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Diabetes management in maternally inherited diabetes and deafness (MIDD): A review and a proposed treatment algorithm.
Chaudhry A, Thompson DM, Chanoine JP. Chaudhry A, et al. Diabetes Obes Metab. 2026 Feb;28(2):826-839. doi: 10.1111/dom.70240. Epub 2025 Oct 27. Diabetes Obes Metab. 2026. PMID: 41145374 Free PMC article. Review.
Accordingly, we share our perspective on a disease-specific algorithm for the management of MIDD diabetes that could delay or prevent the development of cardiovascular and renal complications associated with this mitochondrial disease....
Accordingly, we share our perspective on a disease-specific algorithm for the management of MIDD diabetes that could delay or prevent …
Bridging the gap: mechanisms and novel translational strategies to prevent cisplatin-induced ototoxicity.
Bai J, Wang W, Fu Z, Yang J, Guo Y, Guan G. Bai J, et al. Hear Res. 2026 Jan;469:109487. doi: 10.1016/j.heares.2025.109487. Epub 2025 Nov 24. Hear Res. 2026. PMID: 41308564 Free article. Review.
This review aims to systematically examines the molecular mechanisms underlying cisplatin-induced ototoxicity and evaluate both current and emerging preventive strategies. We find that the central pathological process involves a self-perpetuating cycle of oxidative stress …
This review aims to systematically examines the molecular mechanisms underlying cisplatin-induced ototoxicity and evaluate both current and …
Hearing Loss in Young Adults: Risk Factors, Mechanisms and Prevention Models.
Fleser RC, Necula V, Ujvary LP, Osman A, Orasan A, Maniu AA. Fleser RC, et al. Biomedicines. 2025 Dec 18;13(12):3116. doi: 10.3390/biomedicines13123116. Biomedicines. 2025. PMID: 41463124 Free PMC article. Review.
Aggravating factors include delayed diagnosis, cumulative exposures and lack of preventive strategies. Early detection via advanced audiological assessments, such as extended high-frequency audiometry, otoacoustic emissions, speech-in-noise testing and auditory brainstem r …
Aggravating factors include delayed diagnosis, cumulative exposures and lack of preventive strategies. Early detection via advanced a …
VDAC1: The mitochondrial gatekeeper in the battle against hearing loss (Review).
Ding ZJ, Wang Y. Ding ZJ, et al. Biomed Rep. 2025 Sep 26;23(6):184. doi: 10.3892/br.2025.2062. eCollection 2025 Dec. Biomed Rep. 2025. PMID: 41089345 Free PMC article. Review.
VDAC1 can significantly contribute to the prevention and management of hearing loss. The present review summarizes how the ubiquitination and oligomerization modifications of VDAC1 can balance cell survival and death, while also exploring current hypotheses on mechanisms a …
VDAC1 can significantly contribute to the prevention and management of hearing loss. The present review summarizes how the ubiquitina …
Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions.
Lv X, Yang C, Li X, Liu Y, Yang Y, Jin T, Chen Z, Jia J, Wang M, Li L. Lv X, et al. J Enzyme Inhib Med Chem. 2025 Dec;40(1):2468853. doi: 10.1080/14756366.2025.2468853. Epub 2025 Feb 24. J Enzyme Inhib Med Chem. 2025. PMID: 39992186 Free PMC article. Review.
Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention and regeneration strategies. Ferroptosis, a distinct form of cell death featuring iron-dependent lipid peroxidation, h …
Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effect …
Nigella Sativa and Thymoquinone for Prevention or Mitigation of Acquired Sensorineural Hearing Loss: A Systematic Review.
Horvath HL, Necula V, Dindelegan MG, Blebea CM, Esanu V, Maniu AA. Horvath HL, et al. J Clin Med. 2025 Nov 27;14(23):8433. doi: 10.3390/jcm14238433. J Clin Med. 2025. PMID: 41375733 Free PMC article. Review.
Recent research suggests that natural antioxidants are promising solutions to prevent SNHL. Nigella sativa (NS), through its active compound thymoquinone (TQ), is a potent antioxidant that has shown promising results. ...Overall, our systematic review highlights NS as a pr …
Recent research suggests that natural antioxidants are promising solutions to prevent SNHL. Nigella sativa (NS), through its active c …
Expression and Roles of Free Radicals and Reactive Oxygen Species in Hearing Loss.
Lee JM, Cha YJ, Oh YJ, Kim HO, Kim SS, Kim YJ, Yon DK, Yeo SG. Lee JM, et al. Antioxidants (Basel). 2025 Nov 24;14(12):1397. doi: 10.3390/antiox14121397. Antioxidants (Basel). 2025. PMID: 41462597 Free PMC article. Review.
OBJECTIVE: Although the etiologies and pathogenesis of common hearing disorders-noise-induced hearing loss (NIHL), age-related hearing loss (ARHL), and idiopathic sudden sensorineural hearing loss (ISSNHL)-are diverse, accumulating evidence indicates that reactive oxygen species …
OBJECTIVE: Although the etiologies and pathogenesis of common hearing disorders-noise-induced hearing loss (NIHL), age-related hearing loss …
Uncovering Phenotypes in Sensorineural Hearing Loss: A Systematic Review of Unsupervised Machine Learning Approaches.
Dimitrov L, Barrett L, Chaudhry A, Muzaffar J, Lilaonitkul W, Mehta N. Dimitrov L, et al. Ear Hear. 2025 Nov-Dec 01;46(6):1401-1411. doi: 10.1097/AUD.0000000000001696. Epub 2025 Aug 7. Ear Hear. 2025. PMID: 40770825 Free PMC article.
However, the overall quality of the studies was deemed low, thus preventing definitive conclusions regarding model selection and the actual number of subtypes. ...
However, the overall quality of the studies was deemed low, thus preventing definitive conclusions regarding model selection and the …
Eustachian Tube Dysfunction in Hearing Loss: Mechanistic Pathways to Targeted Interventions.
Kim HY. Kim HY. Biomedicines. 2025 Oct 31;13(11):2686. doi: 10.3390/biomedicines13112686. Biomedicines. 2025. PMID: 41301779 Free PMC article. Review.
Looking forward, integration of physiology-based frameworks with personalized diagnostics and advanced tools such as artificial intelligence (AI) may help prevent progression from reversible conductive deficits to irreversible SNHL or MHL....
Looking forward, integration of physiology-based frameworks with personalized diagnostics and advanced tools such as artificial intelligence …
Age-related hearing loss and dementia risk across the lifespan: mechanisms, equity, and prevention.
Loughrey DG. Loughrey DG. Neuroscience. 2025 Oct 15;585:78-84. doi: 10.1016/j.neuroscience.2025.08.056. Epub 2025 Aug 28. Neuroscience. 2025. PMID: 40885376 Free article. Review.
Inequities in access to hearing care, underrepresentation of marginalised populations in research, and variability in intervention outcomes emphasise the need for a more inclusive and integrated approach to prevention. This review synthesises current evidence on the neuroc …
Inequities in access to hearing care, underrepresentation of marginalised populations in research, and variability in intervention outcomes …
NLRP3 inflammasome and hearing loss: from mechanisms to therapies.
Murillo-Cuesta S, Seoane E, Cervantes B, Zubeldia JM, Varela-Nieto I. Murillo-Cuesta S, et al. J Neuroinflammation. 2025 Oct 4;22(1):225. doi: 10.1186/s12974-025-03561-w. J Neuroinflammation. 2025. PMID: 41046290 Free PMC article. Review.
Targeting NLRP3 may ultimately redefine treatment paradigms for preventing or halting progressive hearing loss....
Targeting NLRP3 may ultimately redefine treatment paradigms for preventing or halting progressive hearing loss....
A review of occupational noise-induced hearing loss: focus on mechanisms and preventive measures.
