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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1987 1
1988 1
1989 5
1990 40
1991 56
1992 100
1993 105
1994 119
1995 177
1996 250
1997 260
1998 247
1999 283
2000 320
2001 349
2002 378
2003 387
2004 440
2005 456
2006 508
2007 505
2008 576
2009 570
2010 570
2011 549
2012 585
2013 599
2014 570
2015 509
2016 502
2017 442
2018 390
2019 160
2020 2
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9,922 results
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Page 1
Src-family tyrosine kinases and the Ca(2+) signal.
Anguita E and Villalobo A. Biochim Biophys Acta Mol Cell Res 2017 - Review. PMID 27818271 Free article.
In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca(2+) transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. ...Finally, the role of the Ca(2+) sensor protein calmodulin on the activity of c-Src, and potentially on other SFKs, will be outlined as well. ...
In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca(2+) tran …
The role of SRC family kinases in FLT3 signaling.
Kazi JU and Rönnstrand L. Int J Biochem Cell Biol 2019 - Review. PMID 30552988
Several of the signal transduction pathways downstream of FLT3 have been shown to include various members of the SRC family of kinases (SFKs). ...Initially studied as the SFKs, as if they were a homogenous group of kinases, recent data suggest that each SFK has its own specific signaling capabilities where some are involved in positive signaling, while others are involved in negative signaling. ...
Several of the signal transduction pathways downstream of FLT3 have been shown to include various members of the SRC family of …
Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture.
Tan BS, et al. PLoS One 2016. PMID 27723793 Free PMC article.
Using inhibitors of cell signaling we have shown that Src family kinases, p38 MAPK, ERK1/2 and GSK3β are required for the transition between mES and EPL cells. ERK1/2, c-Src and GSK3β are likely to be enforcing a receptive, primed state in mES cells, while Src family kinases and p38 MAPK are involved in the establishment of EPL cells. ...
Using inhibitors of cell signaling we have shown that Src family kinases, p38 MAPK, ERK1/2 and GSK3β are required for t …
Src family kinases: at the forefront of platelet activation.
Senis YA, et al. Blood 2014 - Review. PMID 25115887 Free PMC article.
Src family kinases (SFKs) play a central role in mediating the rapid response of platelets to vascular injury. They transmit activation signals from a diverse repertoire of platelet surface receptors, including the integrin αIIbβ3, the immunoreceptor tyrosine-based activation motif-containing collagen receptor complex GPVI-FcR γ-chain, and the von Willebrand factor receptor complex GPIb-IX-V, which are essential for thrombus growth and stability. ...
Src family kinases (SFKs) play a central role in mediating the rapid response of platelets to vascular injury. They tra
An Update on Src Family of Nonreceptor Tyrosine Kinases Biology.
Espada J and Martín-Pérez J. Int Rev Cell Mol Biol 2017 - Review. PMID 28325216
The members of the Src family of nonreceptor tyrosine kinases (SFKs) are implicated in multiple signaling processes that regulate key cellular functions, including proliferation, migration, differentiation, and survival. ...
The members of the Src family of nonreceptor tyrosine kinases (SFKs) are implicated in multiple signaling processes tha …
SRC family kinases in hamster spermatozoa: evidence for the presence of LCK.
Singh DK, et al. Reproduction 2017. PMID 28250239
In this regard, we attempted to study the role of SRC family kinases (SFKs) in the hamster sperm functions. Interestingly, we found the presence of the lymphocyte-specific protein tyrosine kinase, LCK, in mammalian spermatozoa and further characterized it in terms of its localization and function. ...
In this regard, we attempted to study the role of SRC family kinases (SFKs) in the hamster sperm functions. Interesting …
EGFR family and Src family kinase interactions: mechanics matters?
Chen Z, et al. Curr Opin Cell Biol 2018 - Review. PMID 29289897
Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. ...Here we briefly review the classical understanding of EGFR family RTK signaling and then provide a broadened perspective based on recent results....
Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historicall …
Src protein-tyrosine kinase structure and regulation.
Roskoski R. Biochem Biophys Res Commun 2004 - Review. PMID 15504335
Src and Src-family protein kinases are proto-oncogenes that play key roles in cell morphology, motility, proliferation, and survival. v-Src (a viral protein) is encoded by the chicken oncogene of Rous sarcoma virus, and Src (the cellular homologue) is encoded by a physiological gene, the first of the proto-oncogenes. ...Its X-ray structure has been determined, and the SH2 lobe occupies a position that is entirely different from that of Src. Unlike Src, the C-terminal Src kinase SH2 and SH3 domains stabilize an active enzyme conformation. ...
Src and Src-family protein kinases are proto-oncogenes that play key roles in cell morphology, motility, prolife
Src family kinases in the nervous system.
Yu XM and Groveman BR. FEBS J 2012. PMID 22077923 Free article.
Src family kinases (SFKs) are key factors in the process of coupling signals from the cell surface to intracellular machinery and critically involved in the regulation of many neural functions mediated through growth factors, G-protein-coupled receptors or ligand-gated ion channels. ...
Src family kinases (SFKs) are key factors in the process of coupling signals from the cell surface to intracellular mac
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
Kovács M, et al. J Exp Med 2014. PMID 25225462 Free PMC article.
We show that Src family kinases play a critical role in myeloid cell-mediated in vivo inflammatory reactions. Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoietic compartment were completely protected from autoantibody-induced arthritis and skin blistering disease, as well as from the reverse passive Arthus reaction, with functional overlap between the three kinases. ...Src family kinases are required for the generation of the inflammatory environment but not for the intrinsic migratory ability of myeloid cells....
We show that Src family kinases play a critical role in myeloid cell-mediated in vivo inflammatory reactions. Mice lack …
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