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Page 1
The role of the classical complement cascade in synapse loss during development and glaucoma.
Rosen AM, Stevens B. Rosen AM, et al. Adv Exp Med Biol. 2010;703:75-93. doi: 10.1007/978-1-4419-5635-4_6. Adv Exp Med Biol. 2010. PMID: 20711708 Review.
Glaucoma is one of the leading causes of vision loss worldwide, yet the signals that initiate the progressive degeneration of optic nerve axons and the selective loss of retinal ganglion neurons (RGCs) remain elusive. Reactive gliosis, release of inflammatory …
Glaucoma is one of the leading causes of vision loss worldwide, yet the signals that initiate the progressive degeneration of optic nerve ax …
Changes in cytoskeletal protein synthesis following axon injury and during axon regeneration.
Bisby MA, Tetzlaff W. Bisby MA, et al. Mol Neurobiol. 1992 Summer-Fall;6(2-3):107-23. doi: 10.1007/BF02780547. Mol Neurobiol. 1992. PMID: 1476674 Review.
In contrast to this robust response of peripheral neurons to axotomy, injured central nervous system neurons show either an attenuated response that is subsequently aborted (rubrospinal neurons) or overall decreases in cytoskeletal protein mRNA expression (corticospinal and re
In contrast to this robust response of peripheral neurons to axotomy, injured central nervous system neurons show either an attenuated respo …
The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber's Hereditary Optic Neuropathy.
Layrolle P, Orssaud C, Leleu M, Payoux P, Chavanas S. Layrolle P, et al. Biomedicines. 2024 Mar 6;12(3):584. doi: 10.3390/biomedicines12030584. Biomedicines. 2024. PMID: 38540197 Free PMC article. Review.
Notably, Leber's hereditary optic neuropathy (LHON) is a devastating vision disease caused by mitochondrial gene mutations that hinder oxidative phosphorylation and increase oxidative stress, leading to the loss of retinal ganglion neurons and axons. Loss of …
Notably, Leber's hereditary optic neuropathy (LHON) is a devastating vision disease caused by mitochondrial gene mutations that hinder oxida …
Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems.
Giger RJ, Venkatesh K, Chivatakarn O, Raiker SJ, Robak L, Hofer T, Lee H, Rader C. Giger RJ, et al. Restor Neurol Neurosci. 2008;26(2-3):97-115. Restor Neurol Neurosci. 2008. PMID: 18820405 Free PMC article. Review.
Myelin-associated glycoprotein (MAG), for example, employs different mechanisms to inhibit neurite outgrowth of cerebellar, sensory, and retinal ganglion neurons in vitro. Nogo-A harbors distinct growth inhibitory regions, which employ different signaling mec …
Myelin-associated glycoprotein (MAG), for example, employs different mechanisms to inhibit neurite outgrowth of cerebellar, sensory, and …
Cell recognition and pattern formation in the developing nervous system.
Trisler D. Trisler D. J Exp Biol. 1990 Oct;153:11-27. doi: 10.1242/jeb.153.1.11. J Exp Biol. 1990. PMID: 2280219 Review.
The topographic map of cell position in the avian retina is conserved and inverted when retinal ganglion neurons synapse with neurons in the optic tectum. Developmental mechanisms based on molecular gradients that specify positional information and pattern fo …
The topographic map of cell position in the avian retina is conserved and inverted when retinal ganglion neurons synaps …
The cellular mechanism underlying neuronal degeneration in glaucoma: parallels with Alzheimer's disease.
Vickers JC. Vickers JC. Aust N Z J Ophthalmol. 1997 May;25(2):105-9. doi: 10.1111/j.1442-9071.1997.tb01290.x. Aust N Z J Ophthalmol. 1997. PMID: 9267595 Review.
The appearance of glaucoma-like neuronal pathology in Alzheimer's disease may follow the reaction of neurofilament-containing retinal ganglion neurons to persistent damage to their axons by beta-amyloid plaque formation in subcortical visual centers....
The appearance of glaucoma-like neuronal pathology in Alzheimer's disease may follow the reaction of neurofilament-containing retinal