Chen KT, Su SB. Chen KT, et al. Br Med Bull. 2025 Sep 22;156(1):ldaf020. doi: 10.1093/bmb/ldaf020. Br Med Bull. 2025. PMID: 41288965 Free PMC article. Review.
INTRODUCTION: This research investigates the epidemiology, underlying mechanisms, and prevention strategies associated with occupational noise-induced hearing loss (ONIHL), while also presenting effective control measures. ...
INTRODUCTION: This research investigates the epidemiology, underlying mechanisms, and prevention strategies associated with occupatio …
Maternal Exposure to Medications and the Risk of Congenital and Early-Onset Hearing Loss in Children: A Systematic Review and a Meta-Analysis.
Kücükyildiz AS, Thunbo MØ, Swan CZ, Burgner DP, Miller JE, Ovesen T, Pedersen LH. Kücükyildiz AS, et al. Basic Clin Pharmacol Toxicol. 2025 Sep;137(3):e70090. doi: 10.1111/bcpt.70090. Basic Clin Pharmacol Toxicol. 2025. PMID: 40851451 Free PMC article.
CONCLUSION: Our findings highlight the urgent need for robust research to minimise preventable hearing loss in children....
CONCLUSION: Our findings highlight the urgent need for robust research to minimise preventable hearing loss in children....
Assessment of Safety, Tolerability, Pharmacokinetics, and Volume-Dependent Conductive Hearing Loss in Healthy Volunteers: First-in-Human, Open-Label, Placebo-Controlled Study of a Single Intratympanic Injection of AC102.
Lanting C, Robijn S, Nieratschker M, Galetzka C, Meis A, Rommelspacher H, Ahoud-Schoenmakers S, Lackner E, Zeitlinger M, Bauer M, Arnoldner C, Pennings R, Schlingensiepen R. Lanting C, et al. Otol Neurotol. 2025 Sep 1;46(8):884-894. doi: 10.1097/MAO.0000000000004568. Otol Neurotol. 2025. PMID: 40788268 Free PMC article. Clinical Trial.
OBJECTIVE: The objective of this study was to assess the safety and tolerability of the intratympanic delivery of AC102, a novel pharmaceutical therapy based on a thermosensitive gel for preventing and treating a range of hearing impairments, including sudden sensorineural …
OBJECTIVE: The objective of this study was to assess the safety and tolerability of the intratympanic delivery of AC102, a novel pharmaceuti …
Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.
Sun S, Zhao Q, He H, Liu Y, Nie Y, Zhou Y. Sun S, et al. Front Aging Neurosci. 2025 Aug 20;17:1657603. doi: 10.3389/fnagi.2025.1657603. eCollection 2025. Front Aging Neurosci. 2025. PMID: 40908956 Free PMC article. Review.
This narrative review summarizes recent research progress in understanding ARHL pathogenesis and discusses emerging strategies for prevention and treatment, highlighting the imperative for targeted interventions to enhance auditory health and overall well-being in aging po …
This narrative review summarizes recent research progress in understanding ARHL pathogenesis and discusses emerging strategies for preven …
Protective effects of dietary nutrients on hearing loss: a systematic review and meta-analysis.
Lu W, Tang R, Jiahui X, Shipeng Z, Tao G, Hanyua W, Feng X, Hui X. Lu W, et al. Front Nutr. 2025 May 9;12:1528771. doi: 10.3389/fnut.2025.1528771. eCollection 2025. Front Nutr. 2025. PMID: 40416381 Free PMC article.
The World Health Organization reports that over 1.5 billion people worldwide experience hearing loss, with one-third of these cases attributed to preventable factors. Recently, the influence of diet and nutrition on auditory health has garnered increasing attention. ...
The World Health Organization reports that over 1.5 billion people worldwide experience hearing loss, with one-third of these cases attribut …
Hearing Loss and Falls: A Systematic Review and Meta-Analysis.
Yeo BSY, Tan VYJ, Ng JH, Tang JZ, Sim BLH, Tay YL, Chowdhury AR, David AP, Jiam NT, Kozin ED, Rauch SD. Yeo BSY, et al. JAMA Otolaryngol Head Neck Surg. 2025 May 1;151(5):485-494. doi: 10.1001/jamaoto.2025.0056. JAMA Otolaryngol Head Neck Surg. 2025. PMID: 40111358 Free PMC article.
Nonetheless, further randomized clinical trials are needed to elucidate any benefit of treating HL on fall prevention....
Nonetheless, further randomized clinical trials are needed to elucidate any benefit of treating HL on fall prevention....
Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects.
Förster CY, Shityakov S, Stavrakis S, Scheper V, Lenarz T. Förster CY, et al. Front Cell Neurosci. 2025 Apr 7;19:1523149. doi: 10.3389/fncel.2025.1523149. eCollection 2025. Front Cell Neurosci. 2025. PMID: 40260077 Free PMC article. Review.
The primary aim of this review is to examine NIHL in detail and explore its underlying mechanisms, physiological effects, and cutting-edge therapeutic strategies for its effective management and prevention....
The primary aim of this review is to examine NIHL in detail and explore its underlying mechanisms, physiological effects, and cutting-edge t …
Age of detection of congenital hearing loss in South Africa: A systematic review.
Phanguphangu M, Kgare K, Ross AJ. Phanguphangu M, et al. J Public Health Afr. 2025 Jan 27;16(1):777. doi: 10.4102/jphia.v16i1.777. eCollection 2025. J Public Health Afr. 2025. PMID: 40475230 Free PMC article. Review.
CONTRIBUTION: This study highlights the need to strengthen preventative programmes for paediatric HL in SA....
CONTRIBUTION: This study highlights the need to strengthen preventative programmes for paediatric HL in SA....
Hearing Loss and Turner Syndrome: A Scoping Review.
Migliorelli A, Ciorba A, Manuelli M, Corazzi V, Stomeo F, Bianchini C, Pelucchi S, Monzani D, Genovese E, Palma S. Migliorelli A, et al. J Int Adv Otol. 2025 Jan 27;21(1):1-6. doi: 10.5152/iao.2025.241723. J Int Adv Otol. 2025. PMID: 39936645 Free PMC article.
To date, the pathophysiological mechanisms related to HL in TS are still not fully understood; further studies are necessary to clarify these features and to offer therapies or prevention strategies to avoid the progression of HL in TS subjects....
To date, the pathophysiological mechanisms related to HL in TS are still not fully understood; further studies are necessary to clarify thes …
Cisplatin-Induced Hearing Loss, Oxidative Stress, and Antioxidants as a Therapeutic Strategy-A State-of-the-Art Review.
Rose O, Croonenberg T, Clemens S, Hinteregger T, Eppacher S, Huber-Cantonati P, Garcia-Miralles M, Liuni R, Dossena S. Rose O, et al. Antioxidants (Basel). 2024 Dec 21;13(12):1578. doi: 10.3390/antiox13121578. Antioxidants (Basel). 2024. PMID: 39765905 Free PMC article. Review.
Despite the recent approval of sodium thiosulphate for the prevention of cisplatin-induced hearing loss (CIHL) in pediatric patients, structured prevention programs are not routinely implemented in most hospitals, and reducing platinum-induced ototoxicity in adults …
Despite the recent approval of sodium thiosulphate for the prevention of cisplatin-induced hearing loss (CIHL) in pediatric patients, …
Effect of hearing intervention on communicative function: A secondary analysis of the ACHIEVE randomized controlled trial.
Sanchez VA, Arnold ML, Garcia Morales EE, Reed NS, Faucette S, Burgard S, Calloway HN, Coresh J, Deal JA, Goman AM, Gravens-Mueller L, Hayden KM, Huang AR, Mitchell CM, Mosley TH Jr, Pankow JS, Pike JR, Schrack JA, Sherry L, Weycker JM, Lin FR, Chisolm TH; ACHIEVE Collaborative Study. Sanchez VA, et al. J Am Geriatr Soc. 2024 Dec;72(12):3784-3799. doi: 10.1111/jgs.19185. Epub 2024 Sep 12. J Am Geriatr Soc. 2024. PMID: 39266468 Free PMC article. Clinical Trial.
