Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2002 2
2004 1
2005 1
2006 3
2007 5
2008 7
2009 10
2010 8
2011 30
2012 32
2013 52
2014 47
2015 82
2016 93
2017 93
2018 108
2019 122
2020 159
2021 137
2022 125
2023 126
2024 47

Text availability

Article attribute

Article type

Publication date

Search Results

1,132 results

Results by year

Filters applied: . Clear all
Page 1
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.
Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C; Autism Sequencing Consortium; iPSYCH-Broad Consortium; Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Børglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD. Satterstrom FK, et al. Cell. 2020 Feb 6;180(3):568-584.e23. doi: 10.1016/j.cell.2019.12.036. Epub 2020 Jan 23. Cell. 2020. PMID: 31981491 Free PMC article.
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with ASD). ...Expressed early in brain development, most risk genes have roles in regulation of gene expression or neuronal communication (i.e., …
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with …
Brain Organoids and the Study of Neurodevelopment.
Trujillo CA, Muotri AR. Trujillo CA, et al. Trends Mol Med. 2018 Dec;24(12):982-990. doi: 10.1016/j.molmed.2018.09.005. Epub 2018 Oct 28. Trends Mol Med. 2018. PMID: 30377071 Free PMC article. Review.
Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular organization and transcriptional and epigenetic signature of a developing human brain. Advancements using brain organoids have been made to el …
Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular or …
Single-cell brain organoid screening identifies developmental defects in autism.
Li C, Fleck JS, Martins-Costa C, Burkard TR, Themann J, Stuempflen M, Peer AM, Vertesy Á, Littleboy JB, Esk C, Elling U, Kasprian G, Corsini NS, Treutlein B, Knoblich JA. Li C, et al. Nature. 2023 Sep;621(7978):373-380. doi: 10.1038/s41586-023-06473-y. Epub 2023 Sep 13. Nature. 2023. PMID: 37704762 Free PMC article.
We construct a developmental gene regulatory network of cerebral organoids from single-cell transcriptomes and chromatin modalities and identify autism spectrum disorder-associated and perturbation-enriched regulatory modules. ...Specifically, mutating the BAF subun …
We construct a developmental gene regulatory network of cerebral organoids from single-cell transcriptomes and chromatin modalities and iden …
Stem Cell-Based Organoid Models of Neurodevelopmental Disorders.
Wang L, Owusu-Hammond C, Sievert D, Gleeson JG. Wang L, et al. Biol Psychiatry. 2023 Apr 1;93(7):622-631. doi: 10.1016/j.biopsych.2023.01.012. Epub 2023 Jan 24. Biol Psychiatry. 2023. PMID: 36759260 Free PMC article. Review.
These discoveries provide opportunities to understand cellular and molecular mechanisms as well as potential gene-gene and gene-environment interactions to support novel therapies. Stem cell-based models, particularly human brain organoids, can capture disease-associated a …
These discoveries provide opportunities to understand cellular and molecular mechanisms as well as potential gene-gene and gene-environment …
Maturation and circuit integration of transplanted human cortical organoids.
Revah O, Gore F, Kelley KW, Andersen J, Sakai N, Chen X, Li MY, Birey F, Yang X, Saw NL, Baker SW, Amin ND, Kulkarni S, Mudipalli R, Cui B, Nishino S, Grant GA, Knowles JK, Shamloo M, Huguenard JR, Deisseroth K, Pașca SP. Revah O, et al. Nature. 2022 Oct;610(7931):319-326. doi: 10.1038/s41586-022-05277-w. Epub 2022 Oct 12. Nature. 2022. PMID: 36224417 Free PMC article.
MRI reveals post-transplantation organoid growth across multiple stem cell lines and animals, whereas single-nucleus profiling shows progression of corticogenesis and the emergence of activity-dependent transcriptional programs. ...We anticipate that this approach will be …
MRI reveals post-transplantation organoid growth across multiple stem cell lines and animals, whereas single-nucleus profiling shows …
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes.
Jin X, Simmons SK, Guo A, Shetty AS, Ko M, Nguyen L, Jokhi V, Robinson E, Oyler P, Curry N, Deangeli G, Lodato S, Levin JZ, Regev A, Zhang F, Arlotta P. Jin X, et al. Science. 2020 Nov 27;370(6520):eaaz6063. doi: 10.1126/science.aaz6063. Science. 2020. PMID: 33243861 Free PMC article.
We applied a scalable genetic screening approach, in vivo Perturb-Seq, to functionally evaluate 35 autism spectrum disorder/neurodevelopmental delay (ASD/ND) de novo loss-of-function risk genes. Using CRISPR-Cas9, we introduced frameshift mutations in these risk gen …
We applied a scalable genetic screening approach, in vivo Perturb-Seq, to functionally evaluate 35 autism spectrum disorder/ne …
Assembly of functionally integrated human forebrain spheroids.
Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O'Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Paşca SP. Birey F, et al. Nature. 2017 May 4;545(7652):54-59. doi: 10.1038/nature22330. Epub 2017 Apr 26. Nature. 2017. PMID: 28445465 Free PMC article.
However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids from human pluripotent stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GA …
However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids f …
Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids.
Costamagna G, Comi GP, Corti S. Costamagna G, et al. Int J Mol Sci. 2021 Mar 6;22(5):2659. doi: 10.3390/ijms22052659. Int J Mol Sci. 2021. PMID: 33800815 Free PMC article. Review.
In the last decade, different research groups in the academic setting have developed induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular, neural organoids. Their use to model brain biology, early neural development, and human diseases …
In the last decade, different research groups in the academic setting have developed induced pluripotent stem cell-based protocols to …
Stem Cell Therapy in the Treatment of Patients With Autism Spectrum Disorder: a Systematic Review and Meta-analysis.
Villarreal-Martínez L, González-Martínez G, Sáenz-Flores M, Bautista-Gómez AJ, González-Martínez A, Ortiz-Castillo M, Robles-Sáenz DA, Garza-López E. Villarreal-Martínez L, et al. Stem Cell Rev Rep. 2022 Jan;18(1):155-164. doi: 10.1007/s12015-021-10257-0. Epub 2021 Sep 13. Stem Cell Rev Rep. 2022. PMID: 34515938 Review.
OBJECTIVE: Assess the safety and efficacy of upcoming stem cell treatments and analyze their effects on the cognitive and behavioral impairments in patients diagnosed with autism. METHODS: We included controlled and noncontrolled, randomized and non-randomized trial …
OBJECTIVE: Assess the safety and efficacy of upcoming stem cell treatments and analyze their effects on the cognitive and behavioral …
Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism.
D'Incal CP, Van Rossem KE, De Man K, Konings A, Van Dijck A, Rizzuti L, Vitriolo A, Testa G, Gozes I, Vanden Berghe W, Kooy RF. D'Incal CP, et al. Clin Epigenetics. 2023 Mar 21;15(1):45. doi: 10.1186/s13148-023-01450-8. Clin Epigenetics. 2023. PMID: 36945042 Free PMC article. Review.
BACKGROUND: Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. ...ADNP, a zinc finger DNA-binding protein has a role in chromatin remodeling: The protein is associated with the pericentromeric protein HP1, the SWI/SNF c …
BACKGROUND: Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. ...ADNP, a zinc …
1,132 results