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Pulmonary Vascular Disease Due to Plasma Cell Dyscrasia.
Rajapreyar I, Joly J, Tallaj J, Pamboukian SV, Assad AH, Lenneman C, Litovsky S, Chatterjee A, Hoopes C, Lenneman A. Rajapreyar I, et al. Mayo Clin Proc Innov Qual Outcomes. 2020 Nov 20;5(1):210-218. doi: 10.1016/j.mayocpiqo.2020.09.004. eCollection 2021 Feb. Mayo Clin Proc Innov Qual Outcomes. 2020. PMID: 33718795 Free PMC article.
Pulmonary hypertension (PH) has been described in myeloproliferative disorders; monoclonal plasma cell disorder such as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome; and plasma cell dyscrasias such as multiple myelom …
Pulmonary hypertension (PH) has been described in myeloproliferative disorders; monoclonal plasma cell disorder such as polyneuropath …
Bone Marrow Mesenchymal Stem Cells Ameliorate Cisplatin-Induced Renal Fibrosis via miR-146a-5p/Tfdp2 Axis in Renal Tubular Epithelial Cells.
Wu L, Rong C, Zhou Q, Zhao X, Zhuansun XM, Wan S, Sun MM, Wang SL. Wu L, et al. Front Immunol. 2021 Feb 16;11:623693. doi: 10.3389/fimmu.2020.623693. eCollection 2020. Front Immunol. 2021. PMID: 33664736 Free PMC article.
Mesenchymal stem cells (MSCs) have regenerative properties in acute kidney injury (AKI). However, the potential function of MSCs in chronic kidney disease remains elusive. Renal fibrosis is the common endpoint of chronic progressive kidney disea …
Mesenchymal stem cells (MSCs) have regenerative properties in acute kidney injury (AKI). However, the potential function of MS …
Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair.
Zhang R, Xu K, Shao Y, Sun Y, Saredy J, Cutler E, Yao T, Liu M, Liu L, Drummer Iv C, Lu Y, Saaoud F, Ni D, Wang J, Li Y, Li R, Jiang X, Wang H, Yang X. Zhang R, et al. Front Immunol. 2021 Feb 5;11:632239. doi: 10.3389/fimmu.2020.632239. eCollection 2020. Front Immunol. 2021. PMID: 33613572 Free PMC article.
These results suggest that stem cell-shared master genes make tissue Treg as the first T cell type using a Treg niche to maintain their Treg-ness with 80% innate immune pathways, and triple functions of immunosuppression, tissue repair, and homeostasis mainte …
These results suggest that stem cell-shared master genes make tissue Treg as the first T cell type using a Treg niche t …
Modeling Uremic Vasculopathy With Induced Pluripotent Stem Cell-Derived Endothelial Cells as a Drug Screening System.
Jang HR, Cho HJ, Zhou Y, Shao NY, Lee K, Le HHT, Jeon J, Lee JE, Huh W, Ong SG, Lee WH, Kim YG. Jang HR, et al. Front Cell Dev Biol. 2021 Jan 12;8:618796. doi: 10.3389/fcell.2020.618796. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33511129 Free PMC article.
Background: Cardiovascular complications are the leading cause of mortality in patients with chronic kidney disease (CKD). Uremic vasculopathy plays a crucial role in facilitating the progression of cardiovascular complications in advanced CKD. ...Methods and Result …
Background: Cardiovascular complications are the leading cause of mortality in patients with chronic kidney disease (CKD). Ure …
Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells.
Sávio-Silva C, Beyerstedt S, Soinski-Sousa PE, Casaro EB, Balby-Rocha MTA, Simplício-Filho A, Alves-Silva J, Rangel ÉB. Sávio-Silva C, et al. Stem Cells Int. 2020 Nov 20;2020:8833725. doi: 10.1155/2020/8833725. eCollection 2020. Stem Cells Int. 2020. PMID: 33505469 Free PMC article. Review.
Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus (DM) and comprises multifactorial pathophysiologic mechanisms. Despite current treatment, around 30-40% of individuals with type 1 and type 2 DM (DM1 and DM2) have progressive DKD, wh …
Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus (DM) and comprises multifactorial pathophys …
Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants.
Lin S, Lin W, Liao C, Zhou T. Lin S, et al. Stem Cells Int. 2020 Dec 21;2020:8819757. doi: 10.1155/2020/8819757. eCollection 2020. Stem Cells Int. 2020. PMID: 33424979 Free PMC article.
