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Page 1
Antiphospholipid Patients Admitted in the Intensive Care Unit: What Must The Rheumatologist Know?
Moyon Q, Mathian A, Papo M, Combes A, Amoura Z, Pineton de Chambrun M. Moyon Q, et al. Curr Rheumatol Rep. 2024 Apr 23. doi: 10.1007/s11926-024-01148-7. Online ahead of print. Curr Rheumatol Rep. 2024. PMID: 38652403 Review.
Triple therapy - the combination of anticoagulation, high-dose corticosteroids, and either plasma exchange or intravenous immunoglobulins - remains the standard treatment for CAPS patients. Eculizumab, an anti-C5 monoclonal antibody, may be useful in refractory patients. D …
Triple therapy - the combination of anticoagulation, high-dose corticosteroids, and either plasma exchange or intravenous immunoglobulins - …
Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum.
Fujiwara T, Mano E, Nango E. Fujiwara T, et al. FEBS Lett. 2024 Apr 22. doi: 10.1002/1873-3468.14886. Online ahead of print. FEBS Lett. 2024. PMID: 38649293
Among the epimerases specific to alginate, some of them in Azotobacter genera convert beta-d-mannuronic acid to alpha-l-guluronic acid but also have lyase activity to degrade alginate. ...
Among the epimerases specific to alginate, some of them in Azotobacter genera convert beta-d-mannuronic acid to alpha-l-guluronic aci …
Long-term safety and efficacy of zilucoplan in patients with generalized myasthenia gravis: interim analysis of the RAISE-XT open-label extension study.
Howard JF Jr, Bresch S, Farmakidis C, Freimer M, Genge A, Hewamadduma C, Hinton J, Hussain Y, Juntas-Morales R, Kaminski HJ, Maniaol A, Mantegazza R, Masuda M, Nowak RJ, Sivakumar K, Śmiłowski M, Utsugisawa K, Vu T, Weiss MD, Zajda M, Bloemers J, Boroojerdi B, Brock M, de la Borderie G, Duda PW, Vanderkelen M, Leite MI; RAISE-XT Study Team*. Howard JF Jr, et al. Ther Adv Neurol Disord. 2024 Apr 17;17:17562864241243186. doi: 10.1177/17562864241243186. eCollection 2024. Ther Adv Neurol Disord. 2024. PMID: 38638673 Free PMC article.
Artemyriantholides A-K, guaiane-type sesquiterpenoid dimers from Artemisia myriantha var. pleiocephala and their antihepatoma activity.
Wang MF, Li TZ, Ma YB, Ma WJ, Wang YC, Li FJ, Chen JJ. Wang MF, et al. Phytochemistry. 2024 Apr 16;222:114100. doi: 10.1016/j.phytochem.2024.114100. Online ahead of print. Phytochemistry. 2024. PMID: 38636688
The interaction between compound 5 and MAP2K2 was conducted to give docking score of -9.0 kcal/mol by molecular docking and provide K(D) value of 43.7 muM by Surface Plasmon Resonance assay....
The interaction between compound 5 and MAP2K2 was conducted to give docking score of -9.0 kcal/mol by molecular docking and provide K(D …
Luminescent Ln3+-based silsesquioxanes with a β-diketonate antenna ligand: toward the design of efficient temperature sensors.
Félix G, Kulakova AN, Sene S, Khrustalev VN, Hernández-Rodríguez MA, Shubina ES, Pelluau T, Carlos LD, Guari Y, Carneiro Neto AN, Bilyachenko AN, Larionova J. Félix G, et al. Front Chem. 2024 Apr 3;12:1379587. doi: 10.3389/fchem.2024.1379587. eCollection 2024. Front Chem. 2024. PMID: 38633984 Free PMC article.
