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566 results

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Quoted phrase not found in phrase index: "steoroids"
Page 1
Photoprotective properties of new derivatives of kinetin.
Vostálová J, Škařupová D, Plíhalová L, Hönig M, Zálešák B, Rajnochová Svobodová A. Vostálová J, et al. Photochem Photobiol Sci. 2023 Feb;22(2):357-369. doi: 10.1007/s43630-022-00320-1. Epub 2022 Oct 20. Photochem Photobiol Sci. 2023. PMID: 36264480
One of the possible UV light protection strategies is the use of dermal photoprotective preparations. The plant hormone kinetin (N6-furfuryladenine; KIN) exhibits antioxidant and anti-senescent effects in human cells. ...To improve the biological activities of KIN, several …
One of the possible UV light protection strategies is the use of dermal photoprotective preparations. The plant hormone kinetin (N6-f …
Structurally diverse metabolites from a soil-derived fungus Aspergillus calidoustus.
Li F, Mo S, Yin J, Zhang S, Gu S, Ye Z, Wang J, Hu Z, Zhang Y. Li F, et al. Bioorg Chem. 2022 Oct;127:105988. doi: 10.1016/j.bioorg.2022.105988. Epub 2022 Jun 27. Bioorg Chem. 2022. PMID: 35797862
All the isolated drimane sesquiterpenoids were evaluated for the in vitro cytotoxicity against five tumor cell lines, including SW480 (colon cancer), IOMM-Lee (meningioma), HeLa (cervical cancer), FARAGE (diffuse large B-cell lymphoma), and SU-DHL-4 (diffuse …
All the isolated drimane sesquiterpenoids were evaluated for the in vitro cytotoxicity against five tumor cell lines, including SW480 …
Selective Acetogenins and Their Potential as Anticancer Agents.
Jacobo-Herrera N, Pérez-Plasencia C, Castro-Torres VA, Martínez-Vázquez M, González-Esquinca AR, Zentella-Dehesa A. Jacobo-Herrera N, et al. Front Pharmacol. 2019 Jul 18;10:783. doi: 10.3389/fphar.2019.00783. eCollection 2019. Front Pharmacol. 2019. PMID: 31379567 Free PMC article. Review.
These polyketides are inhibitors of Complex I in the respiratory chain of tumor cells, a process that is closely related to tumor metabolism, cell death, apoptosis, and autophagy. ...As a result, we found that the AAs are cytotoxic compounds that can induce apoptosi …
These polyketides are inhibitors of Complex I in the respiratory chain of tumor cells, a process that is closely related to tumor …
Furan-Derived Lipid Nanoparticles for Transporting mRNA to the Central Nervous System.
Liu Z, Zhang Y, Li H, Guo K, Tian M, Cao D, Kang DD, Xue Y, Hou X, Wang C, Wang S, Zhong Y, Yu C, Deng B, McComb DW, Dong Y. Liu Z, et al. J Am Chem Soc. 2025 May 14;147(19):16007-16017. doi: 10.1021/jacs.4c16326. Epub 2025 Apr 30. J Am Chem Soc. 2025. PMID: 40305652
These furan-derived lipids were engineered with different furan cores, functional groups, and tails. We found that tetrahydrofuran (THF)-derived lipid nanoparticles (LNPs) generally displayed exceptional mRNA delivery compared to their furan-based counterparts. ...
These furan-derived lipids were engineered with different furan cores, functional groups, and tails. We found that tetrahydrofuran (T …
Triphenylphosphonium-functionalized dimeric BODIPY-based nanoparticles for mitochondria-targeting photodynamic therapy.
Kim C, Mai DK, Lee J, Jo J, Kim S, Badon IW, Lim JM, Kim HJ, Yang J. Kim C, et al. Nanoscale. 2024 May 16;16(19):9462-9475. doi: 10.1039/d4nr00694a. Nanoscale. 2024. PMID: 38639449
Both BODIPY dimers exhibited solvent-polarity-dependent singlet oxygen ((1)O(2)) quantum yields, with maximum values of 0.84 and 0.55 for BTPP and BeTPP, respectively, in tetrahydrofuran. The compact orthogonal geometry of the BODIPY dimers facilitated the generation of tr …
Both BODIPY dimers exhibited solvent-polarity-dependent singlet oxygen ((1)O(2)) quantum yields, with maximum values of 0.84 and 0.55 for BT …
Kopetdaghinanes, pro-apoptotic hemiacetialic cyclomyrsinanes from Euphorbia kopetdaghi.
