In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes.
Science. 2020 Nov 27;370(6520):eaaz6063. doi: 10.1126/science.aaz6063.
Science. 2020.
PMID: 33243861
Free PMC article.
We applied a scalable genetic screening approach, in vivo Perturb-Seq, to functionally evaluate 35 autism spectrum disorder/neurodevelopmental delay (ASD/ND) de novo loss-of-function risk genes. Using CRISPR-Cas9, we introduced frameshift mutations in these risk gen …
We applied a scalable genetic screening approach, in vivo Perturb-Seq, to functionally evaluate 35 autism spectrum disorder/ne …