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Page 1
The Importance of Leptin to Reproduction.
Childs GV, Odle AK, MacNicol MC, MacNicol AM. Childs GV, et al. Endocrinology. 2021 Feb 1;162(2):bqaa204. doi: 10.1210/endocr/bqaa204. Endocrinology. 2021. PMID: 33165520 Free PMC article. Review.
Hypothalamic control of innate social behaviors.
Mei L, Osakada T, Lin D. Mei L, et al. Science. 2023 Oct 27;382(6669):399-404. doi: 10.1126/science.adh8489. Epub 2023 Oct 26. Science. 2023. PMID: 37883550 Free PMC article. Review.
The reproductive behavior control column (RBCC), which comprises the medial preoptic nucleus (MPN), the ventrolateral part of the ventromedial hypothalamus (VMHvl), and the ventral premammillary nucleus (PMv), is essential for all social behaviors. The RBCC i …
The reproductive behavior control column (RBCC), which comprises the medial preoptic nucleus (MPN), the ventrolateral part of the ventromedi …
The hypothalamic ventral premammillary nucleus: A key site in leptin's regulation of reproduction.
Leshan RL, Pfaff DW. Leshan RL, et al. J Chem Neuroanat. 2014 Nov;61-62:239-47. doi: 10.1016/j.jchemneu.2014.08.008. Epub 2014 Aug 27. J Chem Neuroanat. 2014. PMID: 25172030 Review.
One substantial population lies within the hypothalamic ventral premammillary nucleus (PMv), a region itself linked to reproductive control, which may provide a strategic site for the integration of energy availability, sensory and gonadal cues. ...
One substantial population lies within the hypothalamic ventral premammillary nucleus (PMv), a region itself linked to …
The ventral premammillary nucleus at the interface of environmental cues and social behaviors.
Cavalcante JC, da Silva FG, Sáenz de Miera C, Elias CF. Cavalcante JC, et al. Front Neurosci. 2025 Apr 10;19:1589156. doi: 10.3389/fnins.2025.1589156. eCollection 2025. Front Neurosci. 2025. PMID: 40276575 Free PMC article. Review.
In this review, we will critically evaluate recent studies focused on the ventral premammillary nucleus (PMv) and discuss findings that reveal the PMv as a key, yet sometimes overlooked, node in integrating external and internal environmental cues. ...
In this review, we will critically evaluate recent studies focused on the ventral premammillary nucleus (PMv) and discu …
The neurophysiology of aggressiveness: From adaptive behavior to pathology and deep brain stimulation.
Santin MDN. Santin MDN. Neurophysiol Clin. 2025 Sep;55(5):103090. doi: 10.1016/j.neucli.2025.103090. Epub 2025 Jul 3. Neurophysiol Clin. 2025. PMID: 40614453 Review.
The core aggression circuit (CAC) includes the VMHvl, amygdala, bed nucleus of the stria terminalis, and ventral premammillary nucleus, under modulation by prefrontal inputs. Aggression is expressed through a direct VMHvl-periaqueductal gray (PAG) pathway for …
The core aggression circuit (CAC) includes the VMHvl, amygdala, bed nucleus of the stria terminalis, and ventral premammillary …
A critical view of the use of genetic tools to unveil neural circuits: the case of leptin action in reproduction.
Elias CF. Elias CF. Am J Physiol Regul Integr Comp Physiol. 2014 Jan 1;306(1):R1-9. doi: 10.1152/ajpregu.00444.2013. Epub 2013 Nov 6. Am J Physiol Regul Integr Comp Physiol. 2014. PMID: 24196667 Free PMC article. Review.
Our findings indicate that leptin action in the ventral premammillary nucleus is sufficient, but not required, for leptin action in reproduction and that leptin action in Kiss1 neurons arises after pubertal maturation; therefore, direct leptin signaling in Ki …
Our findings indicate that leptin action in the ventral premammillary nucleus is sufficient, but not required, for lept …