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Year Number of Results
1998 1
2002 2
2004 1
2005 1
2006 3
2007 5
2008 7
2009 10
2010 8
2011 30
2012 32
2013 52
2014 46
2015 82
2016 93
2017 93
2018 108
2019 121
2020 123
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720 results
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Page 1
Brain Organoids and the Study of Neurodevelopment.
Trujillo CA, Muotri AR. Trujillo CA, et al. Trends Mol Med. 2018 Dec;24(12):982-990. doi: 10.1016/j.molmed.2018.09.005. Epub 2018 Oct 28. Trends Mol Med. 2018. PMID: 30377071 Free PMC article. Review.
Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular organization and transcriptional and epigenetic signature of a developing human brain. Advancements using brain organoids have been made to el …
Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular or …
3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders.
Lee CT, Bendriem RM, Wu WW, Shen RF. Lee CT, et al. J Biomed Sci. 2017 Aug 20;24(1):59. doi: 10.1186/s12929-017-0362-8. J Biomed Sci. 2017. PMID: 28822354 Free PMC article. Review.
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain's 3D cytoarchitectural arrangemen …
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem c
Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation.
Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, Wang X, Doré LC, Jin P, Regot S, Zhuang X, Canzar S, He C, Ming GL, Song H. Yoon KJ, et al. Cell. 2017 Nov 2;171(4):877-889.e17. doi: 10.1016/j.cell.2017.09.003. Epub 2017 Sep 28. Cell. 2017. PMID: 28965759 Free PMC article.
Here, we show that m(6)A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis into postnatal stages. m(6)A depletion by Mettl3 knockdown also leads to a prolonged cell cycle and maintenance o …
Here, we show that m(6)A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and ext …
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.
Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C; Autism Sequencing Consortium; iPSYCH-Broad Consortium, Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Børglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD. Satterstrom FK, et al. Cell. 2020 Feb 6;180(3):568-584.e23. doi: 10.1016/j.cell.2019.12.036. Epub 2020 Jan 23. Cell. 2020. PMID: 31981491 Free article.
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with ASD). ...Expressed early in brain development, most risk genes have roles in regulation of gene expression or neuronal communication (i.e., …
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with …
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders.
Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. Mariani J, et al. Cell. 2015 Jul 16;162(2):375-390. doi: 10.1016/j.cell.2015.06.034. Cell. 2015. PMID: 26186191 Free PMC article.
Autism spectrum disorder (ASD) is a disorder of brain development. ...Here we use three-dimensional neural cultures (organoids) derived from induced pluripotent stem cells (iPSCs) to investigate neurodevelopmental alterations in individuals with
Autism spectrum disorder (ASD) is a disorder of brain development. ...Here we use three-dimensional neural cultures (or
Beneficial action of resveratrol: How and why?
Diaz-Gerevini GT, Repossi G, Dain A, Tarres MC, Das UN, Eynard AR. Diaz-Gerevini GT, et al. Nutrition. 2016 Feb;32(2):174-8. doi: 10.1016/j.nut.2015.08.017. Epub 2015 Sep 25. Nutrition. 2016. PMID: 26706021 Review.
Brain-derived neurotrophic factor (BDNF) that is involved in the pathogenesis of obesity, type 2 diabetes mellitus, and metabolic syndrome is also altered in depression, schizophrenia, bipolar disorder, and autism. We noted that BDNF protects against cytotoxic actio …
Brain-derived neurotrophic factor (BDNF) that is involved in the pathogenesis of obesity, type 2 diabetes mellitus, and metabolic syndrome i …
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.
Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. Marchetto MC, et al. Mol Psychiatry. 2017 Jun;22(6):820-835. doi: 10.1038/mp.2016.95. Epub 2016 Jul 5. Mol Psychiatry. 2017. PMID: 27378147 Free PMC article.
Autism spectrum disorders (ASD) are common, complex and heterogeneous neurodevelopmental disorders. ...Here, we reprogrammed fibroblasts to generate induced pluripotent stem cells, neural progenitor cells (NPCs) and neurons from ASD individuals with ea
Autism spectrum disorders (ASD) are common, complex and heterogeneous neurodevelopmental disorders. ...Here, we reprogrammed fibrobla
Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.
Fiddes IT, Lodewijk GA, Mooring M, Bosworth CM, Ewing AD, Mantalas GL, Novak AM, van den Bout A, Bishara A, Rosenkrantz JL, Lorig-Roach R, Field AR, Haeussler M, Russo L, Bhaduri A, Nowakowski TJ, Pollen AA, Dougherty ML, Nuttle X, Addor MC, Zwolinski S, Katzman S, Kriegstein A, Eichler EE, Salama SR, Jacobs FMJ, Haussler D. Fiddes IT, et al. Cell. 2018 May 31;173(6):1356-1369.e22. doi: 10.1016/j.cell.2018.03.051. Epub 2018 May 31. Cell. 2018. PMID: 29856954 Free PMC article.
Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and is a determinant of neuronal number in the mammalian cortex. ...Furthermore, NOTCH2NL genes provide the breakpoin …
Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem
Assembly of functionally integrated human forebrain spheroids.
Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O'Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Paşca SP. Birey F, et al. Nature. 2017 May 4;545(7652):54-59. doi: 10.1038/nature22330. Epub 2017 Apr 26. Nature. 2017. PMID: 28445465 Free PMC article.
However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids from human pluripotent stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GA …
However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids f …
The fetal origins of mental illness.
Al-Haddad BJS, Oler E, Armistead B, Elsayed NA, Weinberger DR, Bernier R, Burd I, Kapur R, Jacobsson B, Wang C, Mysorekar I, Rajagopal L, Adams Waldorf KM. Al-Haddad BJS, et al. Am J Obstet Gynecol. 2019 Dec;221(6):549-562. doi: 10.1016/j.ajog.2019.06.013. Epub 2019 Jun 15. Am J Obstet Gynecol. 2019. PMID: 31207234 Review.
Since then, evidence suggests that a range of infections during pregnancy may also increase risk for autism spectrum disorder and depression in the child. Subsequent studies in animal models demonstrated that both pregnancy infections and inflammation can result in …
Since then, evidence suggests that a range of infections during pregnancy may also increase risk for autism spectrum disorder
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