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17 results

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Page 1
Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts.
Tsai YT, Li CY, Huang YH, Chang TS, Lin CY, Chuang CH, Wang CY, Anuraga G, Chang TH, Shih TC, Lin ZY, Chen YL, Chung I, Lee KH, Chang CC, Sung SY, Yang KH, Tsui WL, Yap CV, Wu MH. Tsai YT, et al. Oncogene. 2022 May;41(21):3011-3023. doi: 10.1038/s41388-022-02309-7. Epub 2022 Apr 22. Oncogene. 2022. PMID: 35459781
The Gal-1-targeting effect was mediated by increased a disintegrin and metalloprotease 17 (ADAM17)-dependent TNF-receptor 1 (TNFR1) shedding/cleavage which inhibited the TNF-alpha JNK c-Jun/ATF2 signaling axis of pro-inflammatory gene transcription. Silencing Gal-1 in CAFs …
The Gal-1-targeting effect was mediated by increased a disintegrin and metalloprotease 17 (ADAM17)-dependent TNF-receptor 1 (TNFR1) shedding …
HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma.
Zou X, Zhang D, Song Y, Liu S, Long Q, Yao L, Li W, Duan Z, Wu D, Liu L. Zou X, et al. Theranostics. 2020 Aug 20;10(23):10434-10447. doi: 10.7150/thno.47286. eCollection 2020. Theranostics. 2020. PMID: 32929358 Free PMC article.
Besides, overexpression of HRG suppressed expression of pro-survival genes by impairing the activation of NF-kappaB signaling in the presence of TNFR1. Moreover, downregulation of HRG was a result of feedback inhibition of NF-kappaB activation in HCC. ...
Besides, overexpression of HRG suppressed expression of pro-survival genes by impairing the activation of NF-kappaB signaling in the …
Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line.
Rebelo SL, Amel-Kashipaz MR, Radford PM, Bainbridge SE, Fiets R, Fang J, McDermott EM, Powell RJ, Todd I, Tighe PJ. Rebelo SL, et al. Arthritis Rheum. 2009 Jan;60(1):269-80. doi: 10.1002/art.24147. Arthritis Rheum. 2009. PMID: 19116900 Free article.
Quantitative reverse transcriptase-polymerase chain reaction and protein expression levels measured by enzyme-linked immunosorbent assay verified transcriptional changes for selected genes both in supernatants from cells expressing mutant TNFRI and in patient plasma. RESUL …
Quantitative reverse transcriptase-polymerase chain reaction and protein expression levels measured by enzyme-linked immunosorbent assay ver …
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. Haybaeck J, et al. Cancer Cell. 2009 Oct 6;16(4):295-308. doi: 10.1016/j.ccr.2009.08.021. Cancer Cell. 2009. PMID: 19800575 Free PMC article.
Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.
Rebelo SL, Bainbridge SE, Amel-Kashipaz MR, Radford PM, Powell RJ, Todd I, Tighe PJ. Rebelo SL, et al. Arthritis Rheum. 2006 Aug;54(8):2674-87. doi: 10.1002/art.21964. Arthritis Rheum. 2006. PMID: 16871532 Free article.
OBJECTIVE: To investigate the effect of mutations in the tumor necrosis factor receptor superfamily 1A (TNFRSF1A) gene on the conformation and behavior of the TNFRSF1A protein. Mutations in TNFRSF1A cause the autosomal-dominant, autoinflammatory TNFR-a …
OBJECTIVE: To investigate the effect of mutations in the tumor necrosis factor receptor superfamily 1A (TNFRSF1A) gene on the …
Anticancer activity evaluation of the solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells.
Kuo KW, Hsu SH, Li YP, Lin WL, Liu LF, Chang LC, Lin CC, Lin CN, Sheu HM. Kuo KW, et al. Biochem Pharmacol. 2000 Dec 15;60(12):1865-73. doi: 10.1016/s0006-2952(00)00506-2. Biochem Pharmacol. 2000. PMID: 11108802
To characterize the anticancer mechanism of solamargine on human hepatoma cells (Hep3B), changes of cell morphology, DNA content, and gene expression of cells after solamargine treatment were studied. The appearance in solamargine-treated cells of chromatin condensation, D …
To characterize the anticancer mechanism of solamargine on human hepatoma cells (Hep3B), changes of cell morphology, DNA content, and gen …
17 results