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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1963 3
1964 2
1965 2
1966 1
1967 5
1968 2
1969 3
1970 2
1971 5
1972 1
1973 3
1974 6
1975 19
1976 12
1977 7
1978 14
1979 10
1980 12
1981 20
1982 34
1983 33
1984 39
1985 29
1986 31
1987 32
1988 21
1989 23
1990 26
1991 18
1992 19
1993 21
1994 14
1995 19
1996 22
1997 13
1998 22
1999 19
2000 22
2001 20
2002 14
2003 15
2004 15
2005 7
2006 17
2007 15
2008 19
2009 26
2010 15
2011 14
2012 10
2013 8
2014 8
2015 11
2016 22
2017 10
2018 7
2019 15
2020 12
2021 12
2022 12
2023 8
2024 10
2025 2

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872 results

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Page 1
3-Deazaadenosine keeps senescence at bay.
Guerrero A, Gil J. Guerrero A, et al. Aging (Albany NY). 2023 Mar 24;15(7):2369-2370. doi: 10.18632/aging.204625. Epub 2023 Mar 24. Aging (Albany NY). 2023. PMID: 36988502 Free PMC article. No abstract available.
Tubercidin inhibits PRRSV replication via RIG-I/NF-kappaB pathways and interrupting viral nsp2 synthesis.
Xu Y, Zhu Z, Zhang M, Chen L, Tian K, Li X. Xu Y, et al. Microbiol Spectr. 2024 Mar 5;12(3):e0347923. doi: 10.1128/spectrum.03479-23. Epub 2024 Feb 1. Microbiol Spectr. 2024. PMID: 38299833 Free PMC article.
Our study found that tubercidin showed effective antiviral effects on PRRSV replication. In terms of mechanism, tubercidin suppressed PRRSV at the entry, replication, and release steps of the viral life cycle. ...Hence, our data showed that tubercidin is prom …
Our study found that tubercidin showed effective antiviral effects on PRRSV replication. In terms of mechanism, tubercidin sup …
First Total Synthesis of 5'-O-alpha-d-Glucopyranosyl Tubercidin.
Ouyang W, Huang H, Yang R, Ding H, Xiao Q. Ouyang W, et al. Mar Drugs. 2020 Jul 29;18(8):398. doi: 10.3390/md18080398. Mar Drugs. 2020. PMID: 32751067 Free PMC article.
The key step involves stereoselective alpha-O-glycosylation of the corresponding 7-bromo-6-chloro-2',3'-O-isopropylidene-beta-d-tubercidin with 2,3,4,6-tetra-O-benzyl-glucopyranosyl trichloroacetimidate. All spectra are in accordance with the reported data for natural 5'-O …
The key step involves stereoselective alpha-O-glycosylation of the corresponding 7-bromo-6-chloro-2',3'-O-isopropylidene-beta-d-tubercidi …
In vitro activity of tubercidin against Mycobacterium tuberculosis and nontuberculosis Mycobacteria.
Sun Q, Liao X, Yan J, Jiang G, Huo F, Wang G, Li H. Sun Q, et al. J Med Microbiol. 2023 Nov;72(11). doi: 10.1099/jmm.0.001763. J Med Microbiol. 2023. PMID: 37910006
Tubercidin is an adenosine analogue that has been shown to exhibit good activity against some tumours and parasites. ...The results indicate that tubercidin has high in vitro activity against some drug-resistance Mtb strains and NTM reference strains, which warrants …
Tubercidin is an adenosine analogue that has been shown to exhibit good activity against some tumours and parasites. ...The results i …
Nucleoside analogs as antiparasitic agents.
Jaffe JJ. Jaffe JJ. Ann N Y Acad Sci. 1975 Aug 8;255:306-16. doi: 10.1111/j.1749-6632.1975.tb29238.x. Ann N Y Acad Sci. 1975. PMID: 1103685 Review. No abstract available.
Manipulation of toxicity and tissue distribution of tubercidin in mice by nitrobenzylthioinosine 5'-monophosphate.
Kolassa N, Jakobs ES, Buzzell GR, Paterson AR. Kolassa N, et al. Biochem Pharmacol. 1982 May 15;31(10):1863-74. doi: 10.1016/0006-2952(82)90489-0. Biochem Pharmacol. 1982. PMID: 7104018
With high NBMPR-P doses (100 mg/kg, i.p.) followed by tubercidin injection (45 mg/kg, i.v.), kidney damage and high mortality occurred. The tissue distribution of 3H following (( G-3H]tubercidin administration paralleled hepatic or renal injury: NBMPR-P treatment de …
With high NBMPR-P doses (100 mg/kg, i.p.) followed by tubercidin injection (45 mg/kg, i.v.), kidney damage and high mortality occurre …
Drug repurposing screens identify Tubercidin as a potent antiviral agent against porcine nidovirus infections.
Wang T, Zheng G, Chen Z, Wang Y, Zhao C, Li Y, Yuan Y, Duan H, Zhu H, Yang X, Li W, Du W, Li Y, Li D. Wang T, et al. Virus Res. 2024 Jan 2;339:199275. doi: 10.1016/j.virusres.2023.199275. Epub 2023 Nov 30. Virus Res. 2024. PMID: 38008220 Free PMC article.
Furthermore, we demonstrated that Tubercidin exhibited significant antiviral activity against both classical and variant PEDV. Time of addition assay showed that Tubercidin displayed a significant inhibitory effect on viral post-entry events but not during other per …
Furthermore, we demonstrated that Tubercidin exhibited significant antiviral activity against both classical and variant PEDV. Time o …
Tubercidin enhances apoptosis in serum-starved and hypoxic mouse cardiomyocytes by inducing nuclear speckle condensation.
Shen G, Cheng Q, Liang L, Qin Y, Cao Y, Li Q, Xiao S. Shen G, et al. BMC Cardiovasc Disord. 2025 Mar 22;25(1):211. doi: 10.1186/s12872-025-04661-4. BMC Cardiovasc Disord. 2025. PMID: 40121465 Free article.
Furthermore, Tubercidin treatment led to a pronounced enlargement of NSs, as detected by immunofluorescence. ...Therefore, a cautious clinical use of Tubercidin for ischemic cardiomyopathy patients is advised to reduce cardiotoxicity risks....
Furthermore, Tubercidin treatment led to a pronounced enlargement of NSs, as detected by immunofluorescence. ...Therefore, a cautious …
The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues.
Aldfer MM, Alfayez IA, Elati HAA, Gayen N, Elmahallawy EK, Milena Murillo A, Marsiccobetre S, Van Calenbergh S, Silber AM, de Koning HP. Aldfer MM, et al. Molecules. 2022 Nov 19;27(22):0. doi: 10.3390/molecules27228045. Molecules. 2022. PMID: 36432150 Free PMC article.
Although the trypanocidal activity of tubercidin (7-deazapurine) has long been known, the identification of a class of 7-substituted tubercidin analogs with potent in vitro and in vivo activity and much-enhanced selectivity has made nucleoside analogs among the most …
Although the trypanocidal activity of tubercidin (7-deazapurine) has long been known, the identification of a class of 7-substituted …
872 results