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Page 1
Protein Micropatterning in 2.5D: An Approach to Investigate Cellular Responses in Multi-Cue Environments.
van der Putten C, Buskermolen ABC, Werner M, Brouwer HFM, Bartels PAA, Dankers PYW, Bouten CVC, Kurniawan NA. van der Putten C, et al. ACS Appl Mater Interfaces. 2021 Jun 9;13(22):25589-25598. doi: 10.1021/acsami.1c01984. Epub 2021 May 25. ACS Appl Mater Interfaces. 2021. PMID: 34032413 Free PMC article.
As a first step, we optimized experimental parameters of the patterning protocol for the patterning of protein matrixes on planar and non-planar (2.5D cell culture chip) substrates and tested the technique with adherent cells (human bone marrow stromal cells). Next, …
As a first step, we optimized experimental parameters of the patterning protocol for the patterning of protein matrixes on planar and …
Cytotoxic and Infection-Controlled Investigations of Novel Dihydropyridine Hybrids: An Efficient Synthesis and Molecular-Docking Studies.
Guda MR, Zyryanov GV, Dubey A, Munagapati VS, Wen JC. Guda MR, et al. Pharmaceuticals (Basel). 2023 Aug 15;16(8):1159. doi: 10.3390/ph16081159. Pharmaceuticals (Basel). 2023. PMID: 37631073 Free PMC article.
A sequence of novel 1,4-dihydropyridines (DHP) and their hybrids was developed using a multicomponent strategy under environmentally benign conditions. In addition, computational studies were performed, and the ligand-protein interactions calculated in different bac …
A sequence of novel 1,4-dihydropyridines (DHP) and their hybrids was developed using a multicomponent strategy under environmentally benign …
Temporal characteristics of astrocytic activation in the TNC in a mice model of pain induced by recurrent dural infusion of inflammatory soup.
Zhang L, Lu C, Kang L, Li Y, Tang W, Zhao D, Yu S, Liu R. Zhang L, et al. J Headache Pain. 2022 Jan 15;23(1):8. doi: 10.1186/s10194-021-01382-9. J Headache Pain. 2022. PMID: 35033010 Free PMC article.
We detected the expression profile of glial fibrillary acidic protein (GFAP) in the TNC through immunofluorescence staining and western blot assay. ...Then, we detected the variation with time of cytokines levels in the TNC tissue extraction and serum, including c-c motif …
We detected the expression profile of glial fibrillary acidic protein (GFAP) in the TNC through immunofluorescence staining and weste …
Synthesis, Docking Study, Cytotoxicity, Antioxidant, and Anti-microbial Activities of Novel 2,4-Disubstituted Thiazoles Based on Phenothiazine.
An TNM, Phuong PT, Quang NM, Son NV, Cuong NV, Tan LV, Tri MD, Alam M, Tat PV. An TNM, et al. Curr Org Synth. 2020;17(2):151-159. doi: 10.2174/1570179417666191220100614. Curr Org Synth. 2020. PMID: 32418517
RESULTS: The total amount of energy, ACE (atomic contact energy), energy of receptor (PDB: 5G5J), and ligand interaction of structure (4) were found to be 22.448 Kcal.mol-1 , -247.68, and -91.91 Kcal.mol-1, respectively. The structure (4) is well binded with the rec …
RESULTS: The total amount of energy, ACE (atomic contact energy), energy of receptor (PDB: 5G5J), and ligand interaction of structure …
New Fluoroquinolone-1,2,4-triazoles as Potent Antibacterial Agents: Design, Synthesis, Docking Studies and in Silico ADME Profiles.
Rao Gollapalli V, Babu Bollikolla H, Rao Allaka T, Ranga Rao Vaddi P, Basireddy S, Ganivada M, Reddy Pindi S. Rao Gollapalli V, et al. Chem Biodivers. 2023 Apr;20(4):e202201259. doi: 10.1002/cbdv.202201259. Epub 2023 Apr 19. Chem Biodivers. 2023. PMID: 36924103
The newly synthesized 1,2,4-triazole derivatives were tested in vitro for their ability to inhibit the growth of seven different microbes including S. epidermidis, S. pneumoniae, S. aureus, B. subtilis, K. pneumoniae, E. coli, and P. aeruginosa. Five FQ derivatives 5d, 5e, …
The newly synthesized 1,2,4-triazole derivatives were tested in vitro for their ability to inhibit the growth of seven different microbes in …
Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents.
