Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents.
Baumert BO, Maretti-Mira AC, Walker DI, Li Z, Stratakis N, Wang H, Zhao Y, Fischer FC, Jia Q, Valvi D, Bartell SM, Chen JC, Inge T, Ryder JR, Jenkins T, Sisley S, Xanthakos S, Kleiner DE, Kohli R, Rock S, Eckel SP, La Merrill MA, Aung MM, Salomon MP, McConnell R, Goodrich J, Conti DV, Golden-Mason L, Chatzi L.
Baumert BO, et al.
Commun Med (Lond). 2025 Oct 29;5(1):430. doi: 10.1038/s43856-025-01168-z.
Commun Med (Lond). 2025.
PMID: 41162609
Free PMC article.
Human liver spheroids were exposed to perfluoroheptanoic acid (PFHpA) in vitro and analyzed by single-cell transcriptomics. The latent unknown clustering with integrated data (LUCID) model was employed to assess associations between PFHpA exposure, multiomic signatu …
Human liver spheroids were exposed to perfluoroheptanoic acid (PFHpA) in vitro and analyzed by single-cell transcriptomics. Th …