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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1786 1
1790 2
1800 22
1805 4
1806 4
1807 1
1808 1
1809 102
1810 15
1813 5
1814 2
1816 1
1817 6
1821 1
1824 28
1828 14
1829 61
1832 1
1835 38
1837 1
1838 7
1839 30
1840 6
1841 40
1842 11
1843 10
1844 27
1845 6
1846 74
1847 12
1848 9
1849 8
1850 13
1851 14
1852 7
1853 41
1854 3
1855 2
1856 3
1857 4
1858 58
1859 1
1860 4
1861 6
1862 5
1863 3
1864 4
1865 131
1866 2
1867 5
1868 147
1869 5
1870 3
1871 3
1872 12
1873 14
1874 13
1875 376
1876 119
1877 110
1878 4
1879 6
1880 17
1881 10
1882 73
1883 108
1884 45
1885 5
1886 3
1887 247
1888 126
1889 59
1890 14
1891 16
1892 256
1893 371
1894 10
1895 84
1896 75
1897 501
1898 36
1899 16
1900 7
1901 412
1902 10
1903 63
1904 58
1905 258
1906 104
1907 117
1908 12
1909 14
1910 44
1911 12
1912 14
1913 16
1914 16
1915 79
1916 11
1917 12
1918 18
1919 18
1920 21
1921 32
1922 14
1923 59
1924 423
1925 33
1926 30
1927 17
1928 304
1929 486
1930 374
1931 53
1932 245
1933 80
1934 52
1935 12
1936 161
1937 60
1938 115
1939 44
1940 14
1941 19
1942 9
1943 121
1944 14
1945 254
1946 1258
1947 1192
1948 907
1949 773
1950 1659
1951 2280
1952 1916
1953 1990
1954 1547
1955 1179
1956 1493
1957 1879
1958 2087
1959 1367
1960 985
1961 1633
1962 1697
1963 2310
1964 1843
1965 2418
1966 3448
1967 7549
1968 6026
1969 4922
1970 5123
1971 5263
1972 5270
1973 4678
1974 6395
1975 7154
1976 9330
1977 9616
1978 7528
1979 8493
1980 8478
1981 10064
1982 10517
1983 12269
1984 12254
1985 12918
1986 13084
1987 14619
1988 15091
1989 16761
1990 20385
1991 18790
1992 22090
1993 22173
1994 23341
1995 23776
1996 25393
1997 25658
1998 26535
1999 28099
2000 28462
2001 33993
2002 36837
2003 37825
2004 38607
2005 42165
2006 48587
2007 51332
2008 56240
2009 54063
2010 61467
2011 68004
2012 73307
2013 74532
2014 80166
2015 85740
2016 89993
2017 85078
2018 88455
2019 92471
2020 116897
2021 142688
2022 152007
2023 116690
2024 40156
2025 1

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2,085,573 results

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The following terms were ignored: %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %, %
The following terms were not found in PubMed: 22Anticancer, 22Axial, 22Cationic, 22Inhibition, 22Inhibition, 22Inhibitory, 22Macrocycles, 22Metalloporphyrins, 22Micromolar, 22Peptidase, 22Protease, 22Proteasome, 22Spectroscopic, 22Uv, 22Water, 22Dyes, 22Metal, 22Scaffolds, 22Anion, 22Antineoplastic, 22Cationic, 22Macrocyclic, 22Proteinase, 22Unclassified, 22Canonical, 22Controlled, 22Drug, 22Drug, 22Drug, 22Drug, 22Drug, 22Drug, 22Enzyme, 22Human, 22Human, 22Static, 22Ultraviolet, 22Enzyme, 22Enzyme, 22Hela, 22Models, 22Proteasome, 22Cations, 22Enzyme, 22Enzyme, 22Porphyrins
Page 1
The Structure-property Relationships of Clinically Approved Protein Kinase Inhibitors.
Choi K. Choi K. Curr Med Chem. 2023;30(22):2518-2541. doi: 10.2174/0929867329666220822123552. Curr Med Chem. 2023. PMID: 35996243 Review.
In modern drug discovery, considering 'drug-like' physicochemical and pharmacokinetic properties as early as possible in drug design is widely acknowledged as an important strategy to reduce drug attrition rates. ...For the other inhibitors, suc …
In modern drug discovery, considering 'drug-like' physicochemical and pharmacokinetic properties as early as possible i …
Antiretroviral drugs.
Warnke D, Barreto J, Temesgen Z. Warnke D, et al. J Clin Pharmacol. 2007 Dec;47(12):1570-9. doi: 10.1177/0091270007308034. J Clin Pharmacol. 2007. PMID: 18048575 Review.
Additional drugs and newer classes of antiretrovirals are in various stages of development. Currently, there are 22 Food and Drug Administration (FDA)-approved antiretroviral agents categorized in 4 classes of drugs: nucleoside/nucleotide analog reverse trans …
Additional drugs and newer classes of antiretrovirals are in various stages of development. Currently, there are 22 Food and Drug …
Development of Cell-Specific Aptamers: Recent Advances and Insight into the Selection Procedures.
Rahimizadeh K, AlShamaileh H, Fratini M, Chakravarthy M, Stephen M, Shigdar S, Veedu RN. Rahimizadeh K, et al. Molecules. 2017 Nov 27;22(12):2070. doi: 10.3390/molecules22122070. Molecules. 2017. PMID: 29186905 Free PMC article. Review.