Participants were randomly assigned (1:1) to a hearing intervention (audiological counseling and provision of hearing aids) or a control intervention of health education (individual sessions with a health educator covering topics on chronic disease prevention) and followed …
Participants were randomly assigned (1:1) to a hearing intervention (audiological counseling and provision of hearing aids) or a control int …
Effectiveness of educational programs in hearing health: a systematic review and meta-analysis.
Bramati L, Allenstein Gondim LM, Schmidt L, Lüders D, Veríssimo Meira Taveira K, Néron N, Miranda de Araujo C, Bender Moreira de Lacerda A. Bramati L, et al. Int J Audiol. 2024 Dec;63(12):936-947. doi: 10.1080/14992027.2024.2313025. Epub 2024 Feb 27. Int J Audiol. 2024. PMID: 38411141 Free article.
OBJECTIVE: To evaluate the effectiveness of hearing health education programs aimed at preventing noise-induced hearing loss (NIHL), of recreational and occupational origin, by means of a systematic review and meta-analysis. ...STUDY SAMPLE: Effectiveness studies that used …
OBJECTIVE: To evaluate the effectiveness of hearing health education programs aimed at preventing noise-induced hearing loss (NIHL), …
The association between anemia and sensorineural hearing loss: A review.
Ye L, Lai D, Tai J. Ye L, et al. Medicine (Baltimore). 2024 Nov 1;103(44):e40326. doi: 10.1097/MD.0000000000040326. Medicine (Baltimore). 2024. PMID: 39496053 Free PMC article. Review.
This review aims to comprehensively analyze the association between various types of anemia and SNHL, including possible biological mechanisms, clinical features, and treatment strategies, and clarify the importance of anemia treatment and management in preventing SNHL....
This review aims to comprehensively analyze the association between various types of anemia and SNHL, including possible biological mechanis …
From sound waves to molecular and cellular mechanisms: Understanding noise-induced hearing loss and pioneering preventive approaches (Review).
Samara P, Athanasopoulos M, Markatos N, Athanasopoulos I. Samara P, et al. Med Int (Lond). 2024 Jul 30;4(6):60. doi: 10.3892/mi.2024.184. eCollection 2024 Nov-Dec. Med Int (Lond). 2024. PMID: 39114262 Free PMC article. Review.
The present review focuses on elucidating the molecular mechanisms of NIHL, with a specific emphasis on findings derived from animal models, alongside the exploration of thorough preventive strategies, including protective measures and probing potential interventions. Unde …
The present review focuses on elucidating the molecular mechanisms of NIHL, with a specific emphasis on findings derived from animal models, …
Effect of Hearing Intervention Versus Health Education Control on Fatigue: A Secondary Analysis of the ACHIEVE Study.
Bessen SY, Zhang W, Huang AR, Arnold M, Burgard S, Chisolm TH, Couper D, Deal JA, Faucette SP, Goman AM, Glynn NW, Gmelin T, Gravens-Mueller L, Hayden KM, Mitchell CM, Pankow JS, Pike JR, Reed NS, Sanchez VA, Schrack JA, Sullivan KJ, Coresh J, Lin FR, Martinez-Amezcua P; ACHIEVE Collaborative Research Group. Bessen SY, et al. J Gerontol A Biol Sci Med Sci. 2024 Nov 1;79(11):glae193. doi: 10.1093/gerona/glae193. J Gerontol A Biol Sci Med Sci. 2024. PMID: 39093692 Free PMC article. Clinical Trial.
Occupational noise exposure and its effects among mill workers: A narrative review.
Salam SNA, Kamaludin NF, Awang N, Ithnin A, Nata DHMS, Mohd Saat NZ. Salam SNA, et al. Noise Health. 2024 Oct-Dec 01;26(123):461-473. doi: 10.4103/nah.nah_43_23. Epub 2024 Dec 30. Noise Health. 2024. PMID: 39787546 Free PMC article. Review.
Overall, most mill workers are exposed to a high noise level exceeding the standard noise exposure limit. Preventive actions should be taken to address and reduce work-related injuries among mill workers worldwide....
Overall, most mill workers are exposed to a high noise level exceeding the standard noise exposure limit. Preventive actions should b …
Individual and combined effects of noise exposure and diabetes mellitus on hearing.
Zhang L, Liao H, Li Z, Yuan J. Zhang L, et al. Noise Health. 2024 Oct-Dec 01;26(123):449-460. doi: 10.4103/nah.nah_71_24. Epub 2024 Dec 30. Noise Health. 2024. PMID: 39787545 Free PMC article. Review.
It is particularly important to explore the independent and combined effects of noise and DM on hearing, which can help healthcare professionals understand the potential risks posed by these factors and inspire prevention strategies and potential interventions for hearing …
It is particularly important to explore the independent and combined effects of noise and DM on hearing, which can help healthcare professio …
Hearing loss during chemotherapy: prevalence, mechanisms, and protection.
Kessler L, Koo C, Richter CP, Tan X. Kessler L, et al. Am J Cancer Res. 2024 Sep 25;14(9):4597-4632. doi: 10.62347/OKGQ4382. eCollection 2024. Am J Cancer Res. 2024. PMID: 39417180 Free PMC article. Review.
Despite the nearly 2,000 publications on chemotherapy-related ototoxicity in the past decade, the understanding of its prevalence, mechanisms, and preventative or therapeutic measures remains ambiguous and subject to debate. To date, only one drug, sodium thiosulfate, has …
Despite the nearly 2,000 publications on chemotherapy-related ototoxicity in the past decade, the understanding of its prevalence, mechanism …
Impact of nutrition on hearing loss.
Almazán-Catalán J, Morais-Moreno C, Puga Giménez de Azcárate AM, Partearroyo Cediel T. Almazán-Catalán J, et al. Nutr Hosp. 2024 Sep 23;41(Spec No3):49-51. doi: 10.20960/nh.05458. Nutr Hosp. 2024. PMID: 39279743 Free article. Review. English.
Therefore, it is necessary to expand knowledge about the relationship between the different factors involved as a first step towards prevention and potential repair of hearing damage before it becomes irreversible and significantly limits the quality of life. Our recent st …
Therefore, it is necessary to expand knowledge about the relationship between the different factors involved as a first step towards prev …
Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review.
Santaolalla Sanchez FJ, Gutierrez Posso JD, Santaolalla Montoya F, Zabala JA, Arrizabalaga-Iriondo A, Revuelta M, Sánchez Del Rey A. Santaolalla Sanchez FJ, et al. Antioxidants (Basel). 2024 Sep 12;13(9):1105. doi: 10.3390/antiox13091105. Antioxidants (Basel). 2024. PMID: 39334764 Free PMC article. Review.
Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat noise-induced hearing loss....
Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat no …
The Role of Molecular and Cellular Aging Pathways on Age-Related Hearing Loss.
Ege T, Tao L, North BJ. Ege T, et al. Int J Mol Sci. 2024 Sep 7;25(17):9705. doi: 10.3390/ijms25179705. Int J Mol Sci. 2024. PMID: 39273652 Free PMC article. Review.
Therefore, understanding how longevity pathways are associated with ARHL will directly influence the development of therapeutic strategies to treat or prevent ARHL. This review explores our current understanding of the molecular and cellular mechanisms of aging and hearing …
Therefore, understanding how longevity pathways are associated with ARHL will directly influence the development of therapeutic strategies t …
Audio-Vestibular Evaluation of Pediatric Pseudo-Conductive Hearing Loss: Third Window Syndromes.
