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Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib.
Yang Y, Sun M, Yao W, Wang F, Li X, Wang W, Li J, Gao Z, Qiu L, You R, Yang C, Ba Q, Wang H. Yang Y, et al. J Immunother Cancer. 2020 Mar;8(1):e000317. doi: 10.1136/jitc-2019-000317. J Immunother Cancer. 2020. PMID: 32179631 Free PMC article.
METHODS: Growth of two murine HCC cells was evaluated in an orthotopic model, a subcutaneous model, two postsurgical recurrence model, and a tumor rechallenge model with CKI and low-dose sorafenib combination treatment. ...CKI and sorafenib combination treatment prevented …
METHODS: Growth of two murine HCC cells was evaluated in an orthotopic model, a subcutaneous model, two postsurgical recurrence model, and a …
Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts.
Tsai YT, Li CY, Huang YH, Chang TS, Lin CY, Chuang CH, Wang CY, Anuraga G, Chang TH, Shih TC, Lin ZY, Chen YL, Chung I, Lee KH, Chang CC, Sung SY, Yang KH, Tsui WL, Yap CV, Wu MH. Tsai YT, et al. Oncogene. 2022 May;41(21):3011-3023. doi: 10.1038/s41388-022-02309-7. Epub 2022 Apr 22. Oncogene. 2022. PMID: 35459781
The Gal-1-targeting effect was mediated by increased a disintegrin and metalloprotease 17 (ADAM17)-dependent TNF-receptor 1 (TNFR1) shedding/cleavage which inhibited the TNF-alpha JNK c-Jun/ATF2 signaling axis of pro-inflammatory gene transcription. Silencing Gal-1 in CAFs …
The Gal-1-targeting effect was mediated by increased a disintegrin and metalloprotease 17 (ADAM17)-dependent TNF-receptor 1 (TNFR1) shedding …
HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma.
Zou X, Zhang D, Song Y, Liu S, Long Q, Yao L, Li W, Duan Z, Wu D, Liu L. Zou X, et al. Theranostics. 2020 Aug 20;10(23):10434-10447. doi: 10.7150/thno.47286. eCollection 2020. Theranostics. 2020. PMID: 32929358 Free PMC article.
Background: Tumor necrosis factor receptor 1 (TNFR1) signaling plays a pleiotropic role in the development of hepatocellular carcinoma (HCC). ...Besides, overexpression of HRG suppressed expression of pro-survival genes by impairing the activation of N …
Background: Tumor necrosis factor receptor 1 (TNFR1) signaling plays a pleiotropic role in the development of hepatocel …
OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.
Damgaard RB, Jolin HE, Allison MED, Davies SE, Titheradge HL, McKenzie ANJ, Komander D. Damgaard RB, et al. Cell Death Differ. 2020 May;27(5):1457-1474. doi: 10.1038/s41418-020-0532-1. Epub 2020 Mar 30. Cell Death Differ. 2020. PMID: 32231246 Free PMC article.
Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-kappaB activation, immune homoeostasis, and prevents tumour necrosis factor (TNF)-induced cell death. The deubiquitinase OTULIN negatively regu …
Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-kappaB activation …
Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.
Rebelo SL, Bainbridge SE, Amel-Kashipaz MR, Radford PM, Powell RJ, Todd I, Tighe PJ. Rebelo SL, et al. Arthritis Rheum. 2006 Aug;54(8):2674-87. doi: 10.1002/art.21964. Arthritis Rheum. 2006. PMID: 16871532 Free article.
OBJECTIVE: To investigate the effect of mutations in the tumor necrosis factor receptor superfamily 1A (TNFRSF1A) gene on the conformation and behavior of the TNFRSF1A protein. ...TNF binding was assessed in HEK 293 cell lines expressing …
OBJECTIVE: To investigate the effect of mutations in the tumor necrosis factor receptor superfamily 1A (TNFRSF1A …
Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line.
Rebelo SL, Amel-Kashipaz MR, Radford PM, Bainbridge SE, Fiets R, Fang J, McDermott EM, Powell RJ, Todd I, Tighe PJ. Rebelo SL, et al. Arthritis Rheum. 2009 Jan;60(1):269-80. doi: 10.1002/art.24147. Arthritis Rheum. 2009. PMID: 19116900 Free article.
OBJECTIVE: To analyze the effects of tumor necrosis factor receptor-associated periodic syndrome (TRAPS)-associated mutant tumor necrosis factor receptor type I (TNFRI) expression in a cell type directly relevant to the infl …
OBJECTIVE: To analyze the effects of tumor necrosis factor receptor-associated periodic syndrome (TRAPS)-associated mut …
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. Haybaeck J, et al. Cancer Cell. 2009 Oct 6;16(4):295-308. doi: 10.1016/j.ccr.2009.08.021. Cancer Cell. 2009. PMID: 19800575 Free PMC article.
Growth inhibition of hepatocellular carcinoma Huh7 cells by Lactobacillus casei extract.
Han DJ, Kim JB, Park SY, Yang MG, Kim H. Han DJ, et al. Yonsei Med J. 2013 Sep;54(5):1186-93. doi: 10.3349/ymj.2013.54.5.1186. Yonsei Med J. 2013. PMID: 23918568 Free PMC article.
After the treatment of L. casei extract on Huh7 cells, cell viability, cell cycle arrest and cell death were analyzed by flow cytometry. The expression levels of tumor necrosis factor-alpha receptor 1 (TNFR1) and death receptor 3 (DR3) mRNA related with extri …
After the treatment of L. casei extract on Huh7 cells, cell viability, cell cycle arrest and cell death were analyzed by flow cytometry. The …
[Expression of tumor necrosis factor receptor on peripheral blood mononuclear cells from patients with primary hepatocellular carcinoma and effects of treatment on the expression].
Bai L, Huang CW, Gao L, Jiang B, Nan QZ. Bai L, et al. Di Yi Jun Yi Da Xue Xue Bao. 2002 Dec;22(12):1099-100. Di Yi Jun Yi Da Xue Xue Bao. 2002. PMID: 12480583 Chinese.
OBJECTIVE: To conduct an intensive investigation of the abnormal immune status of patients with primary hepatocellular carcinoma and explore the possible mechanism of biotherapy for these patients. METHODS: The expression of tumor necrosis factor receptor (TN …
OBJECTIVE: To conduct an intensive investigation of the abnormal immune status of patients with primary hepatocellular carcinoma and explore …
TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression.
Kim S, Moon SM, Kim YS, Kim JJ, Ryu HJ, Kim YJ, Choi JW, Park HS, Kim DG, Shin HD, Rutherford MS, Oh B, Lee JK. Kim S, et al. Biochem Biophys Res Commun. 2008 Apr 4;368(2):395-401. doi: 10.1016/j.bbrc.2008.01.098. Epub 2008 Feb 1. Biochem Biophys Res Commun. 2008. PMID: 18243134
Tumor necrosis factor (TNF) and the TNF receptor (TNFR) superfamily play very important roles for cell death as well as normal immune regulation. ...We investigated the genetic alterations of the TNF-TNFR superfamily genes in hepatocellular carcinoma ( …
Tumor necrosis factor (TNF) and the TNF receptor (TNFR) superfamily play very important roles for cell death as well as …
17 results