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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
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1971 3
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1977 1
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1980 5
1981 5
1982 5
1983 3
1984 7
1985 4
1986 12
1987 5
1988 10
1989 11
1990 3
1991 13
1992 7
1993 12
1994 11
1995 15
1996 25
1997 11
1998 19
1999 13
2000 18
2001 21
2002 19
2003 31
2004 34
2005 26
2006 28
2007 28
2008 34
2009 37
2010 49
2011 59
2012 55
2013 59
2014 64
2015 53
2016 72
2017 74
2018 66
2019 71
2020 75
2021 84
2022 79
2023 87
2024 103
2025 115
2026 46

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1,524 results

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Quoted phrase not found in phrase index: "steoroids"
Page 1
The ErbB/HER family of protein-tyrosine kinases and cancer.
Roskoski R Jr. Roskoski R Jr. Pharmacol Res. 2014 Jan;79:34-74. doi: 10.1016/j.phrs.2013.11.002. Epub 2013 Nov 20. Pharmacol Res. 2014. PMID: 24269963 Review.
Several malignancies are associated with the mutation or increased expression of members of the ErbB family including lung, breast, stomach, colorectal, head and neck, and pancreatic carcinomas and glioblastoma (a brain tumor). Gefitinib, erlotinib, and afatinib are orally …
Several malignancies are associated with the mutation or increased expression of members of the ErbB family including lung, breast, stomach, …
Quinazoline Derivatives as Targeted Chemotherapeutic Agents.
Zayed MF. Zayed MF. Cureus. 2024 May 20;16(5):e60662. doi: 10.7759/cureus.60662. eCollection 2024 May. Cureus. 2024. PMID: 38899242 Free PMC article. Review.
Consequently, the discovery of targeted chemotherapy drugs with high selectivity and low side effects is necessary for cancer treatment. The quinazoline system has a broad range and a long history of biological activities. Numerous quinazoline derivatives hav …
Consequently, the discovery of targeted chemotherapy drugs with high selectivity and low side effects is necessary for cancer treatme …
Quinazoline-2,4(1 H,3 H)-dione Scaffold for development of a novel PARP-targeting PET probe for tumor imaging.
He C, Shi H, Tan B, Jiang Z, Cao R, Zhu J, Qian K, Wang X, Xu X, Qu C, Song S, Cheng Z. He C, et al. Eur J Nucl Med Mol Imaging. 2024 Nov;51(13):3840-3853. doi: 10.1007/s00259-024-06843-2. Epub 2024 Jul 16. Eur J Nucl Med Mol Imaging. 2024. PMID: 39012502
Several PARP-targeting radiotracers have been developed to detect tumor in recent years. Two (18)F labelled probes based on Olaparib and Rucaparib molecular scaffolds have been evaluated in clinical trials, but their slow hepatic clearance hinders their tumor imagin …
Several PARP-targeting radiotracers have been developed to detect tumor in recent years. Two (18)F labelled probes based on Olaparib …
Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents.
Dhuguru J, Ghoneim OA. Dhuguru J, et al. Molecules. 2022 Mar 31;27(7):2294. doi: 10.3390/molecules27072294. Molecules. 2022. PMID: 35408693 Free PMC article. Review.
Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy, radiotherapy and surgery in some cases, cancer cells appear to outsmart and evade almost any method of …
Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocri …
Quinazoline alpha-adrenoreceptor blockers as an adjunct cancer treatment: From bench to bedside.
King L, Christie D, Dare W, Bernaitis N, Chess-Williams R, McDermott C, Forbes A, Anoopkumar-Dukie S. King L, et al. Eur J Pharmacol. 2021 Feb 15;893:173831. doi: 10.1016/j.ejphar.2020.173831. Epub 2020 Dec 23. Eur J Pharmacol. 2021. PMID: 33359146 Review.
