Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 2
1974 1
1977 1
1978 2
1979 2
1980 1
1981 4
1983 3
1984 5
1985 4
1986 1
1987 6
1988 7
1989 7
1990 6
1991 9
1992 8
1993 4
1994 10
1995 4
1996 6
1997 10
1998 10
1999 13
2000 16
2001 20
2002 15
2003 21
2004 25
2005 27
2006 29
2007 22
2008 31
2009 32
2010 41
2011 30
2012 34
2013 38
2014 43
2015 28
2016 38
2017 46
2018 43
2019 48
2020 40
2021 52
2022 2
Text availability
Article attribute
Article type
Publication date

Search Results

761 results
Results by year
Filters applied: . Clear all
Page 1
Targeting the Thioredoxin System for Cancer Therapy.
Zhang J, Li X, Han X, Liu R, Fang J. Zhang J, et al. Trends Pharmacol Sci. 2017 Sep;38(9):794-808. doi: 10.1016/j.tips.2017.06.001. Epub 2017 Jun 22. Trends Pharmacol Sci. 2017. PMID: 28648527 Review.
Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx system which plays pivotal roles in regulating multiple cellular redox signaling pathways. ...In this review we first discuss the structural details of TrxR, the functions
Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx system which plays pivotal roles
Thioredoxin-dependent system. Application of inhibitors.
Jastrząb A, Skrzydlewska E. Jastrząb A, et al. J Enzyme Inhib Med Chem. 2021 Dec;36(1):362-371. doi: 10.1080/14756366.2020.1867121. J Enzyme Inhib Med Chem. 2021. PMID: 33356659 Free PMC article. Review.
One of the systems responsible for maintaining cellular redox homeostasis is the thioredoxin-dependent system. An equally important function of this system is the regulation of the expression of many proteins by the transcription factor NF-kappaB or the apopt …
One of the systems responsible for maintaining cellular redox homeostasis is the thioredoxin-dependent system. An equally impo …
The thioredoxin system and cancer therapy: a review.
Mohammadi F, Soltani A, Ghahremanloo A, Javid H, Hashemy SI. Mohammadi F, et al. Cancer Chemother Pharmacol. 2019 Nov;84(5):925-935. doi: 10.1007/s00280-019-03912-4. Epub 2019 Jul 31. Cancer Chemother Pharmacol. 2019. PMID: 31367788 Review.
Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox regulation and antioxidant defense. ...Inhibition of the Trx system may thus contribute to cancer therapy and improving chemotherapeu
Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox
Natural Molecules Targeting Thioredoxin System and Their Therapeutic Potential.
Zhang J, Duan D, Osama A, Fang J. Zhang J, et al. Antioxid Redox Signal. 2021 May 10;34(14):1083-1107. doi: 10.1089/ars.2020.8213. Epub 2020 Dec 4. Antioxid Redox Signal. 2021. PMID: 33115246 Review.
Significance: Thioredoxin (Trx) and thioredoxin reductase are two core members of the Trx system. ...Thus, the development of potential therapeutic molecules targeting the system is of great significance for disease treatment. Critical Issues: We herei …
Significance: Thioredoxin (Trx) and thioredoxin reductase are two core members of the Trx system. ...Thus, the developm …
The Thioredoxin System: A Promising Target for Cancer Drug Development.
Ghareeb H, Metanis N. Ghareeb H, et al. Chemistry. 2020 Aug 12;26(45):10175-10184. doi: 10.1002/chem.201905792. Epub 2020 Jun 15. Chemistry. 2020. PMID: 32097513 Review.
The thioredoxin system is highly conserved system found in all living cells and comprises NADPH, thioredoxin, and thioredoxin reductase. ...Its critical role is not limited to healthy cells, it is also involved in cancer development, and is over …
The thioredoxin system is highly conserved system found in all living cells and comprises NADPH, thioredoxin, an …
The thioredoxin system as a target for mercury compounds.
Branco V, Carvalho C. Branco V, et al. Biochim Biophys Acta Gen Subj. 2019 Dec;1863(12):129255. doi: 10.1016/j.bbagen.2018.11.007. Epub 2018 Nov 14. Biochim Biophys Acta Gen Subj. 2019. PMID: 30447253 Review.
Selenium pools in living organisms are quite low and the high affinity of mercury to bind selenols pointed out selenoproteins as possible targets of toxicity. Such was the case of the selenoenzyme thioredoxin reductase (TrxR) which is an integrant part of the thioredoxi
Selenium pools in living organisms are quite low and the high affinity of mercury to bind selenols pointed out selenoproteins as possible ta …
Physiological functions of thioredoxin and thioredoxin reductase.
Arnér ES, Holmgren A. Arnér ES, et al. Eur J Biochem. 2000 Oct;267(20):6102-9. doi: 10.1046/j.1432-1327.2000.01701.x. Eur J Biochem. 2000. PMID: 11012661 Free article. Review.
Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. ...Glutaredoxins catalyze glutathione-disulfide oxidoreductions overlapping the functions of thioredoxins and using electrons from NADPH via glutath
Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. ...Gluta
Overview of thioredoxin system and targeted therapies for acute leukemia.
Xie W, Ma W, Liu P, Zhou F. Xie W, et al. Mitochondrion. 2019 Jul;47:38-46. doi: 10.1016/j.mito.2019.04.010. Epub 2019 Apr 25. Mitochondrion. 2019. PMID: 31029641 Review.
The thioredoxin (Trx) system is a major antioxidant system for keeping the intracellular redox state in almost all forms of life, including Trx, Trx reductase (TrxR) and NADPH. ...The potential of thioredoxin system inhibitors as therapeutic age …
The thioredoxin (Trx) system is a major antioxidant system for keeping the intracellular redox state in almost all form …
Thioredoxin system - a novel therapeutic target.
Koháryová M, Kollárová M. Koháryová M, et al. Gen Physiol Biophys. 2015 Jul;34(3):221-33. doi: 10.4149/gpb_2015006. Epub 2015 Apr 30. Gen Physiol Biophys. 2015. PMID: 25926547 Review.
Thanks to these facts, the proteins of thioredoxin system are suitable candidates for new therapeutic purposes. In this review we summarized the basic features of the thioredoxin system, we justified why the proteins of thioredoxin system
Thanks to these facts, the proteins of thioredoxin system are suitable candidates for new therapeutic purposes. In this review …
Thioredoxin reductase as a pharmacological target.
Bjørklund G, Zou L, Wang J, Chasapis CT, Peana M. Bjørklund G, et al. Pharmacol Res. 2021 Dec;174:105854. doi: 10.1016/j.phrs.2021.105854. Epub 2021 Aug 27. Pharmacol Res. 2021. PMID: 34455077 Review.
Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major antioxidant systems that control the redox homeostasis in cells. The thioredoxin
Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase family enzymes that reduce thioredoxin
761 results