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Quoted phrase not found in phrase index: "perhydrothiopyran"
Page 1
Crystal structure of (-)-(2R,3S,4R,5R)-5-(1,3-di-thian-2-yl)-3-methyl-1-(triiso-propyl-sil-yloxy)hexane-2,4-diol.
Cruz-Montanez A, Piñero Cruz DM, Prieto JA. Cruz-Montanez A, et al. Acta Crystallogr Sect E Struct Rep Online. 2014 Nov 21;70(Pt 12):o1285-6. doi: 10.1107/S160053681402443X. eCollection 2014 Dec 1. Acta Crystallogr Sect E Struct Rep Online. 2014. PMID: 25553049 Free PMC article.
They consist of syn,anti,anti-stereo-tetrads with a 1,3-di-thiane motif and a primary alcohol protected as the triisopropyl silyl ether. The 1,3-di-thiane ring adopts a chair conformation, while the rest of each mol-ecule displays a common zigzag conformation. ...
They consist of syn,anti,anti-stereo-tetrads with a 1,3-di-thiane motif and a primary alcohol protected as the triisopropyl silyl eth …
Photomediated ring contraction of saturated heterocycles.
Jurczyk J, Lux MC, Adpressa D, Kim SF, Lam YH, Yeung CS, Sarpong R. Jurczyk J, et al. Science. 2021 Aug 27;373(6558):1004-1012. doi: 10.1126/science.abi7183. Epub 2021 Aug 12. Science. 2021. PMID: 34385352 Free PMC article.
This unconventional transformation is orthogonal to traditional ring contractions, challenging the paradigm for diversification of heterocycles including piperidine, morpholine, thiane, tetrahydropyran, and tetrahydroisoquinoline derivatives. The success of this Norrish ty …
This unconventional transformation is orthogonal to traditional ring contractions, challenging the paradigm for diversification of heterocyc …
Thiolane-type sulfides from garlic, onion, and Welsh onion.
Nohara T, Fujiwara Y, El-Aasr M, Ikeda T, Ono M, Nakano D, Kinjo J. Nohara T, et al. J Nat Med. 2021 Sep;75(4):741-751. doi: 10.1007/s11418-021-01533-x. Epub 2021 Jun 3. J Nat Med. 2021. PMID: 34081271 Free PMC article. Review.
In this paper, we review our work in the last 10 years wherein we examined the sulfides in the acetone extracts of garlic (Allium sativum), onion (A. cepa), and Welsh onion (A. fistulosum), obtained and characterized the structures of new sulfides, three 3,4-dimethylthiolane-type …
In this paper, we review our work in the last 10 years wherein we examined the sulfides in the acetone extracts of garlic (Allium sativum), …
Inhibition of glutamate racemase by substrate-product analogues.
Pal M, Bearne SL. Pal M, et al. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1432-6. doi: 10.1016/j.bmcl.2013.12.114. Epub 2014 Jan 8. Bioorg Med Chem Lett. 2014. PMID: 24507924
The related cyclic substrate-product analogue 1,1-dioxo-tetrahydrothiopyran-4-one was a cooperative mixed-type inhibitor of FnGR (Ki=18.41.2 mM), while linear analogues were only weak inhibitors of the enzyme. ...
The related cyclic substrate-product analogue 1,1-dioxo-tetrahydrothiopyran-4-one was a cooperative mixed-type inhibitor of FnGR (Ki= …
Two-Component Assembly of Thiochroman-4-ones and Tetrahydrothiopyran-4-ones Using a Rhodium-Catalyzed Alkyne Hydroacylation/Thio-Conjugate-Addition Sequence.
Bouisseau A, Glancy J, Willis MC. Bouisseau A, et al. Org Lett. 2016 Nov 4;18(21):5676-5679. doi: 10.1021/acs.orglett.6b02909. Epub 2016 Oct 25. Org Lett. 2016. PMID: 27779887 Free article.
Aryl, alkenyl, and alkyl aldehydes can all be employed, to provide thiochroman-4-ones, hexahydro-4H-thiochromen-4-ones, and tetrahydrothiopyran-4-ones, respectively. A variety of in situ oxidations are also performed, allowing access to S,S-dioxide derivatives, as well as …
Aryl, alkenyl, and alkyl aldehydes can all be employed, to provide thiochroman-4-ones, hexahydro-4H-thiochromen-4-ones, and tetrahydrothi …
Mechanistic studies on cyclohexanone oxygenase.
Ryerson CC, Ballou DP, Walsh C. Ryerson CC, et al. Biochemistry. 1982 May 25;21(11):2644-55. doi: 10.1021/bi00540a011. Biochemistry. 1982. PMID: 7093214
In addition to its ketolactonizing activity, cyclohexanone oxygenase carries out S-oxygenation of thiane to thiane 1-oxide, a reaction which represents a nucleophilic displacement by the sulfur upon the terminal oxygen of the hydroperoxide. ...
In addition to its ketolactonizing activity, cyclohexanone oxygenase carries out S-oxygenation of thiane to thiane 1-oxide, a …
(3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one enhances the inhibitory effect of gemcitabine on pancreatic cancer cells.
Wu P, Wang X, Ma Y, Xu X, Liu W, Sheng Z, Chen M, Zhou R, Zhang K, Goodin S, Zheng X, Li D. Wu P, et al. Bioorg Chem. 2020 Aug;101:104022. doi: 10.1016/j.bioorg.2020.104022. Epub 2020 Jun 17. Bioorg Chem. 2020. PMID: 32599367
In an earlier study, our laboratory found that the curcumin analogue, (3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one (FN2) had strong inhibitory effect on human pancreatic cancer cells. ...
In an earlier study, our laboratory found that the curcumin analogue, (3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one …
Synthesis of Tetrahydro-2H-thiopyran 1,1-Dioxides via [1+1+1+1+1+1] Annulation: An Unconventional Usage of a Tethered C-S Synthon.
Chen XL, Wang HY, Wu CY, Tang BC, Hu YL, Ma JT, Zhuang SY, Yu ZC, Wu YD, Wu AX. Chen XL, et al. Org Lett. 2022 Oct 21;24(41):7659-7664. doi: 10.1021/acs.orglett.2c03194. Epub 2022 Oct 10. Org Lett. 2022. PMID: 36214546
An unprecedented [1+1+1+1+1+1] annulation process has been developed for the construction of tetrahydro-2H-thiopyran 1,1-dioxides. Notably, rongalite acted as a tethered C-S synthon in this reaction and can be chemoselectively used as triple C1 units and as a …
An unprecedented [1+1+1+1+1+1] annulation process has been developed for the construction of tetrahydro-2H-thiopyran 1, …
Extended Diethylglycine Homopeptides Formed by Desulfurization of Their Tetrahydrothiopyran Analogues.
De Zotti M, Clayden J. De Zotti M, et al. Org Lett. 2019 Apr 5;21(7):2209-2212. doi: 10.1021/acs.orglett.9b00501. Epub 2019 Mar 12. Org Lett. 2019. PMID: 30859838
In this paper, we show that reductive desulfurization of oligomers formed from more reactive tetrahydrothiopyran-containing precursors provides a practical way to build the longest Deg homopeptides so far made, and we detail some conformational studies of the Deg oligomers …
In this paper, we show that reductive desulfurization of oligomers formed from more reactive tetrahydrothiopyran-containing precursor …
77 results