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214 results

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Page 1
Effects of o,p'-DDE, a Mitotane Metabolite, in an Adrenocortical Carcinoma Cell Line.
Bach C, Corso CR, Veiga AA, Paraizo MM, de Souza LM. Bach C, et al. Pharmaceuticals (Basel). 2022 Nov 29;15(12):1486. doi: 10.3390/ph15121486. Pharmaceuticals (Basel). 2022. PMID: 36558937 Free PMC article.
The mitotane metabolism occurs via two main reactions: the beta-hydroxylation, which yields the final product o,p'-DDA, and the alpha-hydroxylation, which will give the final product o,p'-DDE. It is speculated that o,p'-DDE may be an acti …
The mitotane metabolism occurs via two main reactions: the beta-hydroxylation, which yields the final product o,p'-DDA, and the alpha-hydrox …
Use of GC/MS/SIM for rapid determination of plasma levels of o,p'-DDD, o,p'-DDE and o,p'-DDA.
Inouye M, Mio T, Sumino K. Inouye M, et al. Clin Chim Acta. 1987 Dec;170(2-3):305-14. doi: 10.1016/0009-8981(87)90141-0. Clin Chim Acta. 1987. PMID: 3436064
It was learned that o,p'-DDA is present in the plasma at a concentration about 10 times higher than the levels of o,p'-DDD and o,p'-DDE....
It was learned that o,p'-DDA is present in the plasma at a concentration about 10 times higher than the levels of o,p'-DDD and o,p …
Comparison of p-p'-DDE and o-p'-DDE on eggshell thickness and Ca binding activity of shell gland in ducks.
Lundholm CE. Lundholm CE. Acta Pharmacol Toxicol (Copenh). 1980 Nov;47(5):377-84. doi: 10.1111/j.1600-0773.1980.tb01576.x. Acta Pharmacol Toxicol (Copenh). 1980. PMID: 7293792
(wet weight) respectively. In the IRD 40 mg/kg of o-p'-DDE in the diet for 45 days was much less potent in reducing the eggshell index (8 +/- 3%) than the p-p' isomer; the amount of residue of the o-p' isomer in the eggs (2.2 +/- 0.1 p.p.m.) was also smaller. …
(wet weight) respectively. In the IRD 40 mg/kg of o-p'-DDE in the diet for 45 days was much less potent in reducing the …
Effects of o,p'-DDE, heptachlor, and 17beta-estradiol on vitellogenin gene expression and the growth hormone/insulin-like growth factor-I axis in the tilapia, Oreochromis mossambicus.
Davis LK, Visitacion N, Riley LG, Hiramatsu N, Sullivan CV, Hirano T, Grau EG. Davis LK, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2009 May;149(4):507-14. doi: 10.1016/j.cbpc.2008.11.007. Epub 2008 Dec 6. Comp Biochem Physiol C Toxicol Pharmacol. 2009. PMID: 19101654
Treatment with E(2) stimulated expression of all three Vg genes. Both o,p'-DDE and heptachlor increased expression of VgB, whereas only o,p'-DDE increased VgA expression. There was no effect of o,p'-DDE or heptachlor …
Treatment with E(2) stimulated expression of all three Vg genes. Both o,p'-DDE and heptachlor increased expression of V …
DDE-induced eggshell thinning in birds: effects of p,p'-DDE on the calcium and prostaglandin metabolism of the eggshell gland.
Lundholm CD. Lundholm CD. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 Oct;118(2):113-28. doi: 10.1016/s0742-8413(97)00105-9. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997. PMID: 9490182 Review.
The detrimental effects of p,p'-DDE on the eggshell gland seem to be unique when comparing the compound with structurally related substances, i.e., similar treatment regimens with o,p'-DDE, p,p'-DDT, o,p'-DDT, and p,p'-DDD do not cause eggshell thinning in du …
The detrimental effects of p,p'-DDE on the eggshell gland seem to be unique when comparing the compound with structurally related substances …
In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).
