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1994 1
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2003 4
2004 5
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2007 6
2008 2
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Page 1
Association analysis identifies 65 new breast cancer risk loci.
Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, Lemaçon A, Soucy P, Glubb D, Rostamianfar A, Bolla MK, Wang Q, Tyrer J, Dicks E, Lee A, Wang Z, Allen J, Keeman R, Eilber U, French JD, Qing Chen X, Fachal L, McCue K, McCart Reed AE, Ghoussaini M, Carroll JS, Jiang X, Finucane H, Adams M, Adank MA, Ahsan H, Aittomäki K, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Arun B, Auer PL, Bacot F, Barrdahl M, Baynes C, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Børresen-Dale AL, Brand JS, Brauch H, Brennan P, Brenner H, Brinton L, Broberg P, Brock IW, Broeks A, Brooks-Wilson A, Brucker SY, Brüning T, Burwinkel B, Butterbach K, Cai Q, Cai H, Caldés T, Canzian F, Carracedo A, Carter BD, Castelao JE, Chan TL, David Cheng TY, Seng Chia K, Choi JY, Christiansen H, Clarke CL; NBCS Collaborators; Collée M, Conroy DM, Cordina-Duverger E, Cornelissen S, Cox DG, Cox A, Cross SS, Cunningham JM, Czene K, Daly MB, Devilee P, Doheny KF, Dörk T, Dos-Santos-Silva I, Dumont M, Durcan L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Ellberg C, Elvira M, Engel C, Eriksson M, Fasching PA, Figueroa J, Flesch-Janys D, Fletche… See abstract for full author list ➔ Michailidou K, et al. Nature. 2017 Nov 2;551(7678):92-94. doi: 10.1038/nature24284. Epub 2017 Oct 23. Nature. 2017. PMID: 29059683 Free PMC article.
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ...The majority of credible risk single-nucleotide …
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding v …
Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy.
Giordano A, Rossi A, Romano G, Bagella L. Giordano A, et al. J Cell Physiol. 2007 Nov;213(2):403-6. doi: 10.1002/jcp.21225. J Cell Physiol. 2007. PMID: 17708530 Review.
Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. ...This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer doma …
Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p1 …
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.
Middha P, Wang X, Behrens S, Bolla MK, Wang Q, Dennis J, Michailidou K, Ahearn TU, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Augustinsson A, Baert T, Freeman LEB, Becher H, Beckmann MW, Benitez J, Bojesen SE, Brauch H, Brenner H, Brooks-Wilson A, Campa D, Canzian F, Carracedo A, Castelao JE, Chanock SJ, Chenevix-Trench G; CTS Consortium; Cordina-Duverger E, Couch FJ, Cox A, Cross SS, Czene K, Dossus L, Dugué PA, Eliassen AH, Eriksson M, Evans DG, Fasching PA, Figueroa JD, Fletcher O, Flyger H, Gabrielson M, Gago-Dominguez M, Giles GG, González-Neira A, Grassmann F, Grundy A, Guénel P, Haiman CA, Håkansson N, Hall P, Hamann U, Hankinson SE, Harkness EF, Holleczek B, Hoppe R, Hopper JL, Houlston RS, Howell A, Hunter DJ, Ingvar C; ABCTB Investigators; kConFab Investigators; Isaksson K, Jernström H, John EM, Jones ME, Kaaks R, Keeman R, Kitahara CM, Ko YD, Koutros S, Kurian AW, Lacey JV, Lambrechts D, Larson NL, Larsson S, Le Marchand L, Lejbkowicz F, Li S, Linet M, Lissowska J, Martinez ME, Maurer T, Mulligan AM, Mulot C, Murphy RA, Newman WG, Nielsen SF, Nordestgaard BG, Norman A, O'Brien KM, Olson JE, Patel AV, Prentice R, Rees-Punia E, Rennert G, Rhenius V, Ruddy … See abstract for full author list ➔ Middha P, et al. Breast Cancer Res. 2023 Aug 9;25(1):93. doi: 10.1186/s13058-023-01691-8. Breast Cancer Res. 2023. PMID: 37559094 Free PMC article.
BACKGROUND: Genome-wide studies of gene-environment interactions (GE) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. ...METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of Europ …
BACKGROUND: Genome-wide studies of gene-environment interactions (GE) may identify variants associated with disease risk in conjuncti …
The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas.
De Luca A, Baldi A, Esposito V, Howard CM, Bagella L, Rizzo P, Caputi M, Pass HI, Giordano GG, Baldi F, Carbone M, Giordano A. De Luca A, et al. Nat Med. 1997 Aug;3(8):913-6. doi: 10.1038/nm0897-913. Nat Med. 1997. PMID: 9256285
The retinoblastoma family contains three members, pRb, p107 and pRb2/p130 (ref. 9), that are phosphorylated in a cell cycle-dependent manner, have cell growth suppressive properties and bind to specific members of the E2F family and various cyclins. Even though mesotheliom …
The retinoblastoma family contains three members, pRb, p107 and pRb2/p130 (ref. 9), that are phosphorylated in a cell cycle-dependent …
Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms.
