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IRIS Toxicological Review of Perfluorohexanoic Acid [PFHxA, CASRN 307-24-4] and Related Salts.
Angrish MM, Dishaw L, Allen Davis J, Dean JL II, Kraft A, Radke EG, Schlosser P, Lin YS, White S, Zhao J, Zurlinden T, Arzuaga X, Congleton J, Druwe IL, Kaiser JP, Owens EO, Taylor MM, Weaver A, Wilkins A, Wright M, Hawkins B, Lambert JC, Garcia K, Gigot C, Greenhalgh A, Hussain S, Schulz B. Angrish MM, et al. Washington (DC): U.S. Environmental Protection Agency; 2023 Apr. Washington (DC): U.S. Environmental Protection Agency; 2023 Apr. PMID: 38484103 Free Books & Documents. Review. No abstract available.
Perfluorohexanoic acid caused disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae.
Zhang S, Guo X, Lu S, He J, Wu Q, Liu X, Han Z, Xie P. Zhang S, et al. Ecotoxicol Environ Saf. 2022 Mar 1;232:113283. doi: 10.1016/j.ecoenv.2022.113283. Epub 2022 Feb 4. Ecotoxicol Environ Saf. 2022. PMID: 35131581 Free article.
Perfluorohexanoic acid (PFHxA) has been recognized as an alternative to the wide usage of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in the fluoropolymer industry for years. ...
Perfluorohexanoic acid (PFHxA) has been recognized as an alternative to the wide usage of perfluorooctanoate (PFOA) and perflu …
Dietary Perfluorohexanoic Acid (PFHxA) Exposures in Juvenile Zebrafish Produce Subtle Behavioral Effects across Generations.
Rericha Y, Truong L, Leong C, Cao D, Field JA, Tanguay RL. Rericha Y, et al. Toxics. 2022 Jul 4;10(7):372. doi: 10.3390/toxics10070372. Toxics. 2022. PMID: 35878277 Free PMC article.
Manufacturing trends have shifted from legacy PFAS to shorter-chain alternatives that are suggested to be safer, such as perfluorohexanoic acid (PFHxA). However, the current amount of data to support safety assessments of these alternatives is not yet sufficient. .. …
Manufacturing trends have shifted from legacy PFAS to shorter-chain alternatives that are suggested to be safer, such as perfluorohexanoi …
A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid.
Borghoff SJ, Fitch S, Rager JE, Huggett D. Borghoff SJ, et al. Regul Toxicol Pharmacol. 2018 Nov;99:168-181. doi: 10.1016/j.yrtph.2018.09.001. Epub 2018 Sep 18. Regul Toxicol Pharmacol. 2018. PMID: 30240830 Free article. Review.
Perfluorohexanoic acid (PFHxA) is a potential impurity and environmental degradation product of C6-based fluorotelomer products. ...
Perfluorohexanoic acid (PFHxA) is a potential impurity and environmental degradation product of C6-based fluorotelomer product …
Comparative analysis of the toxicological databases for 6:2 fluorotelomer alcohol (6:2 FTOH) and perfluorohexanoic acid (PFHxA).
Rice PA, Aungst J, Cooper J, Bandele O, Kabadi SV. Rice PA, et al. Food Chem Toxicol. 2020 Apr;138:111210. doi: 10.1016/j.fct.2020.111210. Epub 2020 Feb 19. Food Chem Toxicol. 2020. PMID: 32087313 Review.
Some published risk assessments have assumed that perfluorohexanoic acid (PFHxA), a metabolite of 6:2 FTOH, adequately models the human health effects of 6:2 FTOH. ...
Some published risk assessments have assumed that perfluorohexanoic acid (PFHxA), a metabolite of 6:2 FTOH, adequately models …
Perfluorohexanoic acid toxicity, part II: Application of human health toxicity value for risk characterization.
Anderson JK, Luz AL, Goodrum P, Durda J. Anderson JK, et al. Regul Toxicol Pharmacol. 2019 Apr;103:10-20. doi: 10.1016/j.yrtph.2019.01.020. Epub 2019 Jan 8. Regul Toxicol Pharmacol. 2019. PMID: 30634020 Free article.
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon PFAA and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used in the United States, Europe and Japan today. ...
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon PFAA and is a primary impurity, degradant, and metabolite associat …
Perfluorohexanoic acid toxicity, part I: Development of a chronic human health toxicity value for use in risk assessment.
Luz AL, Anderson JK, Goodrum P, Durda J. Luz AL, et al. Regul Toxicol Pharmacol. 2019 Apr;103:41-55. doi: 10.1016/j.yrtph.2019.01.019. Epub 2019 Jan 9. Regul Toxicol Pharmacol. 2019. PMID: 30639337 Free article.
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, and metabolite associated with the short-chain fluorotelomer-based chemistry used globally today. ...
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl acid (PFAA) and is a primary impurity, degradant, a …
A comparative review of the toxicity mechanisms of perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS) in fish.
Kreychman M, Ivantsova E, Lu A, Bisesi JH Jr, Martyniuk CJ. Kreychman M, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2024 May;279:109874. doi: 10.1016/j.cbpc.2024.109874. Epub 2024 Feb 27. Comp Biochem Physiol C Toxicol Pharmacol. 2024. PMID: 38423199 Review.
Industrial and consumer goods contain diverse perfluoroalkyl substances (PFAS). These substances, like perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS), are under increased scrutiny due to their potential toxicity to aquatic organisms. ...
Industrial and consumer goods contain diverse perfluoroalkyl substances (PFAS). These substances, like perfluorohexanoic acid …
Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration.
Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Gibbs ST, Granville CA, Blystone CR. Dzierlenga AL, et al. Xenobiotica. 2020 Jun;50(6):722-732. doi: 10.1080/00498254.2019.1683776. Epub 2019 Nov 7. Xenobiotica. 2020. PMID: 31680603
The National Toxicology Program evaluated the toxicokinetics (TK) of several PFAS to provide context for toxicologic findings.Plasma TK parameters and tissue (liver, kidney, brain) concentrations are reported for perfluorohexanoic acid (PFHxA), perfluorooctanoic aci …
The National Toxicology Program evaluated the toxicokinetics (TK) of several PFAS to provide context for toxicologic findings.Plasma TK para …
339 results