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36 results

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Page 1
miR-21 downregulates the tumor suppressor P12 CDK2AP1 and stimulates cell proliferation and invasion.
Zheng J, Xue H, Wang T, Jiang Y, Liu B, Li J, Liu Y, Wang W, Zhang B, Sun M. Zheng J, et al. J Cell Biochem. 2011 Mar;112(3):872-80. doi: 10.1002/jcb.22995. J Cell Biochem. 2011. PMID: 21328460
The present study was undertaken to investigate the regulation of P12(CDK2AP1) by miRNAs. A conserved target site for miR-21 within the CDK2AP1-3'-UTR at nt 349-370 was predicted by bioinformatics software and an inverse correlation of miR-21 and CDK2AP1 prot …
The present study was undertaken to investigate the regulation of P12(CDK2AP1) by miRNAs. A conserved target site for miR-21 within t …
Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality.
Kim Y, McBride J, Kimlin L, Pae EK, Deshpande A, Wong DT. Kim Y, et al. PLoS One. 2009;4(2):e4518. doi: 10.1371/journal.pone.0004518. Epub 2009 Feb 20. PLoS One. 2009. PMID: 19229340 Free PMC article.
A transgenic rescue of the lethality was attempted by crossing Cdk2ap1(+/-) animals with K14-Cdk2ap1 transgenic mice. Resulting Cdk2ap1(+/-:K14-Cdk2ap1) transgenic mice showed an improved incidence of full term animals (16.7% from 0.5%) on a Cdk2ap1 …
A transgenic rescue of the lethality was attempted by crossing Cdk2ap1(+/-) animals with K14-Cdk2ap1 transgenic mice. Resultin …
mRNA Expression of CDK2AP1 in Human Breast Cancer: Correlation with Clinical and Pathological Parameters.
Gera R, Mokbel L, Jiang WG, Mokbel K. Gera R, et al. Cancer Genomics Proteomics. 2018 Nov-Dec;15(6):447-452. doi: 10.21873/cgp.20103. Cancer Genomics Proteomics. 2018. PMID: 30343278 Free PMC article.
CDK2AP1 expression in disease-free patients at 10 years was more than threefold that of patients who died of breast cancer. ...CONCLUSION: To our knowledge, this is the first study in the literature to examine the mRNA expression of CDK2AP1 in human breast cancer ov …
CDK2AP1 expression in disease-free patients at 10 years was more than threefold that of patients who died of breast cancer. ...CONCLU …
miR-205 promotes proliferation and invasion of laryngeal squamous cell carcinoma by suppressing CDK2AP1 expression.
Zhong G, Xiong X. Zhong G, et al. Biol Res. 2015 Oct 29;48:60. doi: 10.1186/s40659-015-0052-5. Biol Res. 2015. PMID: 26515287 Free PMC article.
Gelatin zymography was used to detect the activity of MMP2 and MMP9. CDK2AP1, c-Myc and CyclinD1 expression in cells was assessed with Western blotting. We found that miR-205 was the upstream regulator of CDK2AP1 and could suppress the expression of CDK2AP1 i …
Gelatin zymography was used to detect the activity of MMP2 and MMP9. CDK2AP1, c-Myc and CyclinD1 expression in cells was assessed wit …
Knockdown of CDK2AP1 by RNA interference inhibits cell growth and tumorigenesis of human glioma.
Xu Y, Wang J, Fu S, Wang Z. Xu Y, et al. Neurol Res. 2014 Jul;36(7):659-65. doi: 10.1179/1743132813Y.0000000298. Epub 2013 Dec 19. Neurol Res. 2014. PMID: 24620959
Although the misadjustment of CDK2AP1 has been revealed in several types of human malignancies, the functional role of CDK2AP1 in human glioma remains unknown. The present study was undertaken to investigate the effects of CDK2AP1 knockdown by RNA interferenc …
Although the misadjustment of CDK2AP1 has been revealed in several types of human malignancies, the functional role of CDK2AP1 …
The Association between Cyclin Dependent Kinase 2 Associated Protein 1 (CDK2AP1) and Molecular Subtypes of Lethal Prostate Cancer.