De Falco G, Bellan C, Lazzi S, Claudio P, La Sala D, Cinti C, Tosi P, Giordano A, Leoncini L. De Falco G, et al. Oncogene. 2003 Sep 18;22(40):6214-9. doi: 10.1038/sj.onc.1206637. Oncogene. 2003. PMID: 13679860
The molecular mechanism underlying Tat's oncogenic activity may include deregulation of cellular genes. Among these genes, it has recently been shown that pRb2/p130 oncosuppressor protein is one of the targets in the interaction between HIV gene produc …
The molecular mechanism underlying Tat's oncogenic activity may include deregulation of cellular genes. Among these genes, it …
Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg.
Caracciolo V, Reiss K, Crozier-Fitzgerald C, De Pascali F, Macaluso M, Khalili K, Giordano A, Claudio PP. Caracciolo V, et al. J Cell Physiol. 2007 Jul;212(1):96-104. doi: 10.1002/jcp.21005. J Cell Physiol. 2007. PMID: 17385710
We investigated if the distribution between nucleus and cytoplasm of the transcription factors E2F4 and E2F5 is mediated by pRb2/p130 and if the presence of JCV T-antigen may impair this shuttling by sequestering pRb2/p130. ...Moreover, Small interference RNA experi …
We investigated if the distribution between nucleus and cytoplasm of the transcription factors E2F4 and E2F5 is mediated by pRb2/p130 …
pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.
Macaluso M, Cinti C, Russo G, Russo A, Giordano A. Macaluso M, et al. Oncogene. 2003 Jun 5;22(23):3511-7. doi: 10.1038/sj.onc.1206578. Oncogene. 2003. PMID: 12789259
However, the molecular mechanisms that regulate the ER-alpha gene expression are not fully understood. Here we show a new molecular mechanism of ER-alpha gene inactivation mediated by pRb2/p130 in ER-negative breast cancer cells. We investigated in vivo occup …
However, the molecular mechanisms that regulate the ER-alpha gene expression are not fully understood. Here we show a new molecular m …
pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer.
Cito L, Indovina P, Forte IM, Pentimalli F, Di Marzo D, Somma P, Barone D, Penon A, Penon D, Ceccherini E, Micheli P, Saragoni L, Di Domenico M, Feola A, Roviello F, Mattioli E, Giordano GG, Giordano A. Cito L, et al. J Cell Physiol. 2015 Apr;230(4):802-5. doi: 10.1002/jcp.24805. J Cell Physiol. 2015. PMID: 25205458
Indeed, pRb2/p130 has been found altered in various cancer types in which it functions as a valuable prognostic marker. ...We found a cytoplasmic localization of pRb2/p130 in cancer tissue samples, whereas, in normal counterparts, we observed the expected nuclear lo …
Indeed, pRb2/p130 has been found altered in various cancer types in which it functions as a valuable prognostic marker. ...We found a …
Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer.
Baldi A, Esposito V, De Luca A, Howard CM, Mazzarella G, Baldi F, Caputi M, Giordano A. Baldi A, et al. Clin Cancer Res. 1996 Jul;2(7):1239-45. Clin Cancer Res. 1996. PMID: 9816293
The Rb (retinoblastoma) gene family is composed of three members: the RB gene (one of the best-studied tumor suppressor genes) and two related genes, p107 and pRb2/p130. ...The highest percentage of undetectable levels in all of the specimens ex …
The Rb (retinoblastoma) gene family is composed of three members: the RB gene (one of the best-studied tumor suppressor gen …
Enterocyte differentiation is compatible with SV40 large T expression and loss of p53 function in human colonic Caco-2 cells. Status of the pRb1 and pRb2 tumor suppressor gene products.
Djelloul S, Forgue-Lafitte ME, Hermelin B, Mareel M, Bruyneel E, Baldi A, Giordano A, Chastre E, Gespach C. Djelloul S, et al. FEBS Lett. 1997 Apr 14;406(3):234-42. doi: 10.1016/s0014-5793(97)00208-1. FEBS Lett. 1997. PMID: 9136893 Free article.
When compared to normal human colonic crypts, Caco-2 cell differentiation is related to partial redistribution of pRb1 into hypophosphorylated, antiproliferative forms. The pRb2 protein is found elevated in a subset of human colorectal tumors and their corresponding liver …
When compared to normal human colonic crypts, Caco-2 cell differentiation is related to partial redistribution of pRb1 into hypophosphorylat …
81 results