Ertugrul G, Comert A, Aykul Yagcioglu A. Ertugrul G, et al. Audiol Res. 2024 Sep 6;14(5):790-798. doi: 10.3390/audiolres14050066. Audiol Res. 2024. PMID: 39311219 Free PMC article. Review.
Conductive hearing loss caused by external or middle ear problems prevents the transmission of sound waves from the external auditory canal to the cochlea, and it is a common condition, especially in pediatric patients aged 1-5 years. ...
Conductive hearing loss caused by external or middle ear problems prevents the transmission of sound waves from the external auditory …
Otitis media sequelae and hearing in adolescence after administration of an 11-valent conjugate pneumococcal vaccine in infancy: a prospective cohort study with long-term follow-up of the ARIVAC trial.
Simões EAF, Carosone-Link P, Sanvictores DM, Uhler KM, Lucero M, Tallo V, Chan KH. Simões EAF, et al. Lancet Child Adolesc Health. 2024 Sep;8(9):647-655. doi: 10.1016/S2352-4642(24)00128-7. Epub 2024 Jul 31. Lancet Child Adolesc Health. 2024. PMID: 39096922 Free PMC article. Clinical Trial.
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) have been shown in randomised controlled trials and epidemiological studies to prevent acute otitis media caused by vaccine serotype pneumococci, although their role in preventing complications of acute otitis media …
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) have been shown in randomised controlled trials and epidemiological studies to prevent …
Walking and balance in older adults with age-related hearing loss: A cross-sectional study of cases and matched controls.
Kolasa S, Magnussen LH, Nilsen RM, Wilhelmsen KT, Goplen FK, Nordahl SHG, Meldrum D, Berge JE, Hernes SS, Steihaug OM, Bogen B. Kolasa S, et al. Gait Posture. 2024 Sep;113:398-406. doi: 10.1016/j.gaitpost.2024.07.301. Epub 2024 Jul 29. Gait Posture. 2024. PMID: 39088930 Free article. Review.
This relationship illustrates the importance of assessing physical performance in people with HL to prevent risk of falls and disability....
This relationship illustrates the importance of assessing physical performance in people with HL to prevent risk of falls and disabil …
A burden shared: The evolutionary case for studying human deafness in Drosophila.
Guan C, Shaikh M, Warnecke A, Vona B, Albert JT. Guan C, et al. Hear Res. 2024 Sep 1;450:109047. doi: 10.1016/j.heares.2024.109047. Epub 2024 Jun 15. Hear Res. 2024. PMID: 38896942 Free article. Review.
Despite this staggering disease load, and the vast damage it inflicts on the social, medical and economic fabric of humankind, our ability to predict, or prevent, the loss of hearing is very poor indeed. We here make the case for a paradigm shift in our approach to studyin …
Despite this staggering disease load, and the vast damage it inflicts on the social, medical and economic fabric of humankind, our ability t …
Probucol-bile acid nanoparticles: a novel approach and promising solution to prevent cellular oxidative stress in sensorineural hearing loss.
Wagle SR, Kovacevic B, Foster T, Ionescu CM, Jones M, Mikov M, Wise A, Mooranian A, Al-Salami H. Wagle SR, et al. J Drug Target. 2024 Aug;32(7):737-755. doi: 10.1080/1061186X.2024.2349111. Epub 2024 Jun 21. J Drug Target. 2024. PMID: 38758361 Free article. Review.
The use of antioxidants could thus prove an effective medication to prevent or facilitate recovery from oxidative stress-induced sensorineural hearing loss (SNHL). ...The preclinical, clinical and epidemiological studies support that PB is a proven antioxidant that could e …
The use of antioxidants could thus prove an effective medication to prevent or facilitate recovery from oxidative stress-induced sens …
Hearing Loss and Oxidative Stress: A Comprehensive Review.
Maniaci A, La Via L, Lechien JR, Sangiorgio G, Iannella G, Magliulo G, Pace A, Mat Q, Lavalle S, Lentini M. Maniaci A, et al. Antioxidants (Basel). 2024 Jul 14;13(7):842. doi: 10.3390/antiox13070842. Antioxidants (Basel). 2024. PMID: 39061910 Free PMC article. Review.
Antioxidant therapies have shown promising results in both animal models and clinical studies for preventing and mitigating hearing loss. Emerging therapeutic approaches, including targeted drug delivery systems and gene therapy, offer new possibilities for addressing oxid …
Antioxidant therapies have shown promising results in both animal models and clinical studies for preventing and mitigating hearing l …
Use of Sodium Thiosulfate as an Otoprotectant in Patients With Cancer Treated With Platinum Compounds: A Review of the Literature.
Meijer AJM, Diepstraten FA, Ansari M, Bouffet E, Bleyer A, Fresneau B, Geller JI, Huitema ADR, Kogner P, Maibach R, O'Neill AF, Papadakis V, Rajput KM, Veal GJ, Sullivan M, van den Heuvel-Eibrink MM, Brock PR. Meijer AJM, et al. J Clin Oncol. 2024 Jun 20;42(18):2219-2232. doi: 10.1200/JCO.23.02353. Epub 2024 Apr 22. J Clin Oncol. 2024. PMID: 38648563 Free PMC article. Review.
More studies are needed on the PK of STS and cisplatin drug combinations, the efficacy and safety of STS in patients with disseminated disease, and the ability of STS to prevent further deterioration of pre-established hearing loss....
More studies are needed on the PK of STS and cisplatin drug combinations, the efficacy and safety of STS in patients with disseminated disea …
Hearing Loss in Space Flights: A Review of Noise Regulations and Previous Outcomes.
Avcı AU. Avcı AU. J Int Adv Otol. 2024 Mar 27;20(2):171-174. doi: 10.5152/iao.2024.231434. J Int Adv Otol. 2024. PMID: 39158074 Free PMC article. Review.
Certain precautions must be taken to ensure the habitability of the spacecraft and prevent potential hearing loss in astronauts or space flight participants....
Certain precautions must be taken to ensure the habitability of the spacecraft and prevent potential hearing loss in astronauts or sp …
Hidden hearing loss: Fifteen years at a glance.
Liu J, Stohl J, Overath T. Liu J, et al. Hear Res. 2024 Mar 1;443:108967. doi: 10.1016/j.heares.2024.108967. Epub 2024 Jan 30. Hear Res. 2024. PMID: 38335624 Free article. Review.
Understanding the physiological and perceptual effects of this early auditory deafferentation might inform interventions to prevent later, more severe hearing loss. In the past decade, a large body of work has been devoted to better understand hidden hearing loss, includin …
Understanding the physiological and perceptual effects of this early auditory deafferentation might inform interventions to prevent l …
Establishing multifactorial risk factors for adult-onset hearing loss: A systematic review with topic modelling and synthesis of epidemiological evidence.
Tran Y, Tang D, Lo C, Macken O, Newall J, Bierbaum M, Gopinath B. Tran Y, et al. Prev Med. 2024 Mar;180:107882. doi: 10.1016/j.ypmed.2024.107882. Epub 2024 Jan 29. Prev Med. 2024. PMID: 38296002 Free article.
CONCLUSIONS: The findings of this review, combined with the synthesis of epidemiological evidence, enhance our understanding of hearing loss (HL) pathogenesis and highlight potential areas for intervention, thereby paving the way for more effective prevention and managemen …
CONCLUSIONS: The findings of this review, combined with the synthesis of epidemiological evidence, enhance our understanding of hearing loss …
Drug-induced hearing loss: Listening to the latest advances.
Reynard P, Thai-Van H. Reynard P, et al. Therapie. 2024 Mar-Apr;79(2):283-295. doi: 10.1016/j.therap.2023.10.011. Epub 2023 Oct 31. Therapie. 2024. PMID: 37957052 Free article. Review.
The presumed ototoxic mechanisms were described, together with the therapeutic and preventive options developed over the last ten years....