Papoulias DM, Villalobos SA, Meadows J, Noltie DB, Giesy JP, Tillitt DE. Papoulias DM, et al. Environ Health Perspect. 2003 Jan;111(1):29-32. doi: 10.1289/ehp.5540. Environ Health Perspect. 2003. PMID: 12515675 Free PMC article.
The limited toxicologic data for o,p -DDE suggest that it decreases fecundity and fertility of fishes. We conducted an egg injection study using the d-rR strain of medaka and environmentally relevant concentrations of o,p -DDE to examine …
The limited toxicologic data for o,p -DDE suggest that it decreases fecundity and fertility of fishes. We conducted an …
Determination of mitotane (o,p-DDD) and its metabolites o,p-DDA and o,p-DDE in plasma by high-performance liquid chromatography.
Andersen A, Kasperlik-Zaluska AA, Warren DJ. Andersen A, et al. Ther Drug Monit. 1999 Jun;21(3):355-9. doi: 10.1097/00007691-199906000-00020. Ther Drug Monit. 1999. PMID: 10365653 Clinical Trial.
A new high-performance liquid chromatographic (HPLC) method for measurement of mitotane and two of its metabolites, o,p'-DDA (1,1-(o,p'-dichlorodiphenyl) acetic acid) and o,p'-DDE (1,1-(o,p'-dichlorodiphenyl)-2,2 dichloroethene), in plasma has been developed. …
A new high-performance liquid chromatographic (HPLC) method for measurement of mitotane and two of its metabolites, o,p'-DDA (1,1-(o,p'-dich …
Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study.
Hermsen IG, Fassnacht M, Terzolo M, Houterman S, den Hartigh J, Leboulleux S, Daffara F, Berruti A, Chadarevian R, Schlumberger M, Allolio B, Haak HR, Baudin E. Hermsen IG, et al. J Clin Endocrinol Metab. 2011 Jun;96(6):1844-51. doi: 10.1210/jc.2010-2676. Epub 2011 Apr 6. J Clin Endocrinol Metab. 2011. PMID: 21470991
OBJECTIVE: The study was performed to confirm the correlation of the currently used mitotane (o,p'DDD) threshold of 14 mg/liter with tumor response and to evaluate the additional value of 1,1-(o,p'-dichlorodiphenyl) acetic acid (o,p'DDA) and o,p'DDE (1,1-(o,p …
OBJECTIVE: The study was performed to confirm the correlation of the currently used mitotane (o,p'DDD) threshold of 14 mg/liter with tumor r …
o,p'-DDD (mitotane) therapy of adrenal cortical carcinoma: observations on drug dosage, toxicity, and steroid replacement.
Hogan TF, Citrin DL, Johnson BM, Nakamura S, Davis TE, Borden EC. Hogan TF, et al. Cancer. 1978 Nov;42(5):2177-81. doi: 10.1002/1097-0142(197811)42:5<2177::aid-cncr2820420514>3.0.co;2-x. Cancer. 1978. PMID: 719602
Plasma levels of o,p'-DDD and its metabolites o,p'-DDA and o,p'-DDE were measured. o,p'-DDD was measurable for up to 8 months after stopping therapy, and trace levels of metabolites were detectable at 18 months. ...
Plasma levels of o,p'-DDD and its metabolites o,p'-DDA and o,p'-DDE were measured. o,p'-DDD was measurable for up to 8 …
Behaviors and trophodynamics of o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT) in the aquatic food web: Comparison with p,p'-DDT.
Sun J, Xu C, Peng H, Wan Y, Luo K, Barrett H, Hu J. Sun J, et al. Sci Total Environ. 2022 May 15;821:153447. doi: 10.1016/j.scitotenv.2022.153447. Epub 2022 Jan 29. Sci Total Environ. 2022. PMID: 35092765
A well-controlled laboratory exposure experiment with Japanese medaka (Oryzias latipes) demonstrated that o,p'-DDT was more difficult to metabolize to o,p'-DDE compared with that of p,p'-DDT. Significantly positive regressions were found between trophic level …
A well-controlled laboratory exposure experiment with Japanese medaka (Oryzias latipes) demonstrated that o,p'-DDT was more difficult to met …
214 results