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Year Number of Results
1986 1
1988 2
1989 4
1990 7
1991 7
1992 2
1993 2
1994 6
1995 6
1996 6
1997 4
1998 1
1999 8
2000 4
2001 3
2002 6
2003 2
2004 2
2005 4
2006 2
2008 2
2009 7
2010 4
2011 1
2012 5
2013 4
2014 2
2015 2
2016 2
2017 4
2020 0
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105 results
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Page 1
Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy.
Falik Zaccai TC, et al. Brain 2017. PMID 28007986 Free PMC article.
Next generation sequencing, bioinformatics, and segregation analyses followed, to determine a loss of function sequence variation in the phospholipase A(2)-activating protein encoding gene (PLAA). ...Plaa-null mice were perinatal lethal with reduced brain levels of prostaglandin E(2) The non-functional phospholipase A(2)-activating protein and the associated neurological phenotype, reported herein for the first time, join other complex phospholipid defects that cause leukoencephalopathies in humans, emphasizing the importance of this axis in white matter development and maintenance....
Next generation sequencing, bioinformatics, and segregation analyses followed, to determine a loss of function sequence variation in the …
Membrane-mediated actions of 1,25-dihydroxy vitamin D3: a review of the roles of phospholipase A2 activating protein and Ca(2+)/calmodulin-dependent protein kinase II.
Doroudi M, et al. J Steroid Biochem Mol Biol 2015 - Review. PMID 25448737 Free PMC article.
In its membrane-initiated pathway, after 1α,25(OH)2D3 interacts with protein disulfide isomerase, family A, member 3 (Pdia3) in caveolae, phospholipase A2 (PLA2) and protein kinase C (PKC) are activated. Recent efforts to determine the signaling proteins involved in the 1α,25(OH)2D3 signal from Pdia3 to PLA2 have indicated that phospholipase A2 activating protein (PLAA) and Ca(2+)/calmodulin-dependent kinase II (CaMKII) are required. ...
In its membrane-initiated pathway, after 1α,25(OH)2D3 interacts with protein disulfide isomerase, family A, member 3 (Pdia3) in caveo …
Monosodium urate crystals stimulate phospholipase A2 enzyme activities and the synthesis of a phospholipase A2-activating protein.
Bomalaski JS, et al. J Immunol 1990. PMID 2230125
Specificity was observed, as phospholipase C activities were not affected. Pretreatment with colchicine, but not aspirin, indomethacin, allopurinol, or islet activating protein, abrogated the enhanced phospholipase A2 activities. We have recently isolated and characterized a phospholipase A2 activating protein termed PLAP from synovial fluid from patients with rheumatoid arthritis, and from murine and bovine cell lines. ...
Specificity was observed, as phospholipase C activities were not affected. Pretreatment with colchicine, but not aspirin, indomethaci …
Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes.
Bomalaski JS, et al. J Immunol 1995. PMID 7706741
Phospholipase A2-activating protein (PLAP) is an important mediator of eicosanoid generation. PLAP can also be found in high concentrations in synovial fluid from patients with rheumatoid arthritis, and injection of PLAP into animal joints results in an inflammatory, rheumatoid-like lesion. We have demonstrated previously that TNF-alpha and IL-1 beta stimulate formation of PLAP before phospholipase A2 (PLA2) enzyme activation and production of eicosanoids. ...
Phospholipase A2-activating protein (PLAP) is an important mediator of eicosanoid generation. PLAP can also be f
Tumour necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells.
Clark MA, et al. Biochem J 1988. PMID 3128274 Free PMC article.
Phospholipase A2 activation, [3H]arachidonic acid-metabolite synthesis and passage of iodinated protein A, required both RNA and protein synthesis and were associated with an increase in the synthesis of a recently described phospholipase A2-activating protein. The Bordetella pertussis toxin, islet-activating protein, also inhibited the increase in phospholipase A2 activity, the release of [3H]arachidonic acid metabolites and the passage of iodinated protein A, suggesting that the TNF receptor-ligand interaction resulting in cellular retraction, phospholipase A2 activation and eicosanoid synthesis, is coupled through the Ni guanine nucleotide regulatory protein in these cells....
Phospholipase A2 activation, [3H]arachidonic acid-metabolite synthesis and passage of iodinated protein A, required bot
Phospholipase A2 activating protein (PLAA) is required for 1alpha,25(OH)2D3 signaling in growth plate chondrocytes.
Schwartz Z, et al. J Cell Physiol 2005. PMID 15368540
Phospholipase A2 (PLA2) is pivotal in the rapid membrane-mediated actions of 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. Microarray analysis indicated that PLA2 activating protein (PLAA) mRNA is upregulated 6-fold before rat growth plate cells exhibit 1alpha,25(OH)2D3-dependent protein kinase C (PKC) increases, suggesting that it plays an important role in 1alpha,25(OH)2D3's mechanism of action. ...PLAA protein was shown by Western blot and immunohistochemistry. PLAAs role in 1alpha,25(OH)2D3 signaling was evaluated in growth zone cell cultures using PLAA peptide. ...
Phospholipase A2 (PLA2) is pivotal in the rapid membrane-mediated actions of 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. Micr
Cloning of a phospholipase A2-activating protein.
Clark MA, et al. Proc Natl Acad Sci U S A 1991. PMID 2052621 Free PMC article.
Recently we have described the isolation and biochemical characterization of a phospholipase A2-activating protein (PLAP). We have cloned this protein and found it to be expressed as a 2.5-kilobase mRNA. ...Synthetic antisense DNA was used to block the synthesis of PLAP and this treatment effectively blocked the activation of phospholipase A2 and the increased generation of prostanoids in smooth muscle and endothelial cells treated with leukotriene D4....
Recently we have described the isolation and biochemical characterization of a phospholipase A2-activating protein
Phospholipase A2-activating protein--an important regulatory molecule in modulating cyclooxygenase-2 and tumor necrosis factor production during inflammation.
Ribardo DA, et al. Indian J Exp Biol 2002 - Review. PMID 12622174
This review focuses on eicosanoids and their regulation via phospholipase A2-activating protein, which could be targeted as a new therapeutic tool to control inflammatory diseases....
This review focuses on eicosanoids and their regulation via phospholipase A2-activating protein, which could be …
Molecular characterization of cDNA for phospholipase A2-activating protein.
Chopra AK, et al. Biochim Biophys Acta 1999. PMID 9931468
A phospholipase A2-activating protein (PLAP) cDNA was cloned and sequenced from a human monocyte cDNA library, and expressed as a histidine-tagged fusion protein. ...Anti-sense plap oligonucleotide blocked cholera toxin-induced release of 3H-labeled arachidonic acid from cells, indicating a potential role for PLAP in regulating phospholipase A2 activity....
A phospholipase A2-activating protein (PLAP) cDNA was cloned and sequenced from a human monocyte cDNA library, a …
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