The presumed ototoxic mechanisms were described, together with the therapeutic and preventive options developed over the last ten yea …
Priorities for hearing loss prevention and estimates of global cause-specific burdens of hearing loss: a systematic rapid review.
Prasad K, Borre ED, Dillard LK, Ayer A, Der C, Bainbridge KE, McMahon CM, Tucci DL, Wilson BS, Schmidler GDS, Saunders J. Prasad K, et al. Lancet Glob Health. 2024 Feb;12(2):e217-e225. doi: 10.1016/S2214-109X(23)00514-4. Lancet Glob Health. 2024. PMID: 38245112 Free article.
FINDINGS: An estimated 257.3 million people per year are exposed to these preventable causes of hearing loss, leading to an estimated 33.8 million new cases of hearing loss worldwide per year. ...Prevention of these conditions should be a global health priority. FUN …
FINDINGS: An estimated 257.3 million people per year are exposed to these preventable causes of hearing loss, leading to an estimated …
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss.
Lee J, Fernandez K, Cunningham LL. Lee J, et al. Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:211-230. doi: 10.1146/annurev-pharmtox-033123-114106. Epub 2023 Aug 10. Annu Rev Pharmacol Toxicol. 2024. PMID: 37562496 Free article. Review.
At least 17 clinical trials evaluating 10 therapeutics are currently underway for therapies aimed at preventing aminoglycoside- and/or cisplatin-induced ototoxicity. This review describes the preclinical and clinical development of each of these approaches, provides update …
At least 17 clinical trials evaluating 10 therapeutics are currently underway for therapies aimed at preventing aminoglycoside- and/o …
Prevalence of hearing loss in college students: a meta-analysis.
Kornisch M, Barton A, Park H, Lowe R, Ikuta T. Kornisch M, et al. Front Neurosci. 2024 Jan 5;17:1282829. doi: 10.3389/fnins.2023.1282829. eCollection 2023. Front Neurosci. 2024. PMID: 38249585 Free PMC article.
Therefore, implementing a hearing conservation program may be advised for colleges and universities to help prevent hearing loss in students, particularly for collegiate musicians. In addition, it may be beneficial to screen hearing in college students at 6,000 Hz for bett …
Therefore, implementing a hearing conservation program may be advised for colleges and universities to help prevent hearing loss in s …
Age-related hearing loss: An updated and comprehensive review of the interventions.
Tavanai E, Rahimi V, Khalili ME, Falahzadeh S, Motasaddi Zarandy M, Mohammadkhani G. Tavanai E, et al. Iran J Basic Med Sci. 2024;27(3):256-269. doi: 10.22038/IJBMS.2023.72863.15849. Iran J Basic Med Sci. 2024. PMID: 38333758 Free PMC article. Review.
Several attempts have been conducted to investigate preventive and therapeutic strategy/strategies for age-related auditory dysfunction, such as maintaining a healthy lifestyle through good nutrition, lower anxiety levels, and noise exposure, different pharmacological appr …
Several attempts have been conducted to investigate preventive and therapeutic strategy/strategies for age-related auditory dysfuncti …
Noise-induced hearing loss in the pre-industrial era: early contributions in De Morbis Artificum by Bernardino Ramazzini (1633-1714).
Paladino ME, Belingheri M, Mazzagatti R, Riva MA. Paladino ME, et al. J Laryngol Otol. 2024 Jan;138(1):7-9. doi: 10.1017/S0022215123001457. Epub 2023 Aug 30. J Laryngol Otol. 2024. PMID: 37646190 Free PMC article. Review.
He further suggested the use of earplugs as a preventive measure for these classes of workers. Ramazzini's anatomical and pathological knowledge appears to be based on ancient authors; he did not discuss contemporaneous medical authors' work on hearing function. ...
He further suggested the use of earplugs as a preventive measure for these classes of workers. Ramazzini's anatomical and pathologica …
Cardiovascular Risk Factors, Cerebral Small Vessel Disease, and Subsequent Risk of Stroke in Patients with Idiopathic Sudden Sensorineural Hearing Loss: Systematic Review and Meta-Analyses of the Current Literature.
Oussoren FK, Schermer TR, van Leeuwen RB, Bruintjes TD. Oussoren FK, et al. Audiol Neurootol. 2024;29(1):1-29. doi: 10.1159/000530686. Epub 2023 Aug 9. Audiol Neurootol. 2024. PMID: 37557093 Free PMC article.
Prospective studies with larger study populations are needed to confirm the associations between generalized cardiovascular disease and iSSNHL and to assess whether these patients benefit from cardiovascular risk management to prevent future cardiovascular and cerebrovascu …
Prospective studies with larger study populations are needed to confirm the associations between generalized cardiovascular disease and iSSN …
Congenital Deafness and Deaf-Mutism: A Historical Perspective.
Cozza A, Di Pasquale Fiasca VM, Martini A. Cozza A, et al. Children (Basel). 2023 Dec 30;11(1):51. doi: 10.3390/children11010051. Children (Basel). 2023. PMID: 38255364 Free PMC article. Review.
Therefore, early detection and prompt treatment are of utmost importance in preventing the unwanted sequel of hearing loss on normal language development. The problem of congenital deafness is today addressed on the one hand with hearing screening at birth, on the other wi …
Therefore, early detection and prompt treatment are of utmost importance in preventing the unwanted sequel of hearing loss on normal …
The Role of Fibrinogen, Homocysteine and Metabolic Syndrome's Alterations in Sudden Sensorineural Hearing Loss (SSHL): A Narrative Review.
Monzani D, Liberale C, Segato E, De Cecco F, Arietti V, Palma S, Sacchetto L, Nocini R. Monzani D, et al. Medicina (Kaunas). 2023 Nov 9;59(11):1977. doi: 10.3390/medicina59111977. Medicina (Kaunas). 2023. PMID: 38004026 Free PMC article. Review.
However, although some studies suggest a possible role for these biomarkers and MetS in the prognosis and treatment of SSHL, specific therapeutic and preventive strategies based solely on these factors have yet to be developed. Given their potential role in prognosis and t …
However, although some studies suggest a possible role for these biomarkers and MetS in the prognosis and treatment of SSHL, specific therap …
NIOSH Hearing Loss Prevention Program for Mining.
Peterson JS, Azman AS. Peterson JS, et al. Semin Hear. 2023 Jun 5;44(4):394-411. doi: 10.1055/s-0043-1769500. eCollection 2023 Nov. Semin Hear. 2023. PMID: 37818149 Free PMC article. Review.
As one of the leading health and safety organizations in the world, the National Institute for Occupational Health and Safety (NIOSH) in Pittsburgh maintains a Hearing Loss Prevention Program (HLPP) to conduct research to reduce NIHL loss among the nation's miners. ...
As one of the leading health and safety organizations in the world, the National Institute for Occupational Health and Safety (NIOSH) in Pit …
Preventing Occupational Hearing Loss: 50 Years of Research and Recommendations from the National Institute for Occupational Safety and Health.
Themann CL, Masterson EA, Peterson JS, Murphy WJ. Themann CL, et al. Semin Hear. 2023 Aug 3;44(4):351-393. doi: 10.1055/s-0043-1769499. eCollection 2023 Nov. Semin Hear. 2023. PMID: 37818146 Free PMC article. Review.
For more than 50 years, the National Institute for Occupational Safety and Health (NIOSH), part of the United States (U.S.) Centers for Disease Control and Prevention (CDC), has been actively working to reduce the effects of noise and ototoxic chemicals on worker hearing. …
For more than 50 years, the National Institute for Occupational Safety and Health (NIOSH), part of the United States (U.S.) Centers for Dise …
Workers' Compensation Costs for Occupational Hearing Loss Claims in the United States, 2009-2013.
