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Page 1
IRIS Toxicological Review of Perfluorohexanoic Acid [PFHxA, CASRN 307-24-4] and Related Salts.
Angrish MM, Dishaw L, Allen Davis J, Dean JL II, Kraft A, Radke EG, Schlosser P, Lin YS, White S, Zhao J, Zurlinden T, Arzuaga X, Congleton J, Druwe IL, Kaiser JP, Owens EO, Taylor MM, Weaver A, Wilkins A, Wright M, Hawkins B, Lambert JC, Garcia K, Gigot C, Greenhalgh A, Hussain S, Schulz B. Angrish MM, et al. Washington (DC): U.S. Environmental Protection Agency; 2023 Apr. Washington (DC): U.S. Environmental Protection Agency; 2023 Apr. PMID: 38484103 Free Books & Documents. Review. No abstract available.
Perfluorohexanoic acid exhibits more potential for the proliferation, migration, and invasion of triple-negative breast cancer cells under the 3D culture model.
Han J, Wang H, Wei S, Chen Y, Xu T, Yin D. Han J, et al. J Hazard Mater. 2025 Oct 5;497:139551. doi: 10.1016/j.jhazmat.2025.139551. Epub 2025 Aug 13. J Hazard Mater. 2025. PMID: 40829400
Although three-dimensional (3D) cell culture systems serve as ideal platforms for cancer research by recapitulating key aspects of the tumor microenvironment, their broader applicability and reliability in environmental toxicology and risk assessment require further validation. …
Although three-dimensional (3D) cell culture systems serve as ideal platforms for cancer research by recapitulating key aspects of the tumor …
Perfluorohexanoic acid caused disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae.
Zhang S, Guo X, Lu S, He J, Wu Q, Liu X, Han Z, Xie P. Zhang S, et al. Ecotoxicol Environ Saf. 2022 Mar 1;232:113283. doi: 10.1016/j.ecoenv.2022.113283. Epub 2022 Feb 4. Ecotoxicol Environ Saf. 2022. PMID: 35131581 Free article.
Perfluorohexanoic acid (PFHxA) has been recognized as an alternative to the wide usage of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in the fluoropolymer industry for years. ...
Perfluorohexanoic acid (PFHxA) has been recognized as an alternative to the wide usage of perfluorooctanoate (PFOA) and perflu …
A comparative review of the toxicity mechanisms of perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS) in fish.
Kreychman M, Ivantsova E, Lu A, Bisesi JH Jr, Martyniuk CJ. Kreychman M, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2024 May;279:109874. doi: 10.1016/j.cbpc.2024.109874. Epub 2024 Feb 27. Comp Biochem Physiol C Toxicol Pharmacol. 2024. PMID: 38423199 Review.
Industrial and consumer goods contain diverse perfluoroalkyl substances (PFAS). These substances, like perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS), are under increased scrutiny due to their potential toxicity to aquatic organisms. ...
Industrial and consumer goods contain diverse perfluoroalkyl substances (PFAS). These substances, like perfluorohexanoic acid …
Comparative analysis of the toxicological databases for 6:2 fluorotelomer alcohol (6:2 FTOH) and perfluorohexanoic acid (PFHxA).
Rice PA, Aungst J, Cooper J, Bandele O, Kabadi SV. Rice PA, et al. Food Chem Toxicol. 2020 Apr;138:111210. doi: 10.1016/j.fct.2020.111210. Epub 2020 Feb 19. Food Chem Toxicol. 2020. PMID: 32087313 Review.
Some published risk assessments have assumed that perfluorohexanoic acid (PFHxA), a metabolite of 6:2 FTOH, adequately models the human health effects of 6:2 FTOH. ...
Some published risk assessments have assumed that perfluorohexanoic acid (PFHxA), a metabolite of 6:2 FTOH, adequately models …
A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid.
Borghoff SJ, Fitch S, Rager JE, Huggett D. Borghoff SJ, et al. Regul Toxicol Pharmacol. 2018 Nov;99:168-181. doi: 10.1016/j.yrtph.2018.09.001. Epub 2018 Sep 18. Regul Toxicol Pharmacol. 2018. PMID: 30240830 Free article. Review.
Perfluorohexanoic acid (PFHxA) is a potential impurity and environmental degradation product of C6-based fluorotelomer products. ...
Perfluorohexanoic acid (PFHxA) is a potential impurity and environmental degradation product of C6-based fluorotelomer product …
Perfluorohexanoic acid toxicity, part I: Development of a chronic human health toxicity value for use in risk assessment.
Luz AL, Anderson JK, Goodrum P, Durda J. Luz AL, et al. Regul Toxicol Pharmacol. 2019 Apr;103:41-55. doi: 10.1016/j.yrtph.2019.01.019. Epub 2019 Jan 9. Regul Toxicol Pharmacol. 2019. PMID: 30639337 Free article.
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used globally today. ...
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, a …
Perfluorohexanoic acid toxicity, part II: Application of human health toxicity value for risk characterization.
Anderson JK, Luz AL, Goodrum P, Durda J. Anderson JK, et al. Regul Toxicol Pharmacol. 2019 Apr;103:10-20. doi: 10.1016/j.yrtph.2019.01.020. Epub 2019 Jan 8. Regul Toxicol Pharmacol. 2019. PMID: 30634020 Free article.
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon PFAA and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used in the United States, Europe and Japan today. ...
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon PFAA and is a primary impurity, degradant, and metabolite associat …
Dietary Perfluorohexanoic Acid (PFHxA) Exposures in Juvenile Zebrafish Produce Subtle Behavioral Effects across Generations.
Rericha Y, Truong L, Leong C, Cao D, Field JA, Tanguay RL. Rericha Y, et al. Toxics. 2022 Jul 4;10(7):372. doi: 10.3390/toxics10070372. Toxics. 2022. PMID: 35878277 Free PMC article.
Manufacturing trends have shifted from legacy PFAS to shorter-chain alternatives that are suggested to be safer, such as perfluorohexanoic acid (PFHxA). However, the current amount of data to support safety assessments of these alternatives is not yet sufficient. .. …
Manufacturing trends have shifted from legacy PFAS to shorter-chain alternatives that are suggested to be safer, such as perfluorohexanoi …
Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS.
Gaballah S, Swank A, Sobus JR, Howey XM, Schmid J, Catron T, McCord J, Hines E, Strynar M, Tal T. Gaballah S, et al. Environ Health Perspect. 2020 Apr;128(4):47005. doi: 10.1289/EHP5843. Epub 2020 Apr 9. Environ Health Perspect. 2020. PMID: 32271623 Free PMC article.
METHODS: Zebrafish were developmentally exposed to 4,8-dioxa-3H-perfluorononanoate (ADONA), perfluoro-2-propoxypropanoic acid (GenX Free Acid), perfluoro-3,6-dioxa-4-methyl-7-octene-1-sulfonic acid (PFESA1), perfluorohexanesulfonic acid (PFHxS), perfluorohexanoic acid …
METHODS: Zebrafish were developmentally exposed to 4,8-dioxa-3H-perfluorononanoate (ADONA), perfluoro-2-propoxypropanoic acid (GenX Free Aci …
432 results