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1975 2
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970 results

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Quoted phrase not found in phrase index: "steoroids"
Page 1
Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway.
Liang C, Liu X, Yu J, Shi L, Wei W, Zhu Y, Feng M, Tang T, Li D, Yang T, Zheng J, Ma B, Wei L. Liang C, et al. J Adv Res. 2025 Nov;77:669-688. doi: 10.1016/j.jare.2025.01.042. Epub 2025 Jan 25. J Adv Res. 2025. PMID: 39870303 Free PMC article.
INTRODUCTION: Hypericin (HP), a natural photosensitizer, has demonstrated great efficacy in photodynamic therapy (PDT) for cancer treatment. In addition to the induction of apoptosis and necrosis through reactive oxygen species (ROS) generation, the therapeutic mechanisms …
INTRODUCTION: Hypericin (HP), a natural photosensitizer, has demonstrated great efficacy in photodynamic therapy (PDT) for cancer tre …
Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy.
Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J. Ma X, et al. Int J Nanomedicine. 2025 Feb 4;20:1529-1541. doi: 10.2147/IJN.S510339. eCollection 2025. Int J Nanomedicine. 2025. PMID: 39925681 Free PMC article.
In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs. ...
In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable tox …
Perylene diimide-based treatment and diagnosis of diseases.
Zhao Z, Xu N, Wang Y, Ling G, Zhang P. Zhao Z, et al. J Mater Chem B. 2021 Nov 10;9(43):8937-8950. doi: 10.1039/d1tb01752g. J Mater Chem B. 2021. PMID: 34657950 Review.
Furthermore, perylene diimide-based multifunctional nano-delivery systems are particularly emphasized, showing great therapeutic potential in the field of image-guided combination therapy in tumor therapy. Finally, the great opportunities and challenges still faced …
Furthermore, perylene diimide-based multifunctional nano-delivery systems are particularly emphasized, showing great therapeutic pote …
Hypericin: chemical synthesis and biosynthesis.
Huang LF, Wang ZH, Chen SL. Huang LF, et al. Chin J Nat Med. 2014 Feb;12(2):81-8. doi: 10.1016/S1875-5364(14)60014-5. Chin J Nat Med. 2014. PMID: 24636057 Review.
Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and biosynthesis of this unique compound. ...
Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and …
Perylene-Mediated Cytoskeletal Dysfunction Remodels Cancer-Associated Fibroblasts to Augment Antitumor Immunotherapy.
Shi B, Lou X, Ma F, Nie Y, Chen H, Huang Y, Zhang W, Wang T. Shi B, et al. Adv Healthc Mater. 2024 Apr;13(11):e2303837. doi: 10.1002/adhm.202303837. Epub 2024 Jan 15. Adv Healthc Mater. 2024. PMID: 38183408
Targeted reprogramming of cancer-associated fibroblasts (CAFs) is one of the most essential cancer therapies. However, how to reprogram active CAFs toward deactivated state still remains immense challenge. ...As a result, PDIC-OC can reprogram the activated CAFs and …
Targeted reprogramming of cancer-associated fibroblasts (CAFs) is one of the most essential cancer therapies. However, how to …
Novel manganese and polyester dendrimer-based theranostic nanoparticles for MRI and breast cancer therapy.
Zhou X, Xu X, Hu Q, Wu Y, Yu F, He C, Qian Y, Han Y, Tang J, Hu H. Zhou X, et al. J Mater Chem B. 2023 Jan 18;11(3):648-656. doi: 10.1039/d2tb01855a. J Mater Chem B. 2023. PMID: 36541124
Therapeutic nanoplatforms are widely used in the diagnosis and treatment of breast cancer due to the merits of enabling high soft-tissue resolution and the availability of numerous therapeutic nanoparticles. ...Thus, the high efficiency in MRI contrast enhancement and exce …
Therapeutic nanoplatforms are widely used in the diagnosis and treatment of breast cancer due to the merits of enabling high soft-tis …
Construction and synergistic anti-tumor study of a tumor microenvironment-based multifunctional nano-drug delivery system.
Liu B, Zheng Q, Shi X, Shen J, Li R, Zhou J. Liu B, et al. J Photochem Photobiol B. 2024 Sep;258:112977. doi: 10.1016/j.jphotobiol.2024.112977. Epub 2024 Jul 3. J Photochem Photobiol B. 2024. PMID: 38991294
The system exhibited excellent stability, physiological compatibility and targeted drug release performance in tumor tissues. In the in vitro and in vivo experiments, Hyp released from MSN killed tumor cells through photodynamic therapy (PDT). The degree of hypoxia …
The system exhibited excellent stability, physiological compatibility and targeted drug release performance in tumor tissues. In the …
Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications.
Rajan SS, Chandran R, Abrahamse H. Rajan SS, et al. Int J Nanomedicine. 2024 Nov 1;19:11023-11038. doi: 10.2147/IJN.S486014. eCollection 2024. Int J Nanomedicine. 2024. PMID: 39502636 Free PMC article. Review.
Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer therapeutic option, especially when enhanced by nanoconjugation. This review investigates the methods by which nano-conjugated hypocrellin enhances therapeutic efficacy and precision when targeti …
Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer therapeutic option, especially when enhanced by nanocon …
Hypocrellin B Exerts Its Antitumor Effect on Colorectal Cancer by Inhibiting the AKT Pathway.
Qu H, Sun A, Zhou Y, Ma C, Ye Y, Xu Y, Zhao H, Zhao C, Hu Y, Yang L, Peng L, Zheng S, Wang K. Qu H, et al. J Nat Prod. 2025 Jun 27;88(6):1273-1285. doi: 10.1021/acs.jnatprod.4c01431. Epub 2025 May 20. J Nat Prod. 2025. PMID: 40392701
The natural compound hypocrellin B has been shown to inhibit tumor growth, but its effects and specific mechanisms of action in colorectal cancer remain unclear. Here, we explore the anti-tumor effect of hypocrellin B on human colorectal cancer cells a …
The natural compound hypocrellin B has been shown to inhibit tumor growth, but its effects and specific mechanisms of action in color …
Perylene-Based Reactive Oxygen Species Supergenerator for Immunogenic Photochemotherapy against Hypoxic Tumors.
Lou X, Wang H, Liu Y, Huang Y, Liu Z, Zhang W, Wang T. Lou X, et al. Angew Chem Int Ed Engl. 2023 Mar 6;62(11):e202214586. doi: 10.1002/anie.202214586. Epub 2023 Feb 7. Angew Chem Int Ed Engl. 2023. PMID: 36597125
Reactive oxygen species (ROS) can act as cytotoxic radicals to directly kill tumor cells and concurrently trigger immunogenic cell death (ICD) to efficiently achieve tumor therapy. ...More interesting, the mitochondria- and lung-specific distribution of PMIC-NC also …
Reactive oxygen species (ROS) can act as cytotoxic radicals to directly kill tumor cells and concurrently trigger immunogenic cell de …
970 results