Masterson EA, Wurzelbacher SJ, Bushnell PT, Tseng CY. Masterson EA, et al. Semin Hear. 2023 Jun 22;44(4):412-436. doi: 10.1055/s-0043-1769587. eCollection 2023 Nov. Semin Hear. 2023. PMID: 37818144 Free PMC article. Review.
Workers in a wide range of industry/occupation classifications need special attention to prevent OHL....
Workers in a wide range of industry/occupation classifications need special attention to prevent OHL....
Recent advances in genetic etiology of non-syndromic deafness in children.
Feng Y, Hu S, Zhao S, Chen M. Feng Y, et al. Front Neurosci. 2023 Oct 19;17:1282663. doi: 10.3389/fnins.2023.1282663. eCollection 2023. Front Neurosci. 2023. PMID: 37928735 Free PMC article. Review.
The consequences associated with hearing loss among children encompass the decline of verbal communication, linguistic skills, educational progress, social integration, cognitive aptitude, and overall well-being. Approaches to reversing or preventing genetic hearing loss a …
The consequences associated with hearing loss among children encompass the decline of verbal communication, linguistic skills, educational p …
Intratympanic injection of hydrogel nanodrug for the prevention and treatment of sensorineural hearing loss.
Zhai T, Ai P, Tang Z, He C, Chen X, Yang S, Wu N. Zhai T, et al. J Otol. 2023 Oct;18(4):235-239. doi: 10.1016/j.joto.2023.09.005. Epub 2023 Sep 19. J Otol. 2023. PMID: 37877070 Free PMC article. Review.
Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural deafness. The rapid development of nanodrug delivery systems based on hydrogel has provided a new opportunity. ...
Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural deafness. Th …
Deafness: from genetic architecture to gene therapy.
Petit C, Bonnet C, Safieddine S. Petit C, et al. Nat Rev Genet. 2023 Oct;24(10):665-686. doi: 10.1038/s41576-023-00597-7. Epub 2023 May 12. Nat Rev Genet. 2023. PMID: 37173518 Free article. Review.
The application of these approaches in preclinical studies over the past decade has highlighted key translational opportunities and challenges for achieving effective, safe and sustained inner-ear gene therapy to prevent or cure monogenic forms of SNHI and associated balan …
The application of these approaches in preclinical studies over the past decade has highlighted key translational opportunities and challeng …
Endothelial Dysfunction and Metabolic Disorders in Patients with Sudden Sensorineural Hearing Loss.
Cavallaro G, Pantaleo A, Pontillo V, Barbara F, Murri A, Quaranta N. Cavallaro G, et al. Medicina (Kaunas). 2023 Sep 26;59(10):1718. doi: 10.3390/medicina59101718. Medicina (Kaunas). 2023. PMID: 37893435 Free PMC article. Review.
By addressing these variables, we can deepen our comprehension of the mechanisms underlying SSNHL and potentially uncover strategies for prevention....
By addressing these variables, we can deepen our comprehension of the mechanisms underlying SSNHL and potentially uncover strategies for …
Age-related hearing loss and its potential drug candidates: a systematic review.
Hu S, Sun Q, Xu F, Jiang N, Gao J. Hu S, et al. Chin Med. 2023 Sep 20;18(1):121. doi: 10.1186/s13020-023-00825-6. Chin Med. 2023. PMID: 37730634 Free PMC article. Review.
OBJECTIVES: The goal of this review is to systematically evaluate and analyze recent statistics on the pathologic classifications, risk factors, treatment strategies, and drug candidates of ARHL, including that from traditional Chinese medicine (TCM), to provide potential new app …
OBJECTIVES: The goal of this review is to systematically evaluate and analyze recent statistics on the pathologic classifications, risk fact …
Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial.
Lin FR, Pike JR, Albert MS, Arnold M, Burgard S, Chisolm T, Couper D, Deal JA, Goman AM, Glynn NW, Gmelin T, Gravens-Mueller L, Hayden KM, Huang AR, Knopman D, Mitchell CM, Mosley T, Pankow JS, Reed NS, Sanchez V, Schrack JA, Windham BG, Coresh J; ACHIEVE Collaborative Research Group. Lin FR, et al. Lancet. 2023 Sep 2;402(10404):786-797. doi: 10.1016/S0140-6736(23)01406-X. Epub 2023 Jul 18. Lancet. 2023. PMID: 37478886 Free PMC article. Clinical Trial.
Participants were randomly assigned (1:1) to a hearing intervention (audiological counselling and provision of hearing aids) or a control intervention of health education (individual sessions with a health educator covering topics on chronic disease prevention) and followe …
Participants were randomly assigned (1:1) to a hearing intervention (audiological counselling and provision of hearing aids) or a control in …
Association Between Adult-Onset Hearing Loss and Income: A Systematic Review.
Mossman A, DeMario VK, Price C, Seal SM, Willink A, Reed NS, Nieman CL. Mossman A, et al. Ear Hear. 2023 Sep-Oct 01;44(5):931-939. doi: 10.1097/AUD.0000000000001396. Epub 2023 Jul 6. Ear Hear. 2023. PMID: 37417708 Free PMC article.
An aging population and the negative health outcomes associated with hearing loss, emphasize the importance of understanding and addressing the role of social determinants of health in the prevention and management of hearing loss....
An aging population and the negative health outcomes associated with hearing loss, emphasize the importance of understanding and addressing …
Community Perspectives on Hearing Loss in Rural Alaska.
Inglis-Jenson M, Robler SK, Gallo JJ, Ivanoff P, Ryan S, Hofstetter P, Emmett SD. Inglis-Jenson M, et al. Ear Hear. 2023 Sep-Oct 01;44(5):1078-1087. doi: 10.1097/AUD.0000000000001348. Epub 2023 Mar 24. Ear Hear. 2023. PMID: 36939709 Free PMC article. Clinical Trial.
For hearing-related health care in this region, these findings suggest localized recommendations for approaches for prevention and treatment. For community-based hearing research, this study offers an example of how qualitative methods can be used to generate ecologically …
For hearing-related health care in this region, these findings suggest localized recommendations for approaches for prevention and tr …
Progress on mechanisms of age-related hearing loss.
Yang W, Zhao X, Chai R, Fan J. Yang W, et al. Front Neurosci. 2023 Aug 30;17:1253574. doi: 10.3389/fnins.2023.1253574. eCollection 2023. Front Neurosci. 2023. PMID: 37727326 Free PMC article. Review.
The purpose of this review is to illuminate the various mechanisms underlying this age-related hearing loss, with the goal of advancing our understanding, prevention, and treatment of presbycusis....
The purpose of this review is to illuminate the various mechanisms underlying this age-related hearing loss, with the goal of advancing our …
Evidence reviews for preventing otorrhoea after surgery for hearing loss associated with OME in children: Otitis media with effusion in under 12s: Evidence review K.
[No authors listed] [No authors listed] London: National Institute for Health and Care Excellence (NICE); 2023 Aug. London: National Institute for Health and Care Excellence (NICE); 2023 Aug. PMID: 37792988 Free Books & Documents. Review.
The aim of this review is to assess the effectiveness of intraoperative or postoperative interventions at preventing otorrhoea (ear discharge) after surgery for otitis media with effusion (OME)-related hearing loss in children under 12 years. ...
The aim of this review is to assess the effectiveness of intraoperative or postoperative interventions at preventing otorrhoea (ear d …
Congenital Cytomegalovirus and Hearing Loss: The State of the Art.
Aldè M, Binda S, Primache V, Pellegrinelli L, Pariani E, Pregliasco F, Di Berardino F, Cantarella G, Ambrosetti U. Aldè M, et al. J Clin Med. 2023 Jul 3;12(13):4465. doi: 10.3390/jcm12134465. J Clin Med. 2023. PMID: 37445500 Free PMC article. Review.
Currently, there are many controversies regarding the preventive, diagnostic, and therapeutic approaches to cCMV infection. HL secondary to cCMV is highly variable in onset, side, degree, audiometric configuration, and threshold changes over time. ...
