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Year Number of Results
1828 1
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1970 3
1976 3
1980 1
1981 1
1982 1
1983 5
1984 4
1985 5
1986 3
1987 8
1988 3
1989 4
1990 5
1991 8
1992 7
1993 6
1994 9
1995 5
1996 8
1997 7
1998 9
1999 7
2000 9
2001 7
2002 17
2003 11
2004 20
2005 22
2006 17
2007 31
2008 41
2009 35
2010 45
2011 53
2012 58
2013 84
2014 87
2015 104
2016 100
2017 101
2018 111
2019 124
2020 188
2021 173
2022 1
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1,349 results
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Piperine and Its Role in Chronic Diseases.
Derosa G, Maffioli P, Sahebkar A. Derosa G, et al. Adv Exp Med Biol. 2016;928:173-184. doi: 10.1007/978-3-319-41334-1_8. Adv Exp Med Biol. 2016. PMID: 27671817 Review.
Piperine is responsible for the black pepper distinct biting quality. ...The aim of this chapter is to summarize the effects of piperine, alone or in combination with other drugs and phytochemicals, in chronic diseases....
Piperine is responsible for the black pepper distinct biting quality. ...The aim of this chapter is to summarize the effects of pi
Piper nigrum and piperine: an update.
Meghwal M, Goswami TK. Meghwal M, et al. Phytother Res. 2013 Aug;27(8):1121-30. doi: 10.1002/ptr.4972. Epub 2013 Apr 29. Phytother Res. 2013. PMID: 23625885 Review.
Based on modern cell, animal, and human studies, piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties. In this review, the chemical constituents, biological activities, …
Based on modern cell, animal, and human studies, piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti …
Piperine: A review of its biological effects.
Haq IU, Imran M, Nadeem M, Tufail T, Gondal TA, Mubarak MS. Haq IU, et al. Phytother Res. 2021 Feb;35(2):680-700. doi: 10.1002/ptr.6855. Epub 2020 Sep 14. Phytother Res. 2021. PMID: 32929825 Review.
Furthermore, piperine has also been documented for its hepatoprotective, anti-allergic, anti-inflammatory, and neuroprotective properties. ...In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several …
Furthermore, piperine has also been documented for its hepatoprotective, anti-allergic, anti-inflammatory, and neuroprotective proper …
Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies.
Manayi A, Nabavi SM, Setzer WN, Jafari S. Manayi A, et al. Curr Med Chem. 2018;25(37):4918-4928. doi: 10.2174/0929867324666170523120656. Curr Med Chem. 2018. PMID: 28545378 Review.
Recently many studies showed anticancer activities of piperine, a pungent alkaloid found in black pepper and some other Piper species. ...Besides, about all reviewed studies have reported selective cytotoxic activity of piperine on cancerous cells in compared with n …
Recently many studies showed anticancer activities of piperine, a pungent alkaloid found in black pepper and some other Piper species …
Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-gamma/AKT Pathways.
Ma ZG, Yuan YP, Zhang X, Xu SC, Wang SS, Tang QZ. Ma ZG, et al. EBioMedicine. 2017 Apr;18:179-187. doi: 10.1016/j.ebiom.2017.03.021. Epub 2017 Mar 14. EBioMedicine. 2017. PMID: 28330809 Free PMC article.
However, the effect of piperine on cardiac hypertrophy remains completely unknown. Here, we show that piperine-treated mice had similar hypertrophic responses as mice treated with vehicle but exhibited significantly attenuated cardiac fibrosis after pressure overloa …
However, the effect of piperine on cardiac hypertrophy remains completely unknown. Here, we show that piperine-treated mice ha …
Black pepper and its pungent principle-piperine: a review of diverse physiological effects.
Srinivasan K. Srinivasan K. Crit Rev Food Sci Nutr. 2007;47(8):735-48. doi: 10.1080/10408390601062054. Crit Rev Food Sci Nutr. 2007. PMID: 17987447 Review.
Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive enzymes of pancreas, enhances the digestive capacity and significantly r …
Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decad …
Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen.
Hussaarts KGAM, Hurkmans DP, Oomen-de Hoop E, van Harten LJ, Berghuis S, van Alphen RJ, Spierings LEA, van Rossum-Schornagel QC, Vastbinder MB, van Schaik RHN, van Gelder T, Jager A, van Leeuwen RWF, Mathijssen RHJ. Hussaarts KGAM, et al. Cancers (Basel). 2019 Mar 22;11(3):403. doi: 10.3390/cancers11030403. Cancers (Basel). 2019. PMID: 30909366 Free PMC article.
We compared endoxifen and tamoxifen exposure in breast cancer patients with or without curcumin, and with addition of the bio-enhancer piperine. Tamoxifen (20-30mg per day (q.d.)) was either given alone, or combined with curcumin (1200 mg three times daily (t.i.d.)) +/- …
We compared endoxifen and tamoxifen exposure in breast cancer patients with or without curcumin, and with addition of the bio-enhancer pi
Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IkappaB-alpha/NF-kappaB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice.
Guo G, Shi F, Zhu J, Shao Y, Gong W, Zhou G, Wu H, She J, Shi W. Guo G, et al. Hum Exp Toxicol. 2020 Apr;39(4):477-491. doi: 10.1177/0960327119892042. Epub 2019 Dec 13. Hum Exp Toxicol. 2020. PMID: 31835924

The administration of piperine (20 and 40 mg/kg) significantly inhibited (p < 0.05) these damages. ...TNBS decreased the expressions of tight junction (TJ) protein (claudin-1, occludin, and zonula occludens-1 (ZO-1)) and increased the expressions of proapoptotic (caspas

The administration of piperine (20 and 40 mg/kg) significantly inhibited (p < 0.05) these damages. ...TNBS decreased the expressio

Piperine: Old Spice and New Nutraceutical?
Smilkov K, Ackova DG, Cvetkovski A, Ruskovska T, Vidovic B, Atalay M. Smilkov K, et al. Curr Pharm Des. 2019;25(15):1729-1739. doi: 10.2174/1381612825666190701150803. Curr Pharm Des. 2019. PMID: 31267856 Review.
BACKGROUND: Many of the activities associated with pepper fruits have been attributed to piperine, the most active compound present in these spices. OBJECTIVE: This paper aims to provide an overview of the known properties of piperine, i.e. piperine's chemist …
BACKGROUND: Many of the activities associated with pepper fruits have been attributed to piperine, the most active compound present i …
Piperine protects LPS-induced mastitis by inhibiting inflammatory response.
Yu S, Liu X, Yu D, E C, Yang J. Yu S, et al. Int Immunopharmacol. 2020 Oct;87:106804. doi: 10.1016/j.intimp.2020.106804. Epub 2020 Jul 21. Int Immunopharmacol. 2020. PMID: 32707496
Piperine was given intraperitoneally 1 h before and 12 h after LPS treatment. ...Furthermore, LPS-induced NF-kappaB activation was suppressed by the treatment with piperine. In addition, we found piperine dose-dependently increased the expression of PPARgamma
Piperine was given intraperitoneally 1 h before and 12 h after LPS treatment. ...Furthermore, LPS-induced NF-kappaB activation was su
1,349 results