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167 results

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Quoted phrase not found in phrase index: "steoroids"
Page 1
Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor.
Opoku-Temeng C , Dayal N , Hernandez DE , Naganna N , Sintim HO . Opoku-Temeng C , et al. Chem Commun (Camb). 2018 May 1;54(36):4521-4524. doi: 10.1039/c8cc01154k. Chem Commun (Camb). 2018. PMID: 29629444
Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell …
Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetra …
Understanding and improving platinum anticancer drugs--phenanthriplatin.
Johnstone TC, Park GY, Lippard SJ. Johnstone TC, et al. Anticancer Res. 2014 Jan;34(1):471-6. Anticancer Res. 2014. PMID: 24403503 Free PMC article. Review.
Despite the widespread use of these drugs, the only cure that can be claimed is that of testicular cancer following cisplatin treatment. This article reviews some of our recent work on phenanthriplatin, a cisplatin derivative in which a chloride ion is replaced by phena …
Despite the widespread use of these drugs, the only cure that can be claimed is that of testicular cancer following cisplatin treatme …
Design and synthesis of phenanthridinone and phenanthridine derivatives and their radiosensitizing activity.
Liu WY, Yao CS, Li YW, Gao X, Guo LS, An LK. Liu WY, et al. Bioorg Med Chem. 2025 Jun 1;123:118161. doi: 10.1016/j.bmc.2025.118161. Epub 2025 Mar 19. Bioorg Med Chem. 2025. PMID: 40120150
Colony formation assays indicated that the phenanthridine derivative B9 showed strong radiosensitizing activity in colorectal cancer HCT116 cells in a concentration- and dose-dependent manner. Further investigations revealed that B9 could increase intracellular ioni …
Colony formation assays indicated that the phenanthridine derivative B9 showed strong radiosensitizing activity in colorectal canc …
Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives.
Patel AS, Jain V, Rao VN, Lin YW, Shah A, Lai KC, Su TL, Lee TC. Patel AS, et al. Eur J Med Chem. 2020 Sep 15;202:112516. doi: 10.1016/j.ejmech.2020.112516. Epub 2020 Jun 23. Eur J Med Chem. 2020. PMID: 32622270
These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, delaying cell cycle progression in the G2/M phase and triggering apoptosis. ...We demonstrated that at a dose that did not cause body weight loss in mice, compound 21a could significa …
These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, delaying cell cycle progression in the G2/M …
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?
Frizzell KM, Kraus WL. Frizzell KM, et al. Breast Cancer Res. 2009;11(6):111. doi: 10.1186/bcr2451. Epub 2009 Nov 26. Breast Cancer Res. 2009. PMID: 20017885 Free PMC article.
In a new study, Inbar-Rozensal and colleagues show that phenanthridine-derived PARP inhibitors promote cell cycle arrest and cell death in breast cancer cells lacking BRCA1 and BRCA2 mutations and prevent the growth of tumors from xenografts of these cells in immuno …
In a new study, Inbar-Rozensal and colleagues show that phenanthridine-derived PARP inhibitors promote cell cycle arrest and cell dea …
Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system.
Yang B, Zhang D, Qian J, Cheng Y. Yang B, et al. Mol Cell Biochem. 2020 Nov;474(1-2):199-208. doi: 10.1007/s11010-020-03845-0. Epub 2020 Jul 31. Mol Cell Biochem. 2020. PMID: 32737771
Here, the present study tested their effects on prostate cancer cells. The addition of chelerythrine can significantly inhibit the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 muM, but not on a …
Here, the present study tested their effects on prostate cancer cells. The addition of chelerythrine can significantly inhibit the pr …
Synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones.
Iribarra J, Vásquez D, Theoduloz C, Benites J, Ríos D, Valderrama JA. Iribarra J, et al. Molecules. 2012 Sep 28;17(10):11616-29. doi: 10.3390/molecules171011616. Molecules. 2012. PMID: 23023687 Free PMC article.
A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl-aldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives w …
A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1 …
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new anti-vitiligo compounds.
Yang BJ, Fan SR, Zhang XF, Cai JY, Ruan T, Xiang ZR, Ren J, Hao XJ, Chen DZ. Yang BJ, et al. Bioorg Chem. 2022 Feb;119:105582. doi: 10.1016/j.bioorg.2021.105582. Epub 2021 Dec 25. Bioorg Chem. 2022. PMID: 34971944
In this work, two portions design and synthesis were put into effect. firstly, 17 phenanthridine derivatives with C-4 substitutes were designed and synthesized, which compounds 4, 6, 12, 13 served as H-acceptor with protein showed enhance melanogenesis activity; Secondly, …
In this work, two portions design and synthesis were put into effect. firstly, 17 phenanthridine derivatives with C-4 substitutes wer …
Exclusive destruction of mitotic spindles in human cancer cells.
Visochek L, Castiel A, Mittelman L, Elkin M, Atias D, Golan T, Izraeli S, Peretz T, Cohen-Armon M. Visochek L, et al. Oncotarget. 2017 Mar 28;8(13):20813-20824. doi: 10.18632/oncotarget.15343. Oncotarget. 2017. PMID: 28209915 Free PMC article.
Their activity prevented the binding of NuMA to alpha-tubulin and kinesins in human cancer cells, and caused aberrant spindles. The most efficient cytotoxic activity of the phenanthridine PJ34, caused significantly smaller aberrant spindles with disrupted spindle po …
Their activity prevented the binding of NuMA to alpha-tubulin and kinesins in human cancer cells, and caused aberrant spindles. The m …
Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives.
Wan M, Zhang L, Chen Y, Li Q, Fan W, Xue Q, Yan F, Song W. Wan M, et al. Front Oncol. 2019 Apr 16;9:274. doi: 10.3389/fonc.2019.00274. eCollection 2019. Front Oncol. 2019. PMID: 31058081 Free PMC article.
Based on the structure of sanguinarine, fourteen phenanthridine derivatives were designed and synthesized in the current study. The cytotoxic activities of synthesized compounds were evaluated against five human cancer cell lines (MCF-7, PC3, Hela, A549, and HepG2 c …
Based on the structure of sanguinarine, fourteen phenanthridine derivatives were designed and synthesized in the current study. The c …
167 results