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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients.
Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. Mertens J, et al. Among authors: bohnke l. Cell Stem Cell. 2021 Sep 2;28(9):1533-1548.e6. doi: 10.1016/j.stem.2021.04.004. Epub 2021 Apr 27. Cell Stem Cell. 2021. PMID: 33910058 Free PMC article.
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.
Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. Mertens J, et al. Among authors: bohnke l. Cell Stem Cell. 2015 Dec 3;17(6):705-718. doi: 10.1016/j.stem.2015.09.001. Epub 2015 Oct 8. Cell Stem Cell. 2015. PMID: 26456686 Free PMC article.
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.
Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, Gage FH. Bardy C, et al. Among authors: bohnke l. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2725-34. doi: 10.1073/pnas.1504393112. Epub 2015 Apr 13. Proc Natl Acad Sci U S A. 2015. PMID: 25870293 Free PMC article.
Direct Conversion of Human Fibroblasts to Induced Neurons.
Zhou-Yang L, Eichhorner S, Karbacher L, Böhnke L, Traxler L, Mertens J. Zhou-Yang L, et al. Among authors: bohnke l. Methods Mol Biol. 2021;2352:73-96. doi: 10.1007/978-1-0716-1601-7_6. Methods Mol Biol. 2021. PMID: 34324181
Human neurons to model aging: A dish best served old.
Böhnke L, Traxler L, Herdy JR, Mertens J. Böhnke L, et al. Drug Discov Today Dis Models. 2018 Spring;27:43-49. doi: 10.1016/j.ddmod.2019.01.001. Epub 2019 Feb 12. Drug Discov Today Dis Models. 2018. PMID: 31745399 Free PMC article.