Currently, there are many controversies regarding the preventive, diagnostic, and therapeutic approaches to cCMV infection. HL second …
Do hearing loss interventions prevent dementia?
Dawes P, Völter C. Dawes P, et al. Z Gerontol Geriatr. 2023 Jul;56(4):261-268. doi: 10.1007/s00391-023-02178-z. Epub 2023 May 4. Z Gerontol Geriatr. 2023. PMID: 37140632 Free PMC article. Review.
The Pathogenesis of Cytomegalovirus and Other Viruses Associated with Hearing Loss: Recent Updates.
Shi X, Liu X, Sun Y. Shi X, et al. Viruses. 2023 Jun 16;15(6):1385. doi: 10.3390/v15061385. Viruses. 2023. PMID: 37376684 Free PMC article. Review.
We hope to provide a detailed description of pathogenic characteristics and research progress on pathology, hearing phenotypes, possible associated mechanisms, treatment, and prevention measures. This review aims to provide diagnostic and treatment assistance to clinical w …
We hope to provide a detailed description of pathogenic characteristics and research progress on pathology, hearing phenotypes, possible ass …
Various aspects of hearing loss in newborns: A narrative review.
Al-Ani RM. Al-Ani RM. World J Clin Pediatr. 2023 Jun 9;12(3):86-96. doi: 10.5409/wjcp.v12.i3.86. eCollection 2023 Jun 9. World J Clin Pediatr. 2023. PMID: 37342452 Free PMC article. Review.
Therefore, early detection and prompt treatment are of utmost importance in preventing the unwanted sequel of hearing loss. The hearing screening program is mandatory in many nations, especially for high-risk newborns. ...
Therefore, early detection and prompt treatment are of utmost importance in preventing the unwanted sequel of hearing loss. The heari …
Research progress on the treatment and nursing of sensorineural hearing loss.
Liu F, Han B, Zhou X, Huang S, Huang J. Liu F, et al. Front Neurosci. 2023 Jun 6;17:1199946. doi: 10.3389/fnins.2023.1199946. eCollection 2023. Front Neurosci. 2023. PMID: 37346087 Free PMC article. Review.
In addition, there is a need for health education programs for the general public to raise awareness of SNHL and promote preventive measures to reduce its incidence. The ultimate goal is to ensure the sustainable development of the field of SNHL treatment and care, thus en …
In addition, there is a need for health education programs for the general public to raise awareness of SNHL and promote preventive m …
Research progress in delineating the pathological mechanisms of GJB2-related hearing loss.
Wang Y, Jin Y, Zhang Q, Xiong Y, Gu X, Zeng S, Chen W. Wang Y, et al. Front Cell Neurosci. 2023 Jun 2;17:1208406. doi: 10.3389/fncel.2023.1208406. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37333892 Free PMC article. Review.
Clarifying the pathological mechanism of GJB2-related hearing loss can help develop new prevention and treatment strategies....
Clarifying the pathological mechanism of GJB2-related hearing loss can help develop new prevention and treatment strategies....
Hearing Loss Diagnosis and Management in Adults with Intellectual and Developmental Disabilities.
Danyluk A, Jacob R. Danyluk A, et al. Adv Med. 2023 May 21;2023:6825476. doi: 10.1155/2023/6825476. eCollection 2023. Adv Med. 2023. PMID: 37251596 Free PMC article. Review.
Hearing loss is a common concern in patients with intellectual and developmental disabilities (IDD), and early detection and intervention are crucial to prevent negative impacts on communication, cognition, socialization, safety, and mental health. ...
Hearing loss is a common concern in patients with intellectual and developmental disabilities (IDD), and early detection and intervention ar …
Cisplatin-Induced Ototoxicity: A Concise Review of the Burden, Prevention, and Interception Strategies.
Chattaraj A, Syed MP, Low CA, Owonikoko TK. Chattaraj A, et al. JCO Oncol Pract. 2023 May;19(5):278-283. doi: 10.1200/OP.22.00710. Epub 2023 Mar 15. JCO Oncol Pract. 2023. PMID: 36921239 Free PMC article. Review.
A considerable evidence gap persists regarding the burden and effective prevention and interception strategies for cisplatin-induced ototoxicity, especially in adult patients with cancer. ...
A considerable evidence gap persists regarding the burden and effective prevention and interception strategies for cisplatin-induced …
Prevalence of hearing loss in children living in low- and middle-income countries over the last 10 years: A systematic review.
Ganek HV, Madubueze A, Merritt CE, Bhutta ZA. Ganek HV, et al. Dev Med Child Neurol. 2023 May;65(5):600-610. doi: 10.1111/dmcn.15460. Epub 2022 Nov 17. Dev Med Child Neurol. 2023. PMID: 36397253 Free article.
This systematic review is an initial step toward developing and implementing population-appropriate treatment and prevention programs for childhood hearing loss in LMICs. WHAT THIS PAPER ADDS: The prevalence of childhood hearing loss in low- and middle-income countries is …
This systematic review is an initial step toward developing and implementing population-appropriate treatment and prevention programs …
Occupational noise exposure at sea: A socio-legal study on fish harvesters' perceptions in Newfoundland and Labrador, Canada.
Yadav OP, Shan D, Sarkar A, Moro L. Yadav OP, et al. Front Public Health. 2023 Apr 17;11:1092350. doi: 10.3389/fpubh.2023.1092350. eCollection 2023. Front Public Health. 2023. PMID: 37139364 Free PMC article. Review.
METHODS: A review of legislation and policies governing workplace noise exposure, as well as qualitative, semi-structured interviews, were conducted to assess how fish harvesters in Newfoundland and Labrador (NL) manage onboard occupational noise exposure and perceive noise-induc …
METHODS: A review of legislation and policies governing workplace noise exposure, as well as qualitative, semi-structured interviews, were c …
Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic.
Pisani A, Paciello F, Montuoro R, Rolesi R, Galli J, Fetoni AR. Pisani A, et al. Life (Basel). 2023 Apr 17;13(4):1035. doi: 10.3390/life13041035. Life (Basel). 2023. PMID: 37109564 Free PMC article. Review.
For this reason, several studies focused on the possibility to use exogenous antioxidant to prevent or attenuate noise-induce injury. Thus, several antioxidant molecules, alone or in combination with other compounds, have been tested in both experimental and clinical setti …
For this reason, several studies focused on the possibility to use exogenous antioxidant to prevent or attenuate noise-induce injury. …
The Effect of Noise Exposure on High-Frequency Hearing Loss among Chinese Workers: A Meta-Analysis.
Yang P, Xie H, Li Y, Jin K. Yang P, et al. Healthcare (Basel). 2023 Apr 10;11(8):1079. doi: 10.3390/healthcare11081079. Healthcare (Basel). 2023. PMID: 37107914 Free PMC article. Review.
This study suggests that the detection rate of HFNIHL is high in Chinese workers, the risk of HFNIHL increases rapidly when CNE reaches 90 dB(A).year, and the first 15 years of exposure to noise is a period of increasing risk. Therefore, reasonable measures for preventing …
This study suggests that the detection rate of HFNIHL is high in Chinese workers, the risk of HFNIHL increases rapidly when CNE reaches 90 d …
A Narrative Review of Lifestyle Risk Factors and the Role of Oxidative Stress in Age-Related Hearing Loss.
Tang D, Tran Y, Dawes P, Gopinath B. Tang D, et al. Antioxidants (Basel). 2023 Apr 4;12(4):878. doi: 10.3390/antiox12040878. Antioxidants (Basel). 2023. PMID: 37107253 Free PMC article. Review.
