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Page 1
Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome.
Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Zhang H, Ma N, Wei Y, Stewart M, Lee S, Moonen JR, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson TJ, Nie S, Wu SM, Gu M. Miao Y, et al. Cell Stem Cell. 2020 Oct 1;27(4):574-589.e8. doi: 10.1016/j.stem.2020.07.015. Epub 2020 Aug 17. Cell Stem Cell. 2020. PMID: 32810435 Free PMC article.
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized by abnormalities in the left ventricle, associated valves, and ascending aorta. ...Here, we identify a developmentally impaired endocardial populat …
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized by abnormaliti …
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.
Schneider JW, Oommen S, Qureshi MY, Goetsch SC, Pease DR, Sundsbak RS, Guo W, Sun M, Sun H, Kuroyanagi H, Webster DA, Coutts AW, Holst KA, Edwards BS, Newville N, Hathcock MA, Melkamu T, Briganti F, Wei W, Romanelli MG, Fahrenkrug SC, Frantz DE, Olson TM, Steinmetz LM, Carlson DF, Nelson TJ; Wanek Program Preclinical Pipeline. Schneider JW, et al. Nat Med. 2020 Nov;26(11):1788-1800. doi: 10.1038/s41591-020-1087-x. Epub 2020 Nov 13. Nat Med. 2020. PMID: 33188278 Free PMC article.
Dysregulated RNP granules drive neuromuscular degenerative disease but have not previously been linked to heart failure. By exploring the molecular basis of congenital dilated cardiomyopathy (DCM) in genome-edited pigs homozygous for an RBM20 allele encoding the pathogenic …
Dysregulated RNP granules drive neuromuscular degenerative disease but have not previously been linked to heart failure. By exploring …
Hypoplastic left heart syndrome: From bedside to bench and back.
Saraf A, Book WM, Nelson TJ, Xu C. Saraf A, et al. J Mol Cell Cardiol. 2019 Oct;135:109-118. doi: 10.1016/j.yjmcc.2019.08.005. Epub 2019 Aug 13. J Mol Cell Cardiol. 2019. PMID: 31419439 Free PMC article. Review.
Hypoplastic Left Heart Syndrome (HLHS) is a complex Congenital Heart Disease (CHD) that was almost universally fatal until the advent of the Norwood operation in 1981. ...In this review we (a) discuss current clinical challenges associated in th …
Hypoplastic Left Heart Syndrome (HLHS) is a complex Congenital Heart Disease (CHD) that was almost univer …
Hypoplastic left heart syndrome: What's next?
Burkhart HM, Thompson JL, Nelson TJ. Burkhart HM, et al. J Thorac Cardiovasc Surg. 2016 Apr;151(4):909-10. doi: 10.1016/j.jtcvs.2015.12.032. Epub 2015 Dec 22. J Thorac Cardiovasc Surg. 2016. PMID: 26806478 Free article. No abstract available.
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity.
Birker K, Ge S, Kirkland NJ, Theis JL, Marchant J, Fogarty ZC, Missinato MA, Kalvakuri S, Grossfeld P, Engler AJ, Ocorr K, Nelson TJ, Colas AR, Olson TM, Vogler G, Bodmer R. Birker K, et al. Elife. 2023 Jul 5;12:e83385. doi: 10.7554/eLife.83385. Elife. 2023. PMID: 37404133 Free PMC article.
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. ...Of them, cardiac-spec …
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogeni …
Hypoplastic Left Heart Syndrome: An Overview for Primary Care Providers.
Javed R, Cetta F, Said SM, Olson TM, O'Leary PW, Qureshi MY. Javed R, et al. Pediatr Rev. 2019 Jul;40(7):344-353. doi: 10.1542/pir.2018-0005. Pediatr Rev. 2019. PMID: 31263042 Review.
Hypoplastic left heart syndrome is one of the most complex congenital heart diseases and requires several cardiac surgeries for survival. ...
Hypoplastic left heart syndrome is one of the most complex congenital heart diseases and requires several …
Whole Genome Sequencing in Hypoplastic Left Heart Syndrome.
Theis JL, Olson TM. Theis JL, et al. J Cardiovasc Dev Dis. 2022 Apr 15;9(4):117. doi: 10.3390/jcdd9040117. J Cardiovasc Dev Dis. 2022. PMID: 35448093 Free PMC article.
Hypoplastic left heart syndrome (HLHS) is a genetically complex disorder. Whole genome sequencing enables comprehensive scrutiny of single nucleotide variants and small insertions/deletions, within both coding and regulatory regions of the genome, revo …
Hypoplastic left heart syndrome (HLHS) is a genetically complex disorder. Whole genome sequencing enables compre …
Genetic Association Between Hypoplastic Left Heart Syndrome and Cardiomyopathies.
Theis JL, Hu JJ, Sundsbak RS, Evans JM, Bamlet WR, Qureshi MY, O'Leary PW, Olson TM. Theis JL, et al. Circ Genom Precis Med. 2021 Feb;14(1):e003126. doi: 10.1161/CIRCGEN.120.003126. Epub 2020 Dec 16. Circ Genom Precis Med. 2021. PMID: 33325730
BACKGROUND: Hypoplastic left heart syndrome (HLHS) with risk of poor outcome has been linked to MYH6 variants, implicating overlap in genetic etiologies of structural and myopathic heart disease. ...RESULTS: A pathogenic MYBPC3 nonsense variant …
BACKGROUND: Hypoplastic left heart syndrome (HLHS) with risk of poor outcome has been linked to MYH6 variants, i …
Clinical Presentation and Therapy of Hypoplastic Left Heart Syndrome.
Haas NA, Driscoll DJ, Rickert-Sperling S. Haas NA, et al. Adv Exp Med Biol. 2024;1441:931-936. doi: 10.1007/978-3-031-44087-8_59. Adv Exp Med Biol. 2024. PMID: 38884761
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart defect characterized by several abnormalities that result in a significantly underdeveloped left ventricle and severe hypoplasia of the ascending aorta, often leading to …
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart defect characterized by several abno …
Stem Cell Therapy and Congenital Heart Disease.
Nelson TJ, Cantero Peral S. Nelson TJ, et al. J Cardiovasc Dev Dis. 2016 Jul 5;3(3):24. doi: 10.3390/jcdd3030024. J Cardiovasc Dev Dis. 2016. PMID: 29367570 Free PMC article. Review.
For more than a decade, stem cell therapy has been the focus of intensive efforts for the treatment of adult heart disease, and now has promise for treating the pediatric population. On the basis of encouraging results in the adult field, the application of stem cell-based …
For more than a decade, stem cell therapy has been the focus of intensive efforts for the treatment of adult heart disease, and now h …
75 results