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226 results

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Page 1
Red Blood Cell Transfusion: 2023 AABB International Guidelines.
Carson JL, Stanworth SJ, Guyatt G, Valentine S, Dennis J, Bakhtary S, Cohn CS, Dubon A, Grossman BJ, Gupta GK, Hess AS, Jacobson JL, Kaplan LJ, Lin Y, Metcalf RA, Murphy CH, Pavenski K, Prochaska MT, Raval JS, Salazar E, Saifee NH, Tobian AAR, So-Osman C, Waters J, Wood EM, Zantek ND, Pagano MB. Carson JL, et al. JAMA. 2023 Nov 21;330(19):1892-1902. doi: 10.1001/jama.2023.12914. JAMA. 2023. PMID: 37824153
Recommendation 3: for critically ill children and those at risk of critical illness who are hemodynamically stable and without a hemoglobinopathy, cyanotic cardiac condition, or severe hypoxemia, the international panel recommends a restrictive transfusion strategy conside …
Recommendation 3: for critically ill children and those at risk of critical illness who are hemodynamically stable and without a hemo …
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial.
Taccone FS, Rynkowski CB, Møller K, Lormans P, Quintana-Díaz M, Caricato A, Cardoso Ferreira MA, Badenes R, Kurtz P, Søndergaard CB, Colpaert K, Petterson L, Quintard H, Cinotti R, Gouvêa Bogossian E, Righy C, Silva S, Roman-Pognuz E, Vandewaeter C, Lemke D, Huet O, Mahmoodpoor A, Blandino Ortiz A, van der Jagt M, Chabanne R, Videtta W, Bouzat P, Vincent JL; TRAIN Study Group. Taccone FS, et al. JAMA. 2024 Nov 19;332(19):1623-1633. doi: 10.1001/jama.2024.20424. JAMA. 2024. PMID: 39382241 Free PMC article. Clinical Trial.
IMPORTANCE: Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. OBJECTIVE: To assess the impact on neurological outcome of 2 different hemoglobin thre …
IMPORTANCE: Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion t …
Transfusion thresholds for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Dorée C, Hébert PC. Carson JL, et al. Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. Cochrane Database Syst Rev. 2021. Update in: Cochrane Database Syst Rev. 2025 Oct 20;10:CD002042. doi: 10.1002/14651858.CD002042.pub6. PMID: 34932836 Free PMC article. Updated.
The restrictive transfusion threshold uses a lower haemoglobin concentration as a threshold for transfusion (most commonly, 7.0 g/dL to 8.0 g/dL), and the liberal transfusion threshold uses a higher haemoglobin concentration as a threshold for transfus …
The restrictive transfusion threshold uses a lower haemoglobin concentration as a threshold for transfusion (most commonly, 7. …
Transfusion thresholds and other strategies for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Fergusson DA, Pagano MB, Roubinian NH, Turgeon AF, Valentine S, Trivella M, Dorée C, Hébert PC. Carson JL, et al. Cochrane Database Syst Rev. 2025 Oct 20;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub6. Cochrane Database Syst Rev. 2025. PMID: 41114449
We defined participants randomly allocated to the lower transfusion threshold as being in the 'restrictive transfusion' group and those randomly allocated to the higher transfusion threshold as being in the 'liberal transfusion' group. ...Paediatric th …
We defined participants randomly allocated to the lower transfusion threshold as being in the 'restrictive transfusion' group …
Perioperative Blood Management.
Parikh S, Bentz T, Crowley S, Greenspan S, Costa A, Bergese S. Parikh S, et al. J Clin Med. 2025 May 30;14(11):3847. doi: 10.3390/jcm14113847. J Clin Med. 2025. PMID: 40507614 Free PMC article. Review.
Both liberal and restrictive strategies for blood transfusions established thresholds for hemoglobin: restrictive transfusion threshold of hemoglobin 7-8 g/dL in stable patients, and a higher transfusion threshold of hemoglobin > 8 g/dL may be consi …
Both liberal and restrictive strategies for blood transfusions established thresholds for hemoglobin: restrictive transfusion thre …
Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage.
Carson JL, Guyatt G, Heddle NM, Grossman BJ, Cohn CS, Fung MK, Gernsheimer T, Holcomb JB, Kaplan LJ, Katz LM, Peterson N, Ramsey G, Rao SV, Roback JD, Shander A, Tobian AA. Carson JL, et al. JAMA. 2016 Nov 15;316(19):2025-2035. doi: 10.1001/jama.2016.9185. JAMA. 2016. PMID: 27732721
A restrictive RBC transfusion threshold of 8 g/dL is recommended for patients undergoing orthopedic surgery, cardiac surgery, and those with preexisting cardiovascular disease (strong recommendation, moderate quality evidence). The restrictive transfusion …
A restrictive RBC transfusion threshold of 8 g/dL is recommended for patients undergoing orthopedic surgery, cardiac surgery, …
Society of Cardiovascular Anesthesiologists Clinical Practice Update for Management of Acute Kidney Injury Associated With Cardiac Surgery.
Peng K, McIlroy DR, Bollen BA, Billings FT 4th, Zarbock A, Popescu WM, Fox AA, Shore-Lesserson L, Zhou S, Geube MA, Ji F, Bhatia M, Schwann NM, Shaw AD, Liu H. Peng K, et al. Anesth Analg. 2022 Oct 1;135(4):744-756. doi: 10.1213/ANE.0000000000006068. Epub 2022 May 12. Anesth Analg. 2022. PMID: 35544772 Free article. Review.
Cardiac surgery-associated acute kidney injury (CS-AKI) is common and is associated with increased risk for postoperative morbidity and mortality. Our recent survey of the Society of Cardiovascular Anesthesiologists (SCA) membership showed 6 potentially renoprotective stra …
Cardiac surgery-associated acute kidney injury (CS-AKI) is common and is associated with increased risk for postoperative morbidity a …
Bloodless Total Hip Arthroplasty in Jehovah's Witness Patients: Contemporary Strategies and Outcomes.
Shen V, Salomon KI, Ohanisian LL, Simon P, Miranda MA, Bernasek TL. Shen V, et al. J Arthroplasty. 2025 Apr;40(4):964-970. doi: 10.1016/j.arth.2024.09.035. Epub 2024 Sep 26. J Arthroplasty. 2025. PMID: 39341580

