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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1942 1
1943 2
1946 1
1948 6
1949 2
1950 2
1951 1
1952 1
1953 1
1955 1
1956 1
1957 3
1958 4
1959 3
1960 6
1961 3
1962 2
1963 5
1964 4
1965 6
1966 5
1967 9
1968 3
1969 6
1970 7
1971 7
1972 9
1973 6
1974 8
1975 17
1976 15
1977 31
1978 24
1979 27
1980 46
1981 28
1982 34
1983 60
1984 58
1985 59
1986 60
1987 57
1988 88
1989 89
1990 83
1991 73
1992 95
1993 98
1994 81
1995 89
1996 102
1997 129
1998 141
1999 103
2000 131
2001 144
2002 140
2003 185
2004 165
2005 190
2006 185
2007 181
2008 204
2009 183
2010 196
2011 260
2012 288
2013 315
2014 304
2015 294
2016 380
2017 393
2018 400
2019 451
2020 527
2021 600
2022 589
2023 553
2024 572
2025 632
2026 90

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9,384 results

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Page 1
MTG2 as a Causal and Druggable Target in Uveal Melanoma via Mitochondrial DNA Dynamics: Evidence From Functional Validation and DMSA Identification.
Zhang Y, Min D, Wang Y, Yu W, Cui B, Su Y, Shen Z, Feng C. Zhang Y, et al. Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):30. doi: 10.1167/iovs.67.2.30. Invest Ophthalmol Vis Sci. 2026. PMID: 41677388
We thus explored the causal role of mitochondrial-related genes (MRGs) in uveal melanoma (UM) and the underlying mechanisms. METHODS: We performed Mendelian randomization (MR) analysis using 1693 cis-expression quantitative trait loci (cis-eQTLs) of MRGs as instrume …
We thus explored the causal role of mitochondrial-related genes (MRGs) in uveal melanoma (UM) and the underlying mechanisms. M …
Clinical outcomes of genomically guided trametinib monotherapy across cancer types: results from the IMPRESS-Norway trial.
Slørdahl KS, Puco K, Falk RS, Dyvik I, Brabrand S, Niehusmann P, Steinskog ESS, Blix ES, Flobak Å, Oppedal IA, Meltzer S, Torkildsen CF, Blakstad H, Lindemann K, Smeland S, Amundsen A, Taskén K, Helland Å; InPred Consortium. Slørdahl KS, et al. Acta Oncol. 2026 Feb 10;65:90-96. doi: 10.2340/1651-226X.2026.45086. Acta Oncol. 2026. PMID: 41664938 Free article.
Responses were seen in tumours harbouring BRAF fusions, GNA11, GNAQ, KRAS, NF1, and NRAS alterations, most frequently in low-grade serous ovarian cancer, central nervous system tumours, and uveal melanoma. Forty-eight percent of patients experienced treatment-relate …
Responses were seen in tumours harbouring BRAF fusions, GNA11, GNAQ, KRAS, NF1, and NRAS alterations, most frequently in low-grade serous ov …
Changes in inflammatory blood parameters in patients with radiation-related complications due to radiotherapy for uveal melanoma.
Algedik Tokyürek MÖ, Koç İ, Öztürk E, Yazıcı G, Kıratlı H. Algedik Tokyürek MÖ, et al. Clin Exp Optom. 2026 Feb 9:1-9. doi: 10.1080/08164622.2026.2625884. Online ahead of print. Clin Exp Optom. 2026. PMID: 41662828
BACKGROUND: Radiation retinopathy is a vision-threatening complication of radiotherapy for uveal melanoma and has traditionally been considered a localised microvascular disorder. ...METHODS: A retrospective review was undertaken of hospital records of patients diag …
BACKGROUND: Radiation retinopathy is a vision-threatening complication of radiotherapy for uveal melanoma and has traditionall …
Ligand-Based Computational Design and Preclinical Evaluation of a Novel Cyclic Peptide Radiotracer for FGFR1-Targeted PET Imaging in Uveal Melanoma.
Wang L, Zhu X, Yu M, Zhu H, Huang Z, Xue Y, Wang S, Jiao Y, Li Y, Lian B, Xu C, Hao Y, Fang J, Wang K. Wang L, et al. ACS Sens. 2026 Feb 9:XXX. doi: 10.1021/acssensors.5c04161. Online ahead of print. ACS Sens. 2026. PMID: 41661730
Uveal melanoma (UM), a rare yet aggressive ocular malignancy in adults, highlights the critical need for targeted therapies to improve clinical outcomes. ...
Uveal melanoma (UM), a rare yet aggressive ocular malignancy in adults, highlights the critical need for targeted therapies to …
A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma.