Aptamers selected by Cell-SELEX have the potential to act as cell specific therapeutics, cell specific markers or cell specific drug delivery and imaging agents. However, aptamer development is a laborious and time-consuming process which is often challenging due to …
Aptamers selected by Cell-SELEX have the potential to act as cell specific therapeutics, cell specific markers or cell specific drug …
Tissue-Specific Analysis of Pharmacological Pathways.
Hao Y, Quinnies K, Realubit R, Karan C, Tatonetti NP. Hao Y, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Jul;7(7):453-463. doi: 10.1002/psp4.12305. Epub 2018 Jun 19. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29920991 Free PMC article.
Understanding the downstream consequences of pharmacologically targeted proteins is essential to drug design. Current approaches investigate molecular effects under tissue-naive assumptions. ...We introduced a data-driven method that integrates drug-target …
Understanding the downstream consequences of pharmacologically targeted proteins is essential to drug design. Current approach …
Reporting of methodologies used for clonogenic assays to determine radiosensitivity.
Oike T, Komatsu S, Komatsu Y, Nachankar A, Darwis NDM, Shibata A, Ohno T. Oike T, et al. J Radiat Res. 2020 Nov 16;61(6):828-831. doi: 10.1093/jrr/rraa064. J Radiat Res. 2020. PMID: 32823284 Free PMC article. Review.
In reality, the reporting standards of methodologies pertaining to clonogenic assays remain unclear. To address this, we performed a literature search and qualitative analysis of the reporting of methodologies pertaining to clonogenic assays. A comprehensive …
In reality, the reporting standards of methodologies pertaining to clonogenic assays remain unclear. To address this, we performed a …
Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure.
Libera V, Andreeva EA, Martel A, Thureau A, Longo M, Petrillo C, Paciaroni A, Schirò G, Comez L. Libera V, et al. J Phys Chem Lett. 2021 Aug 26;12(33):8096-8102. doi: 10.1021/acs.jpclett.1c01840. Epub 2021 Aug 18. J Phys Chem Lett. 2021. PMID: 34406777
Here, a structure-based strategy, integrating complementary probes, is employed to study the interaction between TMPyP4 porphyrin and a 22-base human telomeric sequence (Tel22) before and after irradiation with blue light. Porphyrin binding is d …
Here, a structure-based strategy, integrating complementary probes, is employed to study the interaction between TMPyP4 porphyrin …
Comprehensive clinical pharmacology characterization of AZD4635 in healthy participants to support dosing considerations.
Moorthy G, Pouliot GP, Graham L, Pilling E, Jung L, Alcobi R, Zhu Y, Li Y, Sidhu S, Forte P, Mugundu G. Moorthy G, et al. Br J Clin Pharmacol. 2023 Sep;89(9):2775-2787. doi: 10.1111/bcp.15742. Epub 2023 May 22. Br J Clin Pharmacol. 2023. PMID: 37055936
In Part B, these participants were administered a 50-mg capsule either following a high-fat meal or with a PPI in the fasted state. In Study 2 (CYP1A2 mediated drug-drug interaction study), a 25-mg AZD4635 capsule was administered to smokers and nonsmokers (fasted) …
In Part B, these participants were administered a 50-mg capsule either following a high-fat meal or with a PPI in the fasted state. In Study …
A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy.
Yang M, Deng J, Guo D, Zhang J, Yang L, Wu F. Yang M, et al. Org Biomol Chem. 2019 May 29;17(21):5367-5374. doi: 10.1039/c9ob00698b. Org Biomol Chem. 2019. PMID: 31106316
The results suggested that the modification of the carboxyl group with a porphyrin compound did not decrease the binding affinity of folic acid to FR positive cancer cells. ...Upon the treatment of Por 4 at the concentration of 20 muM, the cell viability was determi …
The results suggested that the modification of the carboxyl group with a porphyrin compound did not decrease the binding affin …
Metabolic Benefits of MicroRNA-22 Inhibition.
Thibonnier M, Esau C. Thibonnier M, et al. Nucleic Acid Ther. 2020 Apr;30(2):104-116. doi: 10.1089/nat.2019.0820. Epub 2019 Dec 23. Nucleic Acid Ther. 2020. PMID: 31873061
Diabesity is a growing pandemic with substantial health and financial consequences. We are developing microRNA (miRNA)-based drug candidates that transform fat storing adipocytes into fat burning adipocytes (browning effect) to treat metabolic diseases characterized …
Diabesity is a growing pandemic with substantial health and financial consequences. We are developing microRNA (miRNA)-based drug can …
Quantitative cationic-activity relationships for predicting toxicity of metals.
Walker JD, Enache M, Dearden JC. Walker JD, et al. Environ Toxicol Chem. 2003 Aug;22(8):1916-35. doi: 10.1897/02-568. Environ Toxicol Chem. 2003. PMID: 12924590 Review.
However, a number of simplifying assumptions can be used to develop and validate (Q)CARs to predict the toxicity of metals: The ionic form is the most active form of a metal; the bioactivity of a dissolved metal is correlated with its free ion concentration o …
However, a number of simplifying assumptions can be used to develop and validate (Q)CARs to predict the toxicity of metals: The ionic …
2,085,573 results
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