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Page 1
TNFα and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer?
Benoot T, Piccioni E, De Ridder K, Goyvaerts C. Benoot T, et al. Int J Mol Sci. 2021 Aug 13;22(16):8691. doi: 10.3390/ijms22168691. Int J Mol Sci. 2021. PMID: 34445397 Free PMC article. Review.
Tumor necrosis factor-alpha (TNFalpha) can bind two distinct receptors (TNFR1/2). ...This assortment empowers TNFalpha with a plethora of opposing roles in the processes of tumor cell survival (and apoptosis) and anti-tumor immune stimula …
Tumor necrosis factor-alpha (TNFalpha) can bind two distinct receptors (TNFR1/2). ...This assortment empowers TN …
Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis.
Yang YF, Jan YH, Liu YP, Yang CJ, Su CY, Chang YC, Lai TC, Chiou J, Tsai HY, Lu J, Shen CN, Shew JY, Lu PJ, Lin YF, Huang MS, Hsiao M. Yang YF, et al. Am J Respir Crit Care Med. 2014 Sep 15;190(6):675-87. doi: 10.1164/rccm.201404-0714OC. Am J Respir Crit Care Med. 2014. PMID: 25152164
Mechanistically, SQS contributed to a lipid-raft-localized enrichment of tumor necrosis factor receptor 1 in a cholesterol-dependent manner, which resulted in the enhancement of nuclear factor-kappaB activation leading to matrix metallopeptidase 1 up-r …
Mechanistically, SQS contributed to a lipid-raft-localized enrichment of tumor necrosis factor receptor 1 in a choleste …
Identification of necroptosis-related gene signature and characterization of tumour microenvironment infiltration in non-small-cell lung cancer.
Dai J, Fu Y. Dai J, et al. J Cell Mol Med. 2022 Sep;26(17):4698-4709. doi: 10.1111/jcmm.17494. Epub 2022 Jul 24. J Cell Mol Med. 2022. PMID: 35871768 Free PMC article.
Necroptosis is a programmed necrosis in a caspase-independent fashion. The role of necroptosis-related genes (NRGs) in lung cancer remains unknow. ...Then, we established an NRG prognosis model (NRG score) composed of six NRGs (RIPK3, MLKL, TLR2, TLR4, TNFRSF1A …
Necroptosis is a programmed necrosis in a caspase-independent fashion. The role of necroptosis-related genes (NRGs) in lung ca …
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells.
You BR, Han BR, Park WH. You BR, et al. Oncotarget. 2017 Mar 14;8(11):17726-17737. doi: 10.18632/oncotarget.14628. Oncotarget. 2017. PMID: 28099148 Free PMC article.
All tested caspase inhibitors prevented apoptotic cell death in SAHA-treated A549 and Calu-6 lung cancer cells. Treatment with tumor necrosis factor-alpha (TNF-alpha) enhanced apoptosis in SAHA-treated lung cancer cells through caspase-8 and caspase-9 activat …
All tested caspase inhibitors prevented apoptotic cell death in SAHA-treated A549 and Calu-6 lung cancer cells. Treatment with tumor …
Tumour necrosis factor-alpha and transforming growth factor-beta are significantly associated with better prognosis in non-small cell lung carcinoma: putative relation with BCL-2-mediated neovascularization.
Boldrini L, Calcinai A, Samaritani E, Pistolesi F, Mussi A, Lucchi M, Angeletti CA, Basolo F, Fontanini G. Boldrini L, et al. Br J Cancer. 2000 Aug;83(4):480-6. doi: 10.1054/bjoc.2000.1345. Br J Cancer. 2000. PMID: 10945495 Free PMC article.
Recent in vivo and in vitro studies have demonstrated a wide spectrum of biologic activities of cytokines in the pathogenesis and progression of malignancy. Tumour necrosis factor alpha (TNF-alpha) and transforming growth factor beta (TGF-beta) have emerged a …
Recent in vivo and in vitro studies have demonstrated a wide spectrum of biologic activities of cytokines in the pathogenesis and progressio …
Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation.
