Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD.
Olvera N, Sánchez-Valle J, Núñez-Carpintero I, Rojas-Quintero J, Noell G, Casas-Recasens S, Faiz A, Hansbro P, Guirao A, Lepore R, Cirillo D, Agustí A, Polverino F, Valencia A, Faner R.
Olvera N, et al.
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202303-0500OC. Online ahead of print.
Am J Respir Crit Care Med. 2024.
PMID: 38626356
Two communities (C#3 and C#4) had both similarly low FEV(1) values and emphysema, but were molecularly different: C#3, but not C#4, presented B and T cell signatures and a downregulation of secretory (SCGB1A1/SCGB3A1) and ciliated cells. ...Finally, using spatial transcrip …
Two communities (C#3 and C#4) had both similarly low FEV(1) values and emphysema, but were molecularly different: C#3, but not C#4, presente …