By addressing modifiable lifestyle risk factors that exacerbate oxidative stress, there may be an opportunity to prevent hearing loss. Therefore, this narrative review provides an overview of the major modifiable lifestyle risk factors associated with age-related hearing l …
By addressing modifiable lifestyle risk factors that exacerbate oxidative stress, there may be an opportunity to prevent hearing loss …
Mitochondrial redox system: A key target of antioxidant therapy to prevent acquired sensorineural hearing loss.
Baek JI, Kim YR, Lee KY, Kim UK. Baek JI, et al. Front Pharmacol. 2023 Mar 31;14:1176881. doi: 10.3389/fphar.2023.1176881. eCollection 2023. Front Pharmacol. 2023. PMID: 37063286 Free PMC article. Review.
In this review, we will discuss the scientific possibility of developing drugs that target particular key elements of the mitochondrial redox network in prevention or treatment of noise- and ototoxic drug-induced hearing loss....
In this review, we will discuss the scientific possibility of developing drugs that target particular key elements of the mitochondrial redo …
Noise-Induced Hearing Loss.
Natarajan N, Batts S, Stankovic KM. Natarajan N, et al. J Clin Med. 2023 Mar 17;12(6):2347. doi: 10.3390/jcm12062347. J Clin Med. 2023. PMID: 36983347 Free PMC article. Review.
Essential aspects of decreasing the burden of NIHL are prevention and early detection, such as implementation of educational and screening programs in routine primary care and specialty clinics. ...Future directions should include personalized prevention and targete …
Essential aspects of decreasing the burden of NIHL are prevention and early detection, such as implementation of educational and scre …
Ototoxicity of Long-Term alpha-Difluoromethylornithine for Skin Cancer Prevention.
Chow CL, Havighurst T, Lozar T, Jones TD, Kim K, Bailey HH. Chow CL, et al. Laryngoscope. 2023 Mar;133(3):676-682. doi: 10.1002/lary.30231. Epub 2022 May 27. Laryngoscope. 2023. PMID: 35620919 Free PMC article. Clinical Trial.
CONCLUSIONS: This randomized controlled trial revealed the presence of increased hearing thresholds associated with long-term DFMO use. As a whole, DFMO may help prevent and treat certain types of cancers; however, it can result in some degree of hearing loss even when adm …
CONCLUSIONS: This randomized controlled trial revealed the presence of increased hearing thresholds associated with long-term DFMO use. As a …
Occupational Noise-Induced Hearing Loss in Iran: A Systematic Review and Meta-Analysis.
Etemadinezhad S, Sammak Amani A, Moosazadeh M, Rahimlou M, Samaei SE. Etemadinezhad S, et al. Iran J Public Health. 2023 Feb;52(2):278-289. doi: 10.18502/ijph.v52i2.11881. Iran J Public Health. 2023. PMID: 37089160 Free PMC article. Review.
The results also highlighted the urgent need for taking appropriate preventive and control measures in the work-places; particularly by encouraging the employers and health-related policymakers to focus on preventive noise control techniques along with administrativ …
The results also highlighted the urgent need for taking appropriate preventive and control measures in the work-places; particularly …
Redox Imbalance as a Common Pathogenic Factor Linking Hearing Loss and Cognitive Decline.
Paciello F, Ripoli C, Fetoni AR, Grassi C. Paciello F, et al. Antioxidants (Basel). 2023 Jan 31;12(2):332. doi: 10.3390/antiox12020332. Antioxidants (Basel). 2023. PMID: 36829891 Free PMC article. Review.
As such, antioxidant therapy seems to be a promising approach to prevent and/or counteract both sensory and cognitive neurodegeneration. Here, we review experimental evidence suggesting that redox imbalance is a key pathogenetic factor underlying the association between se …
As such, antioxidant therapy seems to be a promising approach to prevent and/or counteract both sensory and cognitive neurodegenerati …
Alcohol as a risk factor for hearing loss: A systematic review and meta-analysis.
Qian P, Zhao Z, Liu S, Xin J, Liu Y, Hao Y, Wang Y, Yang L. Qian P, et al. PLoS One. 2023 Jan 20;18(1):e0280641. doi: 10.1371/journal.pone.0280641. eCollection 2023. PLoS One. 2023. PMID: 36662896 Free PMC article.
Drinking limitations may be useful for preventing hearing loss....
Drinking limitations may be useful for preventing hearing loss....
Environmental Factors for Hearing Loss and Middle Ear Disease in Alaska Native Children and Adolescents: A Cross-Sectional Analysis from a Cluster Randomized Trial.
Hicks KL, Robler SK, Platt A, Morton SN, Egger JR, Emmett SD. Hicks KL, et al. Ear Hear. 2023 Jan-Feb 01;44(1):2-9. doi: 10.1097/AUD.0000000000001265. Epub 2022 Aug 23. Ear Hear. 2023. PMID: 35998103 Free PMC article. Clinical Trial.
OBJECTIVES: Infection-related childhood hearing loss is one of the few preventable chronic health conditions that can affect a child's lifelong trajectory. This study sought to quantify relationships between infection-mediated hearing loss and middle ear disease and enviro …
OBJECTIVES: Infection-related childhood hearing loss is one of the few preventable chronic health conditions that can affect a child' …
The ubiquitin-proteasome system in normal hearing and deafness.
Pouyo R, Chung K, Delacroix L, Malgrange B. Pouyo R, et al. Hear Res. 2022 Dec;426:108366. doi: 10.1016/j.heares.2021.108366. Epub 2021 Sep 29. Hear Res. 2022. PMID: 34645583 Free article. Review.
The most common outcome of protein ubiquitination is degradation by the ubiquitin-proteasome system (UPS), preventing the accumulation of misfolded, damaged, and excess proteins. In addition to proteasomal degradation, ubiquitination regulates other cellular processes, suc …
The most common outcome of protein ubiquitination is degradation by the ubiquitin-proteasome system (UPS), preventing the accumulatio …
Linking Cerebrovascular Dysfunction to Age-Related Hearing Loss and Alzheimer's Disease-Are Systemic Approaches for Diagnosis and Therapy Required?
Förster CY, Shityakov S, Scheper V, Lenarz T. Förster CY, et al. Biomolecules. 2022 Nov 19;12(11):1717. doi: 10.3390/biom12111717. Biomolecules. 2022. PMID: 36421731 Free PMC article. Review.
Finally, there are options for the treatment of ARHL by targeted neurotrophic factor supplementation to the cochlea to improve cognitive outcomes; they can also prevent AD development and AD-related comorbidity in the future....
Finally, there are options for the treatment of ARHL by targeted neurotrophic factor supplementation to the cochlea to improve cognitive out …
Clinical Features and Prognosis of Facial Palsy and Hearing Loss in Patients With Ramsay Hunt Syndrome.
Malhotra R, Mudey A, Agrawal I. Malhotra R, et al. Cureus. 2022 Oct 31;14(10):e30897. doi: 10.7759/cureus.30897. eCollection 2022 Oct. Cureus. 2022. PMID: 36465761 Free PMC article. Review.
Early diagnosis and treatment go a long way in preventing these complications and increasing the chances of complete recovery. Treatment options most commonly studied included antiviral drugs such as acyclovir, steroids, and anti-inflammatory agents....
Early diagnosis and treatment go a long way in preventing these complications and increasing the chances of complete recovery. Treatm …
Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets.
Zou T, Ye B, Chen K, Zhang A, Guo D, Pan Y, Ding R, Hu H, Sun X, Xiang M. Zou T, et al. Front Neurosci. 2022 Oct 5;16:998507. doi: 10.3389/fnins.2022.998507. eCollection 2022. Front Neurosci. 2022. PMID: 36278017 Free PMC article. Review.
The impacts of impaired mitochondrial dynamics on hearing loss are discussed, and the potential of mitochondrial dynamics for the prevention and treatment of hearing loss is considered....
The impacts of impaired mitochondrial dynamics on hearing loss are discussed, and the potential of mitochondrial dynamics for the prevent …
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