In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants. ...The results also indicate that MSC treatment alleviated inflammatory cells, necrotic …
In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment o …
Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk.
Howden SE, Wilson SB, Groenewegen E, Starks L, Forbes TA, Tan KS, Vanslambrouck JM, Holloway EM, Chen YH, Jain S, Spence JR, Little MH. Howden SE, et al. Cell Stem Cell. 2021 Apr 1;28(4):671-684.e6. doi: 10.1016/j.stem.2020.12.001. Epub 2020 Dec 29. Cell Stem Cell. 2021. PMID: 33378647 Free PMC article.
During development, distinct progenitors contribute to the nephrons versus the ureteric epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of kidney tissue either contain nephrons or pattern specifically to the ureter …
During development, distinct progenitors contribute to the nephrons versus the ureteric epithelium of the kidney. Indeed, previous hu …
BMSCs-derived exosomal microRNA-let-7a plays a protective role in diabetic nephropathy via inhibition of USP22 expression.
Mao R, Shen J, Hu X. Mao R, et al. Life Sci. 2021 Mar 1;268:118937. doi: 10.1016/j.lfs.2020.118937. Epub 2020 Dec 24. Life Sci. 2021. PMID: 33347877 Retracted.
OBJECTIVE: Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease. The molecular pathogenesis of DN is still poorly understood. This study was designed to investigate the protective effect of bone marrow mesenchymal stem cell (BMSCs …
OBJECTIVE: Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease. The molecular pathogenesis of DN is sti …
A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies.
Dvela-Levitt M, Shaw JL, Greka A. Dvela-Levitt M, et al. Trends Mol Med. 2021 Apr;27(4):394-409. doi: 10.1016/j.molmed.2020.11.008. Epub 2020 Dec 16. Trends Mol Med. 2021. PMID: 33341352 Review.
Mutations in the MUC1 gene cause ADTKD-MUC1 (MUC1 kidney disease, MKD), a disorder with no available therapies. Recent studies have identified the molecular and cellular mechanisms that drive MKD disease pathogenesis. Armed with patient-derived cell li …
Mutations in the MUC1 gene cause ADTKD-MUC1 (MUC1 kidney disease, MKD), a disorder with no available therapies. Recent studies …
Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease.
Ribeiro PC, Lojudice FH, Fernandes-Charpiot IMM, Baptista MASF, de Almeida Araújo S, Mendes GEF, Sogayar MC, Abbud-Filho M, Caldas HC. Ribeiro PC, et al. Stem Cell Res Ther. 2020 Dec 9;11(1):530. doi: 10.1186/s13287-020-02060-4. Stem Cell Res Ther. 2020. PMID: 33298161 Free PMC article.
BACKGROUND: Chronic kidney disease (CKD) is a global public health problem. Cell therapy using pluripotent stem cells represents an attractive therapeutic approach for the treatment of CKD. METHODS: We transplanted mitomycin C (MMC)-treated human induc …
BACKGROUND: Chronic kidney disease (CKD) is a global public health problem. Cell therapy using pluripotent stem …
High-Fat Diet Induced Hedgehog Signaling Modifications during Chronic Kidney Damage.
Mehmood R, Sheikh N, Khawar MB, Abbasi MH, Tayyeb A, Ashfaq I, Mukhtar M, Fatima N. Mehmood R, et al. Biomed Res Int. 2020 Nov 27;2020:8073926. doi: 10.1155/2020/8073926. eCollection 2020. Biomed Res Int. 2020. PMID: 33294454 Free PMC article.
Lipids, important key regulators of Hedgehog signaling, are involved in triggering fibrotic chronic kidney disease. The present study encompasses the assessment of renal morphofunctional modifications and alteration of lipid metabolism influencing the changes in gen …
Lipids, important key regulators of Hedgehog signaling, are involved in triggering fibrotic chronic kidney disease. The presen …
The Pattern of Cyclosporine Nephrotoxicity and Urinary Kidney Injury Molecule 1 in Allogenic Hematopoietic Stem Cell Transplant Patients.
Karimzadeh I, Jafari M, Davani-Davari D, Ramzi M. Karimzadeh I, et al. Exp Clin Transplant. 2021 Jun;19(6):553-562. doi: 10.6002/ect.2020.0123. Epub 2020 Nov 27. Exp Clin Transplant. 2021. PMID: 33272156 Free article.