For compound 1, theoretical calculations on the intramolecular energy transfer and multiphonon rates indicate a thermal balance between the (5)D(4) Stark components, while the mixed Tb(3+)/Eu(3+) analog 2, with a Tb:Eu ratio of 3:1, showcases intra-cluster Tb(3+)-to-Eu(3+) …
For compound 1, theoretical calculations on the intramolecular energy transfer and multiphonon rates indicate a thermal balance between the …
Functional Characterization of a CruP-Like Isomerase in Dunaliella.
Chen HH, Pang XH, Dai JL, Jiang JG. Chen HH, et al. J Agric Food Chem. 2024 Apr 16. doi: 10.1021/acs.jafc.4c01912. Online ahead of print. J Agric Food Chem. 2024. PMID: 38626461
However, there are still many mysteries about the enzymes of the D. bardawil lycopene synthesis pathway that have not been revealed. ...Functional activity of DbLyISO was also performed by overexpressing gene in both E. coli and D. bardawil. Results revealed that Db …
However, there are still many mysteries about the enzymes of the D. bardawil lycopene synthesis pathway that have not been revealed. …
Complement inhibition in paroxysmal nocturnal hemoglobinuria: From biology to therapy.
Versino F, Fattizzo B. Versino F, et al. Int J Lab Hematol. 2024 Apr 15. doi: 10.1111/ijlh.14281. Online ahead of print. Int J Lab Hematol. 2024. PMID: 38622956 Review.
More recently, several other anti-C5 compounds (crovalimab, pozelimab, tesidolumab, cemdisiran, zilucoplan, and coversin) are on study in clinical trials. Upstream inhibition of complement cascade was also explored with the anti-C3 pegcetacoplan, and with the alternative p …
More recently, several other anti-C5 compounds (crovalimab, pozelimab, tesidolumab, cemdisiran, zilucoplan, and coversin) are on stud …
Structure and function of therapeutic antibodies approved by the US FDA in 2023.
Strohl WR. Strohl WR. Antib Ther. 2024 Mar 19;7(2):132-156. doi: 10.1093/abt/tbae007. eCollection 2024 Apr. Antib Ther. 2024. PMID: 38617189 Free PMC article. Review.
Of the approved antibodies, two targeted programmed cell death receptor-1 (PD-1) for orphan indications, two targeted CD20 for diffuse large B cell lymphoma, two targeted different receptors (B-cell maturation antigen [BCMA] and G-coupled protein receptor class C, group 5, member …
Of the approved antibodies, two targeted programmed cell death receptor-1 (PD-1) for orphan indications, two targeted CD20 for diffuse large …
Triel Bonds between BH3/C5H4BX and M(MDA)2 (X = H, CN, F, CH3, NH2; M = Ni, Pd, Pt, MDA = Enolated Malondialdehyde) and Group 10 Transition Metal Electron Donors.
Wang X, Niu Z, McDowell SAC, Li Q. Wang X, et al. Molecules. 2024 Apr 3;29(7):1602. doi: 10.3390/molecules29071602. Molecules. 2024. PMID: 38611881 Free PMC article.
The orbital effect within these systems is largely due to charge transfer from the d(z)(2) orbital of M into the empty p(z) orbital of B....
The orbital effect within these systems is largely due to charge transfer from the d(z)(2) orbital of M into the empty p(z) orbital o …
Genomic and metabolic instability during long-term fermentation of an industrial Saccharomyces cerevisiae strain engineered for C5 sugar utilization.
Duperray M, Delvenne M, François JM, Delvigne F, Capp JP. Duperray M, et al. Front Bioeng Biotechnol. 2024 Mar 26;12:1357671. doi: 10.3389/fbioe.2024.1357671. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38595997 Free PMC article.
These criteria were here explored in an industrial ethanol-producer strain of Saccharomyces cerevisiae able to co-ferment D-xylose and L-arabinose with glucose through the chromosomal integration of several copies of pivotal genes for the use of these pentose (C5) s …
These criteria were here explored in an industrial ethanol-producer strain of Saccharomyces cerevisiae able to co-ferment D-xylose an …
5,487 results