Ahmed HEA, Ihmaid SK, Omar AM, Shehata AM, Rateb HS, Zayed MF, Ahmed S, Elaasser MM. Ahmed HEA, et al. Bioorg Chem. 2018 Feb;76:332-342. doi: 10.1016/j.bioorg.2017.11.019. Epub 2017 Dec 2. Bioorg Chem. 2018. PMID: 29227917
The in vitro antimicrobial screening of the target compounds was screened to assess their antibacterial and antifungal activity. As a result, seven compounds namely; 5a, 5c, 5d, 6a, 6c, 8b and 8c showed a promising broad spectrum antibacterial activity against both Gram-po …
The in vitro antimicrobial screening of the target compounds was screened to assess their antibacterial and antifungal activity. As a result …
Blocking constitutive activity of GHSR1a in the lateral amygdala facilitates acquisition of conditioned taste aversion.
Li N, Song G, Wang Y, Zhu Q, Han F, Zhang C, Zhou Y. Li N, et al. Neuropeptides. 2018 Apr;68:22-27. doi: 10.1016/j.npep.2017.12.001. Epub 2017 Dec 6. Neuropeptides. 2018. PMID: 29254662
Interestingly, GHSR1a was once characterized by highly constitutive, ligand-independent activity. However, the physiological importance of such ligand-independent signaling on aversive memory processing has not been tested yet. ...In contrast, pre-administration of …
Interestingly, GHSR1a was once characterized by highly constitutive, ligand-independent activity. However, the physiological importan …
Moderately Fermentable Potato Fiber Attenuates Signs and Inflammation Associated with Experimental Colitis in Mice.
Panasevich MR, Allen JM, Wallig MA, Woods JA, Dilger RN. Panasevich MR, et al. J Nutr. 2015 Dec;145(12):2781-8. doi: 10.3945/jn.115.218578. Epub 2015 Oct 21. J Nutr. 2015. PMID: 26491118 Free article.
Body weights and food and water intakes were collected daily from day 14 through day 22. Distal colon tissue was analyzed for histologic outcomes and changes in gene expression, and cecal contents were analyzed for SCFA concentrations. ...Mice fed PF+DSS had lower (P < …
Body weights and food and water intakes were collected daily from day 14 through day 22. Distal colon tissue was analyzed for histolo …
Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins.
Pauwels PJ, Tardif S, Colpaert FC, Wurch T. Pauwels PJ, et al. Biochem Pharmacol. 2001 May 1;61(9):1079-92. doi: 10.1016/s0006-2952(01)00575-5. Biochem Pharmacol. 2001. PMID: 11301041
Replacement of the last six amino acids at the C-terminal portion of the G(alphao)-protein by the corresponding amino acid region of either the G(alphaz)-, G(alphas)-, G(alphaq)-, or G(alpha15)-protein and co-expression with the alpha(2A) AR resulted in similar maxi …
Replacement of the last six amino acids at the C-terminal portion of the G(alphao)-protein by the corresponding amino acid region of …
The circulating soluble TRAIL is a negative marker for inflammation inversely associated with the mortality risk in chronic kidney disease patients.
Liabeuf S, Barreto DV, Barreto FC, Chasseraud M, Brazier M, Choukroun G, Kamel S, Massy ZA. Liabeuf S, et al. Nephrol Dial Transplant. 2010 Aug;25(8):2596-602. doi: 10.1093/ndt/gfq042. Epub 2010 Feb 26. Nephrol Dial Transplant. 2010. PMID: 20190248
RESULTS: CKD stage 5D patients had significantly lower serum sTRAIL levels (median: 46 pg/ml) than patients at CKD stages 2 and 3 (median: 62 pg/ml) or stages 4 and 5 (median: 71 pg/ml). There was no correlation between serum sTRAIL and the estimated glomerular filtration …
RESULTS: CKD stage 5D patients had significantly lower serum sTRAIL levels (median: 46 pg/ml) than patients at CKD stages 2 and 3 (me …
17 results