Riahi F, Dashti N, Ghanadian M, Aghaei M, Faez F, Jafari SM, Zargar N. Riahi F, et al. Fitoterapia. 2020 Oct;146:104636. doi: 10.1016/j.fitote.2020.104636. Epub 2020 May 26. Fitoterapia. 2020. PMID: 32464255
Cytotoxic activity of kopetdaghinane A was evaluated using standard MTT assay against MCF-7 breast cancer and OVCAR-3 ovary cells. HUVEC cells were used as a normal cell line for calculation of the selectivity index. ...Taken together, these results showed that kope …
Cytotoxic activity of kopetdaghinane A was evaluated using standard MTT assay against MCF-7 breast cancer and OVCAR-3 ovary ce …
Synthetic 1,2,4-triazole-3-carboxamides Induce Cell Cycle Arrest and Apoptosis in Leukemia Cells.
Ekaterina Z, Daria S, Lyubov G, Ekaterina M, Varvara M, Diana G, Andrey M, Ekaterina L. Ekaterina Z, et al. Curr Pharm Des. 2023;29(43):3478-3487. doi: 10.2174/0113816128275084231202153602. Curr Pharm Des. 2023. PMID: 38083885
BACKGROUND: A number of studies demonstrate the efficacy of ribavirin against various cancer types in in vitro and in vivo models. However, ribavirin induces the development of multiple side effects, suggesting a high demand for ribavirin analogues with improved therapeuti …
BACKGROUND: A number of studies demonstrate the efficacy of ribavirin against various cancer types in in vitro and in vivo models. Ho …
Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment.
Andrade VHB, M Rodrigues EY, Dias NAF, Ferreira GFC, Carvalho DB, das Neves AR, Coronel PMV, Yonekawa MKA, Parisotto EB, Santos EAD, Souza AS, Paredes-Gamero EJ, de Sousa KS, Souza LL, Resstel LBM, Baroni ACM, Lagatta DC. Andrade VHB, et al. ACS Chem Neurosci. 2023 Dec 20;14(24):4298-4310. doi: 10.1021/acschemneuro.3c00443. Epub 2023 Dec 4. ACS Chem Neurosci. 2023. PMID: 38048522
Alzheimer's disease (AD) is a neurodegenerative disorder caused by accumulation of amyloid-beta oligomers (AbetaO) in the brain, neuroinflammation, oxidative stress, and cognitive decline. Grandisin, a tetrahydrofuran neolignan, exhibits relevant anti-inflammatory and anti …
Alzheimer's disease (AD) is a neurodegenerative disorder caused by accumulation of amyloid-beta oligomers (AbetaO) in the brain, neuroinflam …
Guidongnins I-J: Two New 6,7-seco-7,20-Olide-ent-kaurene Diterpenes with Unusual Structures from Isodon rubescens.
Zou J, Ye J, Zhao C, Zhang J, Liu Y, Pan L, He K, Zhang H. Zou J, et al. Int J Mol Sci. 2023 Aug 30;24(17):13451. doi: 10.3390/ijms241713451. Int J Mol Sci. 2023. PMID: 37686256 Free PMC article.
Compound 1 was determined to contain an unprecedented 23 carbons in the skeleton by bearing an extra isopropyl group at C-17 out of the diterpenoid parent structure, and compound 2 was the first example of 6,7-seco-7,20-olide-ent-kaurenes with two fused-tetrahydrofuran rin …
Compound 1 was determined to contain an unprecedented 23 carbons in the skeleton by bearing an extra isopropyl group at C-17 out of the dite …
Small-Molecule Phototheranostic Agent with Extended π-Conjugation for Efficient NIR-II Photoacoustic-Imaging-Guided Photothermal Therapy.
Wang Z, Liu Y, He C, Zhang X, Li X, Li Y, Tang Y, Lu X, Fan Q. Wang Z, et al. Small. 2024 Apr;20(17):e2307829. doi: 10.1002/smll.202307829. Epub 2023 Dec 3. Small. 2024. PMID: 38044585
Consequently, CY-1234 exhibits a maximum absorption peak at 1234 nm in tetrahydrofuran. Nanoaggregates of CY-1234 are synthesized via F-127 encapsulation. They exhibit an excellent photothermal conversion efficiency of 76.01% upon NIR-II light irradiation. After intravenou …
Consequently, CY-1234 exhibits a maximum absorption peak at 1234 nm in tetrahydrofuran. Nanoaggregates of CY-1234 are synthesized via …
566 results