We studied cyclosporine nephrotoxicity epidemiology in hematopoietic stem cell transplant patients and compared the pattern and urinary levels of the KIM-1 kidney injury molecule versus serum and urine creatinine levels. ...All patients met the following crit …
We studied cyclosporine nephrotoxicity epidemiology in hematopoietic stem cell transplant patients and compared the pattern an …
Multiple myeloma with chronic kidney disease dependent on peritoneal dialysis and autologous stem cell transplant.
Tyszkiewicz A, Heras Benito M, Urzola Rodriguez G, Rey Búa B, Baile González M, Sánchez-Jáuregui Castillo M. Tyszkiewicz A, et al. Nefrologia (Engl Ed). 2020 Nov 24:S0211-6995(20)30168-5. doi: 10.1016/j.nefro.2020.07.014. Online ahead of print. Nefrologia (Engl Ed). 2020. PMID: 33246783 Free article. English, Spanish. No abstract available.
The roles of collagen in chronic kidney disease and vascular calcification.
Huang A, Guo G, Yu Y, Yao L. Huang A, et al. J Mol Med (Berl). 2021 Jan;99(1):75-92. doi: 10.1007/s00109-020-02014-6. Epub 2020 Nov 25. J Mol Med (Berl). 2021. PMID: 33236192 Review.
Stem cell therapy seems to be an effective strategy to alleviate these two conditions. ...A comprehensive understanding of the role of collagen in these diseases and its effect on stem cell biology will assist in improving the unmet requirements for tr …
Stem cell therapy seems to be an effective strategy to alleviate these two conditions. ...A comprehensive understanding of the …
Concise review: current trends on applications of stem cells in diabetic nephropathy.
Liu D, Zheng W, Pan S, Liu Z. Liu D, et al. Cell Death Dis. 2020 Nov 21;11(11):1000. doi: 10.1038/s41419-020-03206-1. Cell Death Dis. 2020. PMID: 33221823 Free PMC article. Review.
With the development of stem cell technology, stem cell-based regenerative medicine has been tried to be applied to the treatment of DN. ...However, stem cell therapy still remains certain thorny issues during treatment. ...
With the development of stem cell technology, stem cell-based regenerative medicine has been tried to be applied …
Methylation of the PKD1 Promoter Inversely Correlates with its Expression in Autosomal Dominant Polycystic Kidney Disease.
Hajirezaei F, Ghaderian SMH, Hasanzad M, Nafar M, Ghadiani MH, Biglari S, Sohrabifar N, Jafari H. Hajirezaei F, et al. Rep Biochem Mol Biol. 2020 Jul;9(2):193-198. doi: 10.29252/rbmb.9.2.193. Rep Biochem Mol Biol. 2020. PMID: 33178869 Free PMC article.
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD), a multisystem disorder, is the most prevalent type of hereditary kidney disease. ...
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD), a multisystem disorder, is the most prevalent type of heredi …
Multiple Myeloma and Change of ABO Blood Group Type: A Case Report.
Waleed MS, Sadiq W. Waleed MS, et al. Cureus. 2020 Sep 25;12(9):e10654. doi: 10.7759/cureus.10654. Cureus. 2020. PMID: 33133824 Free PMC article.
Multiple myeloma is a hematopoietic stem cell malignancy that involves the plasma cells. It starts insidiously and usually involves males in their 60's. Clinical manifestations usually include anemia, kidney disease, hypercalcemia, and bone pains. We p …
Multiple myeloma is a hematopoietic stem cell malignancy that involves the plasma cells. It starts insidiously and usually inv …
Daily Low-intensity Pulsed Ultrasound Ameliorates Renal Fibrosis and Inflammation in Experimental Hypertensive and Diabetic Nephropathy.
Aibara Y, Nakashima A, Kawano KI, Yusoff FM, Mizuki F, Kishimoto S, Kajikawa M, Maruhashi T, Higashi Y. Aibara Y, et al. Hypertension. 2020 Dec;76(6):1906-1914. doi: 10.1161/HYPERTENSIONAHA.120.15237. Epub 2020 Nov 2. Hypertension. 2020. PMID: 33131306
The estimated morbidity rate of chronic kidney disease is 8% to 16% worldwide, and many patients with chronic kidney disease eventually develop renal failure. ...Finally, LIPUS stimulation suppressed TGF-beta1 (transforming growth factor-beta1)-induced …
The estimated morbidity rate of chronic kidney disease is 8% to 16% worldwide, and many patients with chronic kidney …
129 results