Imre G, Gekeler V, Leja A, Beckers T, Boehm M. Imre G, et al. Cancer Res. 2006 May 15;66(10):5409-18. doi: 10.1158/0008-5472.CAN-05-4225. Cancer Res. 2006. PMID: 16707469
We found that in the NSCLC cell lines, A549 and NCI-H460, the NF-kappaB pathway was strongly inducible, for example, by stimulation with tumor necrosis factor-alpha (TNF-alpha). Incubation of several NSCLC cell lines with HDIs resulted in greatly reduced g …
We found that in the NSCLC cell lines, A549 and NCI-H460, the NF-kappaB pathway was strongly inducible, for example, by stimulation with …
Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.
Saito Y, Nagae G, Motoi N, Miyauchi E, Ninomiya H, Uehara H, Mun M, Okumura S, Ohyanagi F, Nishio M, Satoh Y, Aburatani H, Ishikawa Y. Saito Y, et al. Cancer Sci. 2016 Mar;107(3):320-5. doi: 10.1111/cas.12876. Epub 2016 Feb 19. Cancer Sci. 2016. PMID: 26748784 Free PMC article.
We investigated the genome-wide DNA methylation status of 28 tumor and 13 normal lung tissues, and gene expression profiling of 25 SCLC tissues. ...Ontology analyses suggested that the extrinsic apoptosis pathway was suppressed, including TNFRSF1A, TNFRSF10A …
We investigated the genome-wide DNA methylation status of 28 tumor and 13 normal lung tissues, and gene expression profiling o …
Lung cancer signature biomarkers: tissue specific semantic similarity based clustering of digital differential display (DDD) data.
Srivastava M, Khurana P, Sugadev R. Srivastava M, et al. BMC Res Notes. 2012 Nov 2;5:617. doi: 10.1186/1756-0500-5-617. BMC Res Notes. 2012. PMID: 23122428 Free PMC article.
However, the process of identifying the most likely tissue for a specific disease in which to search for candidate genes from the pool of differentially expressed genes remains difficult. Therefore, we have used 'Gene Ontology semantic similarity score' to me …
However, the process of identifying the most likely tissue for a specific disease in which to search for candidate genes from the poo …
Action of solamargine on human lung cancer cells--enhancement of the susceptibility of cancer cells to TNFs.
Liu LF, Liang CH, Shiu LY, Lin WL, Lin CC, Kuo KW. Liu LF, et al. FEBS Lett. 2004 Nov 5;577(1-2):67-74. doi: 10.1016/j.febslet.2004.09.064. FEBS Lett. 2004. PMID: 15527763 Free article.
SM-induced apoptosis of these cells by PS externalization in a dose-dependent manner and increased sub-G1 fraction were observed. Quenching of the expression of tumor necrosis factor receptors (TNFRs) during the progress of human lung carcinogenesis ha …
SM-induced apoptosis of these cells by PS externalization in a dose-dependent manner and increased sub-G1 fraction were observed. Quenching …
An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding.
Cui X, Rouhani FN, Hawari F, Levine SJ. Cui X, et al. J Biol Chem. 2003 Aug 1;278(31):28677-85. doi: 10.1074/jbc.M300456200. Epub 2003 May 14. J Biol Chem. 2003. PMID: 12748171 Free article.
Aminopeptidase regulator of TNFR1 shedding (ARTS-1) binds to the type I tumor necrosis factor receptor (TNFR1) and promotes receptor shedding. ...Thus, ARTS-1 promotes the shedding of two cytokine receptor superfamilies, the type I cytokine rece …
Aminopeptidase regulator of TNFR1 shedding (ARTS-1) binds to the type I tumor necrosis factor receptor (TNFR1) a …
16 results