Subgroup analysis showed that preoperatively anemic patients (closed circuit, Hgb < 12 g/dL) had significantly less Hgb drop postoperatively (P = 0.003). No patients met the recommended transfusion threshold (Hgb < 7 g/dL). ...Preoperatively anemic pati

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Subgroup analysis showed that preoperatively anemic patients (closed circuit, Hgb < 12 g/dL) had significantly less Hgb drop postopera

…
Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery.
Mazer CD, Whitlock RP, Fergusson DA, Hall J, Belley-Cote E, Connolly K, Khanykin B, Gregory AJ, de Médicis É, McGuinness S, Royse A, Carrier FM, Young PJ, Villar JC, Grocott HP, Seeberger MD, Fremes S, Lellouche F, Syed S, Byrne K, Bagshaw SM, Hwang NC, Mehta C, Painter TW, Royse C, Verma S, Hare GMT, Cohen A, Thorpe KE, Jüni P, Shehata N; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group. Mazer CD, et al. N Engl J Med. 2017 Nov 30;377(22):2133-2144. doi: 10.1056/NEJMoa1711818. Epub 2017 Nov 12. N Engl J Med. 2017. PMID: 29130845 Free article. Clinical Trial.
METHODS: In this multicenter, open-label, noninferiority trial, we randomly assigned 5243 adults undergoing cardiac surgery who had a European System for Cardiac Operative Risk Evaluation (EuroSCORE) I of 6 or more (on a scale from 0 to 47, with higher scores indicating a higher …
METHODS: In this multicenter, open-label, noninferiority trial, we randomly assigned 5243 adults undergoing cardiac surgery who had a Europe …
The Limits of Acute Anemia.
Tomić Mahečić T, Brooks R, Noitz M, Sarmiento I, Baronica R, Meier J. Tomić Mahečić T, et al. J Clin Med. 2022 Sep 7;11(18):5279. doi: 10.3390/jcm11185279. J Clin Med. 2022. PMID: 36142930 Free PMC article. Review.
It was accepted that a hemoglobin concentration (Hb) of less than 10 g/dL was a general transfusion threshold and the majority of patients were transfused immediately. In recent years, there has been increasing evidence that even significantly lower hemoglobin conce …
It was accepted that a hemoglobin concentration (Hb) of less than 10 g/dL was a general transfusion threshold and the majority …
226 results