Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
1992 2
1993 11
1994 15
1995 18
1996 26
1997 26
1998 22
1999 27
2000 21
2001 36
2002 33
2003 30
2004 44
2005 34
2006 35
2007 32
2008 30
2009 27
2010 38
2011 39
2012 34
2013 34
2014 43
2015 30
2016 29
2017 16
2018 22
2019 7
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

701 results
Results by year
Filters applied: . Clear all
Page 1
The multifaceted roles of perlecan in fibrosis.
Lord MS, et al. Matrix Biol 2018 - Review. PMID 29475023
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. ...This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system....
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and
A current view of perlecan in physiology and pathology: A mosaic of functions.
Gubbiotti MA, et al. Matrix Biol 2017 - Review. PMID 27613501 Free PMC article.
Here we provide a contemporary review germane to the biology of perlecan encompassing its genetic regulation as well as an analysis of its modular protein structure as it pertains to function. As perlecan signaling from the extracellular matrix converges on master regulators of autophagy, including AMPK and mTOR, via a specific interaction with vascular endothelial growth factor receptor 2, we specifically focus on the mechanism of action of perlecan in autophagy and angiogenesis and contrast the role of endorepellin, the C-terminal fragment of perlecan, in these cellular and morphogenic events....
Here we provide a contemporary review germane to the biology of perlecan encompassing its genetic regulation as well as an analysis o …
Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle.
Yamashita Y, et al. Sci Rep 2018. PMID 29773865 Free PMC article.
Here, we show physiological roles of perlecan in both obesity and the onset of metabolic syndrome. The perinatal lethality-rescued perlecan knockout (Hspg2(-/-)-Tg) mice showed a smaller mass and cell size of white adipose tissues than control (WT-Tg) mice. ...Our data suggest that downregulation of perlecan is a promising strategy to control metabolic syndrome....
Here, we show physiological roles of perlecan in both obesity and the onset of metabolic syndrome. The perinatal lethality-rescued …
Proteoglycans in liver cancer
Baghy K, et al. World J Gastroenterol 2016 - Review. PMID 26755884 Free PMC article.
This article details and discusses the roles of syndecan-1, glypicans, agrin, perlecan, collagen XVIII/endostatin, endocan, serglycin, decorin, biglycan, asporin, fibromodulin, lumican, and versican in liver function. ...
This article details and discusses the roles of syndecan-1, glypicans, agrin, perlecan, collagen XVIII/endostatin, endocan, serglycin …
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan.
Vennin C, et al. Nat Commun 2019. PMID 31406163 Free PMC article.
We identify perlecan as a key component of this pro-metastatic environment. Using intravital imaging, we observe that these dominant CAFs delay cancer cell response to chemotherapy. Lastly, we reveal that depleting perlecan in the stroma combined with chemotherapy prolongs mouse survival, supporting it as a potential target for anti-stromal therapies in pancreatic cancer....
We identify perlecan as a key component of this pro-metastatic environment. Using intravital imaging, we observe that these dominant …
IL-1 and TGF-β Modulation of Epithelial Basement Membrane Components Perlecan and Nidogen Production by Corneal Stromal Cells.
Saikia P, et al. Invest Ophthalmol Vis Sci 2018. PMID 30480706 Free PMC article.
PURPOSE: To determine whether (1) the in vitro expression of epithelial basement membrane components nidogen-1, nidogen-2, and perlecan by keratocytes, corneal fibroblasts, and myofibroblasts is modulated by cytokines/growth factors, and (2) perlecan protein is produced by stromal cells after photorefractive keratectomy. ...IL-1α significantly upregulated, while TGF-β1 significantly downregulated, perlecan protein expression in keratocytes. Perlecan protein expression was upregulated in anterior stromal cells at 1 and 2 days after -4.5 or -9 diopters (D) PRK, but the subepithelial localization of perlecan became disrupted at 7 days and later time points in -9-D PRK corneas when myofibroblasts populated the anterior stroma. ...
PURPOSE: To determine whether (1) the in vitro expression of epithelial basement membrane components nidogen-1, nidogen-2, and perlecan
Injury derived autoimmunity: Anti-perlecan/LG3 antibodies in transplantation.
Dieudé M, et al. Hum Immunol 2019 - Review. PMID 31029511
In this review, we present the evidence for the release of LG3, an immunogenic fragment of perlecan, as a consequence of caspase-3 dependent vascular apoptosis leading to the genesis of anti-LG3 autoantibodies and the consequences of these autoantibodies in native and transplanted kidneys....
In this review, we present the evidence for the release of LG3, an immunogenic fragment of perlecan, as a consequence of caspase-3 de …
The importance of non-HLA antibodies in transplantation
Zhang Q and Reed EF. Nat Rev Nephrol 2016 - Review. PMID 27345243 Free PMC article.
Although our knowledge of non-HLA antibodies is incomplete, compelling experimental and clinical findings demonstrate that antibodies directed against autoantigens such as angiotensin type 1 receptor, perlecan and collagen, contribute to the process of antibody-mediated acute and chronic rejection. ...
Although our knowledge of non-HLA antibodies is incomplete, compelling experimental and clinical findings demonstrate that antibodies direct …
Perlecan Diversely Regulates the Migration and Proliferation of Distinct Cell Types in vitro.
Nakamura R, et al. Cells Tissues Organs 2015. PMID 26562025
However, the full range of multifunctionality of perlecan remains to be elucidated. We cultured various cell types, which were derived from epithelial/endothelial, connective and muscle tissues, in the presence of either antiserum against perlecan or exogenous perlecan, and examined the effects of perlecan on cell migration and proliferation. ...Blocking of perlecan by anti-perlecan antiserum inhibited the migration of vascular endothelial cells (VECs) and bone marrow-derived mesenchymal stem cells, and exogenous perlecan added to the culture medium promoted the migration of these cell types. ...
However, the full range of multifunctionality of perlecan remains to be elucidated. We cultured various cell types, which were derive …
Diverse functions of perlecan in central nervous system cells in vitro.
Nakamura R, et al. Anim Sci J 2015. PMID 25781054
The coated perlecan and the perlecan added to the culture medium suppressed astrocyte proliferation; however, perlecan added to the medium promoted NS/PC proliferation. Neurons were promoted to extend their neurites on the perlecan-coated substrate, and perlecan added to the medium also showed a similar effect. ...
The coated perlecan and the perlecan added to the culture medium suppressed astrocyte proliferation; however, perlecan
701 results
Jump to page
Feedback