1b …
However, the mechanism by which epithelial NF-x03BA;B activation leading to CAC development had not previously been rigorously studied. We a …
247 results