Some of the drugs in this class, notably the quinazoline derivatives, have been found to display cytotoxic properties, identifying them as potential options in the treatment of cancer. This review will examine the currently available evidence that investigates the c …
Some of the drugs in this class, notably the quinazoline derivatives, have been found to display cytotoxic properties, identifying th …
Advances in the design and synthesis of prazosin derivatives over the last ten years.
Desiniotis A, Kyprianou N. Desiniotis A, et al. Expert Opin Ther Targets. 2011 Dec;15(12):1405-18. doi: 10.1517/14728222.2011.641534. Epub 2011 Dec 13. Expert Opin Ther Targets. 2011. PMID: 22148952 Free PMC article. Review.
AREAS COVERED: Advances over the last decade in the design and optimization of Prazosin, Doxazosin and Terazosin quinazoline-based derivatives as alpha1-AR antagonists. Evidence on the metabolic and growth interference action by these agents, in addition to their smooth-mu …
AREAS COVERED: Advances over the last decade in the design and optimization of Prazosin, Doxazosin and Terazosin quinazoline-based de …
Identification and exploration of quinazoline-1,2,3-triazole inhibitors targeting EGFR in lung cancer.
Kumar S, Sengupta S, Ali I, Gupta MK, Lalhlenmawia H, Azizov S, Kumar D. Kumar S, et al. J Biomol Struct Dyn. 2023;41(21):11353-11372. doi: 10.1080/07391102.2023.2204360. Epub 2023 Apr 28. J Biomol Struct Dyn. 2023. PMID: 37114510
The purpose of this study is to find out a novel anticancer agent that inhibits EGFR and reduces the chances of lung cancer. A series of triazole-substituted quinazoline hybrid compounds were designed by Chemdraw software and docked against five different crystallog …
The purpose of this study is to find out a novel anticancer agent that inhibits EGFR and reduces the chances of lung cancer. A series …
The antibreast cancer therapeutic potential of quinazoline hybrids-Part I.
Chen W, Wang R, Lin Y, Wang X, Cai F, Lin M, Wang J, Zhang H, Chen M. Chen W, et al. Future Med Chem. 2025 May;17(9):1055-1069. doi: 10.1080/17568919.2025.2498881. Epub 2025 Apr 30. Future Med Chem. 2025. PMID: 40304260 Free PMC article. Review.
Breast cancer is the most commonly diagnosed cancer in women and is the leading cause of cancer-related mortality among female patients across the world. ...Notably, lapatinib, a quinazoline-furan-sulfone hybrid, has already been launched for breast …
Breast cancer is the most commonly diagnosed cancer in women and is the leading cause of cancer-related mortality among …
Six-Membered Aromatic Nitrogen Heterocyclic Anti-Tumor Agents: Synthesis and Applications.
Li J, Gu A, Nong XM, Zhai S, Yue ZY, Li MY, Liu Y. Li J, et al. Chem Rec. 2023 Dec;23(12):e202300293. doi: 10.1002/tcr.202300293. Epub 2023 Nov 27. Chem Rec. 2023. PMID: 38010365 Review.
Cancer stands as a serious malady, posing substantial risks to human well-being and survival. ...This entails an in-depth analysis of synthesis pathways for pyridine, quinoline, pyrimidine, and quinazoline. Additionally, we explore the historical progression, target …
Cancer stands as a serious malady, posing substantial risks to human well-being and survival. ...This entails an in-depth analysis of …
Quinazoline Derivatives as Potential Therapeutic Agents in Urinary Bladder Cancer Therapy.
Wdowiak P, Matysiak J, Kuszta P, Czarnek K, Niezabitowska E, Baj T. Wdowiak P, et al. Front Chem. 2021 Nov 3;9:765552. doi: 10.3389/fchem.2021.765552. eCollection 2021. Front Chem. 2021. PMID: 34805097 Free PMC article. Review.
Cancer diseases remain major health problems in the world despite significant developments in diagnostic methods and medications. ...A very promising direction in bladder cancer treatment is targeted therapy directed at specific molecular pathways. Derivatives of qu …
Cancer diseases remain major health problems in the world despite significant developments in diagnostic methods and medications. ... …
1,524 results