Xu X, Liu X, Jarajapu V, Neelature Sriramareddy S, Konecny F, Posorske B, Dollar JJ, Liu X, Jasani N, Wang K, Mecozzi N, Soto-Vargas Z, Ochoa-Rios SL, Murikipudi H, Phan N, Chadourne M, Kuznetsoff JN, Sinard J, Bennett RL, Licht JD, Smalley KSM, Harbour JW, Yu X, Karreth FA. Xu X, et al. Cancer Res. 2026 Feb 9. doi: 10.1158/0008-5472.CAN-25-2684. Online ahead of print. Cancer Res. 2026. PMID: 41661679
Uveal melanoma (UM) is a highly aggressive intraocular malignancy with limited therapeutic options for metastatic disease. ...
Uveal melanoma (UM) is a highly aggressive intraocular malignancy with limited therapeutic options for metastatic disease. ...
ROS-responsive transmembrane peptide-antibody conjugate eyedrops for the non-invasive treatment of choroidoretinopathy.
Qu L, Lu T, Tan J, Chen X, Tian T, Liu S, Gong Y, Jiang Z, He Z, Sun P, Sun J, Ma X, Gu R. Qu L, et al. Mater Today Bio. 2026 Jan 17;37:102819. doi: 10.1016/j.mtbio.2026.102819. eCollection 2026 Apr. Mater Today Bio. 2026. PMID: 41660128 Free PMC article.
In mouse models of choroidal neovascularization and choroidal melanoma, this conjugate demonstrated significant therapeutic efficacy, highlighting its broad clinical potential for the treatment of choroidoretinopathy....
In mouse models of choroidal neovascularization and choroidal melanoma, this conjugate demonstrated significant therapeutic ef …
Optic nerve and susceptibility imaging at asymptomatic stage of multiple sclerosis: impact and predictive value.
Lafontaine JC, Bordier C, Labreuche J, Alberto T, Lemarchant B, Zéphir H, Outteryck O. Lafontaine JC, et al. Brain Commun. 2026 Jan 21;8(1):fcag020. doi: 10.1093/braincomms/fcag020. eCollection 2026. Brain Commun. 2026. PMID: 41659034 Free PMC article.
We included 32 untreated patients (63 eyes; one eye excluded due to the fortuitous discovery of an ocular melanoma). Nine optic nerves showed lesions on MRI in the orbital or canalicular part. ...
We included 32 untreated patients (63 eyes; one eye excluded due to the fortuitous discovery of an ocular melanoma). Nine opti …
Conjunctival Melanocytic Neoplasia.
Stagner AM. Stagner AM. Surg Pathol Clin. 2026 Mar;19(1):63-71. doi: 10.1016/j.path.2025.08.004. Epub 2025 Dec 1. Surg Pathol Clin. 2026. PMID: 41651613 Review.
This review discusses the distinct origins and molecular genetics of conjunctival melanocytic neoplasms, especially in sun-exposed areas like the bulbar conjunctiva, which share similarities with their cutaneous counterparts. Uveal melanoma, which is not the topic o …
This review discusses the distinct origins and molecular genetics of conjunctival melanocytic neoplasms, especially in sun-exposed areas lik …
Chromosome 3p deletion leads to extensive genomic alterations in diverse cancers and confers synthetic lethality in uveal melanoma.
Cutler MC, Howland PB, Hejna M, Song JS. Cutler MC, et al. bioRxiv [Preprint]. 2026 Jan 23:2026.01.21.700826. doi: 10.64898/2026.01.21.700826. bioRxiv. 2026. PMID: 41648238 Free PMC article. Preprint.
Across cancers, isochromosomes form most frequently on chr8 to amplify the MYC -containing q-arm and chr17 to delete the TP53 -containing p-arm. In the most aggressive uveal melanoma (UVM) subtype, chr3 deletion also includes MITF , a critical melanocyte differentia …
Across cancers, isochromosomes form most frequently on chr8 to amplify the MYC -containing q-arm and chr17 to delete the TP53 -containing p- …
Mutations with prognostic value in uveal melanoma. Analytical study of variants detected by targeted NGS.
Pérez-Pérez M, de Sola-Llamas CG, Agostino A, Ruvolo M, Vilches-Arenas A, Relimpio-López MI, Macías-García L, De Miguel-Rodríguez M, Umbria-Jimenez S, García-Escudero A, Idoate MA, Ríos-Martín JJ. Pérez-Pérez M, et al. Can J Ophthalmol. 2026 Feb 2:S0008-4182(26)00010-4. doi: 10.1016/j.jcjo.2026.01.014. Online ahead of print. Can J Ophthalmol. 2026. PMID: 41644099
PURPOSE: To identify genetic variants with prognostic value in uveal melanoma (UM) using targeted next-generation sequencing (NGS) and evaluate their association with metastasis and histologic subtype. ...METHODS: Targeted NGS was performed on tumour samples from 69 …
PURPOSE: To identify genetic variants with prognostic value in uveal melanoma (UM) using targeted next-generation sequencing ( …
9,384 results