Gamallat Y, Bakker A, Khosh Kish E, Choudhry M, Walker S, Aldakheel S, Seyedi S, Huang KC, Ghosh S, Gotto G, Bismar TA. Gamallat Y, et al. Int J Mol Sci. 2022 Nov 1;23(21):13326. doi: 10.3390/ijms232113326. Int J Mol Sci. 2022. PMID: 36362115 Free PMC article.
Cyclin dependent kinase 2 associate protein 1(CDK2AP1) is an epigenetic and cell cycle regulator gene which has been downregulated in several malignancies, but its involvement in PCa has not yet been investigated in a clinical setting. ...In conclusion, our results …
Cyclin dependent kinase 2 associate protein 1(CDK2AP1) is an epigenetic and cell cycle regulator gene which has been downregul …
Consistent DNA Hypomethylations in Prostate Cancer.
Araúzo-Bravo MJ, Erichsen L, Ott P, Beermann A, Sheikh J, Gerovska D, Thimm C, Bendhack ML, Santourlidis S. Araúzo-Bravo MJ, et al. Int J Mol Sci. 2022 Dec 26;24(1):386. doi: 10.3390/ijms24010386. Int J Mol Sci. 2022. PMID: 36613831 Free PMC article.
Here, we present a basic study on an epigenetic screening approach by Methylated DNA Immunoprecipitation (MeDIP). We identified genes associated with hypomethylated CpG islands in three PCa sample cohorts. By adjusting our computational biology analyses to focus on single …
Here, we present a basic study on an epigenetic screening approach by Methylated DNA Immunoprecipitation (MeDIP). We identified genes …
The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs.
Stabile R, Cabezas MR, Verhagen MP, Tucci FA, van den Bosch TPP, De Herdt MJ, van der Steen B, Nigg AL, Chen M, Ivan C, Shimizu M, Koljenović S, Hardillo JA, Verrijzer CP, Baatenburg de Jong RJ, Calin GA, Fodde R. Stabile R, et al. Cell Death Dis. 2023 May 22;14(5):337. doi: 10.1038/s41419-023-05857-2. Cell Death Dis. 2023. PMID: 37217493 Free PMC article.
Accordingly, CDK2AP1 protein-deficient oral cancer cell lines express as much CDK2AP1 mRNA as proficient cell lines. ...Of note, no synergistic effects were observed of the different miRs on the CDK2AP1-3-UTR common target. We also developed a novel approach …
Accordingly, CDK2AP1 protein-deficient oral cancer cell lines express as much CDK2AP1 mRNA as proficient cell lines. ...Of not …
Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer.
Sun M, Jiang R, Wang G, Zhang C, Li J, Jin C, Zhang X. Sun M, et al. Int J Oncol. 2013 Apr;42(4):1376-82. doi: 10.3892/ijo.2013.1813. Epub 2013 Feb 8. Int J Oncol. 2013. PMID: 23404055
Injection of the ectopically CDK2AP1-overexpressing A549 cells into nude mice resulted in growth arrest of solid lung cancer tumors in vivo. ...Hence, this study extends our knowledge on the relationship between CDK2AP1 and oncogenesis of lung cancer, indicating tha …
Injection of the ectopically CDK2AP1-overexpressing A549 cells into nude mice resulted in growth arrest of solid lung cancer tumors i …
Novel tumor growth inhibition mechanism by cell cycle regulator cdk2ap1 involves antiangiogenesis modulation.
Zolochevska O, Figueiredo ML. Zolochevska O, et al. Microvasc Res. 2010 Dec;80(3):324-31. doi: 10.1016/j.mvr.2010.06.001. Epub 2010 Jun 10. Microvasc Res. 2010. PMID: 20541561 Free PMC article.
We observed several alterations in gene expression consistent with classical functions of cdk2ap1, including upregulation of cell cycle inhibitory genes, and an upregulation in expression of genes belonging to both intrinsic and extrinsic apoptotic cas …
We observed several alterations in gene expression consistent with classical functions of cdk2ap1, including upregulation of c …
36 results